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Article: Dual-targeting CD44 and mucin by hyaluronic acid and 5TR1 aptamer for epirubicin delivery into cancer cells: Synthesis, characterization,

Jamshidi, Zahra / Dehghan, Reza / Nejabat, Mojgan / Abnous, Khalil / Taghdisi, Seyed Mohammad / Hadizadeh, Farzin

2024 Volume 10, Issue 2, Page(s) e24833

Abstract: One of the revolutionized cancer treatment is active targeting nanomedicines. This study aims to create a dual-targeted drug delivery system for Epirubicin (EPI) to cancer cells. Hyaluronic acid (HA) is the first targeting ligand, and 5TR1 aptamer (5TR1) ...

Abstract	One of the revolutionized cancer treatment is active targeting nanomedicines. This study aims to create a dual-targeted drug delivery system for Epirubicin (EPI) to cancer cells. Hyaluronic acid (HA) is the first targeting ligand, and 5TR1 aptamer (5TR1) is the second targeting ligand to guide the dual-targeted drug delivery system to the cancer cells. HA is bound to highly expressed receptors like CD44 on cancer cells. 5TR1, DNA aptamer, is capable of recognizing MUC1 glycoprotein, which is overexpressed in cancer cells. The process involved binding EPI and 5TR1 to HA using adipic acid dihydrazide (AA) as a linker. The bond between the components was confirmed using
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24833
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Article ; Online: Molecular dynamics simulation as a promising approach for computational study of liquid crystal-based aptasensors.

Zahraee, Hamed / Arab, Seyed Shahriar / Khoshbin, Zahra / Taghdisi, Seyed Mohammad / Abnous, Khalil

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–13

Abstract: As a potent computational methodology, molecular dynamics (MD) simulation provides advantageous knowledge about biological compounds from the molecular viewpoint. In particular, MD simulation gives exact information about aptamer strands, such as the ... ...

Abstract	As a potent computational methodology, molecular dynamics (MD) simulation provides advantageous knowledge about biological compounds from the molecular viewpoint. In particular, MD simulation gives exact information about aptamer strands, such as the short synthetic oligomers, their orientation, binding sites, folding-unfolding state, and conformational re-arrangement. Also, the effect of the different chemicals and biochemicals as the components of aptamer-based sensors (aptasensors) on the aptamer-target interaction can be investigated by MD simulation. Liquid crystals (LCs) as soft substances with characteristics of both solid anisotropy and liquid fluidity are new candidates for designing label-free aptasensors. To now, diverse aptasensors have been developed experimentally based on the optical anisotropy, fluidity, and long-range orientational order of LCs. Here, we represent a computational model of an LC-based aptasensor through a detailed MD simulation study. The different parameters are defined and studied to achieve a comprehensive understanding of the computational design of the LC-based aptasensor, including the density of LCs, their orientation angle, and lognormal distribution in the absence and presence of aptamer strands, both aptamer and target molecules with various concentrations, and interfering substance. As a case study, the tobramycin antibiotic is considered the target molecule for the computational model of the LC-based aptasensor.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2315326
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Article ; Online: CRISPR-Cas12a-based colorimetric aptasensor for aflatoxin M1 detection based on oxidase-mimicking activity of flower-like MnO

Esmaelpourfarkhani, Masoomeh / Ramezani, Mohammad / Alibolandi, Mona / Abnous, Khalil / Taghdisi, Seyed Mohammad

Talanta

2024 Volume 271, Page(s) 125729

Abstract: Given the highly mutagenic and carcinogenic nature of Aflatoxin M1 (AFM1), the quantity assessment of AFM1 residues in milk and dairy products is necessary to maintain consumer health and food safety. Herein, CRISPR-Cas12a-based colorimetric aptasensor ... ...

Abstract	Given the highly mutagenic and carcinogenic nature of Aflatoxin M1 (AFM1), the quantity assessment of AFM1 residues in milk and dairy products is necessary to maintain consumer health and food safety. Herein, CRISPR-Cas12a-based colorimetric aptasensor was developed using the catalytic activity of flower-like nanozymes of MnO
MeSH term(s)	Aflatoxin M1/analysis ; Oxidoreductases ; CRISPR-Cas Systems ; Colorimetry ; Manganese Compounds ; Biosensing Techniques/methods ; Oxides
Chemical Substances	Aflatoxin M1 (6795-23-9) ; Oxidoreductases (EC 1.-) ; Manganese Compounds ; Oxides
Language	English
Publishing date	2024-01-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2024.125729
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Article ; Online: Signal-off nanozyme-based colorimetric aptasensor for sensitive detection of ampicillin using MnO

Esmaelpourfarkhani, Masoomeh / Ramezani, Mohammad / Alibolandi, Mona / Abnous, Khalil / Taghdisi, Seyed Mohammad

Analytical biochemistry

2024 Volume 687, Page(s) 115459

Abstract: The combination of nanomaterials possessing distinct characteristics and the precision of aptamers facilitates the creation of biosensors that exhibit exceptional selectivity and sensitivity. In this manuscript, we present a highly sensitive aptasensor ... ...

