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  1. Article ; Online: A suspected case of intertrabecular systemic bone metastasis of small-cell lung cancer.

    Hamamoto, Yoichiro / Fukui, Yukari / Isogai, Tsuyoshi / Takahashi, Mai

    Japanese journal of clinical oncology

    2022  Volume 53, Issue 2, Page(s) 182–183

    MeSH term(s) Humans ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/secondary ; Fluorodeoxyglucose F18 ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Positron-Emission Tomography ; Radiopharmaceuticals ; Small Cell Lung Carcinoma/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2022-11-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyac165
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    Zs.A 1298: Show issues Location:
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  2. Article ; Online: Hospital factor and prognosis of COVID-19 in New York City, the United States of America: insights from a retrospective cohort study.

    Takahashi, Mai / Egorova, Natalia N / Iwagami, Masao / Kuno, Toshiki

    BMC health services research

    2022  Volume 22, Issue 1, Page(s) 164

    Abstract: Background: April 22nd, 2020, New York City (NYC) was the epicenter of the pandemic of Coronavirus disease 2019 (COVID-19) in the US with differences of death rates among its 5 boroughs. We aimed to investigate the difference in mortality associated ... ...

    Abstract Background: April 22nd, 2020, New York City (NYC) was the epicenter of the pandemic of Coronavirus disease 2019 (COVID-19) in the US with differences of death rates among its 5 boroughs. We aimed to investigate the difference in mortality associated with hospital factors (teaching versus community hospital) in NYC.
    Design: Retrospective cohort study.
    Methods: We obtained medical records of 6509 hospitalized patients with laboratory confirmed COVID-19 from the Mount Sinai Health System including 4 teaching hospitals in Manhattan and 2 community hospitals located outside of Manhattan (Queens and Brooklyn) retrospectively. Propensity score analysis using inverse probability of treatment weighting (IPTW) with stabilized weights was performed to adjust for differences in the baseline characteristics of patients initially presenting to teaching or community hospitals, and those who were transferred from community hospitals to teaching hospitals.
    Results: Among 6509 patients, 4653 (72.6%) were admitted in teaching hospitals, 1462 (22.8%) were admitted in community hospitals, and 293 (4.6%) were originally admitted in community and then transferred into teaching hospitals. Patients in community hospitals had higher mortality (42.5%) than those in teaching hospitals (17.6%) or those transferred from community to teaching hospitals (23.5%, P < 0.001). After IPTW-adjustment, when compared to patients cared for at teaching hospitals, the hazard ratio (HR) and 95% confidence interval (CI) of mortality were as follows: community hospitals 2.47 (2.03-2.99); transfers 0.80 (0.58-1.09)).
    Conclusions: Patients admitted to community hospitals had higher mortality than those admitted to teaching hospitals.
    MeSH term(s) COVID-19 ; Hospital Mortality ; Hospitalization ; Hospitals, Community ; Humans ; New York City/epidemiology ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; United States/epidemiology
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-022-07570-w
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  3. Article ; Online: The Association Between Convalescent Plasma Treatment and Survival of Patients with COVID-19.

    Kuno, Toshiki / Takahashi, Mai / Egorova, Natalia N

    Journal of general internal medicine

    2021  Volume 36, Issue 8, Page(s) 2528–2531

    MeSH term(s) COVID-19/therapy ; Coronavirus Infections ; Humans ; Immunization, Passive ; SARS-CoV-2 ; Treatment Outcome
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Letter
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-021-06894-3
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    Zs.A 2205: Show issues Location:
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  4. Article ; Online: Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn-BNP)-Coupled Metagenomics.

    Wang, Zongqiang / Kasper, Amanda / Takahashi, Mai / Morales Amador, Adrian / Bhattacharjee, Abir / Kan, Jingbo / Hernandez, Yozen / Ternei, Melinda / Brady, Sean F

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 17, Page(s) e202317187

    Abstract: DNA topoisomerases are attractive targets for anticancer agents. Dual topoisomerase I/II inhibitors are particularly appealing due to their reduced rates of resistance. A number of therapeutically relevant topoisomerase inhibitors are bacterial natural ... ...

