Article ; Online: Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy.
2014 Volume 31, Issue 2, Page(s) 613–618
Abstract: S-1 has been recommended as adjuvant chemotherapy in patients after curative surgery for gastric cancer. However, some patients suffer recurrence even after S-1 adjuvant chemotherapy. The present study was conducted to find a predictive marker of the ... ...
| Abstract | S-1 has been recommended as adjuvant chemotherapy in patients after curative surgery for gastric cancer. However, some patients suffer recurrence even after S-1 adjuvant chemotherapy. The present study was conducted to find a predictive marker of the efficacy of S-1 adjuvant chemotherapy. We examined the microRNA (miRNA) expression of 35 patients who underwent S-1 adjuvant chemotherapy after curative surgery (R0) for pathological stage II or III gastric cancer. miRNAs were extracted from formalin-fixed, paraffin-embedded specimens for analysis and miRNA expression was examined using miRNA oligo chips. Fifteen patients relapsed and 20 did not over 5 years. Five miRNAs (miR-92b, 422a, 4732-5p, 4758-3p and 221) were highly expressed according to the tumor/normal (T/N) ratio in the patients who relapsed but not in those who did not relapse (P-value <0.05) by microarray analysis. If tumors showed high expression of 4 miRNAs (miR-92b, 422a, 4732-5p and 4758-3p) their positive predictive value of relapse was 93.8% and negative predictive value was 92.3%. In this case, their disease-free survival rate and overall survival rate were very poor. Our findings indicate that miR-92b, miR‑422a, miR-4732-5p and miR-4758-3p are closely associated with relapse following S-1 adjuvant chemotherapy in gastric cancer. |
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| MeSH term(s) | Aged ; Antimetabolites, Antineoplastic/therapeutic use ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Drug Combinations ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/mortality ; Oxonic Acid/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Stomach Neoplasms/mortality ; Survival ; Tegafur/therapeutic use | |||||
| Chemical Substances | Antimetabolites, Antineoplastic ; Drug Combinations ; MicroRNAs ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG) | |||||
| Language | English | |||||
| Publishing date | 2014-02 | |||||
| Publishing country | Greece | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1222484-4 | |||||
| ISSN | 1791-2431 ; 1021-335X | |||||
| ISSN (online) | 1791-2431 | |||||
| ISSN | 1021-335X | |||||
| DOI | 10.3892/or.2013.2900 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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