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Article ; Online: Subpial AAV Delivery for Spinal Parenchymal Gene Regulation in Adult Mammals.

Bravo-Hernández, Mariana / Tadokoro, Takahiro / Marsala, Martin

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1950, Page(s) 209–233

Abstract: The use of adeno-associated virus (AAV) vectors has become an attractive method for treatment of a variety of neurodegenerative disorders by permitting targeted gene upregulation or silencing in the CNS. Systemic and intrathecal infusion, while ... ...

Abstract	The use of adeno-associated virus (AAV) vectors has become an attractive method for treatment of a variety of neurodegenerative disorders by permitting targeted gene upregulation or silencing in the CNS. Systemic and intrathecal infusion, while preferable routes of vector delivery, have shown encouraging but variable efficacy due to the poor permeability of AAV into spinal cord and brain parenchyma in adult mammals. Recently we have developed a novel and relatively noninvasive technique of spinal subpial vector delivery. This technique confers widespread transgene expression throughout the spinal parenchyma, including both white and gray matter. We have demonstrated that this technique can be performed safely, with a high level of accuracy, and is effective in both small (mouse or rat) and large preclinical (adult pig or nonhuman primate) animal models. In this chapter we provide a comprehensive description of the subpial vector delivery technique in adult rodents (mouse and rat) and large preclinical animals (adult pig and nonhuman primates).
MeSH term(s)	Animals ; Dependovirus/genetics ; Gene Expression Regulation ; Gene Transfer Techniques ; Genes, Reporter ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Mice ; Primates ; Rats ; Spinal Cord/metabolism ; Swine ; Transduction, Genetic ; Transgenes
Language	English
Publishing date	2019-02-19
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-9139-6_12
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Article: Monitoring of Post-Brain Injuries By Measuring Plasma Levels of Neuron-Derived Extracellular Vesicles.

Hotta, Naoshi / Tadokoro, Takahiro / Henry, John / Koga, Daisuke / Kawata, Keisuke / Ishida, Hiroyuki / Oguma, Yuko / Hirata, Akihiro / Mitsuhashi, Masato / Yoshitani, Kenji

Biomarker insights

2022 Volume 17, Page(s) 11772719221128145

Abstract: Background: Extracellular vesicles (EV) released from neurons into the blood can reflect the state of nervous tissue. Measurement of neuron derived EV (NDE) may serve as an indicator of brain injury.: Methods: A sandwich immunoassay was established ... ...

Abstract	Background: Extracellular vesicles (EV) released from neurons into the blood can reflect the state of nervous tissue. Measurement of neuron derived EV (NDE) may serve as an indicator of brain injury. Methods: A sandwich immunoassay was established to measure plasma NDE using anti-neuron CD171 and anti-EV CD9 ([CD171 Results: The specificity, linearity, and reproducibility of NDE assay (measurement of [CD171 Conclusions: The blood test to determine plasma levels of NDE was established by a sandwich immunoassay using 2 antibodies against neuron (CD171) and exosomes (CD9). NDE levels varied widely in different individuals and decreased with age, indicating that NDE levels should be considered as a normalizer of NDE biomarker studies. However, NDE levels were stable over time in each individual, and increased rapidly after TAR with greater increases associated with patients developing POD. This assay may serve as a surrogate for evaluating and monitoring brain injuries.
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2256754-9
ISSN	1177-2719
ISSN	1177-2719
DOI	10.1177/11772719221128145
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Article ; Online: The Effectiveness of Applying Soft Tissue Bonding Adhesive Composed of 2-Ethyl Cyanoacrylate to Epidural Catheter Fixations Using Film Dressings: An Open-Label, Randomized, Parallel-Group Comparative Study.

Tadokoro, Takahiro / Kakinohana, Manabu / Navarro, Michael / Goya, Motoaki / Odo, Yuichiro

Anesthesia and analgesia

2018 Volume 129, Issue 1, Page(s) 149–154

Abstract: Background: Insufficient fixation of an epidural catheter may result in migration of the catheter and eventual catheter failure. However, the best fixation method remains to be established. Aron Alpha A (2-ethyl cyanoacrylate) adhesive is approved for ... ...

