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Article ; Online: Quantitative analysis of wing interference patterns in Drosophila spp. using hyperspectral images

Takahashi, Kazuo H.

Physiological Entomology. 2023 Sept., v. 48, no. 2-3 p.83-89

2023

Abstract: Recent studies have reported wing interference patterns (WIPs), which reflect the microstructure of the wing, for small insects belonging to the Diptera and Hymenoptera orders. WIPs have been evaluated using RGB or multispectral images, but in contrast ... ...

Abstract	Recent studies have reported wing interference patterns (WIPs), which reflect the microstructure of the wing, for small insects belonging to the Diptera and Hymenoptera orders. WIPs have been evaluated using RGB or multispectral images, but in contrast to these approaches, hyperspectral images allow a more detailed analysis of spectral variation, which may not be captured by RGB or multispectral images. Here, I investigated the WIPs of 12 Drosophila species using hyperspectral images. The average spectrum was calculated for each of the six compartments of the wing region and for the entire wing, including all six compartments. This information was used to evaluate sexual and interspecific differences in the WIPs of 12 Drosophila species. In addition, the possibility of species discrimination based on WIPs was explored using the random forest machine learning algorithm. The present study demonstrates significant sex and interspecific differences in WIPs for each of the six compartments of the wing regions as well as for the entire wing region. The results of the random forest machine learning algorithm suggested the possibility of species identification based on WIPs.
Keywords	Drosophila ; Hymenoptera ; algorithms ; entomology ; forestry equipment ; microstructure ; quantitative analysis ; species identification
Language	English
Dates of publication	2023-09
Size	p. 83-89.
Publishing place	The Royal Entomological Society
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	194751-5
ISSN	0307-6962
ISSN	0307-6962
DOI	10.1111/phen.12405
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Article ; Online: Multiple modes of canalization: Links between genetic, environmental canalizations and developmental stability, and their trait-specificity.

Takahashi, Kazuo H

Seminars in cell & developmental biology

2018 Volume 88, Page(s) 14–20

Abstract: The robustness of biological systems against mutational and environmental perturbations is termed canalization. Because reducing phenotypic variability under environmental and genetic perturbations can be adaptive and facilitated by natural selection, it ...

Abstract	The robustness of biological systems against mutational and environmental perturbations is termed canalization. Because reducing phenotypic variability under environmental and genetic perturbations can be adaptive and facilitated by natural selection, it has been suggested that once canalization mechanisms have evolved to buffer the effects of environmental perturbations, they may act to buffer any and all sources of variation. Although whether canalization mechanisms are general or specific to the types of perturbation or phenotypic traits that they buffer is often addressed, the links between different canalization mechanisms remain unclear. In this review, three major sources of phenotypic variation, associated canalization concepts and indicators of the degree of canalization are first outlined. Then, the molecular bases of canalization mechanisms based on recent empirical studies are overviewed. Finally, the links between the underlying processes of different canalization mechanisms are explored.
MeSH term(s)	Adaptation, Physiological/genetics ; Animals ; Biological Evolution ; Developmental Biology/history ; Developmental Biology/trends ; Epigenesis, Genetic ; Gene Regulatory Networks ; Gene-Environment Interaction ; Genetic Variation ; Genotype ; History, 20th Century ; History, 21st Century ; Humans ; Models, Genetic ; Morphogenesis/genetics ; Phenotype ; Selection, Genetic
Language	English
Publishing date	2018-05-22
Publishing country	England
Document type	Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2018.05.018
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Article ; Online: Macrophage-1 antigen exacerbates histone-induced acute lung injury and promotes neutrophil extracellular trap formation.

Mizuno, Tomohiro / Nagano, Fumihiko / Takahashi, Kazuo / Yamada, Shigeki / Fruhashi, Kazuhiro / Maruyama, Shoichi / Tsuboi, Naotake

FEBS open bio

2024 Volume 14, Issue 4, Page(s) 574–583

Abstract: Acute lung injury (ALI), which occurs in association with sepsis, trauma, and coronavirus disease 2019 (COVID-19), is a serious clinical condition with high mortality. Excessive platelet-leukocyte aggregate (PLA) formation promotes neutrophil ... ...

