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Article ; Online: Effect of the local energy distribution of x-ray beams generated through inverse Compton scattering in dual-energy imaging applications.

Paternò, G / Cardarelli, P / Fantoni, S / Masoumi, F / Mettivier, G / Cialdi, S / Taibi, A

Applied optics

2023 Volume 62, Issue 17, Page(s) 4399–4408

Abstract: X-ray sources based on the inverse Compton interaction between a laser and a relativistic electron beam are emerging as a promising compact alternative to synchrotron for the production of intense monochromatic and tunable radiation. The emission ... ...

Abstract	X-ray sources based on the inverse Compton interaction between a laser and a relativistic electron beam are emerging as a promising compact alternative to synchrotron for the production of intense monochromatic and tunable radiation. The emission characteristics enable several innovative imaging techniques, including dual-energy K-edge subtraction (KES) imaging. The performance of these techniques is optimal in the case of perfectly monochromatic x-ray beams, and the implementation of KES was proven to be very effective with synchrotron radiation. Nonetheless, the features of inverse Compton scattering (ICS) sources make them good candidates for a more compact implementation of KES techniques. The energy and intensity distribution of the emitted radiation is related to the emission direction, which means different beam qualities in different spatial positions. In fact, as the polar angle increases, the average energy decreases, while the local energy bandwidth increases and the emission intensity decreases. The scope of this work is to describe the impact of the local energy distribution variations on KES imaging performance. By means of analytical simulations, the reconstructed signal, signal-to-noise ratio, and background contamination were evaluated as a function of the position of each detector pixel. The results show that KES imaging is possible with ICS x-ray beams, even if the image quality slightly degrades at the detector borders for a fixed collimation angle and, in general, as the beam divergence increases. Finally, an approach for the optimization of specific imaging tasks is proposed by considering the characteristics of a given source.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.489239
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Article ; Online: ACACIAS 1: The physiological and subjective impacts of high fidelity simulation of the breaking of bad news.

Deluche, E / Salle, H / Leobon, S / Facchini-Joguet, T / Fourcade, L / Taibi, A

Journal of visceral surgery

2023 Volume 160, Issue 5, Page(s) 323–329

Abstract: Study objective: Breaking bad news (BN) is difficult and necessitates targeted training. To be effective, training may call for High Fidelity Simulation (HFS). This prospective study was conducted to objectively assess the impact of HFS as a tool ... ...

Abstract	Study objective: Breaking bad news (BN) is difficult and necessitates targeted training. To be effective, training may call for High Fidelity Simulation (HFS). This prospective study was conducted to objectively assess the impact of HFS as a tool conducive to the development of clinical competence in situations involving the delivery of bad news. Methods: This feasibility study was conducted from January to May 2021 and included students in medical oncology and digestive surgery. The subjective and objective impacts of HFS were evaluated by means of a self-administered questionnaire and a wristband, Affect-tag, which recorded several indicators: emotional power (EP), emotional density (DE) and cognitive load (CL) in students undergoing training. Results: Forty-six (46) students with a median age of 25 years (21-34 years) were included. While the participants were effectively and emotionally involved in the HFS training, they were not completely overwhelmed by their emotions, a possible occurrence in this type of program. After two training programs, the students presented with lower EP (P<0.001) and higher DE (P=0.005), while their CL remained stable (P=0.751). The information given in the self-administered questionnaires and the evaluations by outside professionals (actor, nurse, psychologist…) highlighted improved skills. Conclusion: Taking into account the emotional parameters observed and the questionnaires collected, HFS can be considered as a suitable and effective tool in the breaking of bad news.
MeSH term(s)	Humans ; Adult ; Truth Disclosure ; Acacia ; High Fidelity Simulation Training ; Prospective Studies ; Clinical Competence
Language	English
Publishing date	2023-03-31
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2023.03.006
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Article ; Online: Comprehensive data set to include interference effects in Monte Carlo models of x-ray coherent scattering inside biological tissues.

Paternò, G / Cardarelli, P / Gambaccini, M / Taibi, A

Physics in medicine and biology

2020 Volume 65, Issue 24, Page(s) 245002

Abstract: Interference effects are included in the x-ray coherent scattering models used in Monte Carlo codes by modifying each material form factor through a proper interference function, which is obtained directly from the measured scattering pattern. This ... ...