Abstract	Background: Insufficient fixation of an epidural catheter may result in migration of the catheter and eventual catheter failure. However, the best fixation method remains to be established. Aron Alpha A (2-ethyl cyanoacrylate) adhesive is approved for clinical use and can be used for surgical adhesion to both skin and blood vessels. We hypothesized that the addition of Aron Alpha A adhesive to film dressing would result in consistent and dependable catheter fixation. Methods: In this study, 58 women who were scheduled for cesarean delivery under spinal and epidural anesthesia were recruited. Patients were randomly assigned to a control or treatment group. In the control group, the catheter was fixed solely by film dressing. In the treatment group, a small amount of Aron Alpha A was applied at 2 sites along the catheter. The fixation area was then covered by film dressing. The catheter insertion length was recorded after fixation (T0), immediately postoperatively (T1), on postoperative day 1 (T2), and when the catheter was removed (T3). The change in insertion length from T0 to T3 between the 2 groups was the primary outcome measure. The incidence of catheter failure was also recorded. For all comparisons, P < .05 was considered statistically significant. Results: Initially, 58 women were enrolled; however, 3 patients were excluded. From the remaining 55 patients, 27 and 28 were assigned to the control and treatment groups, respectively, and were evaluated. The change in insertion length from T0 to T3 was significantly more in the control group compared with the treatment group (-1.9 ± 2.2 vs 0 ± 0 cm, respectively; P < .001). In the control group, 11 catheters (41%) failed; in the treatment group, all catheters provided effective analgesia throughout the study (P < .001). Conclusions: Epidural catheter fixation using film dressing combined with 2-ethyl cyanoacrylate adhesive application at 2 sites along the catheter resulted in secure fixation in patients receiving postoperative epidural analgesia for cesarean delivery.
MeSH term(s)	Adult ; Anesthesia, Epidural/adverse effects ; Anesthesia, Epidural/instrumentation ; Anesthesia, Obstetrical/adverse effects ; Anesthesia, Obstetrical/instrumentation ; Bandages ; Catheters, Indwelling ; Cesarean Section ; Cyanoacrylates/administration & dosage ; Cyanoacrylates/adverse effects ; Device Removal ; Equipment Failure ; Female ; Humans ; Japan ; Pregnancy ; Time Factors ; Treatment Outcome
Chemical Substances	Cyanoacrylates ; ethyl 2-cyanoacrylate (2G95FOH7SF) ; aron alpha (37370-55-1)
Language	English
Publishing date	2018-03-07
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000003326
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Article: [A Quantitative Verification for Operability of Three PCA Devices Attached to the Disposable Infusion Pumps].

Tadokoro, Takahiro / Fuchibe, Makoto / Odo, Yuichiro / Kakinohana, Manabu

Masui. The Japanese journal of anesthesiology

2015 Volume 64, Issue 11, Page(s) 1206–1210

Abstract: Background: In this study using 3 different PCA devices (Baxter infuser LVBB +PCM 2 ml: Pump B, Coopdech Balloonjector +PCA 3 ml: Pump C, Rakuraku fuser +PCA 3 ml: Pump S), we investigated how easily PCA devices could be handled.: Methods: In this ... ...

Abstract	Background: In this study using 3 different PCA devices (Baxter infuser LVBB +PCM 2 ml: Pump B, Coopdech Balloonjector +PCA 3 ml: Pump C, Rakuraku fuser +PCA 3 ml: Pump S), we investigated how easily PCA devices could be handled. Methods: In this study with 42 volunteers (14 elders and 28 nurses), we compared 3 PCA ejection volume and ejection rate among three PCA devices. PCA ejection rate was defined as the ratio of actual ejection volume to the maximum ejection volume (MEV) of each PCA device. Results: Although not only elders but also nurses failed to produce accurate PCA ejection volume in the Pump B, Pump S could provide the MEV even by elders. In the Pump C, approximately 80% of MEV could be achieved by nurses, but 60% of MEV by elders (P < 0.05). Conclusions: Our data suggested that accuracy of PCA ejection volume might be dependent on PCA device.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Infusion Pumps ; Male ; Middle Aged ; Passive Cutaneous Anaphylaxis
Language	Japanese
Publishing date	2015-11
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
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Article ; Online: TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo.

Miki, Shunichiro / Koga, Tomoyuki / Mckinney, Andrew M / Parisian, Alison D / Tadokoro, Takahiro / Vadla, Raghavendra / Marsala, Martin / Hevner, Robert F / Costello, Joseph F / Furnari, Frank

Neuro-oncology

2022 Volume 24, Issue 12, Page(s) 2063–2075

Abstract: Background: Heterozygous TERT (telomerase reverse transcriptase) promoter mutations (TPMs) facilitate TERT expression and are the most frequent mutation in glioblastoma (GBM). A recent analysis revealed this mutation is one of the earliest events in ... ...

