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Article: Image of a thawed frozen specimen obtained using a cryoprobe floated with oil droplets in normal saline: An endobronchial lipomatous hamartoma image.

Takigawa, Yuki / Sato, Ken / Inoue, Tomoyoshi / Takada, Masahiro / Fujiwara, Keiichi

2024 Volume 12, Issue 3, Page(s) e01318

Abstract: Hereby, we present a rare case of a resected endobronchial tumour that floated or showed oil droplets in saline. In this study, we report an interesting image related to endobronchial lipomatous hamartoma cryotherapy. ...

Abstract	Hereby, we present a rare case of a resected endobronchial tumour that floated or showed oil droplets in saline. In this study, we report an interesting image related to endobronchial lipomatous hamartoma cryotherapy.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1318
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Article ; Online: Neoadjuvant treatment for HER2-positive breast cancer.

Takada, Masahiro / Toi, Masakazu

Chinese clinical oncology

2020 Volume 9, Issue 3, Page(s) 32

Abstract: Neoadjuvant therapy has become a standard clinical practice to downsize the tumor and increase the breast-conserving rate. The addition of trastuzumab to neoadjuvant chemotherapy roughly doubles the proportion of patients with HER2-positive breast cancer ...

Abstract	Neoadjuvant therapy has become a standard clinical practice to downsize the tumor and increase the breast-conserving rate. The addition of trastuzumab to neoadjuvant chemotherapy roughly doubles the proportion of patients with HER2-positive breast cancer who achieve pathological complete response (pCR). Patients with pCR show better prognosis compared with those with residual disease after neoadjuvant therapy. Targeting the HER2 pathway with trastuzumab and pertuzumab can further increase the pCR rate. Several studies have shown that neoadjuvant chemotherapy with trastuzumab plus pertuzumab is tolerable, increases the pCR rate compared with trastuzumab alone, and results in about 50-70% pCR rate. One of the most important studies on neoadjuvant therapy is the KATHERINE trial, in which improved prognostic outcome for patients with residual disease after neoadjuvant therapy was observed. In the trial, improved invasive disease-free survival (DFS) was observed with the administration of postoperative trastuzumab emtansine in patients with HER2-positive breast cancer who had residual disease after neoadjuvant therapy. The indication of neoadjuvant therapy in patients with HER2-positive breast cancer may be changed because the opportunity for residual disease-guided approach, demonstrated in the KATHERINE trial, will be lost when patients had first undergone surgery. Translational studies are promising for further patient selection for HER2-targeted therapy and the development of a novel treatment strategy including PI3K-targeted therapy and immune checkpoint inhibitors. Feasibility studies to evaluate the ability of needle-biopsy to predict pCR after neoadjuvant therapy suggested that standardization and refinements in biopsy procedure (i.e., needle size, number of samples, etc.) are essential for the design of clinical trials of omitted surgery for patients with radiologic complete response.
MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Female ; Humans ; Neoadjuvant Therapy/methods
Language	English
Publishing date	2020-06-03
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2828547-5
ISSN	2304-3873 ; 2304-3865
ISSN (online)	2304-3873
ISSN	2304-3865
DOI	10.21037/cco-20-123
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Article: [Ⅱ.POTENT, a Randomized Phase Ⅲ Trial].

Takada, Masahiro / Toi, Masakazu

Gan to kagaku ryoho. Cancer & chemotherapy

2020 Volume 47, Issue 12, Page(s) 1678–1680

Language	Japanese
Publishing date	2020-12-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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Article ; Online: Unilateral Reduction of 18F-FDG Accumulation in Brown Adipose Tissue by Sympathectomy for Hyperhidrosis.

Shirakawa, Chigusa / Koyasu, Sho / Takada, Masahiro / Toi, Masakazu / Nakamoto, Yuji

Clinical nuclear medicine

2022 Volume 48, Issue 1, Page(s) 79–80

Abstract: Abstract: A 30-year-old woman with left breast cancer underwent 18F-FDG PET/CT for staging. Intense FDG uptake was observed in the primary lesion, as well as on the left side of the neck to the supraclavicular fossa and left paravertebral region. ... ...