Abstract	Interference effects are included in the x-ray coherent scattering models used in Monte Carlo codes by modifying each material form factor through a proper interference function, which is obtained directly from the measured scattering pattern. This approach is effective for non-biological materials, but it is impractical for biological tissues, due the wide composition variability they can feature. Instead, a given biological sample can be considered as a proper mixture of four basis materials: fat, water, collagen and calcium hydroxyapatite. The sample form factor can then be obtained through a weighted mean of the form factors of the basis materials, which include interference effects. Here, we fully demonstrate the validity of the proposed segmentation method by applying it to 31 biological tissue samples whose form factors are available in the literature. The segmentation, namely the determination of the optimal weight of the basis components, was carried out through a multiple linear regression or, in some cases, by using a controlled trial and error sequence. The form factors of the basis materials were extracted from previous works and elaborated to include more scattering features. In particular, they were interpolated at a denser grid. Furthermore, the data measured separately in wide angle and small angle regimes, for fat and collagen, were merged. In general, a very good agreement was obtained between the original sample and the calculated mixture, being the mean relative difference of their scattering profiles and their attenuation coefficients ∼10%. The segmentation method is fully supported by our extension to the Geant4 model of x-ray coherent scattering, which was used to compare simulated scatter distributions with known experimental data. The developed Geant4 code and a series of molecular form factors, including those of the basis materials, are freely downloadable from a dedicated web repository.
MeSH term(s)	Humans ; Models, Biological ; Monte Carlo Method ; Scattering, Radiation ; Water ; X-Rays
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2020-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/aba7d2
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Article ; Online: Update on the Surgical Treatment of Pancreatic Neuroendocrine Tumors.

Jeune, F / Taibi, A / Gaujoux, S

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

2020 Volume 109, Issue 1, Page(s) 42–52

Abstract: Background and aims: Pancreatic neuroendocrine tumors (PNET) arise from uncontrolled proliferation of neuroendocrine cell and further genetic alterations that may induce hormone secretion such as glucagon/insulin/gastrin/VIP. Their incidence is ... ...

Abstract	Background and aims: Pancreatic neuroendocrine tumors (PNET) arise from uncontrolled proliferation of neuroendocrine cell and further genetic alterations that may induce hormone secretion such as glucagon/insulin/gastrin/VIP. Their incidence is rapidelly growing, especially because of the frequent incidental diagnosis of small asymptomatic non-functionnal neuroendocrine tumors with the widespread use of cross-sectional imaging. The vast majority of pancreatic neuroendocrine tumors are sporadic but up to 5%-10% of them arise from genetic syndromes, the main one being Multiple Endocrine Neopalsm type 1 (MEN1). Appropriate management of patients with PNET is a complex challenge for surgeons, and require extensive medical collaboration. This review aims to summarize major and recent updates regarding the medico-surgical management of PNETs. Material and methods: Review of pertinent English language literature. Results: This article provides a concise summary of the clinical presentation, diagnosis, surgical management, alternative treatments and follow up of PNETs. Conclusion: PNET are a rare, heterogeneous group of neoplasms with a generally favorable prognosis at least compared to pancreatic adenocarcinoma. Surgical resection is the cornerstone of their management, particularly for localized disease, and should always be discussed in multidisciplinary tumor board.
MeSH term(s)	Aftercare ; Humans ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/surgery ; Neuroendocrine Tumors/therapy ; Pancreatectomy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/therapy ; Prognosis
Language	English
Publishing date	2020-01-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2077691-3
ISSN	1799-7267 ; 1457-4969
ISSN (online)	1799-7267
ISSN	1457-4969
DOI	10.1177/1457496919900417
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Article ; Online: Prise en charge de l’extravasation de chimiothérapie sur site implantable par la technique de lavage sous cutané (avec vidéo).

Taibi, A / Ferrero, P A / Derbal, S

Gynecologie, obstetrique, fertilite & senologie

2020 Volume 48, Issue 4, Page(s) 398–399

Title translation	Chemotherapy drug extravasation in totally implantable venous access port systems: use of subcutaneous wash-out technique (with vidéo).
MeSH term(s)	Antineoplastic Agents/administration & dosage ; Extravasation of Diagnostic and Therapeutic Materials/therapy ; Humans ; Infusion Pumps, Implantable/adverse effects ; Neoplasms/drug therapy ; Subcutaneous Tissue ; Therapeutic Irrigation/methods ; Vascular Access Devices/adverse effects
Chemical Substances	Antineoplastic Agents
Language	French
Publishing date	2020-01-25
Publishing country	France
Document type	Journal Article ; Video-Audio Media
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2020.01.010
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Article ; Online: Will Endoscopic-Ultrasound-Guided Choledocoduodenostomy with Electrocautery-Enhanced Lumen-Apposing Metal Stent Placement Replace Endoscopic Retrograde Cholangiopancreatography When Treating Distal Malignant Biliary Obstructions?