Abstract	Background: Heterozygous TERT (telomerase reverse transcriptase) promoter mutations (TPMs) facilitate TERT expression and are the most frequent mutation in glioblastoma (GBM). A recent analysis revealed this mutation is one of the earliest events in gliomagenesis. However, no appropriate human models have been engineered to study the role of this mutation in the initiation of these tumors. Method: We established GBM models by introducing the heterozygous TPM in human induced pluripotent stem cells (hiPSCs) using a two-step targeting approach in the context of GBM genetic alterations, CDKN2A/B and PTEN deletion, and EGFRvIII overexpression. The impact of the mutation was evaluated through the in vivo passage and in vitro experiment and analysis. Results: Orthotopic injection of neuronal precursor cells (NPCs) derived from hiPSCs with the TPM into immunodeficient mice did not enhance tumorigenesis compared to TERT promoter wild type NPCs at initial in vivo passage presumably due to relatively long telomeres. However, the mutation recruited GA-Binding Protein and engendered low-level TERT expression resulting in enhanced tumorigenesis and maintenance of short telomeres upon secondary passage as observed in human GBM. These results provide the first insights regarding increased tumorigenesis upon introducing a TPM compared to isogenic controls without TPMs. Conclusion: Our novel GBM models presented the growth advantage of heterozygous TPMs for the first time in the context of GBM driver mutations relative to isogenic controls, thereby allowing for the identification and validation of TERT promoter-specific vulnerabilities in a genetically accurate background.
MeSH term(s)	Humans ; Mice ; Animals ; Telomere Shortening/genetics ; Induced Pluripotent Stem Cells ; Telomerase/genetics ; Telomere/genetics ; Glioblastoma/genetics ; Mutation ; Carcinogenesis
Chemical Substances	Telomerase (EC 2.7.7.49) ; TERT protein, human (EC 2.7.7.49)
Language	English
Publishing date	2022-03-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noac080
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Article ; Online: Usefulness of stroke volume variation to assess blood volume during blood removal for autologous blood transfusion in pediatric patients.

Tadokoro, Takahiro / Kakinohana, Manabu / Fukumoto, Chihiro / Kawabata, Tetsuya / Yoza, Kouji

Paediatric anaesthesia

2016 Volume 26, Issue 3, Page(s) 300–306

Abstract: Background: Dynamic variables based on the heart-lung interaction induced by positive pressure ventilation have not been shown to be useful in assessing cardiac preload in pediatric patients.: Objective: To evaluate whether stroke volume variation ( ... ...

Abstract	Background: Dynamic variables based on the heart-lung interaction induced by positive pressure ventilation have not been shown to be useful in assessing cardiac preload in pediatric patients. Objective: To evaluate whether stroke volume variation (SVV) obtained from the FloTrac/Vigileo(TM) monitoring system can reflect a change in blood volume during the blood removal and fluid replacement protocol in acute normovolemic hemodilution (ANH). Methods: Sixteen pediatric patients scheduled for elective cranioplasty were recruited. In the ANH protocol, 10 ml · kg(-1) blood removal and fluid replacement were performed. SVV, heart rate, mean blood pressure, and femoral venous pressure were recorded. Differences at four time points (T0: baseline, T1: 5 ml · kg(-1) blood loss, T2: 10 ml · kg(-1) blood loss, and T3: after fluid replacement) during ANH were compared. The blood volume (EBV) was estimated as 70 ml · kg(-1) at T0 and decreased to 60 ml · kg(-1) at T2. Results: Of the 16 patients, four were excluded and 12 were analyzed. Significant differences in all of the parameters were observed between each time point. The SVV significantly increased after the blood removal and decreased after the fluid replacement (P < 0.01, Bonferroni adjustment). In addition, the increases in SVV during the blood removal, T0-T1 and T0-T2, were 70% ± 40% and 159% ± 91%, respectively. SVV showed a significant correlation with EBV during the blood removal in ANH (rs = -0.68, 95% confidence interval -0.73 to -0.63, P < 0.001). Conclusion: Stroke volume variation obtained from the FloTrac/Vigileo(TM) monitoring system revealed a strong correlation with EBV during ANH without surgical stimulation. The usefulness of this device as an indicator of cardiac preload under hypovolemic or normovolemic conditions in children during surgery remains to be determined.
MeSH term(s)	Blood Transfusion, Autologous ; Blood Volume/physiology ; Child, Preschool ; Female ; Fluid Therapy ; Hemodilution ; Humans ; Male ; Monitoring, Physiologic/methods ; Preoperative Care/methods ; Prospective Studies ; Reproducibility of Results ; Stroke Volume/physiology
Language	English
Publishing date	2016-03
Publishing country	France
Document type	Journal Article
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.12838
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Article ; Online: Subpial delivery of adeno-associated virus 9-synapsin-caveolin-1 (

