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Article: Noise Pareidolia Test in Parkinson's Disease and Atypical Parkinsonian Syndromes: A Retrospective Study.

Matsumoto, Takuya / Koh, Jinsoo / Sakata, Mayumi / Nakayama, Yoshiaki / Yorozu, Shoko / Taruya, Junko / Takahashi, Maiko / Miyamoto, Katsuichi / Ito, Hidefumi

Cureus

2024 Volume 16, Issue 3, Page(s) e55436

Abstract: Introduction: Pareidolias, or visual misperceptions, are a non-motor symptom of Parkinson's disease (PD) with unclear pathophysiology. The noise pareidolia test (NPT) is a tool for screening pareidolias. The usefulness of the NPT in differentiating PD ... ...

Abstract	Introduction: Pareidolias, or visual misperceptions, are a non-motor symptom of Parkinson's disease (PD) with unclear pathophysiology. The noise pareidolia test (NPT) is a tool for screening pareidolias. The usefulness of the NPT in differentiating PD from atypical parkinsonian syndromes (APS) is also unknown. Methods: We retrospectively investigated 74 patients with PD and 18 patients with APS who took the NPT. Correlations between the number of pareidolic responses, gray matter volume, and cerebral blood flow were also examined in the patients with PD. Results: The median number of pareidolic responses in patients with PD and patients with APS was 0 (interquartile range (IQR): 0-3) and 0 (IQR: 0-1), respectively, and tended to be higher in patients with PD than in those with APS (p = 0.077). It was significantly higher in patients with PD who had hallucinations (2; IQR: 0-9) (p = 0.016). The area under the receiver operating characteristic curve for the number of pareidolic responses in the NPT was 0.62 when used to differentiate PD and APS, and the optimal cutoff number of pareidolic responses was 2/3. Sensitivity and specificity were 25.7% and 100%, respectively. In the PD group, the number of pareidolic responses was correlated with age (r = 0.27; p = 0.021) and the Frontal Assessment Battery (FAB) score (r = -0.34; p = 0.0099). Magnetic resonance imaging showed no significant correlation between the number of pareidolic responses and the volume of focal gray matter. On cerebral hypoperfusion mapping, the left parietal lobe had a significant correlation with the number of pareidolic responses (r = 0.35; p = 0.027). Conclusion: The number of pareidolic responses in NPT was suggested to be useful as a red flag to rule out APS in differentiating PD from APS. In PD without dementia, the number of pareidolic responses was associated with reduced blood flow in the left parietal lobe.
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55436
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Article ; Online: A case of anti-MOG antibody-positive ADEM following COVID-19 mRNA vaccination.

Miyamoto, Katsuichi / Koh, Jinsoo / Takahashi, Maiko / Niwa, Mayako / Ito, Hidefumi

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022 Volume 43, Issue 6, Page(s) 3513–3514

MeSH term(s)	Autoantibodies ; COVID-19/prevention & control ; Encephalomyelitis, Acute Disseminated ; Humans ; Myelin-Oligodendrocyte Glycoprotein ; RNA, Messenger ; Vaccination/adverse effects
Chemical Substances	Autoantibodies ; Myelin-Oligodendrocyte Glycoprotein ; RNA, Messenger
Language	English
Publishing date	2022-03-19
Publishing country	Italy
Document type	Case Reports ; Letter ; Comment
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-022-06019-6
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Article ; Online: [Acute-onset autoimmune autonomic ganglionopathy remarkably effective in intravenous high-dose immunoglobulin therapy].

Murakami, Keishu / Koh, Jinsoo / Takahashi, Maiko / Ito, Hidefumi

Rinsho shinkeigaku = Clinical neurology

2021 Volume 61, Issue 10, Page(s) 687–691

Abstract: A 77-year-old woman developed acute onset of orthostatic hypotension, urinary retention, and constipation. Neurological examination on admission showed severe orthostatic hypotension accompanied by syncope, mydriatic pupils, and attenuation of light ... ...

Abstract	A 77-year-old woman developed acute onset of orthostatic hypotension, urinary retention, and constipation. Neurological examination on admission showed severe orthostatic hypotension accompanied by syncope, mydriatic pupils, and attenuation of light reflexes with no abnormalities in other neurological systems. Autonomic testing revealed denervation hypersensitivity in norepinephrine (NE) intravenous infusion test and 0.125% pilocarpine instillation test, low NE in the serum, and decreased amount of sweating in quantitative sudomotor axon reflex test. These findings indicated dysfunction of postganglionic autonomic nerves. Autoimmune autonomic ganglionopathy (AAG) was diagnosed due to the presence of anti-ganglionic acetylcholine receptors. The patient was given intravenous high-dose immunoglobulin therapy (IVIg), improving orthostatic hypotension, urinary retention, and constipation. Previous reports indicated that the response to IVIg varied from case to case. Thus, this case suggests that IVIg is effective in acute-onset AAG cases.
MeSH term(s)	Aged ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Constipation ; Female ; Humans ; Hypotension, Orthostatic/diagnosis ; Hypotension, Orthostatic/drug therapy ; Hypotension, Orthostatic/etiology ; Immunization, Passive ; Immunoglobulins, Intravenous/administration & dosage ; Immunoglobulins, Intravenous/therapeutic use ; Peripheral Nervous System Diseases ; Primary Dysautonomias ; Urinary Retention
Chemical Substances	Immunoglobulins, Intravenous
Language	Japanese
Publishing date	2021-09-25
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001631
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Article: The relationship between work-related outcomes and symptoms in early breast cancer survivors receiving adjuvant endocrine therapy.