Guilmoteau, Thomas / Albouys, Jérémie / Taibi, Abdelkader / Legros, Romain / Schaefer, Marion / Jacques, Jérémie

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 2

Abstract: Malignant distal biliary obstructions are becoming increasingly common, especially in patients with cancers of the pancreatic head, despite progress in medical oncology research. ERCP is the current gold standard for management of such strictures, but ... ...

Abstract	Malignant distal biliary obstructions are becoming increasingly common, especially in patients with cancers of the pancreatic head, despite progress in medical oncology research. ERCP is the current gold standard for management of such strictures, but the emergence of EC-LAMS has rendered EUS-CDS both safe and efficient. It is a "game changer"; originally intended for ERCP failure, two randomised clinical trials recently proposed EUS-CDS as a first-intent procedure in palliative settings. For resectable diseases, the absence of iatrogenic pancreatitis associated with a lower rate of postsurgical adverse events (compared with ERCP) leads us to believe that EUS-CDS might be used in first-intent as a pre-operative endoscopic biliary drainage.
MeSH term(s)	Humans ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Cholestasis/etiology ; Cholestasis/surgery ; Stents ; Neoplasms/etiology ; Electrocoagulation/methods ; Ultrasonography, Interventional/methods
Language	English
Publishing date	2024-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60020220
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Article: The role of intestinal microbiota and microRNAs in the anti-inflammatory effects of cranberry: from pre-clinical to clinical studies.

Taibi, Amel / Lofft, Zoe / Laytouni-Imbriaco, Bianca / Comelli, Elena Maria

Frontiers in nutrition

2023 Volume 10, Page(s) 1092342

Abstract: Cranberries have known anti-inflammatory properties, which extend their benefits in the context of several chronic diseases. These benefits highly rely on the polyphenol profile of cranberries, one of few foods rich in A-type proanthocyanidin (PAC). A- ... ...

Abstract	Cranberries have known anti-inflammatory properties, which extend their benefits in the context of several chronic diseases. These benefits highly rely on the polyphenol profile of cranberries, one of few foods rich in A-type proanthocyanidin (PAC). A-type PAC comprises flavan-3-ol subunits with an additional interflavan ether bond in the conformational structure of the molecule, separating them from the more commonly found B-type PAC. PACs with a degree of polymerization higher than three are known to reach the colon intact, where they can be catabolyzed by the gut microbiota and biotransformed into lower molecular weight organic acids that are available for host absorption. Gut microbiota-derived metabolites have garnered much attention in the past decade as mediators of the health effects of parent compounds. Though, the mechanisms underlying this phenomenon remain underexplored. In this review, we highlight emerging evidence that postulates that polyphenols, including ones derived from cranberries, and their metabolites could exert anti-inflammatory effects by modulating host microRNAs. Our review first describes the chemical structure of cranberry PACs and a pathway for how they are biotransformed by the gut microbiota. We then provide a brief overview of the benefits of microbial metabolites of cranberry in the intestinal tract, at homeostasis and in inflammatory conditions. Finally, we discuss the role of microRNAs in intestinal health and in response to cranberry PAC and how they could be used as targets for the maintenance of intestinal homeostasis. Most of this research is pre-clinical and we recognize that conducting clinical trials in this context has been hampered by the lack of reliable biomarkers. Our review discusses the use of miRNA as biomarkers in this context.
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1092342
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Article ; Online: Cystic mass appended to the greater curvature of the stomach? Cystic lymphangioma of the greater omentum.