Abstract	Acute lung injury (ALI), which occurs in association with sepsis, trauma, and coronavirus disease 2019 (COVID-19), is a serious clinical condition with high mortality. Excessive platelet-leukocyte aggregate (PLA) formation promotes neutrophil extracellular trap (NET) release and thrombosis, which are involved in various diseases, including ALI. Macrophage-1 antigen (Mac-1, CD11b/CD18), which is expressed on the surface of leukocytes, is known to promote NET formation. This study aimed to elucidate the role of Mac-1 in extracellular histone-induced ALI. Exogenous histones were administered to Mac-1-deficient mice and wild-type (WT) mice with or without neutrophil or platelet depletion, and several parameters were investigated 1 h after histone injection. Depletion of neutrophils or platelets improved survival time and macroscopic and microscopic properties of lung tissues, and decreased platelet-leukocyte formation and plasma myeloperoxidase levels. These improvements were also observed in Mac-1
MeSH term(s)	Animals ; Mice ; Extracellular Traps/metabolism ; Macrophage-1 Antigen/metabolism ; Histones ; Neutrophils/metabolism ; Acute Lung Injury
Chemical Substances	Macrophage-1 Antigen ; Histones
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13779
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Article: Cannibalism and potential predation in larval drosophilids

Kakeya, Yuika / Takahashi, Kazuo H

Ecological entomology. 2021 Apr., v. 46, no. 2

2021

Abstract: 1. Although yeast encompasses the major food source of Drosophila melanogaster, a recent study demonstrated that D. melanogaster larvae can complete their development on an exclusively cannibalistic diet. If cannibalism is an adaptive behaviour under ... ...

Abstract	1. Although yeast encompasses the major food source of Drosophila melanogaster, a recent study demonstrated that D. melanogaster larvae can complete their development on an exclusively cannibalistic diet. If cannibalism is an adaptive behaviour under nutritional stress, not only conspecific larvae but also allospecific larvae could be the target of predation. Under natural conditions, stings of parasitoids can cause a larval injury that attracts cannibalistic larvae, however, the effect of parasitism on larval cannibalism has never been investigated in drosophillids. 2. Here, we investigated the cannibalistic and predatory behaviour of four frugivorous Drosophila species (Drosophila simulans, D. melanogaster, Drosophila auraria, Drosophila triauraria) towards the conspecific or allospecific source of attraction (SOA) larvae. We also investigated their attraction to parasitised conspecific SOA larvae. 3. The present study demonstrates that the cannibalism observed previously could be potentially extended to predation in D. simulans and D. melanogaster, leading to intra‐guild predation that has not been previously observed. Although D. auraria and D. triauraria were not significantly attracted to conspecific SOA, some level of attraction was suggested for allospecific SOA. In agreement with this, larvae of these species did not complete their development to adulthood when reared on an exclusively cannibalistic diet. The injury inflicted by parasitoid wasps was shown to attract cannibals in some cases. 4. The current results indicate that cannibalistic behaviour might not be a general feature in drosophilids. The environmental conditions or selective pressure that drives the evolution of cannibalism within this group should be a target of future studies.
Keywords	Drosophila melanogaster ; Drosophila simulans ; adulthood ; cannibalism ; conspecificity ; diet ; entomology ; evolution ; frugivores ; malnutrition ; parasitism ; predation ; yeasts
Language	English
Dates of publication	2021-04
Size	p. 342-351.
Publishing place	Blackwell Publishing Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	196048-9
ISSN	0307-6946
ISSN	0307-6946
DOI	10.1111/een.12968
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Article ; Online: Little effect of HSP90 inhibition on the quantitative wing traits variation in Drosophila melanogaster.

Takahashi, Kazuo H

Genetica

2017 Volume 145, Issue 1, Page(s) 9–18

Abstract: Drosophila wings have been a model system to study the effect of HSP90 on quantitative trait variation. The effect of HSP90 inhibition on environmental buffering of wing morphology varies among studies while the genetic buffering effect of it was ... ...

