Article ; Online: Diet, commensal microbiota-derived extracellular vesicles, and host immunity.
European journal of immunology
2023 Volume 53, Issue 7, Page(s) e2250163
Abstract: The gut microbiota has co-evolved with its host, and commensal bacteria can influence both the host's immune development and function. Recently, a role has emerged for bacterial extracellular vesicles (BEVs) as potent immune modulators. BEVs are ... ...
| Abstract | The gut microbiota has co-evolved with its host, and commensal bacteria can influence both the host's immune development and function. Recently, a role has emerged for bacterial extracellular vesicles (BEVs) as potent immune modulators. BEVs are nanosized membrane vesicles produced by all bacteria, possessing the membrane characteristics of the originating bacterium and carrying an internal cargo that may include nucleic acid, proteins, lipids, and metabolites. Thus, BEVs possess multiple avenues for regulating immune processes, and have been implicated in allergic, autoimmune, and metabolic diseases. BEVs are biodistributed locally in the gut, and also systemically, and thus have the potential to affect both the local and systemic immune responses. The production of gut microbiota-derived BEVs is regulated by host factors such as diet and antibiotic usage. Specifically, all aspects of nutrition, including macronutrients (protein, carbohydrates, and fat), micronutrients (vitamins and minerals), and food additives (the antimicrobial sodium benzoate), can regulate BEV production. This review summarizes current knowledge of the powerful links between nutrition, antibiotics, gut microbiota-derived BEV, and their effects on immunity and disease development. It highlights the potential of targeting or utilizing gut microbiota-derived BEV as a therapeutic intervention. |
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| MeSH term(s) | Microbiota ; Diet ; Gastrointestinal Microbiome/physiology ; Bacteria ; Anti-Bacterial Agents ; Extracellular Vesicles/metabolism | ||||||||||
| Chemical Substances | Anti-Bacterial Agents | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2023-05-17 | ||||||||||
| Publishing country | Germany | ||||||||||
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 120108-6 | ||||||||||
| ISSN | 1521-4141 ; 0014-2980 | ||||||||||
| ISSN (online) | 1521-4141 | ||||||||||
| ISSN | 0014-2980 | ||||||||||
| DOI | 10.1002/eji.202250163 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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