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  1. Article ; Online: Chronic limping in childhood, what else other than juvenile idiopathic arthritis: a case series.

    Tumminelli, Cristina / Pastore, Serena / Taddio, Andrea

    Pediatric rheumatology online journal

    2023  Volume 21, Issue 1, Page(s) 142

    Abstract: Background: Limping is a common clinical symptom in childhood; different clinical conditions may lead to limping and the diagnosis of the underlying cause may often be a challenge for the pediatrician.: Case presentation: We describe the clinical ... ...

    Abstract Background: Limping is a common clinical symptom in childhood; different clinical conditions may lead to limping and the diagnosis of the underlying cause may often be a challenge for the pediatrician.
    Case presentation: We describe the clinical manifestations, radiological pictures and disease course of other causes of limping in childhood, through a case series of seven cases and a brief discussion of each disease.
    Conclusions: although trauma is the most common cause of acute limping, when there is no history of traumatic events and the limping has a chronic course, Juvenile Idiopathic Arthritis is usually the most likely clinical diagnosis. However, other some rare conditions should be taken into account if JIA is not confirmed or if it presents with atypical clinical picture.
    MeSH term(s) Humans ; Arthritis, Juvenile/complications ; Arthritis, Juvenile/diagnosis ; Synovitis/diagnosis ; Diagnosis, Differential
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2279468-2
    ISSN 1546-0096 ; 1546-0096
    ISSN (online) 1546-0096
    ISSN 1546-0096
    DOI 10.1186/s12969-023-00927-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Variant STAT4 and Treatment of an Autoinflammatory Syndrome.

    Pastore, Serena / De Martino, Eleonora / Taddio, Andrea

    The New England journal of medicine

    2023  Volume 389, Issue 12, Page(s) 1151

    MeSH term(s) Humans ; Pyrazoles ; Syndrome ; STAT4 Transcription Factor
    Chemical Substances ruxolitinib (82S8X8XX8H) ; Pyrazoles ; STAT4 protein, human ; STAT4 Transcription Factor
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2308588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Multi-Inflammatory Syndrome in Children (MIS-C) in 2023: Is It Time to Forget about It?

    La Torre, Francesco / Taddio, Andrea / Conti, Chiara / Cattalini, Marco

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 6

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is defined as a clinically serious condition requiring hospitalization involving fever, multi-system organ dysfunction, and an increase in inflammatory biomarkers. The syndrome was originally ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) is defined as a clinically serious condition requiring hospitalization involving fever, multi-system organ dysfunction, and an increase in inflammatory biomarkers. The syndrome was originally described as a post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which usually causes COVID-19. During the COVID-19 pandemic, not only did the virus undergo mutations but vaccines against SARS-CoV-2 were also developed. Both these conditions led to a decrease in the incidence of MIS-C. This narrative review summarizes the recent updates for MIS-C, particularly regarding the change in incidence, the link between the SARS-CoV-2 vaccine and MIS-C, and new updates of MIS-C treatments.
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10060980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Palmar erythema: A diagnostic clue of juvenile dermatomyositis.

    Amoroso, Stefano / Pastore, Serena / Tommasini, Alberto / Taddio, Andrea

    Journal of paediatrics and child health

    2022  

    Language English
    Publishing date 2022-12-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.14739
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  5. Article ; Online: Palmar erythema: A diagnostic clue of juvenile dermatomyositis.

    Amoroso, Stefano / Pastore, Serena / Tommasini, Alberto / Taddio, Andrea

    Journal of paediatrics and child health

    2020  Volume 56, Issue 7, Page(s) 1159

    Language English
    Publishing date 2020-09-10
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.1_14739
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  6. Article ; Online: Young child with painful edema and purpura: a case report.

    Contorno, Sarah / Cozzi, Giorgio / Berti, Irene / Barbi, Egidio / Taddio, Andrea

    Italian journal of pediatrics

    2021  Volume 47, Issue 1, Page(s) 61

    Abstract: Background: We reported the case of a two-old-year boy with a painful acute hemorrhagic edema. This is a self-limited benign condition: usually, affected children are well appearing and this strongly support the diagnosis. In the opposite, in our case, ... ...

    Abstract Background: We reported the case of a two-old-year boy with a painful acute hemorrhagic edema. This is a self-limited benign condition: usually, affected children are well appearing and this strongly support the diagnosis. In the opposite, in our case, we observed a painful presentation of the edema. Therefore, we demonstrated that rarely, this condition could have also a painful presentation.
    Conclusions: This case report helps clinician to know that also acute hemorrhagic edema could have a painful presentation, so we must considered it in the differential diagnosis with sepsis, sickle cell crisis and child abuse. We believe that these findings will be of interest to pediatricians.
    MeSH term(s) Acute Disease ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Diagnosis, Differential ; Edema/diagnosis ; Edema/drug therapy ; Hemorrhage/diagnosis ; Hemorrhage/drug therapy ; Humans ; Ibuprofen/therapeutic use ; Infant ; Male ; Pain Measurement ; Purpura/diagnosis ; Purpura/drug therapy
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-021-01001-y
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  7. Article: Case Report: Simil-Appendicitis Presentation May Precede Cardiac Involvement in MIS-C Patient.