Abstract	The combination of nanomaterials possessing distinct characteristics and the precision of aptamers facilitates the creation of biosensors that exhibit exceptional selectivity and sensitivity. In this manuscript, we present a highly sensitive aptasensor that utilizes the distinctive characteristics of MnO
MeSH term(s)	Humans ; Gold ; Limit of Detection ; Metal Nanoparticles ; Colorimetry/methods ; Manganese Compounds ; Aptamers, Nucleotide ; Oxides ; Biosensing Techniques/methods ; Ampicillin
Chemical Substances	Gold (7440-57-5) ; Manganese Compounds ; Aptamers, Nucleotide ; Oxides ; Ampicillin (7C782967RD)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1110-1
ISSN	1096-0309 ; 0003-2697
ISSN (online)	1096-0309
ISSN	0003-2697
DOI	10.1016/j.ab.2024.115459
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Article ; Online: A label-free aptasensor for colorimetric detection of food toxin: Mediation of catalytically active gold nanozymes and smartphone imaging strategy.

Khoshbin, Zahra / Moeenfard, Marzieh / Abnous, Khalil / Taghdisi, Seyed Mohammad

Food chemistry

2023 Volume 433, Page(s) 137355

Abstract: A portable colorimetric aptasensor was developed on the surface of a plastic sheet for on-site detection of acrylamide. The mechanism of aptasensor is based on the disruption of the aptamer complex with its complementary strand on the sensing zone, and ... ...

Abstract	A portable colorimetric aptasensor was developed on the surface of a plastic sheet for on-site detection of acrylamide. The mechanism of aptasensor is based on the disruption of the aptamer complex with its complementary strand on the sensing zone, and subsequently, the catalytic activity of gold nanoparticles (AuNPs) for the reduction process of 4-nitrophenol (4-NP) in the presence of sodium borohydride (NaBH
MeSH term(s)	Colorimetry/methods ; Gold ; Smartphone ; Metal Nanoparticles ; Aptamers, Nucleotide ; Acrylamides ; Biosensing Techniques/methods ; Limit of Detection
Chemical Substances	Gold (7440-57-5) ; Aptamers, Nucleotide ; Acrylamides
Language	English
Publishing date	2023-09-03
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.137355
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Article ; Online: Targeted co-delivery of FOXM1 aptamer and DOX by nucleolin aptamer-functionalized pH-responsive biocompatible nanodelivery system to enhance therapeutic efficacy against breast cancer: in vitro and in vivo.

Masoudi, Mina / Taghdisi, Seyed Mohammad / Hashemitabar, Gholamreza / Abnous, Khalil

Drug delivery and translational research

2023 Volume 14, Issue 6, Page(s) 1535–1550

Abstract: Targeted nanodelivery systems offer a promising approach to cancer treatment, including the most common cancer in women, breast cancer. In this study, a targeted, pH-responsive, and biocompatible nanodelivery system based on nucleolin aptamer- ... ...