Nakao, Mayumi / Komatsu, Hiroko / Hayashida, Tetsu / Takahashi, Maiko / Seki, Tomoko / Yagasaki, Kaori

Asia-Pacific journal of oncology nursing

2022 Volume 9, Issue 3, Page(s) 174–178

Abstract: Objective: This study examined the relationship between symptom burdens and work-related outcomes, including work participation and overall work impairment (OWI) among breast cancer survivors (BCS) receiving adjuvant endocrine therapy (AET).: Methods!# ...

Abstract	Objective: This study examined the relationship between symptom burdens and work-related outcomes, including work participation and overall work impairment (OWI) among breast cancer survivors (BCS) receiving adjuvant endocrine therapy (AET). Methods: This was a cross-sectional study with 140 BCS of working age receiving AET. Data were collected using self-report questionnaires that included an assessment of symptoms and their employment status, and OWI. Data were analyzed using descriptive statistics and multiple logistic regression analysis. Results: A total of 111 (79%) survivors reported being employed at the time of the survey. Symptom burdens were not associated with unemployment. Of the 110 working BCS receiving AET, symptom burdens were significantly related to a higher degree of OWI (OR = 2.14, 95% CI, 1.58-2.89, Conclusions: Participating BCS receiving AET continued to work while experiencing symptoms, with survivors who experienced high symptom burdens being negatively affected in their work life. Healthcare providers need to assess and manage symptoms and their impact on work, with the help of employers, to improve the quality of work life of BCS receiving AET.
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2984639-0
ISSN	2349-6673 ; 2347-5625
ISSN (online)	2349-6673
ISSN	2347-5625
DOI	10.1016/j.apjon.2022.01.003
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Article: Blautia coccoides

Nomura, Shoko / Sukowati, Erike W / Shigeno, Yuko / Takahashi, Maiko / Kato, Akari / Benno, Yoshimi / Yamashita, Fumiyoshi / Mukai, Hidefumi

Pharmaceutics

2023 Volume 15, Issue 3

Abstract: We demonstrate ... ...

Abstract	We demonstrate that
Language	English
Publishing date	2023-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15030989
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Article ; Online: Two-Chain Mature Hepatocyte Growth Factor-Specific Positron Emission Tomography Imaging in Tumors Using

Warashina, Shota / Sato, Hiroki / Zouda, Maki / Takahashi, Maiko / Wada, Yasuhiro / Passioura, Toby / Suga, Hiroaki / Watanabe, Yasuyoshi / Matsumoto, Kunio / Mukai, Hidefumi

Molecular pharmaceutics

2023 Volume 20, Issue 4, Page(s) 2029–2038

Abstract: Two-chain hepatocyte growth factor (tcHGF), the mature form of HGF, is associated with malignancy and anticancer drug resistance; therefore, its quantification is an important indicator for cancer diagnosis. In tumors, activated tcHGF hardly discharges ... ...

Abstract	Two-chain hepatocyte growth factor (tcHGF), the mature form of HGF, is associated with malignancy and anticancer drug resistance; therefore, its quantification is an important indicator for cancer diagnosis. In tumors, activated tcHGF hardly discharges into the systemic circulation, indicating that tcHGF is an excellent target for molecular imaging using positron emission tomography (PET). We recently discovered HGF-inhibitory peptide-8 (HiP-8) that binds specifically to human tcHGF with nanomolar affinity. The purpose of this study was to investigate the usefulness of HiP-8-based PET probes in human
MeSH term(s)	Mice ; Humans ; Animals ; Hepatocyte Growth Factor/metabolism ; Peptides/chemistry ; Neoplasms/diagnostic imaging ; Positron-Emission Tomography/methods ; Chelating Agents/chemistry ; Copper Radioisotopes/chemistry ; Cell Line, Tumor
Chemical Substances	Hepatocyte Growth Factor (67256-21-7) ; Peptides ; Chelating Agents ; Copper Radioisotopes
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.2c01020
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Article ; Online: Preventive effect of a heparinoid-containing product on the application site reaction of the rotigotine transdermal patch in Parkinson's disease: A pilot randomized clinical trial (the SkinHeRo study).

