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  1. AU="Tairmae Kangarloo"
  2. AU="Khan, Qaisar Imran"
  3. AU="Alberton, Michele D"
  4. AU="Chou, Tsung-Ching"
  5. AU="Mehdizadeh, Rana"
  6. AU="Sue Chen"
  7. AU=Smrcka A V
  8. AU="Costache, Oana"
  9. AU="Jungilligens, Johannes"
  10. AU="Kegel, S"
  11. AU="Frances P. Rodriguez-Rivera"
  12. AU="Viennet, Hervé"
  13. AU="Martínez-Silva, María G"
  14. AU="Christino, Melissa A"
  15. AU="Silva, Larissa L"
  16. AU="Tonks, Michael R."
  17. AU="Korhonen, H"
  18. AU="Mukendi, John T"
  19. AU="Athira S. Raj"
  20. AU="Corbacho, Belen"
  21. AU="Andrei, Adin Cristian" AU="Andrei, Adin Cristian"
  22. AU="Erminia Donnarumma"
  23. AU="Albores-Figueroa, Rosenberg"
  24. AU="Squillace, Lino"
  25. AU="Laufs, Sebastian"
  26. AU="McCanny, Suzette"
  27. AU="McHardy, John Alexander"
  28. AU="Erdal, Ranya"
  29. AU="Li, Long-Xia"
  30. AU="Esapa, Benjamina"

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  1. Artikel ; Online: Central precocious puberty in Boston boys

    Lisa Swartz Topor / Kimberly Bowerman / Jason T Machan / Courtney L Gilbert / Tairmae Kangarloo / Natalie D Shaw

    PLoS ONE, Vol 13, Iss 6, p e

    A 10-year single center experience.

    2018  Band 0199019

    Abstract: OBJECTIVE:Recent studies in the US and abroad suggest that boys are undergoing puberty at a younger age. It is unknown if this secular trend extends to boys with central precocious puberty (CPP), who sit at the extreme end of the pubertal spectrum, and ... ...

    Abstract OBJECTIVE:Recent studies in the US and abroad suggest that boys are undergoing puberty at a younger age. It is unknown if this secular trend extends to boys with central precocious puberty (CPP), who sit at the extreme end of the pubertal spectrum, and if neuroimaging should remain a standard diagnostic tool. STUDY DESIGN:Retrospective chart review of all boys with CPP seen by Endocrinology at a US pediatric hospital from 2001-2010. RESULTS:Fifty boys had pubertal onset at an average age of 7.31 years (95CI 6.83-7.89), though many did not present until nearly one year thereafter, by which time 30% were mid-to-late pubertal. Boys were predominantly non-Hispanic White and 64% were overweight/obese. The majority (64%) of boys had neurogenic CPP (CNS-CPP) with neurofibromatosis type I being the most common diagnosis. Diagnosis of CPP led to discovery of a neurogenic lesion in only 3 of 32 (9%) CNS-CPP cases. The remaining boys, with idiopathic CPP (36%), were indistinguishable from those with CNS-CPP aside from four boys who endorsed a family history of PP (22% vs. 0% among CNS-CPP cases). Importantly, there was no change in the incidence of male CPP after accounting for the increase in clinic volume during this time period. CONCLUSION:In this contemporary Boston-based cohort of 50 boys with CPP, most cases were neurogenic, consistent with older literature. Several idiopathic cases had a family history of PP but were otherwise indistinguishable from CNS-CPP cases. Thus, neuroimaging remains a critical diagnostic tool. We find no evidence for an increase in the prevalence of male CPP.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 900
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: mHealth and wearable technology should replace motor diaries to track motor fluctuations in Parkinson’s disease

    M. Kelley Erb / Daniel R. Karlin / Bryan K. Ho / Kevin C. Thomas / Federico Parisi / Gloria P. Vergara-Diaz / Jean-Francois Daneault / Paul W. Wacnik / Hao Zhang / Tairmae Kangarloo / Charmaine Demanuele / Chris R. Brooks / Craig N. Detheridge / Nina Shaafi Kabiri / Jaspreet S. Bhangu / Paolo Bonato

    npj Digital Medicine, Vol 3, Iss 1, Pp 1-

    2020  Band 10

    Abstract: Abstract Accurately monitoring motor and non-motor symptoms as well as complications in people with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials investigating new treatments. A variety ...