Wang, Shanshan / Ichinomiya, Taiga / Savchenko, Paul / Wang, Dongsheng / Sawada, Atsushi / Li, Xiaojing / Duong, Tiffany / Li, Wenxi / Bonds, Jacqueline A / Kim, Eun Jung / Miyanohara, Atsushi / Roth, David M / Patel, Hemal H / Patel, Piyush M / Tadokoro, Takahiro / Marsala, Martin / Head, Brian P

Theranostics

2022 Volume 12, Issue 12, Page(s) 5389–5403

Abstract: Elevating neuroprotective proteins using adeno-associated virus (AAV)-mediated gene delivery shows great promise in combating devastating neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) is one such disease resulting from loss of upper and ...

Abstract	Elevating neuroprotective proteins using adeno-associated virus (AAV)-mediated gene delivery shows great promise in combating devastating neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) is one such disease resulting from loss of upper and lower motor neurons (MNs) with 90-95% of cases sporadic (SALS) in nature. Due to the unknown etiology of SALS, interventions that afford neuronal protection and preservation are urgently needed. Caveolin-1 (Cav-1), a membrane/lipid rafts (MLRs) scaffolding and neuroprotective protein, and MLR-associated signaling components are decreased in degenerating neurons in postmortem human brains. We previously showed that, when crossing our SynCav1 transgenic mouse (TG) with the mutant human superoxide dismutase 1 (hSOD1
MeSH term(s)	Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/therapy ; Animals ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Caveolin 1/therapeutic use ; Dependovirus/genetics ; Dependovirus/metabolism ; Disease Models, Animal ; Female ; Gene Transfer Techniques ; Humans ; Male ; Mice ; Mice, Transgenic ; Motor Neurons/metabolism ; Neuromuscular Junction/metabolism ; Rats ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; Synapsins/genetics ; Synapsins/metabolism ; Synapsins/therapeutic use
Chemical Substances	Caveolin 1 ; Synapsins ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2022-07-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.72614
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Article ; Online: Effects of Perioperative Administration of Acetaminophen on Postoperative Shivering: A Randomized, Triple-Blind, Placebo-Controlled Trial.

Kinjo, Takehiro / Tadokoro, Takahiro / Tokushige, Akihiro / Zamami, Taketo / Taira, Sumire / Ikehara, Yumi / Tsuhako, Chiemi / Ohtsu, Hiroshi / Ueda, Shinichiro / Kakinohana, Manabu

Anesthesia and analgesia

2019 Volume 130, Issue 4, Page(s) 983–990

Abstract: Background: In this randomized, triple-blind, placebo-controlled trial, we tested the hypothesis that perioperative acetaminophen administration has a prophylactic effect on postoperative shivering.: Methods: Forty-five women scheduled for ... ...

Abstract	Background: In this randomized, triple-blind, placebo-controlled trial, we tested the hypothesis that perioperative acetaminophen administration has a prophylactic effect on postoperative shivering. Methods: Forty-five women scheduled for gynecological laparotomy were randomized to either the acetaminophen or the placebo groups. After induction of general anesthesia, the test drug (acetaminophen 15 mg/kg) or placebo (0.9% saline) was intravenously administered over 15 minutes. The primary outcome measure was the incidence of severe postoperative shivering (ie, shivering score >2) in the postanesthesia care unit, where patients stayed for 30 minutes after their emergence from anesthesia. For the secondary outcomes, core body temperature (BT) was recorded at the forehead just before anesthesia induction (time 0 [T0]), at the start of surgery (time 1 [T1]), at the end of surgery (time 2 [T2]), at the initiation of postoperative observation in the postanesthesia care unit (time 3 [T3]), and 30 minutes after T3 (time 4 [T4]). At 1 hour after T4 (ie, time 5 [T5]), the BT was recorded from the axilla (BTA). Primary outcome was analyzed using a χ test. BT recorded at the forehead (BTF) and BTA were analyzed using a 2-way repeated-measures analysis of variance (ANOVA) and a 2-sample t test, respectively. For all comparisons, a P value <.05 was considered statistically significant. Results: The study duration was 2 years. Of the 45 patients initially enrolled, 8 patients were excluded. The acetaminophen and placebo groups included 18 and 19 patients, respectively. The incidence of severe postoperative shivering in the postanesthesia care unit was significantly lower in the acetaminophen group (22.2%) than in the placebo group (73.7%) (relative risk, 0.302; 95% confidence interval, 0.122-0.746; P = .005). Two-way repeated-measures ANOVA showed a significant effect of time (F4,140 = 54.8; P < .001) and a significant time by treatment interaction (F4,140 = 9.61; P < .001) but did not show a main effect of the treatment (F1,35 = 1.83; P = .185) in BTF. Moreover, BTA at T5 was significantly lower in the acetaminophen group (mean [standard deviation {SD}], 37.2°C [0.48°C]) than in the placebo group (37.9°C [0.63°C]; P < .001). Conclusions: Our findings in patients undergoing gynecological laparotomy suggest that perioperative acetaminophen administration can prevent postoperative severe shivering. This prophylactic effect might be due to suppressing the postoperative increase in the BT set point, rather than lowering the threshold for shivering, as observed with clonidine.
MeSH term(s)	Acetaminophen/therapeutic use ; Adult ; Aged ; Analgesics, Non-Narcotic/therapeutic use ; Body Temperature/drug effects ; Female ; Gynecologic Surgical Procedures ; Humans ; Incidence ; Laparotomy ; Middle Aged ; Postoperative Care ; Postoperative Complications/prevention & control ; Shivering/drug effects ; Treatment Outcome
Chemical Substances	Analgesics, Non-Narcotic ; Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2019-07-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000004306
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Article ; Online: The influence of preoperative mental health on clinical outcomes after laminectomy in patients with lumbar spinal stenosis.