Taibi, A / Derbal, S / Mathonnet, M / Durand Fontanier, S

Journal of visceral surgery

2020 Volume 157, Issue 5, Page(s) 443–445

MeSH term(s)	Humans ; Lymphangioma, Cystic/diagnosis ; Lymphangioma, Cystic/pathology ; Lymphangioma, Cystic/surgery ; Male ; Middle Aged ; Omentum/diagnostic imaging ; Omentum/pathology ; Omentum/surgery ; Peritoneal Neoplasms/diagnosis ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/surgery
Language	English
Publishing date	2020-04-10
Publishing country	France
Document type	Case Reports ; Journal Article
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2020.03.010
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Article ; Online: Evaluation of microcalcification contrast in clinical images for digital mammography and synthetic mammography.

Baldelli, P / Cardarelli, P / Flanagan, F / Maguire, S / Phelan, N / Tomasi, S / Taibi, A

European journal of radiology

2021 Volume 140, Page(s) 109751

Abstract: Purpose: The aim of this work was to compare, in a clinical study, digital mammography and synthetic mammography imaging by evaluating the contrast in microcalcifications of different sizes.: Methods: A retrospective review of microcalcifications ... ...

Abstract	Purpose: The aim of this work was to compare, in a clinical study, digital mammography and synthetic mammography imaging by evaluating the contrast in microcalcifications of different sizes. Methods: A retrospective review of microcalcifications from 46 patients was undertaken. A Hologic 3-Dimensions mammography system and a HD Combo protocol was used for simultaneous acquisition of the digital and synthetic images. Microcalcifications were classified in accordance with their size, and patient breast images were classified in accordance with their density as adipose, moderately dense and dense. The contrast of the microcalcifications was measured and the contrast ratio between synthetic and digital images was compared. An additional qualitative assessment of the images was presented to correlate the conspicuity of the microcalcifications with the suppression of the structure noise. Results: Microcalcifications in adipose background always exhibit a comparable or better contrast on synthetic images, regardless their size. For moderately dense background, synthetic images show a better contrast in 91.2 % of cases for small microcalcifications and in 90.9 % of cases for large microcalcifications. For a dense background, better contrast is seen in 89.5 % of cases for small microcalcifications, and in 85.7 % of cases for large microcalcifications. The contrast ratio increases with increasing breast glandularity. The suppression of structure noise also contributes to the enhancement of microcalcifications in the synthetic images. Conclusions: Synthetic mammography imaging is superior to digital mammography imaging in terms of microcalcification contrast, regardless their size and breast density.
Language	English
Publishing date	2021-05-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2021.109751
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Article ; Online: Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth.

Mohammadyari, Parvin / Gadda, Giacomo / Taibi, Angelo

Scientific reports

2021 Volume 11, Issue 1, Page(s) 4672

Abstract: Cardiovascular haemodynamics alters during posture changes and exposure to microgravity. Vascular auto-remodelling observed in subjects living in space environment causes them orthostatic intolerance when they return on Earth. In this study we modelled ... ...

Abstract	Cardiovascular haemodynamics alters during posture changes and exposure to microgravity. Vascular auto-remodelling observed in subjects living in space environment causes them orthostatic intolerance when they return on Earth. In this study we modelled the human haemodynamics with focus on head and neck exposed to different hydrostatic pressures in supine, upright (head-up tilt), head-down tilt position, and microgravity environment by using a well-developed 1D-0D haemodynamic model. The model consists of two parts that simulates the arterial (1D) and brain-venous (0D) vascular tree. The cardiovascular system is built as a network of hydraulic resistances and capacitances to properly model physiological parameters like total peripheral resistance, and to calculate vascular pressure and the related flow rate at any branch of the tree. The model calculated 30.0 mmHg (30%), 7.1 mmHg (78%), 1.7 mmHg (38%) reduction in mean blood pressure, intracranial pressure and central venous pressure after posture change from supine to upright, respectively. The modelled brain drainage outflow percentage from internal jugular veins is 67% and 26% for supine and upright posture, while for head-down tilt and microgravity is 65% and 72%, respectively. The model confirmed the role of peripheral veins in regional blood redistribution during posture change from supine to upright and microgravity environment as hypothesized in literature. The model is able to reproduce the known haemodynamic effects of hydraulic pressure change and weightlessness. It also provides a virtual laboratory to examine the consequence of a wide range of orthostatic stresses on human haemodynamics.
MeSH term(s)	Adaptation, Physiological ; Dizziness ; Earth, Planet ; Hemodynamics ; Humans ; Hydrostatic Pressure ; Intracranial Pressure/physiology ; Models, Biological ; Weightlessness
Language	English
Publishing date	2021-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-84197-7
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