Abstract	Abstract: A 30-year-old woman with left breast cancer underwent 18F-FDG PET/CT for staging. Intense FDG uptake was observed in the primary lesion, as well as on the left side of the neck to the supraclavicular fossa and left paravertebral region. History taking revealed that she had undergone a right thoracic sympathectomy for hyperhidrosis, which resulted in attenuated FDG uptake in the right-sided brown adipose tissue (BAT). With another examination keeping adequate warming, the accumulation of BAT was reduced and a diagnosis of cT1N1M0 was made. Unilateral sympathetic blockade can cause asymmetric FDG accumulation in BAT, which interferes with interpretation in tumors.
MeSH term(s)	Female ; Humans ; Adult ; Fluorodeoxyglucose F18 ; Adipose Tissue, Brown/diagnostic imaging ; Adipose Tissue, Brown/pathology ; Positron Emission Tomography Computed Tomography/methods ; Sympathectomy ; Hyperhidrosis/diagnostic imaging ; Hyperhidrosis/pathology ; Neoplasms/pathology
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-09-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004393
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Zs.A 1276: Show issues

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Article ; Online: Cryosurgery for primary breast cancers, its biological impact, and clinical outcomes.

Takada, Masahiro / Toi, Masakazu

International journal of clinical oncology

2019 Volume 24, Issue 6, Page(s) 608–613

Abstract: Recently, a number of new minimally invasive image-guided percutaneous ablation treatments, including cryoablation, radiofrequency ablation, microwave ablation, high-intensity focused ultrasound, laser ablation, and irreversible electroporation have been ...

Abstract	Recently, a number of new minimally invasive image-guided percutaneous ablation treatments, including cryoablation, radiofrequency ablation, microwave ablation, high-intensity focused ultrasound, laser ablation, and irreversible electroporation have been developed. Several studies have shown the feasibility and safety of these cryoablation therapies for the treatment of benign breast tumors and small invasive breast cancer. Although the complete response rate of cryoablation for breast cancer is reported to be relatively good, most studies enrolled a small number of patients, and so reliable conclusions could not be drawn. In this review, we introduce the mechanisms of action of cryoablation, and summarize the current literature on the efficacy and safety of cryoablation for breast cancer. Cryoablation also induces an immunomodulatory effect, which is an interesting topic of research in the era of immune checkpoint inhibitors. Cryoablation for primary tumor may enhance the treatment effect of immune checkpoint inhibitors in patients with breast cancer. Further investigations of this new therapeutic strategy are needed.
MeSH term(s)	Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Cryosurgery/methods ; Female ; Humans ; Treatment Outcome
Language	English
Publishing date	2019-04-13
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-019-01448-4
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Zs.A 4828: Show issues

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Article ; Online: Non-surgical ablation for breast cancer: an emerging therapeutic option.

Toi, Masakazu / Kinoshita, Takayuki / Benson, John R / Jatoi, Ismail / Kataoka, Masako / Han, Wonshik / Yamauchi, Chikako / Inamoto, Takashi / Takada, Masahiro

The Lancet. Oncology

2024 Volume 25, Issue 3, Page(s) e114–e125

Abstract: Non-surgical ablation is emerging as an alternative local therapy option for patients with early-stage breast cancer and encompasses two main types of percutaneous therapeutic procedures: radiofrequency ablation and cryoablation. Both techniques involve ... ...

Abstract	Non-surgical ablation is emerging as an alternative local therapy option for patients with early-stage breast cancer and encompasses two main types of percutaneous therapeutic procedures: radiofrequency ablation and cryoablation. Both techniques involve obliteration of a spherical lesion and feasibility studies have shown that complete tumour ablation is achievable with good or excellent cosmetic results. Although few clinical studies have directly compared non-surgical ablation with conventional surgical resection, observational studies indicate that clinical outcomes are favourable with acceptable rates of local control and no detriment to long-term survival. There remain outstanding issues with these percutaneous ablative techniques that require resolution before they could be incorporated into routine clinical practice. Hence, a consensus meeting was convened to discuss the challenges of non-surgical ablation and clarify indications for its use alongside clinical management pathways. In this Policy Review we will address some of the broader biological aspects of non-surgical ablation, including immune-modulatory effects and potential novel applications for the future.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/surgery ; Catheter Ablation ; Consensus ; Critical Pathways
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(23)00615-0
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 460: Show issues

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Article ; Online: Breast cancer detection using volatile compound profiles in exhaled breath via selected ion-flow tube mass spectrometry.