    Abstract DNA topoisomerases are attractive targets for anticancer agents. Dual topoisomerase I/II inhibitors are particularly appealing due to their reduced rates of resistance. A number of therapeutically relevant topoisomerase inhibitors are bacterial natural products. Mining the untapped chemical diversity encoded by soil microbiomes presents an opportunity to identify additional natural topoisomerase inhibitors. Here we couple metagenome mining, bioinformatic structure prediction algorithms, and chemical synthesis to produce the dual topoisomerase inhibitor tapcin. Tapcin is a mixed p-aminobenzoic acid (PABA)-thiazole with a rare tri-thiazole substructure and picomolar antiproliferative activity. Tapcin reduced colorectal adenocarcinoma HT-29 cell proliferation and tumor volume in mouse hollow fiber and xenograft models, respectively. In both studies it showed similar activity to the clinically used topoisomerase I inhibitor irinotecan. The study suggests that the interrogation of soil microbiomes using synthetic bioinformatic natural product methods has the potential to be a rewarding strategy for identifying potent, biomedically relevant, antiproliferative agents.
    MeSH term(s) Humans ; Mice ; Animals ; Topoisomerase I Inhibitors/pharmacology ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology ; DNA Topoisomerases, Type I/metabolism ; Biological Products/pharmacology ; DNA Topoisomerases, Type II/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Computational Biology ; Soil ; Thiazoles ; Cell Line, Tumor
    Chemical Substances Topoisomerase I Inhibitors ; Topoisomerase II Inhibitors ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; Biological Products ; DNA Topoisomerases, Type II (EC 5.99.1.3) ; Antineoplastic Agents ; Soil ; Thiazoles
    Language English
    Publishing date 2024-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202317187
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  5. Article: Oral Corticosteroid Reduction Between Biologics Initiated and Non-Initiated Patients with Severe Asthma.

    Tanaka, Akihiko / Takahashi, Mai / Fukui, Ayako / Arita, Yoshifumi / Fujiwara, Masakazu / Makita, Naoyuki / Tashiro, Naoki

    Journal of asthma and allergy

    2023  Volume 16, Page(s) 839–849

    Abstract: Purpose: The oral corticosteroid (OCS)-sparing effect of several biologics (BIOs) has been shown in clinical trials. To date, no study has evaluated differences in OCS dose reduction between BIO-initiated and BIO-non-initiated patients in real-world ... ...

    Abstract Purpose: The oral corticosteroid (OCS)-sparing effect of several biologics (BIOs) has been shown in clinical trials. To date, no study has evaluated differences in OCS dose reduction between BIO-initiated and BIO-non-initiated patients in real-world clinical practice. We compared dose reductions in maintenance OCS between BIO-initiated and BIO-non-initiated severe asthma patients in a real-world setting.
    Patients and methods: This retrospective cohort study used the data from the Diagnosis Procedure Combination database of Medical Data Vision in Japan. Severe asthma patients with continuous use of OCS were selected from December 2015 to February 2020. The primary endpoint was the proportion reduction in daily maintenance OCS dose from Week 0 to Week 24. Analyses were performed using inverse probability treatment weighting.
    Results: In total, 2927 patients were included (BIO-initiated: 239 patients, BIO-non-initiated: 2688 patients). Adjusted median (quartile [Q] 1-Q3) proportion reduction in daily maintenance OCS dose at Week 24 from the index date was 25.0% (0.0-100.0%) and 0.0% (0.0-83.3%) in the BIO-initiated and BIO-non-initiated groups, respectively (Hodges-Lehmann estimate [95% confidence interval], 0.0000% [0.0000-0.3365%]). Respective proportions of patients in the BIO-initiated and BIO-non-initiated groups achieving dose reductions from the index date in the daily maintenance OCS dose at Week 24 were >0% reduction, 56.6% and 44.1% (odds ratio [OR] 1.6554); ≥25% reduction, 50.5% and 40.6% (OR 1.4888); ≥50% reduction, 42.8% and 33.7% (OR 1.4714); and 100% reduction, 26.2% and 24.4% (OR 1.1005).
    Conclusion: Among severe asthma patients, the daily dose of maintenance OCS was reduced with BIO treatment. Although a higher percentage of patients in the BIO-initiated group had an OCS reduction of ≤75% than the BIO-non-initiated group, we found no clear difference in OCS reduction. Our findings will be justified by further research that incorporates a longer observation period and variables excluded from this study.
    Trial registration: ClinicalTrials.gov (NCT05136547).
    Language English
    Publishing date 2023-08-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S411404
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  6. Article ; Online: Cardiovascular comorbidities, cardiac injury, and prognosis of COVID-19 in New York City.

    Kuno, Toshiki / Takahashi, Mai / Obata, Reiichiro / Maeda, Tetsuro

    American heart journal

    2020  Volume 226, Page(s) 24–25

    Abstract: Using Mt. Sinai (New York City) EMR health system data, we retrospectively analyzed a cohort of 8438 COVID-19 patients seen between March 1 and April 22, 2020. Risk of intubation and of death rose as a function of increasing age and as a function of ... ...

    Abstract Using Mt. Sinai (New York City) EMR health system data, we retrospectively analyzed a cohort of 8438 COVID-19 patients seen between March 1 and April 22, 2020. Risk of intubation and of death rose as a function of increasing age and as a function of greater cardiovascular comorbidity. Combining age and specific comorbidity markers showed patterns suggesting that cardiovascular comorbidities increased relative risks for adverse outcomes most substantially in the younger subjects with progressively diminishing relative effects at older ages.
    MeSH term(s) Age Factors ; Aged ; Betacoronavirus ; COVID-19 ; Cardiomyopathies/complications ; Cardiomyopathies/epidemiology ; Cardiomyopathies/mortality ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/mortality ; Comorbidity ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/mortality ; Coronavirus Infections/blood ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Electronic Health Records/statistics & numerical data ; Female ; Heart Failure/epidemiology ; Heart Failure/mortality ; Humans ; Male ; Middle Aged ; New York City/epidemiology ; Pandemics ; Peripheral Arterial Disease/epidemiology ; Peripheral Arterial Disease/mortality ; Pneumonia, Viral/blood ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Respiration, Artificial/mortality ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; Risk ; SARS-CoV-2 ; Troponin I/blood
    Chemical Substances Troponin I
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Letter
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2020.05.005
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    Ui IV Zs.15: Show issues Location:
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  7. Article ; Online: COVID-19 and influenza testing in New York City.

