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  1. AU="Taggart, Michael"
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  1. Article ; Online: Patients with piperacillin-tazobactam allergy labels tolerate other beta-lactams.

    Taggart, Michael / Hew, Mark / Zubrinich, Celia

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2024  

    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14490
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 767: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Physiological resilience across the lifecourse: in utero and beyond.

    Taggart, Michael J / Tribe, Rachel M

    Experimental physiology

    2022  Volume 107, Issue 5, Page(s) 395–397

    MeSH term(s) Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP090320
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  3. Article ; Online: Multibacillary leprosy with an incubation period exceeding 50 years.

    Taggart, Michael / Kelly, Albert / Stell, Rick / Chu, Eric

    BMJ case reports

    2022  Volume 15, Issue 7

    Abstract: Leprosy is a chronic granulomatous infection predominantly involving the skin and peripheral nervous system. The condition is caused by infection with the obligate intracellular ... ...

    Abstract Leprosy is a chronic granulomatous infection predominantly involving the skin and peripheral nervous system. The condition is caused by infection with the obligate intracellular bacillus
    MeSH term(s) Drug Therapy, Combination ; Humans ; Infectious Disease Incubation Period ; Leprostatic Agents/therapeutic use ; Leprosy/drug therapy ; Leprosy, Multibacillary/diagnosis ; Leprosy, Multibacillary/drug therapy ; Mycobacterium leprae
    Chemical Substances Leprostatic Agents
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250835
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  4. Article ; Online: Doctors should expect to repay state investment with NHS service.

    Taggart, Michael J

    BMJ (Clinical research ed.)

    2015  Volume 350, Page(s) h2882

    MeSH term(s) Humans ; Physicians/ethics ; Private Practice/ethics
    Language English
    Publishing date 2015-05-27
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.h2882
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  5. Article ; Online: Uterus Modeling From Cell to Organ Level: Towards Better Understanding of Physiological Basis of Uterine Activity.

    Xu, Yuhang / Liu, Haipeng / Hao, Dongmei / Taggart, Michael / Zheng, Dingchang

    IEEE reviews in biomedical engineering

    2022  Volume 15, Page(s) 341–353

    Abstract: The relatively limited understanding of the physiology of uterine activation prevents us from achieving optimal clinical outcomes for managing serious pregnancy disorders such as preterm birth or uterine dystocia. There is increasing awareness that multi- ...

    Abstract The relatively limited understanding of the physiology of uterine activation prevents us from achieving optimal clinical outcomes for managing serious pregnancy disorders such as preterm birth or uterine dystocia. There is increasing awareness that multi-scale computational modeling of the uterus is a promising approach for providing a qualitative and quantitative description of uterine physiology. The overarching objective of such approach is to coalesce previously fragmentary information into a predictive and testable model of uterine activity that, in turn, informs the development of new diagnostic and therapeutic approaches to these pressing clinical problems. This article assesses current progress towards this goal. We summarize the electrophysiological basis of uterine activation as presently understood and review recent research approaches to uterine modeling at different scales from single cell to tissue, whole organ and organism with particular focus on transformative data in the last decade. We describe the positives and limitations of these approaches, thereby identifying key gaps in our knowledge on which to focus, in parallel, future computational and biological research efforts.
    MeSH term(s) Computer Simulation ; Female ; Humans ; Infant, Newborn ; Pelvis ; Pregnancy ; Premature Birth ; Uterus/physiology
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1941-1189
    ISSN (online) 1941-1189
    DOI 10.1109/RBME.2020.3023535
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  6. Article ; Online: Regional identification of information flow termination of electrohysterographic signals: Towards understanding human uterine electrical propagation.

    Xu, Yuhang / Hao, Dongmei / Taggart, Michael J / Zheng, Dingchang

    Computer methods and programs in biomedicine

    2022  Volume 223, Page(s) 106967

    Abstract: Background and objective: The uterine electrohysterogram (EHG) contains important information about electrical signal propagation which may be useful to monitor and predict the progress of pregnancy towards parturition. Directed information processing ... ...

    Abstract Background and objective: The uterine electrohysterogram (EHG) contains important information about electrical signal propagation which may be useful to monitor and predict the progress of pregnancy towards parturition. Directed information processing has the potential to be of use in studying EHG recordings. However, so far, there is no directed information-based estimation scheme that has been applied to investigating the propagation of human EHG recordings. To realize this, the approach of directed information and its reliability and adaptability should be scientifically studied.
    Methods: We demonstrated an estimation scheme of directed information to identify the spatiotemporal relationship between the recording channels of EHG signal and assess the algorithm reliability initially using simulated data. Further, a regional identification of information flow termination (RIIFT) approach was developed and applied for the first time to extant multichannel EHG signals to reveal the terminal zone of propagation of the electrical activity associated with uterine contraction. RIIFT operates by estimating the pairwise directed information between neighboring EHG channels and identifying the location where there is the strongest inward flow of information. The method was then applied to publicly-available experimental data obtained from pregnant women with the use of electrodes arranged in a 4-by-4 grid.
    Results: Our results are consistent with the suggestions from the previous studies with the added identification of preferential sites of excitation termination - within the estimated area, the direction of surface action potential propagation towards the medial axis of uterus during contraction was discovered for 72.15% of the total cases, demonstrating that our RIIFT method is a potential tool to investigate EHG propagation for advancing our understanding human uterine excitability.
    Conclusions: We developed a new approach and applied it to multichannel human EHG recordings to investigate the electrical signal propagation involved in uterine contraction. This provides an important platform for future studies to fill knowledge gaps in the spatiotemporal patterns of electrical excitation of the human uterus.
    MeSH term(s) Algorithms ; Electromyography/methods ; Female ; Humans ; Monitoring, Physiologic/methods ; Pregnancy ; Reproducibility of Results ; Uterine Contraction ; Uterus
    Language English
    Publishing date 2022-06-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2022.106967
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    Zs.B 521: Show issues Location:
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  7. Article ; Online: The knack of resisting increases in intravascular pressure: the potential role for epithelial Na(+) channel protein subunits in arterial myogenic reactivity.