Abstract	Targeted nanodelivery systems offer a promising approach to cancer treatment, including the most common cancer in women, breast cancer. In this study, a targeted, pH-responsive, and biocompatible nanodelivery system based on nucleolin aptamer-functionalized biogenic titanium dioxide nanoparticles (TNP) was developed for targeted co-delivery of FOXM1 aptamer and doxorubicin (DOX) to improve breast cancer therapy. The developed targeted nanodelivery system exhibited almost spherical morphology with 124.89 ± 12.97 nm in diameter and zeta potential value of - 23.78 ± 3.66 mV. FOXM1 aptamer and DOX were loaded into the nanodelivery system with an efficiency of 100% and 97%, respectively. Moreover, the targeted nanodelivery system demonstrated excellent stability in serum and a pH-responsive sustained drug release profile over a period of 240 h following Higuchi kinetic and Fickian diffusion mechanism. The in vitro cytotoxicity experiments demonstrated that the targeted nanodelivery system provided selective internalization and strong growth inhibition effects of about 45 and 51% against nucleolin-positive 4T1 and MCF-7 breast cancer cell lines. It is noteworthy that these phenomena were not observed in nucleolin-negative cells (CHO). The preclinical studies revealed that a single-dose intravenous injection of the targeted nanodelivery system into 4T1-bearing mice inhibited tumor growth by 1.7- and 1.4-fold more efficiently than the free drug and the non-targeted nanodelivery system, respectively. Our results suggested that the developed innovative targeted pH-responsive biocompatible nanodelivery system could serve as a prospectively potential platform to improve breast cancer treatment.
MeSH term(s)	Animals ; Nucleolin ; Doxorubicin/administration & dosage ; Doxorubicin/chemistry ; Doxorubicin/pharmacokinetics ; Doxorubicin/pharmacology ; Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/administration & dosage ; Female ; Phosphoproteins/administration & dosage ; Humans ; Hydrogen-Ion Concentration ; RNA-Binding Proteins/administration & dosage ; Breast Neoplasms/drug therapy ; Forkhead Box Protein M1 ; MCF-7 Cells ; Drug Liberation ; Mice, Inbred BALB C ; Mice ; Cell Line, Tumor ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/pharmacokinetics ; Antibiotics, Antineoplastic/chemistry ; Drug Delivery Systems ; Nanoparticles/chemistry ; Nanoparticles/administration & dosage
Chemical Substances	Nucleolin ; Doxorubicin (80168379AG) ; Aptamers, Nucleotide ; Phosphoproteins ; RNA-Binding Proteins ; Forkhead Box Protein M1 ; Antibiotics, Antineoplastic ; FOXM1 protein, human
Language	English
Publishing date	2023-12-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-023-01495-5
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Article ; Online: Three-way junction skeleton biosensors based on aptamers, DNAzymes, and DNA hybridization probes

Zahraee, Hamed / Khoshbin, Zahra / Mohammadi, Fatemeh / Mashreghi, Mansour / Abnous, Khalil / Taghdisi, Seyed Mohammad

Trends in Analytical Chemistry. 2023 Aug., v. 165 p.117160-

2023

Abstract: Nucleic acids can be used as building blocks for highly regular and complex structures at the nanoscale due to their inherent self-assembly and programmability resulting from intra- and inter-molecular interactions. Three-way junctions (TWJs) structure ... ...

Abstract	Nucleic acids can be used as building blocks for highly regular and complex structures at the nanoscale due to their inherent self-assembly and programmability resulting from intra- and inter-molecular interactions. Three-way junctions (TWJs) structure is recognized as the smallest type of junction in nucleic acids. To form TWJ nanostructures, three DNA or RNA strands with complementary segments at each end are hybridized and form a Y-shaped structure. TWJ skeletons, having three independent arms, provide multifunctional sites for beneficial amplification, recognition, and signaling purposes in specific biomolecular nanoarchitecture. In this study, we represent the superiority aspects on the achievements of the biosensors with the cooperation of DNA/RNA TWJ nanoskeletons for monitoring different targets. Moreover, some discussions are declared to achieve a perspective for developing promising TWJ-based aptasensors in the future. This in-depth study can open a constructive way for commercializing and miniaturizing TWJ-tuned aptasensors as user-friendly lab-on-chip sensing devices.
Keywords	DNA ; RNA ; analytical chemistry ; aptasensors ; lab-on-a-chip technology ; nanomaterials ; nucleic acid hybridization ; oligonucleotides ; skeleton ; DNA origami ; Three-way junction ; Signal amplification ; Multifunctional ; Nanostructure ; Aptasensor
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2014041-1
ISSN	0165-9936
ISSN	0165-9936
DOI	10.1016/j.trac.2023.117160
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Article: Nano-gold mediated aptasensor for colorimetric monitoring of acrylamide: Smartphone readout strategy for on-site food control

Khoshbin, Zahra / Moeenfard, Marzieh / Abnous, Khalil / Taghdisi, Seyed Mohammad

Food chemistry. 2023 Jan. 15, v. 399

2023

Abstract: A simple aptasensor is embedded in the internal surface of a micropipette tip as the aptasensor substrate for the label-free monitoring of acrylamide. The aptasensor is based on the formation of the triple-helix molecular switch (THMS) structure of the ... ...