Nakayama, Yoshie / Hanada, Mariko / Koda, Hiroshi / Sugimoto, Masahiro / Takada, Masahiro / Toi, Masakazu

Journal of breath research

2022 Volume 17, Issue 1

Abstract: This study aimed to evaluate volatile compounds in exhaled breath as a non-invasive screening method to detect breast neoplasms. Exhaled breath samples were collected from patients with breast cancer (BC; ...

Abstract	This study aimed to evaluate volatile compounds in exhaled breath as a non-invasive screening method to detect breast neoplasms. Exhaled breath samples were collected from patients with breast cancer (BC;
MeSH term(s)	Humans ; Female ; Breath Tests/methods ; Volatile Organic Compounds/analysis ; Mass Spectrometry/methods ; Exhalation ; Breast Neoplasms/diagnosis
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2381007-5
ISSN	1752-7163 ; 1752-7155
ISSN (online)	1752-7163
ISSN	1752-7155
DOI	10.1088/1752-7163/aca696
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Article ; Online: Ultrafast Dynamic Contrast-Enhanced MRI of the Breast: From Theory to Practice.

Kataoka, Masako / Honda, Maya / Sagawa, Hajime / Ohashi, Akane / Sakaguchi, Rena / Hashimoto, Hina / Iima, Mami / Takada, Masahiro / Nakamoto, Yuji

Journal of magnetic resonance imaging : JMRI

2023

Abstract: The development of ultrafast dynamic contrast-enhanced (UF-DCE) MRI has occurred in tandem with fast MRI scan techniques, particularly view-sharing and compressed sensing. Understanding the strengths of each technique and optimizing the relevant ... ...

Abstract	The development of ultrafast dynamic contrast-enhanced (UF-DCE) MRI has occurred in tandem with fast MRI scan techniques, particularly view-sharing and compressed sensing. Understanding the strengths of each technique and optimizing the relevant parameters are essential to their implementation. UF-DCE MRI has now shifted from research protocols to becoming a part of clinical scan protocols for breast cancer. UF-DCE MRI is expected to compensate for the low specificity of abbreviated MRI by adding kinetic information from the upslope of the time-intensity curve. Because kinetic information from UF-DCE MRI is obtained from the shape and timing of the initial upslope, various new kinetic parameters have been proposed. These parameters may be associated with receptor status or prognostic markers for breast cancer. In addition to the diagnosis of malignant lesions, more emphasis has been placed on predicting and evaluating treatment response because hyper-vascularity is linked to the aggressiveness of breast cancers. In clinical practice, it is important to note that breast lesion images obtained from UF-DCE MRI are slightly different from those obtained by conventional DCE MRI in terms of morphology. A major benefit of using UF-DCE MRI is avoidance of the marked or moderate background parenchymal enhancement (BPE) that can obscure the target enhancing lesions. BPE is less prominent in the earlier phases of UF-DCE MRI, which offers better lesion-to-noise contrast. The excellent contrast of early-enhancing vessels provides a key to understanding the detailed pathological structure of tumor-associated vessels. UF-DCE MRI is normally accompanied by a large volume of image data for which automated/artificial intelligence-based processing is expected to be useful. In this review, both the theoretical and practical aspects of UF-DCE MRI are summarized. EVIDENCE LEVEL: 5 TECHNICAL EFFICACY: Stage 2.
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.29082
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 236: Show issues

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Article ; Online: Fosfomycin as salvage therapy for persistent methicillin-resistant Staphylococcus aureus bacteremia: A case series and review of the literature.

Omori, Keitaro / Kitagawa, Hiroki / Takada, Masahiro / Maeda, Ryuto / Nomura, Toshihito / Kubo, Yuko / Shigemoto, Norifumi / Ohge, Hiroki

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2023 Volume 30, Issue 4, Page(s) 352–356

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can be persistent and refractory; however, the optimal approach for its treatment has not been determined. Although fosfomycin (FOM) has been shown to have synergistic effects with anti-MRSA ... ...