Abstract	Drosophila wings have been a model system to study the effect of HSP90 on quantitative trait variation. The effect of HSP90 inhibition on environmental buffering of wing morphology varies among studies while the genetic buffering effect of it was examined in only one study and was not detected. Variable results so far might show that the genetic background influences the environmental and genetic buffering effect of HSP90. In the previous studies, the number of the genetic backgrounds used is limited. To examine the effect of HSP90 inhibition with a larger number of genetic backgrounds than the previous studies, 20 wild-type strains of Drosophila melanogaster were used in this study. Here I investigated the effect of HSP90 inhibition on the environmental buffering of wing shape and size by assessing within-individual and among-individual variations, and as a result, I found little or very weak effects on environmental and genetic buffering. The current results suggest that the role of HSP90 as a global regulator of environmental and genetic buffering is limited at least in quantitative traits.
MeSH term(s)	Animals ; Benzoquinones/pharmacology ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/genetics ; Female ; Genetic Variation ; Genotype ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Inheritance Patterns/drug effects ; Lactams, Macrocyclic/pharmacology ; Male ; Phenotype ; Quantitative Trait, Heritable ; Wings, Animal/anatomy & histology
Chemical Substances	Benzoquinones ; HSP90 Heat-Shock Proteins ; Lactams, Macrocyclic ; geldanamycin (Z3K3VJ16KU)
Language	English
Publishing date	2017-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2165-9
ISSN	1573-6857 ; 0016-6707
ISSN (online)	1573-6857
ISSN	0016-6707
DOI	10.1007/s10709-016-9940-z
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Article ; Online: COVID-19 mRNA vaccination is associated with IgA nephropathy: an analysis of the Japanese adverse drug event report database.

Nakao, Hiroka / Koseki, Takenao / Kato, Koki / Yamada, Shigeki / Tsuboi, Naotake / Takahashi, Kazuo / Mizuno, Tomohiro

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2023 Volume 26, Page(s) 11453

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Glomerulonephritis, IGA/genetics ; COVID-19 Vaccines/adverse effects ; East Asian People ; Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions ; Vaccination/adverse effects ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; mRNA Vaccines
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422972-9
ISSN	1482-1826 ; 1482-1826
ISSN (online)	1482-1826
ISSN	1482-1826
DOI	10.3389/jpps.2023.11453
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Article ; Online ; Research data: (with research data) Novel genetic capacitors and potentiators for the natural genetic variation of sensory bristles and their trait specificity in Drosophila melanogaster.

Takahashi, Kazuo H

Molecular ecology

2015 Volume 24, Issue 22, Page(s) 5561–5572

Abstract: Cryptic genetic variation (CGV) is defined as the genetic variation that has little effect on phenotypic variation under a normal condition, but contributes to heritable variation under environmental or genetic perturbations. Genetic buffering systems ... ...

Abstract	Cryptic genetic variation (CGV) is defined as the genetic variation that has little effect on phenotypic variation under a normal condition, but contributes to heritable variation under environmental or genetic perturbations. Genetic buffering systems that suppress the expression of CGV and store it in a population are called genetic capacitors, and the opposite systems are called genetic potentiators. One of the best-known candidates for a genetic capacitor and potentiator is the molecular chaperone protein, HSP90, and one of its characteristics is that it affects the genetic variation in various morphological traits. However, it remains unclear whether the wide-ranging effects of HSP90 on a broad range of traits are a general feature of genetic capacitors and potentiators. In the current study, I searched for novel genetic capacitors and potentiators for quantitative bristle traits of Drosophila melanogaster and then investigated the trait specificity of their genetic buffering effect. Three bristle traits of D. melanogaster were used as the target traits, and the genomic regions with genetic buffering effects were screened using the 61 genomic deficiencies examined previously for genetic buffering effects in wing shape. As a result, four and six deficiencies with significant effects on increasing and decreasing the broad-sense heritability of the bristle traits were identified, respectively. Of the 18 deficiencies with significant effects detected in the current study and/or by the previous study, 14 showed trait-specific effects, and four affected the genetic buffering of both bristle traits and wing shape. This suggests that most genetic capacitors and potentiators exert trait-specific effects, but that general capacitors and potentiators with effects on multiple traits also exist.
MeSH term(s)	Animals ; Drosophila melanogaster/anatomy & histology ; Drosophila melanogaster/genetics ; Female ; Genetic Variation ; Genotype ; Male ; Phenotype ; Quantitative Trait Loci ; Quantitative Trait, Heritable ; Sensilla/anatomy & histology ; Wings, Animal/anatomy & histology
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083 ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.13407
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Article: Little effect of HSP90 inhibition on the quantitative wing traits variation in Drosophila melanogaster