Abstract	A simple aptasensor is embedded in the internal surface of a micropipette tip as the aptasensor substrate for the label-free monitoring of acrylamide. The aptasensor is based on the formation of the triple-helix molecular switch (THMS) structure of the DNA strands that induces the salt-enforced aggregation of gold nanoparticles (AuNPs). A smartphone imaging readout-based strategy is applied to quantify acrylamide. The developed aptasensor is novel for the naked-eye monitoring of the target through the color change of the solution inside the micropipette tip. The colorimetric aptasensor detects acrylamide in the concentration range of 0.05–200 nmol L⁻¹ and at the trace level of 0.038 nmol L⁻¹ with the comparable selectivity. The aptasensor can successfully quantify acrylamide in the chips, coffee, and bread samples with recoveries range from 92 to 102 %. The designed aptasensor paves an efficient device for the portable, on-site, facile, and real-time target sensing, superior for food safety control.
Keywords	DNA ; acrylamides ; aptasensors ; breads ; color ; colorimetry ; food chemistry ; food safety ; mobile telephones ; nanogold
Language	English
Dates of publication	2023-0115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.133983
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Article ; Online: Self-targeted hyaluronic acid-b-poly (β-amino ester) pH-switchable polymersome for guided doxorubicin delivery to metastatic breast cancer

Borhaninia, Morvarid / Zahiri, Mahsa / Abnous, Khalil / Taghdisi, Seyed Mohammad / Ramaz̤ānī, Muḥammad / Alibolandi, Mona

International Journal of Biological Macromolecules. 2023 July 18, p.125882-

2023 , Page(s) 125882–

Abstract: In this study, a targeted pH-sensitive polymersome incorporating doxorubicin (DOX) was manufactured implementing diblock copolymer of hyaluronic acid-b-pPoly (β-amino ester) (HA-PBAE). The hydrophilic DOX was loaded into the aqueous compartment of HA- ... ...

Abstract	In this study, a targeted pH-sensitive polymersome incorporating doxorubicin (DOX) was manufactured implementing diblock copolymer of hyaluronic acid-b-pPoly (β-amino ester) (HA-PBAE). The hydrophilic DOX was loaded into the aqueous compartment of HA-PBAE polymersomal structure during nanoprecipitation process with 60 % ± 3.0 entrapment efficiency (EE%) and 5.3 % ± 0.2 loading content (LC%) while demonstrating spherical morphology with size of 196 ± 3.8 nm and PDI of 0.3. The prepared platform (DOX-HA-PBAE) illustrated accelerated DOX release in acidic pH 5.4, and showed significantly higher cytotoxicity and cellular internalization in comparison with free DOX against 4T1 cell line (CD44 positive cell). In contrast, no significant growth inhibition was observed in CHO cell line (CD44 negative cell). Furthermore, DOX-HA-PBAE platform displayed higher therapeutic efficacy, favorable tumor accumulation and lower systemic toxicity in comparison with free DOX based on obtained experimental data in ectopic 4T1 tumor model in BALB/c Female mice in terms of tumor growth rate, survival rate, body weight loss, ex vivo biodistribution and pathological evaluations. The obtained results demonstrated that DOX-HA-PBAE polymersomes have potential to be used in metastatic breast cancer therapy with promising characteristics in terms of tumor growth suppression and safety profile.
Keywords	body weight changes ; breast neoplasms ; cancer therapy ; cell lines ; composite polymers ; cytotoxicity ; doxorubicin ; females ; growth retardation ; hydrophilicity ; metastasis ; models ; nanotechnology ; pH ; survival rate ; pH sensitive ; Hyaluronic acid ; Poly (β-amino ester) ; Targeted drug delivery ; Metastatic breast cancer
Language	English
Dates of publication	2023-0718
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125882
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Article ; Online: Nano-gold mediated aptasensor for colorimetric monitoring of acrylamide: Smartphone readout strategy for on-site food control.

Khoshbin, Zahra / Moeenfard, Marzieh / Abnous, Khalil / Taghdisi, Seyed Mohammad

Food chemistry

2022 Volume 399, Page(s) 133983

Abstract	A simple aptasensor is embedded in the internal surface of a micropipette tip as the aptasensor substrate for the label-free monitoring of acrylamide. The aptasensor is based on the formation of the triple-helix molecular switch (THMS) structure of the DNA strands that induces the salt-enforced aggregation of gold nanoparticles (AuNPs). A smartphone imaging readout-based strategy is applied to quantify acrylamide. The developed aptasensor is novel for the naked-eye monitoring of the target through the color change of the solution inside the micropipette tip. The colorimetric aptasensor detects acrylamide in the concentration range of 0.05-200 nmol L
MeSH term(s)	Acrylamide ; Aptamers, Nucleotide/chemistry ; Biosensing Techniques/methods ; Colorimetry/methods ; Gold ; Limit of Detection ; Metal Nanoparticles/chemistry ; Smartphone
Chemical Substances	Aptamers, Nucleotide ; Acrylamide (20R035KLCI) ; Gold (7440-57-5)
Language	English
Publishing date	2022-08-20
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.133983
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