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  1. Article ; Online: The 50th anniversary of the Konopka and Benzer 1971 paper in PNAS: "Clock Mutants of

    Takahashi, Joseph S

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 39

    MeSH term(s) Animals ; Anniversaries and Special Events ; Circadian Rhythm ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Mutation ; Period Circadian Proteins/genetics ; Period Circadian Proteins/metabolism
    Chemical Substances Drosophila Proteins ; Period Circadian Proteins
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2110171118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Patricia J. DeCoursey (28 December 1932 to 1 January 2022).

    Harrington, Mary / Takahashi, Joseph S

    Journal of biological rhythms

    2023  Volume 38, Issue 3, Page(s) 242–244

    MeSH term(s) Animals ; Circadian Rhythm ; Butterflies
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/07487304231161950
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  3. Book: Circadian clocks

    Takahashi, Joseph S.

    (Handbook of behavioral neurobiology ; 12)

    2001  

    Author's details ed. by Joseph S. Takahashi
    Series title Handbook of behavioral neurobiology ; 12
    Collection
    Keywords Behavior ; Neurophysiology ; Psychophysics ; Tagesrhythmus ; Neurobiologie
    Subject Circadianer Rhythmus ; Zirkadianer Rhythmus ; Tagesperiodik ; Tagesrhythmik ; Circadiane Rhythmik
    Language English
    Size XXIII, 770 S. : Ill., graph. Darst
    Publisher Kluwer/Plenum
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013194517
    ISBN 0-306-46504-3 ; 978-0-306-46504-8
    Database Catalogue ZB MED Medicine, Health

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    2004 A 3357 order for loan Magazin

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  4. Article: Introduction to the Clock System.

    Cox, Kimberly H / Takahashi, Joseph S

    Advances in experimental medicine and biology

    2021  Volume 1344, Page(s) 3–20

    Abstract: Circadian (24-h) rhythms dictate almost everything we do, setting our clocks for specific times of sleeping and eating, as well as optimal times for many other basic functions. The physiological systems that coordinate circadian rhythms are intricate, ... ...

    Abstract Circadian (24-h) rhythms dictate almost everything we do, setting our clocks for specific times of sleeping and eating, as well as optimal times for many other basic functions. The physiological systems that coordinate circadian rhythms are intricate, but at their core, they all can be distilled down to cell-autonomous rhythms that are then synchronized within and among tissues. At first glance, these cell-autonomous rhythms may seem rather straight-forward, but years of research in the field has shown that they are strikingly complex, responding to many different external signals, often with remarkable tissue-specificity. To understand the cellular clock system, it is important to be familiar with the major players, which consist of pairs of proteins in a triad of transcriptional/translational feedback loops. In this chapter, we will go through each of the core protein pairs one-by-one, summarizing the literature as to their regulation and their broader impacts on circadian gene expression. We will conclude by briefly examining the human genetics literature, as well as providing perspectives on the future of the study of the molecular clock.
    MeSH term(s) Circadian Rhythm/genetics ; Humans ; Organ Specificity ; Sleep
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-81147-1_1
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  5. Article ; Online: Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior.

    Kembro, Jackelyn Melissa / Flesia, Ana Georgina / Acosta-Rodríguez, Victoria América / Takahashi, Joseph S / Nieto, Paula Sofía

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 303

    Abstract: Animal behavior emerges from integration of many processes with different spatial and temporal scales. Dynamical behavioral patterns, including daily and ultradian rhythms and the dynamical microstructure of behavior (i.e., autocorrelations properties), ... ...

    Abstract Animal behavior emerges from integration of many processes with different spatial and temporal scales. Dynamical behavioral patterns, including daily and ultradian rhythms and the dynamical microstructure of behavior (i.e., autocorrelations properties), can be differentially affected by external cues. Identifying these patterns is important for understanding how organisms adapt to their environment, yet unbiased methods to quantify dynamical changes over multiple temporal scales are lacking. Herein, we combine a wavelet approach with Detrended Fluctuation Analysis to identify behavioral patterns and evaluate changes over 42-days in mice subjected to different dietary restriction paradigms. We show that feeding restriction alters dynamical patterns: not only are daily rhythms modulated but also the presence, phase and/or strength of ~12h-rhythms, as well as the nature of autocorrelation properties of feed-intake and wheel running behaviors. These results highlight the underlying complexity of behavioral architecture and offer insights into the multi-scale impact of feeding habits on physiology.
    MeSH term(s) Mice ; Animals ; Ultradian Rhythm ; Motor Activity/physiology ; Behavior, Animal/physiology ; Eating ; Agriculture
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-024-05991-3
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  6. Article ; Online: Metabolic and chemical architecture of the mammalian circadian clock.