Takahashi, Kazuo H

Genetica. 2017 Feb., v. 145, no. 1

2017

Abstract	Drosophila wings have been a model system to study the effect of HSP90 on quantitative trait variation. The effect of HSP90 inhibition on environmental buffering of wing morphology varies among studies while the genetic buffering effect of it was examined in only one study and was not detected. Variable results so far might show that the genetic background influences the environmental and genetic buffering effect of HSP90. In the previous studies, the number of the genetic backgrounds used is limited. To examine the effect of HSP90 inhibition with a larger number of genetic backgrounds than the previous studies, 20 wild-type strains of Drosophila melanogaster were used in this study. Here I investigated the effect of HSP90 inhibition on the environmental buffering of wing shape and size by assessing within-individual and among-individual variations, and as a result, I found little or very weak effects on environmental and genetic buffering. The current results suggest that the role of HSP90 as a global regulator of environmental and genetic buffering is limited at least in quantitative traits.
Keywords	Drosophila melanogaster ; genetic background ; models ; quantitative traits ; wings
Language	English
Dates of publication	2017-02
Size	p. 9-18.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	2165-9
ISSN	1573-6857 ; 0016-6707
ISSN (online)	1573-6857
ISSN	0016-6707
DOI	10.1007/s10709-016-9940-z
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Article ; Online: Correction: Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster.

Takahara, Baku / Takahashi, Kazuo H

PloS one

2018 Volume 13, Issue 10, Page(s) e0205301

Abstract: This corrects the article DOI: 10.1371/journal.pone.0132846.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0132846.].
Language	English
Publishing date	2018-10-02
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0205301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones

Nagano, Fumihiko / Mizuno, Tomohiro / Imai, Masaki / Takahashi, Kazuo / Tsuboi, Naotake / Maruyama, Shoichi / Mizuno, Masashi

FEBS Open Bio. 2022 Jan., v. 12, no. 1

2022

Abstract: Acute lung injury (ALI) occurs in patients with severe sepsis and has a mortality rate of 40%–60%. Severe sepsis promotes the release of histones from dying cells, which can induce platelet aggregation, activate coagulation and cause endothelial cell (EC) ...

Abstract	Acute lung injury (ALI) occurs in patients with severe sepsis and has a mortality rate of 40%–60%. Severe sepsis promotes the release of histones from dying cells, which can induce platelet aggregation, activate coagulation and cause endothelial cell (EC) death. We previously reported that the expression of membrane complement receptor type 1‐related gene Y (Crry)/p65, which plays a principal role in defence against abnormal activation of complement in the blood, is reduced in response to peritoneal mesothelial cell injury, and we hence hypothesized that a similar mechanism occurs in pulmonary ECs. In this study, we examined the role of Crry/p65 in histone‐mediated ALI using an experimental animal model. In ALI model mice, exposure to extracellular histones induces lung injury and results in a decrease in Crry/p65 expression. The levels of lactic acid dehydrogenase (LDH), a marker of cell damage, were significantly increased in the serum of ALI model compared with vehicle mice. The significant inverse correlation between the expression of Crry/p65 and LDH levels in plasma revealed an association between Crry/p65 expression and cell damage. The levels of complement component 3a (C3a) were also significantly increased in the serum of the ALI model compared with vehicle mice. Notably, a C3a receptor antagonist ameliorated lung injury induced by histones. We hypothesize that extracellular histones induce complement activation via down‐regulation of Crry/p65 and that C3a might serve as a therapeutic target for the treatment of ALI.
Keywords	animal models ; antagonists ; blood serum ; coagulation ; complement ; death ; endothelial cells ; genes ; histones ; laboratory animals ; lactate dehydrogenase ; lungs ; mortality ; platelet aggregation ; therapeutics
Language	English
Dates of publication	2022-01
Size	p. 192-202.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2651702-4
ISSN	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13322
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