Kobayashi, Yoshiomi / Ogura, Yoji / Kitagawa, Takahiro / Tadokoro, Takahiro / Yonezawa, Yoshiro / Takahashi, Yohei / Yasuda, Akimasa / Shinozaki, Yoshio / Ogawa, Jun

Clinical neurology and neurosurgery

2019 Volume 185, Page(s) 105481

Abstract: Objective: The influence of preoperative mental health on health-related quality of life (HRQOL) in patients with lumbar spinal stenosis (LSS) remains unclear. This study aims to investigate the influence of preoperative mental health HRQOL after ... ...

Abstract	Objective: The influence of preoperative mental health on health-related quality of life (HRQOL) in patients with lumbar spinal stenosis (LSS) remains unclear. This study aims to investigate the influence of preoperative mental health HRQOL after laminectomy in patients with LSS. Patients and methods: We retrospectively reviewed 122 patients who had lumbar spinous process splitting laminectomy (LSPSL) for LSS. We assessed clinical information; Japanese Orthopedic Association (JOA) score; numerical rating scale (NRS) for low back pain, for leg pain, and for leg numbness; Zurich Claudication Questionnaire (ZCQ); JOA Back Pain Evaluation Questionnaire (JOABPEQ); Roland-Morris Disability Questionnaire (RMDQ); and Short Form 8 (SF-8) as patient reported outcomes. Patients were divided into two groups (Group L ≤ 36.2 points and Group NL > 36.2 points) based on the results of the preoperative mental health (MH) score in SF-8 to examine the influence of MH in LSS. We compared the HRQOL between the two groups postoperatively. Results: The JOA score, NRS, and ZCQ score significantly improved after surgery. HRQOL outcomes including JOABPEQ, RMDQ, and SF-8 showed that the LSPSL improved not only the physical but also the mental function in patients with LSS. All HRQOL outcomes in Group L exhibited significantly worse scores preoperatively; however, no significant differences between two groups were found postoperatively. Conclusions: LSPSL greatly reduced low back pain, leg pain, and leg numbness. LSPSL resulted in a significant improvement based on HRQOL questionnaires even in patients with preoperative depressive mood. Not only the physical status but also the mental health may improve after LSPSL even in patients with LSS with a depressive mood preoperatively.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Depression/psychology ; Female ; Humans ; Laminectomy ; Lumbar Vertebrae/surgery ; Male ; Mental Health ; Middle Aged ; Preoperative Period ; Prognosis ; Quality of Life ; Retrospective Studies ; Spinal Stenosis/physiopathology ; Spinal Stenosis/psychology ; Spinal Stenosis/surgery ; Treatment Outcome
Language	English
Publishing date	2019-08-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2019.105481
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Article ; Online: Guidewire advancement is interrupted by an internal jugular vein valve with a restricted opening: an ultrasound image.

Tadokoro, Takahiro / Yoza, Kouji / Sugahara, Kazuhiro

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2013 Volume 60, Issue 11, Page(s) 1163–1164

MeSH term(s)	Aged ; Aortic Valve/pathology ; Aortic Valve/surgery ; Catheterization, Central Venous/methods ; Heart Valve Prosthesis Implantation/methods ; Humans ; Jugular Veins/diagnostic imaging ; Male ; Ultrasonography, Interventional/methods ; Venous Valves/diagnostic imaging
Language	English
Publishing date	2013-11
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-013-0022-8
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