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  1. Article: Safeguarding equitable HIV service delivery at the health facility-level in a resource-limited setting during the pandemic.

    Tactacan-Abrenica, Rosario Jessica / Almonte, Dennis Gregg / Agrupis, Kristal An / Malijan, Greco Mark / Suzuki, Shuichi / Dela Cruz, Ralph / Valdez, Rich King / Arcangel, Lalaine / Ariyoshi, Koya / Smith, Chris

    Tropical medicine and health

    2022  Volume 50, Issue 1, Page(s) 48

    Abstract: The COVID-19 pandemic had a severe impact on delivering essential health services, including HIV service delivery. Among the challenges encountered and addressed by the HIV and AIDS Department of the San Lazaro Hospital were ensuring continued access to ... ...

    Abstract The COVID-19 pandemic had a severe impact on delivering essential health services, including HIV service delivery. Among the challenges encountered and addressed by the HIV and AIDS Department of the San Lazaro Hospital were ensuring continued access to antiretroviral therapy and ensuring continuity of client education and empowerment. Two years into the pandemic, challenges still ensue, such as protecting health care providers from COVID-19 and regular clinical monitoring of clients. This highlights the importance of urgent action to strengthen the resilience of health systems at all its levels, not only to respond to sudden disturbances, but also to transform and evolve to be able to better face future pandemics.
    Language English
    Publishing date 2022-07-22
    Publishing country Japan
    Document type Letter
    ZDB-ID 2209835-5
    ISSN 1349-4147 ; 1348-8945
    ISSN (online) 1349-4147
    ISSN 1348-8945
    DOI 10.1186/s41182-022-00441-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: HIV-1 Subtype Shift in the Philippines is Associated With High Transmitted Drug Resistance, High Viral Loads, and Fast Immunologic Decline.

    Salvaña, Edsel Maurice T / Dungca, Niña Theresa / Arevalo, Geraldine / Li, Kingbherly / Francisco, Christian / Penalosa, Christine / Dela Tonga, Angelo / Leyritana, Katerina / Solante, Rontgene / Tactacan-Abrenica, Rosario Jessica / Lim, Jodor / Alejandria, Marissa / Palaypayon, Noel / Schwem, Brian

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 122, Page(s) 936–943

    Abstract: Objectives: The Philippines has one of the fastest growing HIV epidemics in the world. A subtype shift from B to CRF01_AE may have contributed to the increase in cases. We undertook a genotyping and transmitted drug resistance (TDR) study to determine ... ...

    Abstract Objectives: The Philippines has one of the fastest growing HIV epidemics in the world. A subtype shift from B to CRF01_AE may have contributed to the increase in cases. We undertook a genotyping and transmitted drug resistance (TDR) study to determine if the dominant subtype has any advantages in resistance and transmission.
    Methods: Filipinos who were treatment-naive who were living with HIV were recruited from two large government treatment hubs from March 2016 to August 2018. HIV-1 viral load, CD4 count, genotyping, and TDR testing were performed. Demographic and clinical data were collected and compared across subtypes.
    Results: A total of 298 Filipinos living with HIV were recruited. Median CD4 count was 143 cells/µl and HIV viral load was 2,345,431 copies/ml. Sanger-based sequencing showed 230/298 (77.2%) had subtype CRF01_AE, 41 (13.8%) subtype B, and the rest had other subtypes or recombinants. Overall TDR was 11.7%. TDR was associated with lower viral loads and no previous HIV testing. CRF01_AE had a higher likelihood of a viral load >100,000 copies/ml and having a baseline CD4 count <50 cells/mm
    Conclusion: TDR in the Philippines is high at 11.7%. CRF01_AE was observed to have a higher baseline viral load and lower CD4 counts compared with other cocirculating subtypes. Further research needs to confirm this observation because it suggests that CRF01_AE may have a survival advantage that led to replacement of subtype B as the dominant subtype. Drug resistance testing is recommended in the Philippines when initiating NNRTI-based antiretroviral therapy but may not be necessary for INSTI-based regimens.
    MeSH term(s) Drug Resistance ; Drug Resistance, Viral/genetics ; Genotype ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV-1/genetics ; Humans ; Philippines/epidemiology ; Viral Load
    Language English
    Publishing date 2022-07-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.06.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
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  3. Article ; Online: Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection.

    Padilla, Shirley T / Niki, Toshiro / Furushima, Daisuke / Bai, Gaowa / Chagan-Yasutan, Haorile / Telan, Elizabeth Freda / Tactacan-Abrenica, Rosario Jessica / Maeda, Yosuke / Solante, Rontgene / Hattori, Toshio

    Biomolecules

    2020  Volume 10, Issue 11

    Abstract: Acquired immunodeficiency syndrome (AIDS) complicated with tuberculosis (TB) is a global public issue. Due to the paucity of bacteria in AIDS/TB, blood-based biomarkers that reflect disease severity are desired. Plasma levels of matricellular proteins, ... ...