    Taggart, Michael

    Experimental physiology

    2012  Volume 97, Issue 4, Page(s) 474–475

    MeSH term(s) Animals ; Epithelial Sodium Channels/physiology ; Male ; Mechanotransduction, Cellular/physiology ; Muscle, Smooth, Vascular/physiology ; Posterior Cerebral Artery/physiology ; Vasoconstriction/physiology
    Chemical Substances Epithelial Sodium Channels ; Scnn1b protein, rat ; Scnn1g protein, rat
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/expphysiol.2011.063347
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  8. Article ; Online: Vascular function in health and disease review series.

    Taggart, Michael

    Journal of cellular and molecular medicine

    2010  Volume 14, Issue 5, Page(s) 1017

    MeSH term(s) Animals ; Blood Vessels/physiology ; Blood Vessels/physiopathology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Health ; Humans
    Language English
    Publishing date 2010-05
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/j.1582-4934.2010.01050.x
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    Zs.A 5752: Show issues Location:
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  9. Article ; Online: Strategies for Peptide-Mediated Cargo Delivery to Human Smooth Muscle Cells.

    Gurney, Leo / Robson, Stephen C / Sweeney, Michèle / Jones, Arwyn T / Taggart, Michael J

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2383, Page(s) 459–471

    Abstract: Diseases involving dysfunction of smooth muscle cells present a major health and socioeconomic burden, and have remained stubbornly resistant to standard therapeutic strategies. Examples include many cardiovascular diseases and spontaneous preterm birth, ...

    Abstract Diseases involving dysfunction of smooth muscle cells present a major health and socioeconomic burden, and have remained stubbornly resistant to standard therapeutic strategies. Examples include many cardiovascular diseases and spontaneous preterm birth, a complication affecting up to 11% of all pregnancies worldwide. This fuels the continued search for new drug delivery strategies to treat these conditions. The use of cell penetrating peptides (CPPs) for this purpose remains a promising, if as yet unrealized, avenue to explore. In part, this may relate to a paucity of studies investigating the application of CPPs as drug delivery vectors to human smooth muscle cells and tissues. We have sought to address this knowledge gap by reporting methods for examining the uptake of different CPP-cargo vectors to human uterine and vascular smooth muscle cells. In particular, we report here (a) that four different CPP-fluorophore conjugates, spanning masses of 1309-3435 Da, and net charges of +2 to +7, can be delivered to human isolated uterine smooth muscle cells without inducing cell toxicity; (b) that the cargo delivered by such CPPs can be fluorescent moieties and/or biologically active peptides; (c) that CPP delivery in a short time frame to native smooth muscle cells in human tissues ex vivo can be achieved. Further exploration of CPPs as tools to facilitate targeted drug delivery to native human smooth muscle tissues will assist in improving our understanding of scientific mechanisms underlying major diseases involving smooth muscle dysfunction as well as facilitating therapeutic investigations.
    MeSH term(s) Cell-Penetrating Peptides ; Drug Delivery Systems ; Female ; Humans ; Infant, Newborn ; Myocytes, Smooth Muscle ; Pharmaceutical Preparations ; Pregnancy ; Premature Birth
    Chemical Substances Cell-Penetrating Peptides ; Pharmaceutical Preparations
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1752-6_29
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  10. Article: Signaling and structures underpinning conducted vasodilation in human and porcine intramyocardial coronary arteries.

    Dora, Kim A / Lin, JinHeng / Borysova, Lyudmyla / Beleznai, Timea / Taggart, Michael / Ascione, Raimondo / Garland, Christopher

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 980628

    Abstract: Background: Adequate blood flow into coronary micro-arteries is essential for myocardial function. Here we assess the mechanisms responsible for amplifying blood flow into myogenically-contracting human and porcine intramyocardial micro-arteries : ... ...

    Abstract Background: Adequate blood flow into coronary micro-arteries is essential for myocardial function. Here we assess the mechanisms responsible for amplifying blood flow into myogenically-contracting human and porcine intramyocardial micro-arteries
    Methods: Human and porcine atrial and ventricular small intramyocardial coronary arteries (IMCAs) were studied with pressure myography and imaged using confocal microscopy and serial section/3-D reconstruction EM.
    Results: 3D rendered ultrastructure images of human right atrial (RA-) IMCAs revealed extensive homo-and hetero-cellular contacts, including to longitudinally-arranged smooth muscle cells (l-SMCs) found between the endothelial cells (ECs) and radially-arranged medial SMCs (r-SMCs). Local and conducted vasodilatation followed focal application of bradykinin in both human and porcine RA-IMCAs, and relied on hyperpolarization of SMCs, but not nitric oxide. Bradykinin initiated asynchronous oscillations in endothelial cell Ca
    Conclusions: These data extend our understanding of the mechanisms that coordinate human coronary microvascular blood flow and the mechanistic overlap with porcine IMCAs. The unusual presence of l-SMCs provides an additional pathway for rapid intercellular signaling between cells of the coronary artery wall. Local and conducted vasodilation follow hyperpolarization of the ECs or SMCs, and contact-coupling between l-SMCs and r-SMCs likely facilitates this vasodilation.
    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.980628
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