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  1. Article ; Online: Advanced treatment strategies in breast cancer: A comprehensive mechanistic review.

    Mumtaz, Samaira / Ali, Shaukat / Mumtaz, Shumaila / Pervaiz, Asim / Tahir, Hafiz M / Farooq, Muhammad A / Mughal, Tafail A

    Science progress

    2023  Volume 106, Issue 2, Page(s) 368504231175331

    Abstract: Breast cancer is a destructive lump type that affects women globally. Despite the availability of multi-directional therapeutic strategies, advanced stages of breast cancer are difficult to treat and impose major healthcare burdens. This situation ... ...

    Abstract Breast cancer is a destructive lump type that affects women globally. Despite the availability of multi-directional therapeutic strategies, advanced stages of breast cancer are difficult to treat and impose major healthcare burdens. This situation reinforces the need to identify new potential therapeutic compounds with better clinical features. In this context, different treatment methods were included such as Endocrine therapy, chemotherapy, Radiation therapy, antimicrobial peptide-dependent growth inhibitor, liposome-based drug delivery, antibiotics used as a co-medication, photothermal, immunotherapy, and nano drug delivery systems such as
    MeSH term(s) Animals ; Female ; Humans ; Sericins/metabolism ; Sericins/pharmacology ; Bombyx/metabolism ; Breast Neoplasms/therapy ; Nanoparticles/therapeutic use
    Chemical Substances Sericins
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 128412-5
    ISSN 2047-7163 ; 0036-8504 ; 0302-1785
    ISSN (online) 2047-7163
    ISSN 0036-8504 ; 0302-1785
    DOI 10.1177/00368504231175331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 731: Show issues Location:
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  2. Article ; Online: Optimization of enhanced microbial production of zinc bacitracin by submerged fermentation technology.

    Hassan, Ali / Ali, Shaukat / Farooq, Muhammad A / Tahir, Hafiz M / Awan, Muhammad U / Mughal, Tafail A

    Journal of basic microbiology

    2020  Volume 60, Issue 7, Page(s) 585–599

    Abstract: Bacitracin is one of the most important antibiotics used in different biomedical fields. It helps to achieve sizeable amount of foreign exchange due to its use in the poultry feed. The cheap agricultural wastes are readily available for the preparation ... ...

    Abstract Bacitracin is one of the most important antibiotics used in different biomedical fields. It helps to achieve sizeable amount of foreign exchange due to its use in the poultry feed. The cheap agricultural wastes are readily available for the preparation of fermentation media used for bacitracin production. The microorganisms could be mutated with different chemicals and UV radiation to improve bacitracin production. Thus, the current study was focused on the synthesis of low-cost and effective bacitracin by mutant strains of Bacillus licheniformis, employing the submerged fermentation technique. The bacteria were exposed to the UV irradiation for various time periods ranging from 5 to 40 min. These mutants were named as BLAA-5-BLAA-40. Mutant strain BLAA-25 produced maximum bacitracin, with significantly high activity (142.81 IU/mg) against Klebsiella pneumoniae but less activity against Escherichia coli (115.19 IU/mg). Several fermentation conditions were investigated to optimize bacitracin production. The highest bacitracin yield was obtained by an inoculum size of 10%, fermentation period 48 hr, pH 7, T = 37°C, using soybean meal as a substrate. Among all substrates, cucumber peel was the substrate showing the highest minimum inhibitory concentration (2.3 mg/ml and 2.7 mg/ml against K. pneumoniae and E. coli respectively). A comparison between commercial and experimentally produced Zn bacitracin showed that commercial bacitracin has a low activity (63.2 IU/mg) as compared with experimental bacitracin. Hence, the agro wastes and mutation could be used to increase the synthesis of Zn bacitracin in B. licheniformis.
    MeSH term(s) Anti-Bacterial Agents/biosynthesis ; Anti-Bacterial Agents/pharmacology ; Bacillus licheniformis/metabolism ; Bacitracin/biosynthesis ; Bacitracin/pharmacology ; Bioreactors/microbiology ; Escherichia coli/drug effects ; Fermentation ; Klebsiella pneumoniae/drug effects ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Bacitracin (1405-87-4)
    Language English
    Publishing date 2020-05-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632513-0
    ISSN 1521-4028 ; 0233-111X
    ISSN (online) 1521-4028
    ISSN 0233-111X
    DOI 10.1002/jobm.201900694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 824: Show issues Location:
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  3. Article: Optimization of enhanced microbial production of zinc bacitracin by submerged fermentation technology

    Hassan, Ali / Ali, Shaukat / Farooq, Muhammad A / Tahir, Hafiz M / Awan, Muhammad U / Mughal, Tafail A

    Journal of basic microbiology. 2020 July, v. 60, no. 7

    2020  

    Abstract: Bacitracin is one of the most important antibiotics used in different biomedical fields. It helps to achieve sizeable amount of foreign exchange due to its use in the poultry feed. The cheap agricultural wastes are readily available for the preparation ... ...