    Abstract Acquired immunodeficiency syndrome (AIDS) complicated with tuberculosis (TB) is a global public issue. Due to the paucity of bacteria in AIDS/TB, blood-based biomarkers that reflect disease severity are desired. Plasma levels of matricellular proteins, such as osteopontin (OPN) and galectin-9 (Gal-9), are known to be elevated in AIDS and TB. Therefore, full-length (FL)-Gal9 and FL-OPN, and their truncated forms (Tr-Gal9, Ud-OPN), and 38 cytokines/chemokines were measured in the plasma of 24 AIDS (other than TB), 49 TB, and 33 AIDS/TB patients. Receiver-operating characteristic analysis was used to screen molecules that could distinguish either between disease and normal group, among each disease group, or between deceased patients and survivors. Selected molecules were further analyzed for significant differences. Tr-Gal9 had the highest ability to differentiate TB from AIDS or AIDS/TB, while Ud-OPN distinguished multidrug resistance (MDR)-TB from non-MDR TB, and extra-pulmonary TB from pulmonary TB. Molecules significantly elevated in deceased patients included; FL-Gal9, Tr-Gal9, interleukin (IL)-1 receptor antagonist, IL-17A and transforming growth factor-α in AIDS; IL-6, granulocyte colony-stimulating factor and monocyte chemotactic protein-1 in TB; and macrophage inflammatory protein-1β in AIDS/TB. From the sensitivity, specificity, and significant elevation, Tr-Gal9 is the best biomarker of inflammation and severity in AIDS and AIDS/TB.
    MeSH term(s) Acquired Immunodeficiency Syndrome/blood ; Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/microbiology ; Acquired Immunodeficiency Syndrome/virology ; Adult ; Biomarkers/blood ; Coinfection/blood ; Coinfection/microbiology ; Coinfection/virology ; Female ; Galectins/blood ; Humans ; Male ; Middle Aged ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/pathogenicity ; Osteopontin/genetics ; Tuberculosis/blood ; Tuberculosis/complications ; Tuberculosis/microbiology ; Tuberculosis/virology
    Chemical Substances Biomarkers ; Galectins ; LGALS9 protein, human ; Osteopontin (106441-73-0)
    Language English
    Publishing date 2020-10-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom10111495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High rates of tenofovir failure in a CRF01_AE-predominant HIV epidemic in the Philippines.

    Salvana, Edsel Maurice T / Samonte, Genesis May J / Telan, Elizabeth / Leyritana, Katerina / Tactacan-Abrenica, Rosario Jessica / Ching, Patrick R / Arevalo, Geraldine M / Dungca, Niña Theresa / Peñalosa-Ramos, Christine / Mendoza, Kevin Anthony R / Trinidad, Lyka F / Tonga, Angelo Dela / Lim, Jodor / Destura, Raul / Alejandria, Marissa / Solante, Rontgene / Arcangel, Lalaine / Palaypayon, Noel S / Schwem, Brian E

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 95, Page(s) 125–132

    Abstract: Background: The Philippines has the fastest growing HIV epidemic in the Asia-Pacific. This increase was accompanied by a shift in the predominant HIV subtype from B to CRF01_AE. Increasing evidence points to a difference in treatment responses between ... ...

    Abstract Background: The Philippines has the fastest growing HIV epidemic in the Asia-Pacific. This increase was accompanied by a shift in the predominant HIV subtype from B to CRF01_AE. Increasing evidence points to a difference in treatment responses between subtypes. We examined treatment failure and acquired drug resistance (ADR) in people living with HIV (PLHIVs) after one year on antiretrovirals (ARVs).
    Methods: PLHIV maintained on ARVs for one year were recruited. Treatment failure was defined as a viral load of ≥1000 copies/mL. Sanger sequencing for genotyping and drug resistance mutation (DRM) detection was performed on patients failing treatment.
    Results: 513 PLHIV were enrolled. The most common antiretroviral regimens were TDF+3TC + EFV (269) and AZT+3TC + EFV (155). 53 (10.3%) subjects failed treatment. Among these, 48 (90.6%) had DRMs, 84.9% were subtype CRF01_AE. Tenofovir-based regimens performed worse than zidovudine-based regimens (OR 3.28, 95% CI 1.58-7.52 p < 0.001). Higher rates of NRTI, NNRTI, K65R tenofovir resistance, and multi-class resistance were found compared to those reported in literature.
    Conclusions: HIV treatment failure at one year of treatment in the Philippines is 10.3%. We found unusually high tenofovir and multiclass resistance, and optimal ARV regimens may need to be reevaluated for CRF01_AE-predominant epidemics.
    MeSH term(s) Adult ; Anti-HIV Agents/therapeutic use ; Drug Resistance, Viral/genetics ; Drug Therapy, Combination ; Epidemics ; Female ; HIV/classification ; HIV/genetics ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/virology ; Humans ; Male ; Philippines/epidemiology ; Tenofovir/therapeutic use ; Treatment Failure ; Viral Load ; Zidovudine/therapeutic use
    Chemical Substances Anti-HIV Agents ; Zidovudine (4B9XT59T7S) ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2020-02-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Design and implementation of an HIV/AIDS electronic medical record system (HIV/AIDS EMR) in the Philippines.

    Zabat, Gelza Mae A / Caoili, Janice Campos / Anduyon, Albert / Ramos, Genesis J / Morin, Mary Joy A / Ditangco, Rosanna A / Tactacan-Abrenica, Rosario Jessica / Ilustre, Janie Rose J / Tupasi, Thelma E

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2007  , Page(s) 1166

    Abstract: An electronic medical record system can help scale up the HIV/AIDS treatment program of a country. The authors illustrate how an HIV/AIDS electronic medical record system (HIV/AIDS EMR) was designed and implemented among treatment facilities across the ... ...

    Abstract An electronic medical record system can help scale up the HIV/AIDS treatment program of a country. The authors illustrate how an HIV/AIDS electronic medical record system (HIV/AIDS EMR) was designed and implemented among treatment facilities across the Philippines.
    MeSH term(s) Acquired Immunodeficiency Syndrome ; HIV Infections/therapy ; Humans ; Medical Records Systems, Computerized ; Philippines
    Language English
    Publishing date 2007-10-11
    Publishing country United States
    Document type Journal Article
    ISSN 1942-597X
    ISSN (online) 1942-597X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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