    Laothamatas, Isara / Rasmussen, Emil Sjulstok / Green, Carla B / Takahashi, Joseph S

    Cell chemical biology

    2023  Volume 30, Issue 9, Page(s) 1033–1052

    Abstract: Circadian rhythms are endogenous periodic biological processes that occur on a daily timescale. These rhythms are generated by a transcriptional/translational feedback loop that consists of the CLOCK-BMAL1 heterodimeric transcriptional activator complex ... ...

    Abstract Circadian rhythms are endogenous periodic biological processes that occur on a daily timescale. These rhythms are generated by a transcriptional/translational feedback loop that consists of the CLOCK-BMAL1 heterodimeric transcriptional activator complex and the PER1/2-CRY1/2-CK1δ/ε repressive complex. The output pathways of this molecular feedback loop generate circadian rhythmicity in various biological processes. Among these, metabolism is a primary regulatory target of the circadian clock which can also feedback to modulate clock function. This intertwined relationship between circadian rhythms and metabolism makes circadian clock components promising therapeutic targets. Despite this, pharmacological therapeutics that target the circadian clock are relatively rare. In this review, we hope to stimulate interest in chemical chronobiology by providing a comprehensive background on the molecular mechanism of mammalian circadian rhythms and their connection to metabolism, highlighting important studies in the chemical approach to circadian research, and offering our perspectives on future developments in the field.
    MeSH term(s) Animals ; Circadian Clocks ; Circadian Rhythm ; Mammals
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.08.014
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  7. Article ; Online: Enriching the Circadian Proteome.

    Takahashi, Joseph S

    Cell metabolism

    2017  Volume 25, Issue 1, Page(s) 1–2

    Abstract: Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., ... ...

    Abstract Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of the nuclear and phosphoproteome.
    MeSH term(s) Animals ; Circadian Clocks ; Circadian Rhythm ; Mice ; Proteome ; Proteomics ; Transcriptome
    Chemical Substances Proteome
    Language English
    Publishing date 2017-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2016.12.014
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    Zs.A 6169: Show issues Location:
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  8. Book: What's wrong with my mouse?

    Takahashi, Joseph S.

    new interplays between mouse genetics and behavior ; 1996 Short Course 1 Syllabus ; Washington, DC, November 16, 1996

    (021 ... short course ... syllabus / Society for Neuroscience ; 1996. Washington, DC, November 16, 1996)

    1996  

    Author's details [Joseph S. Takahashi, organizer]
    Series title 021 ... short course ... syllabus / Society for Neuroscience ; 1996. Washington, DC, November 16, 1996
    Shourt course / Society for Neuroscience
    021 ... short course ... syllabus / Society for Neuroscience
    Collection Shourt course / Society for Neuroscience
    021 ... short course ... syllabus / Society for Neuroscience
    Language English
    Size VII, 86 S. : Ill., graph. Darst.
    Publisher Soc. for Neuroscience
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT008945619
    Database Catalogue ZB MED Medicine, Health

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    1998 A 5487 order for loan Magazin

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  9. Article: Time to target the circadian clock for drug discovery.

    Rasmussen, Emil Sjulstok / Takahashi, Joseph S / Green, Carla B

    Trends in biochemical sciences

    2022  Volume 47, Issue 9, Page(s) 745–758

    Abstract: The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse and extensive processes throughout the body. The clock mechanism comprises a core transcription/translation negative feedback loop that is modulated by a ... ...

    Abstract The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse and extensive processes throughout the body. The clock mechanism comprises a core transcription/translation negative feedback loop that is modulated by a complex set of additional interlocking feedback loops. Pharmacological manipulation of the clock may be valuable for treating many maladies including jet lag, shift work and related sleep disorders, various metabolic diseases, and cancer. We review recent identification of small-molecule clock modulators and discuss the biochemical features of the core clock that may be amenable to future drug discovery.
    MeSH term(s) Circadian Clocks ; Circadian Rhythm ; Drug Discovery
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2022.04.009
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  10. Article ; Online: Transcriptional architecture of the mammalian circadian clock.

    Takahashi, Joseph S

    Nature reviews. Genetics

    2016  Volume 18, Issue 3, Page(s) 164–179

    Abstract: Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription-translation-based autoregulatory feedback loop. With the development of ... ...

    Abstract Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription-translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling. The genomic targets of circadian clocks are pervasive and are intimately linked to the regulation of metabolism, cell growth and physiology.
    MeSH term(s) Animals ; Chromatin Assembly and Disassembly/genetics ; Circadian Clocks/genetics ; Epigenesis, Genetic ; Gene Expression Profiling ; Genome-Wide Association Study ; Humans ; Mammals/genetics ; RNA Polymerase II/metabolism ; Transcription, Genetic
    Chemical Substances RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2016-12-19
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/nrg.2016.150
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