    Trevisan, Matteo / Amaddeo, Alessandro / Taddio, Andrea / Boscarelli, Alessandro / Barbi, Egidio / Cozzi, Giorgio

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 832391

    Abstract: Introduction: Multisystem inflammatory syndrome in children (MIS-C) is a new clinical entity characterized by a systemic hyperinflammation triggered by SARS-CoV-2 infection in children and adolescents. This condition could potentially involve all organs ...

    Abstract Introduction: Multisystem inflammatory syndrome in children (MIS-C) is a new clinical entity characterized by a systemic hyperinflammation triggered by SARS-CoV-2 infection in children and adolescents. This condition could potentially involve all organs with main complications concerning cardiovascular system. Despite up to 90% of patients complain gastrointestinal symptoms (nausea, vomit, and diarrhea), a presentation mimicking acute appendicitis has rarely been reported, and can be the presenting feature of the disease, potentially leading to misdiagnosis and delayed treatment.
    Case description: A 15-year-old boy presented to the Emergency Department for a 2-day history of fever, vomiting, and mild abdominal pain. One month before, the patient complained ageusia and anosmia while his mother tested positive for Sars-CoV2 nasopharyngeal swab. At admission, laboratory tests showed leukocytosis with lymphopenia and elevation of inflammatory markers, while cardiac enzymes, electrocardiogram and echocardiography were unremarkable. An abdominal ultrasound displayed a thickening of terminal ileus and cecum with ascites. Because of the worsening abdominal pain and a physical examination suggestive of acute appendicitis, a laparoscopy was performed but no surgical condition was found. After surgery, fever and generalized malaise persisted, so a cardiac evaluation was repeated, showing a relevant increase in inflammatory markers and cardiac enzymes. Electrocardiogram demonstrated a QTc prolongation with mild decrease in left ventricular ejection fraction at echocardiogram. A MIS-C was diagnosed and intravenous immunoglobulin along with a steroid treatment started. After 36 h, the patient presented a complete clinical recovery with fever cessation. Cardiac anomalies normalized in 3 weeks.
    Conclusion: MIS-C has been defined as a systemic inflammation, involving at least two organs, after a previous SARS-CoV2 infection in children and adolescents. Physicians should be aware that while gastrointestinal manifestations are common, a pseudo appendicitis presentation may also occur, leading to misdiagnosis and delayed treatment. This report suggests that in patients with symptoms suggestive of an acute appendicitis, the presence of lymphopenia, hypoalbuminemia and ultrasound images of terminal ileus inflammation, should raise the suspect for MIS-C even without initial overt signs of cardiac involvement.
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.832391
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  8. Article: Ultrasonographic Assessment for Tenosynovitis in Juvenile Idiopathic Arthritis with Ankle Involvement: Diagnostic and Therapeutic Significance.

    Della Paolera, Sara / Pastore, Serena / Zabotti, Alen / Tommasini, Alberto / Taddio, Andrea

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 4

    Abstract: Background: The role of musculoskeletal ultrasound in JIA is still controversial, although there is growing evidence on its utility, especially in the diagnosis of tenosynovitis.: Methods: We presented a retrospective cross-sectional study of a group ...

    Abstract Background: The role of musculoskeletal ultrasound in JIA is still controversial, although there is growing evidence on its utility, especially in the diagnosis of tenosynovitis.
    Methods: We presented a retrospective cross-sectional study of a group of patients with JIA with ankle swelling followed in a Pediatric Rheumatology Service of a tertiary-level pediatric hospital in Northern Italy during the follow-up period between January 1st 2003 and December 31st 2019. Preliminary results have been presented at the EULAR Congress 2021. We enrolled only patients who underwent msk-US, and we identified those with a clinical and sonographic diagnosis of tenosynovitis. For each patient, we collected data on demographics, clinical characteristics, and therapeutic strategies during the follow-up.
    Results: On December 31st 2019, 56 swollen ankles of 48 patients were assessed with msk-US. Twenty-two ankles showed sonographic signs of joint synovitis, sixteen ankles presented signs of both joint synovitis and tenosynovitis, and fourteen ankles presented sonographic signs of tenosynovitis only. Overall, tenosynovitis was detected on 27 (56%) out of 48 children with at least a swollen ankle. In 13 patients out of 27 with tenosynovitis (48%), there was no joint synovitis of ankle or foot. Twenty-five patients with tenosynovitis (92%) achieved clinical and radiological remission: seven patients achieved remission of tenosynovitis with methotrexate only, and fifteen patients with biological drugs alone or in combination therapy.
    Conclusions: We observed that more than half of the patients with ankle swelling presented a tenosynovitis, and about 50% of them did not show sonographic signs of an active joint synovitis. Among patients with tenosynovitis, biological therapy alone or in association with DMARDs showed effectiveness in inducing disease remission.
    Language English
    Publishing date 2022-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9040509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Infant with a big head and 'crossed' polysyndactyly.

    Tamaro, Gianluca / Baldo, Francesco / Spedicati, Beatrice / Taddio, Andrea / Faletra, Flavio / Barbi, Egidio

    Journal of paediatrics and child health

    2022  Volume 59, Issue 5, Page(s) 770–771

    Language English
    Publishing date 2022-06-18
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Boy with an unusual oral allergy syndrome.

    Mazzolai, Michele / Badina, Laura / Di Leo, Grazia / Bramuzzo, Matteo / Taddio, Andrea / Barbi, Egidio

    Journal of paediatrics and child health

    2022  

    Language English
    Publishing date 2022-12-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.15042
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