Abstract	Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can be persistent and refractory; however, the optimal approach for its treatment has not been determined. Although fosfomycin (FOM) has been shown to have synergistic effects with anti-MRSA agents in vitro, clinical experience with FOM combination therapy is limited. Thus, we present cases of persistent MRSA bacteremia that improved with the addition of FOM. In case 1, a 48-year-old man with prosthetic vascular graft infection developed persistent MRSA bacteremia despite vancomycin (VCM) and daptomycin (DAP) administration. On day 46, after the first positive blood culture, we added FOM to DAP. The blood culture became negative on day 53. In case 2, an 85-year-old woman presented with pacemaker-related MRSA bacteremia. She was treated with VCM, followed by DAP and DAP plus rifampicin. However, the bacteremia persisted for 32 days because of difficulties in immediate pacemaker removal. After adding FOM to DAP, the blood culture became negative on day 38. In case 3, a 57-year-old woman developed persistent MRSA bacteremia due to pulmonary valve endocarditis and pulmonary artery thrombosis after total esophagectomy for esophageal cancer. The bacteremia continued for 50 days despite treatment with DAP, followed by VCM, VCM plus minocycline, DAP plus linezolid (LZD), and VCM plus LZD. She was managed conservatively because of surgical complications. After adding FOM to VCM on day 51, the blood culture became negative on day 58. FOM combination therapy may be effective in eliminating bacteria and can serve as salvage therapy for refractory MRSA bacteremia.
MeSH term(s)	Male ; Female ; Humans ; Aged, 80 and over ; Middle Aged ; Salvage Therapy ; Methicillin-Resistant Staphylococcus aureus ; Fosfomycin/therapeutic use ; Bacteremia/drug therapy ; Daptomycin/therapeutic use ; Linezolid
Chemical Substances	Fosfomycin (2N81MY12TE) ; Daptomycin (NWQ5N31VKK) ; Linezolid (ISQ9I6J12J)
Language	English
Publishing date	2023-11-03
Publishing country	Netherlands
Document type	Review ; Case Reports
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2023.10.024
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Zs.A 5236: Show issues

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Article: Real-World Patient Characteristics, Treatment Patterns, and Outcomes of HR+, HER2- Early Breast Cancer Patients in Japan: An Analysis with National Database(NDB).

Komatsu, Shuichiro / Kawai, Masaaki / Takada, Masahiro / Nakayama, Takahiro / Masuda, Norikazu / Shiheido, Hirokazu / Cai, Zhihong / Huang, Yu Jing / Kawaguchi, Tsutomu / Tanizawa, Yoshinori

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 12, Page(s) 1283–1294

Abstract: Real-world evidence for clinical outcomes and treatment patterns in patients with hormone receptor-positive(HR+)and human epidermal growth factor receptor 2-negative(HER2-)early breast cancer(EBC)in Japan is limited. We aimed to provide recent evidence ... ...

Abstract	Real-world evidence for clinical outcomes and treatment patterns in patients with hormone receptor-positive(HR+)and human epidermal growth factor receptor 2-negative(HER2-)early breast cancer(EBC)in Japan is limited. We aimed to provide recent evidence in this population using the National Database of Health Insurance Claims and Specific Health Check-ups of Japan(NDB). Adults ≥20 years old who were diagnosed with HR+/HER2- breast cancer and underwent breast resection surgery were followed up. Patient characteristics and treatment patterns were evaluated. Durations of overall post-operative endocrine therapy(ET)and luteinizing hormone-releasing hormone(LH-RH)agonist therapy, and time to metastasis/recurrence after surgery were analyzed using Kaplan-Meier method. Overall, 294,904 patients were included. Cyclophosphamide and tamoxifen were the most common peri-operative chemotherapeutic and ET drugs. Median(95% confidence interval[CI])duration of post-operative ET and LH-RH agonist therapy was 5.01(5.01-5.01)years and 2.13 (2.12-2.14)years, respectively. Five-year cumulative rate(95% CI)of any recurrence was 8.6%(8.5-8.7), visceral metastasis being the most common. Nation-wide treatment patterns were described, which were consistent with guideline recommendations for patients with HR+, HER2- EBC. Further discussion is required to delay metastasis/recurrence and improve clinical outcomes(Fig. 1: Plain language summary of the study).
MeSH term(s)	Adult ; Humans ; Young Adult ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Japan ; Cyclophosphamide ; Tamoxifen ; Gonadotropin-Releasing Hormone
Chemical Substances	Cyclophosphamide (8N3DW7272P) ; Tamoxifen (094ZI81Y45) ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2024-01-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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