    Abstract Bacitracin is one of the most important antibiotics used in different biomedical fields. It helps to achieve sizeable amount of foreign exchange due to its use in the poultry feed. The cheap agricultural wastes are readily available for the preparation of fermentation media used for bacitracin production. The microorganisms could be mutated with different chemicals and UV radiation to improve bacitracin production. Thus, the current study was focused on the synthesis of low‐cost and effective bacitracin by mutant strains of Bacillus licheniformis, employing the submerged fermentation technique. The bacteria were exposed to the UV irradiation for various time periods ranging from 5 to 40 min. These mutants were named as BLAA‐5–BLAA‐40. Mutant strain BLAA‐25 produced maximum bacitracin, with significantly high activity (142.81 IU/mg) against Klebsiella pneumoniae but less activity against Escherichia coli (115.19 IU/mg). Several fermentation conditions were investigated to optimize bacitracin production. The highest bacitracin yield was obtained by an inoculum size of 10%, fermentation period 48 hr, pH 7, T = 37°C, using soybean meal as a substrate. Among all substrates, cucumber peel was the substrate showing the highest minimum inhibitory concentration (2.3 mg/ml and 2.7
    Keywords Bacillus licheniformis ; Escherichia coli ; Klebsiella pneumoniae ; agricultural wastes ; bacitracin ; bacteria ; cucumbers ; fields ; foreign exchange ; inoculum ; minimum inhibitory concentration ; mutants ; mutation ; pH ; poultry ; soybean meal ; strains ; submerged fermentation ; synthesis ; ultraviolet radiation ; zinc
    Language English
    Dates of publication 2020-07
    Size p. 585-599.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-light ; JOURNAL ARTICLE
    ZDB-ID 632513-0
    ISSN 1521-4028 ; 0233-111X
    ISSN (online) 1521-4028
    ISSN 0233-111X
    DOI 10.1002/jobm.201900694
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 824: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Therapeutic Applications of Garlic and Turmeric for the Diabetic Wound Healing in Mice.

    Farooq, Muhammad A / Ali, Shaukat / Sulayman, Rida / Hassan, Ali / Tahir, Hafiz M / Shahzad, Hafsa / Fiaz, Umaima / Mughal, Tafail A / Liaqat, Irfana / Mumtaz, Samaira / Nauroze, Tooba / Mumtaz, Shumaila

    Journal of burn care & research : official publication of the American Burn Association

    2022  Volume 44, Issue 4, Page(s) 800–809

    Abstract: Diabetes is involved in delayed wound healing that can be cured by natural products such as garlic, turmeric, and fibroin extracts. Alloxan monohydrate is used for inducing diabetes in mice. The percent wound contraction of garlic (150 mg/ml), turmeric ( ... ...

    Abstract Diabetes is involved in delayed wound healing that can be cured by natural products such as garlic, turmeric, and fibroin extracts. Alloxan monohydrate is used for inducing diabetes in mice. The percent wound contraction of garlic (150 mg/ml), turmeric (100 mg/ml), and fibroin (50 mg/ml), individually and in combinations garlic (150 mg/ml) + fibroin (50 mg/ml), turmeric (100 mg/ml) + fibroin (50 mg/ml), garlic (150 mg/ml) + turmeric (100 mg/ml), and garlic (150 mg/ml) + turmeric (100 mg/ml) + fibroin (50 mg/ml) was checked by evaluating the healing time, % wound contraction and histological analysis. The serum level of MMPs (MMP 2, MMP7, MMP 9), pro-inflammatory cytokines (TNF-α, IL-6, IL-8), and TIMPs were evaluated. With the combination of three extracts (Ga+Tu+Fi) garlic (150 mg/ml), turmeric (100 mg/ml) and fibroin (50 mg/ml), wounds healed in 12 days and had 97.3 ± 2.2% wound contraction. While the positive control (polyfax) and diabetic control (saline) wounds healed in 17- and 19-days with wound contraction of 96.7 ± 1.4% and 96.3 ± 1.1%, respectively. Histological analysis showed that the combination of Ga+Tu+Fi exhibited an increase in the growth of collagen fibers, fibroblasts number, and keratinocytes, and lessened inflammation of blood vessels. The combination of Ga+Tu+Fi significantly alleviated the serum concentration of TNF-α (14.2 ± 0.7 pg/ml), IL-6 (10.0 ± 1.0 pg/ml), IL-8 (16.0 ± 1.5 pg/ml), MMP2 (228.0 ± 18.1 pg/ml), MMP7 (271.0 ± 9.9 pg/ml), and MMP9 (141.0 ± 5.3 pg/ml) to diabetic control. The level of TIMPs (193.0 ± 9.1 pg/ml) was increased significantly with respect to diabetic control. We conclude that the combination of these biomaterials possessed high regenerative and healing capabilities and can be an effective remedy in the healing of chronic wounds in diabetic patients.
    MeSH term(s) Mice ; Animals ; Garlic ; Curcuma ; Matrix Metalloproteinase 7 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Interleukin-8 ; Fibroins ; Burns ; Wound Healing ; Diabetes Mellitus
    Chemical Substances Matrix Metalloproteinase 7 (EC 3.4.24.23) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Interleukin-8 ; Fibroins (9007-76-5)
    Language English
    Publishing date 2022-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2224246-6
    ISSN 1559-0488 ; 1559-047X
    ISSN (online) 1559-0488
    ISSN 1559-047X
    DOI 10.1093/jbcr/irac169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6223: Show issues Location:
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