    Abstract Abstract Accurately monitoring motor and non-motor symptoms as well as complications in people with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials investigating new treatments. A variety of strategies have been relied upon including questionnaires, motor diaries, and the serial administration of structured clinical exams like part III of the MDS-UPDRS. To evaluate the potential use of mobile and wearable technologies in clinical trials of new pharmacotherapies targeting PD symptoms, we carried out a project (project BlueSky) encompassing four clinical studies, in which 60 healthy volunteers (aged 23–69; 33 females) and 95 people with PD (aged 42–80; 37 females; years since diagnosis 1–24 years; Hoehn and Yahr 1–3) participated and were monitored in either a laboratory environment, a simulated apartment, or at home and in the community. In this paper, we investigated (i) the utility and reliability of self-reports for describing motor fluctuations; (ii) the agreement between participants and clinical raters on the presence of motor complications; (iii) the ability of video raters to accurately assess motor symptoms, and (iv) the dynamics of tremor, dyskinesia, and bradykinesia as they evolve over the medication cycle. Future papers will explore methods for estimating symptom severity based on sensor data. We found that 38% of participants who were asked to complete an electronic motor diary at home missed ~25% of total possible entries and otherwise made entries with an average delay of >4 h. During clinical evaluations by PD specialists, self-reports of dyskinesia were marked by ~35% false negatives and 15% false positives. Compared with live evaluation, the video evaluation of part III of the MDS-UPDRS significantly underestimated the subtle features of tremor and extremity bradykinesia, suggesting that these aspects of the disease may be underappreciated during remote assessments. On the other hand, live and video raters agreed on aspects ...
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: mHealth and wearable technology should replace motor diaries to track motor fluctuations in Parkinson’s disease

    M. Kelley Erb / Daniel R. Karlin / Bryan K. Ho / Kevin C. Thomas / Federico Parisi / Gloria P. Vergara-Diaz / Jean-Francois Daneault / Paul W. Wacnik / Hao Zhang / Tairmae Kangarloo / Charmaine Demanuele / Chris R. Brooks / Craig N. Detheridge / Nina Shaafi Kabiri / Jaspreet S. Bhangu / Paolo Bonato

    npj Digital Medicine, Vol 3, Iss 1, Pp 1-

    2020  Band 10

    Abstract: Abstract Accurately monitoring motor and non-motor symptoms as well as complications in people with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials investigating new treatments. A variety ...

    Abstract Abstract Accurately monitoring motor and non-motor symptoms as well as complications in people with Parkinson’s disease (PD) is a major challenge, both during clinical management and when conducting clinical trials investigating new treatments. A variety of strategies have been relied upon including questionnaires, motor diaries, and the serial administration of structured clinical exams like part III of the MDS-UPDRS. To evaluate the potential use of mobile and wearable technologies in clinical trials of new pharmacotherapies targeting PD symptoms, we carried out a project (project BlueSky) encompassing four clinical studies, in which 60 healthy volunteers (aged 23–69; 33 females) and 95 people with PD (aged 42–80; 37 females; years since diagnosis 1–24 years; Hoehn and Yahr 1–3) participated and were monitored in either a laboratory environment, a simulated apartment, or at home and in the community. In this paper, we investigated (i) the utility and reliability of self-reports for describing motor fluctuations; (ii) the agreement between participants and clinical raters on the presence of motor complications; (iii) the ability of video raters to accurately assess motor symptoms, and (iv) the dynamics of tremor, dyskinesia, and bradykinesia as they evolve over the medication cycle. Future papers will explore methods for estimating symptom severity based on sensor data. We found that 38% of participants who were asked to complete an electronic motor diary at home missed ~25% of total possible entries and otherwise made entries with an average delay of >4 h. During clinical evaluations by PD specialists, self-reports of dyskinesia were marked by ~35% false negatives and 15% false positives. Compared with live evaluation, the video evaluation of part III of the MDS-UPDRS significantly underestimated the subtle features of tremor and extremity bradykinesia, suggesting that these aspects of the disease may be underappreciated during remote assessments. On the other hand, live and video raters agreed on aspects of postural instability and gait. Our results highlight the significant opportunity for objective, high-resolution, continuous monitoring afforded by wearable technology to improve upon the monitoring of PD symptoms.
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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