    Takahashi, Mai / Egorova, Natalia N / Kuno, Toshiki

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 698–701

    MeSH term(s) Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19 Testing/statistics & numerical data ; Female ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Humans ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Male ; Medical Records ; Middle Aged ; New York City/epidemiology ; Retrospective Studies ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26500
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    Zs.A 1320: Show issues Location:
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  8. Article ; Online: The Randomized TIDES-ACS Trial.

    Kuno, Toshiki / Takahashi, Mai / Hamaya, Rikuta

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 20, Page(s) 2444

    MeSH term(s) Acute Coronary Syndrome ; Drug-Eluting Stents ; Everolimus ; Humans ; Stents ; Titanium ; Treatment Outcome
    Chemical Substances titanium-nitride-oxide ; Everolimus (9HW64Q8G6G) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2020-10-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.08.004
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    Zs.A 6669: Show issues Location:
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  9. Article ; Online: U shape association of hemoglobin level with in-hospital mortality for COVID-19 patients.

    Kuno, Toshiki / So, Matsuo / Takahashi, Mai / Egorova, Natalia N

    Journal of thrombosis and thrombolysis

    2021  Volume 53, Issue 1, Page(s) 113–117

    Abstract: Our hypothesis was that high hemoglobin (Hb) level might be associated with hypercoagulable state and death due to COVID-19. Of the 9467 hospitalized COVID-19 patients, patients were subdivided into 5 groups based on the level of Hb; Hb < 10 g/dL, 10 g/ ... ...

    Abstract Our hypothesis was that high hemoglobin (Hb) level might be associated with hypercoagulable state and death due to COVID-19. Of the 9467 hospitalized COVID-19 patients, patients were subdivided into 5 groups based on the level of Hb; Hb < 10 g/dL, 10 g/dL ≤ Hb < 12 g/dL, 12 g/dL ≤ Hb < 14 g/dL, 14 g/dL ≤ Hb < 16 g/dL, and Hb ≥ 16 g/dL. Compared to patients with 12 g/dL ≤ Hb < 14 g/dL, patients with Hb ≥ 16 g/dL had significantly higher adjusted in-hospital mortality (OR [95% CI] 1.62 [1.15-2.27], P = 0.005).
    MeSH term(s) COVID-19/mortality ; Hemoglobins/analysis ; Hospital Mortality ; Humans
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2021-07-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02516-1
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    Zs.A 4352: Show issues Location:
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  10. Article ; Online: Prophylactic versus therapeutic anticoagulation for survival of patients with COVID-19 on steroid.

    Kuno, Toshiki / So, Matsuo / Takahashi, Mai / Egorova, Natalia N

    Journal of thrombosis and thrombolysis

    2021  Volume 53, Issue 2, Page(s) 352–358

    Abstract: Previous observational and randomized studies suggested potential benefit of therapeutic anticoagulation during hospitalization, but this treatment remains controversial. As of June 30th 2021, steroids is the standard treatment of COVID patients. We ... ...

    Abstract Previous observational and randomized studies suggested potential benefit of therapeutic anticoagulation during hospitalization, but this treatment remains controversial. As of June 30th 2021, steroids is the standard treatment of COVID patients. We aimed to investigate the association of prophylactic and therapeutic anticoagulation with mortality for patients with COVID-19 who were treated with steroids. We retrospectively reviewed the medical records of 2533 patients discharged between March 1st, 2020 and March 30th, 2021, with laboratory-confirmed COVID-19 in the Mount Sinai Health System and treated with steroids. We evaluated the effect of therapeutic versus prophylactic anticoagulation on the outcomes using propensity score analyses. Subgroup analyses were conducted by stratification of patients by endotracheal intubation. Among the 2533 eligible patients, 465 (18.4%) received therapeutic anticoagulation. After 1:1 propensity score matching (N = 383 pairs), in-hospital mortality was similar between those with therapeutic versus prophylactic anticoagulation (36.0% versus 30.0%, P = 0.091). In-hospital mortality regardless of endotracheal intubation were not significantly different between the two groups. Therapeutic anticoagulation was not associated with reduced or increased risk of in-hospital mortality in patients with COVID-19 treated with steroids.
    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/drug therapy ; COVID-19/mortality ; Hospital Mortality ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Steroids/therapeutic use
    Chemical Substances Anticoagulants ; Steroids
    Language English
    Publishing date 2021-09-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02569-2
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