Koh, Jinsoo / Takahashi, Maiko / Sakata, Mayumi / Yasui, Masaaki / Yorozu, Shoko / Ito, Hidefumi

Clinical parkinsonism & related disorders

2021 Volume 5, Page(s) 100105

Abstract: Introduction: The rotigotine transdermal patch (RTP) is a dopamine agonist used to treat Parkinson's disease (PD) but is sometimes discontinued because of application site reactions (ASRs). We aimed to investigate the effect of a heparinoid-containing ... ...

Abstract	Introduction: The rotigotine transdermal patch (RTP) is a dopamine agonist used to treat Parkinson's disease (PD) but is sometimes discontinued because of application site reactions (ASRs). We aimed to investigate the effect of a heparinoid-containing product (HCP) for preventing ASRs due to the RTP by conducting a randomized controlled pilot trial. Methods: Twenty patients with idiopathic non-demented PD were randomized to the skin care group using a HCP (group H) and the non-skin care group (group N). The primary outcome was the change in the baseline Skindex-16 score (ΔSkindex-16) at week 4. In addition, skin symptoms were also evaluated using the Dermatology Life Quality Index (DLQI) and International Contact Dermatitis Research Group (ICDRG) system for clinical scoring allergic patch test reactions up to week 8. Results: The ΔSkindex-16 score at week 4 tended to be lower in group H than in group N, although the difference was not statistically significant (-1.5 ± 2.0 vs 1.3 ± 10.9, p = 0.53). When the patients with baseline Skindex-16 scores ≥ 7 were excluded, the ΔSkindex-16 at week 4 was significantly lower in group H (-1.5 ± 2.0 vs 6.1 ± 8.6, p = 0.042). The DLQI also tended to be lower in group H at weeks 4 and 8, but not significantly (p = 0.066 and p = 0.077, respectively). The ICDRG score at week 4 was significantly lower in group H (p = 0.044). Conclusion: We suggest that the HCP has a preventive effect against ASRs cause by the RTP.
Language	English
Publishing date	2021-08-13
Publishing country	England
Document type	Journal Article
ISSN	2590-1125
ISSN (online)	2590-1125
DOI	10.1016/j.prdoa.2021.100105
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Article ; Online: A transposon screen identifies enhancement of NF-κB pathway as a mechanism of resistance to eribulin.

Teng, Xiaozhong / Hayashida, Tetsu / Murata, Takeshi / Nagayama, Aiko / Seki, Tomoko / Takahashi, Maiko / Kitagawa, Yuko

Breast cancer (Tokyo, Japan)

2021 Volume 28, Issue 4, Page(s) 884–895

Abstract: Background: Eribulin mesylate (eribulin) is an efficient microtubule inhibitor that is used for metastatic breast cancer. However, breast cancer can develop resistance to eribulin. This resistance mechanism needs to be elucidated.: Methods: A ... ...

Abstract	Background: Eribulin mesylate (eribulin) is an efficient microtubule inhibitor that is used for metastatic breast cancer. However, breast cancer can develop resistance to eribulin. This resistance mechanism needs to be elucidated. Methods: A transposon mutagenesis screen was conducted using a pPB-SB-CMV-puro-SD plasmid and pCMV-PBase transposase. Viability and cytotoxicity were analyzed by MTT assay and flow cytometry, respectively. Real-time PCR and western blot were used for gene expression analysis. In addition, vivo study was also designed to analyze therapy efficiency. Results: TAB2, which is part of the nuclear factor-kappa B (NF-κB) pathway, was identified as a candidate eribulin-resistant gene. TAB2 down-regulation resulted in significantly lower cell viability and higher cytotoxicity of cells treated with eribulin, while TAB2 up-regulation showed opposite results. Similarly, combination of NF-κB inhibitors [Bay-117082 and QNZ (quinazoline derivative)] with eribulin showed significantly lower cell viability and higher drug cytotoxicity than single agent treatment with eribulin in MDA-MB-231 cells. However, QNZ increased NF-κB activity in MCF7 cells by up-regulating TAB2, which reduced the sensitivity to eribulin. Furthermore, combination of Bay-117082 with eribulin induced greater regression of MDA-MB-231 tumors compared to eribulin monotherapy in vivo. Conclusions: These results consistently illustrated that TAB2-NF-κB pathway may increases resistance to eribulin in breast cancer models. Moreover, these results support the use of a combination strategy of eribulin with NF-κB inhibitors, and provide evidence that transposon mutagenesis screens are capable of identifying drug-resistant genes.
MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Down-Regulation ; Drug Resistance, Neoplasm/genetics ; Female ; Furans/therapeutic use ; Humans ; Kaplan-Meier Estimate ; Ketones/therapeutic use ; Mutagenicity Tests ; NF-kappa B/metabolism ; Signal Transduction/drug effects ; Tubulin Modulators/therapeutic use
Chemical Substances	Furans ; Ketones ; NF-kappa B ; Tubulin Modulators ; eribulin (LR24G6354G)
Language	English
Publishing date	2021-02-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-021-01224-1
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Article ; Online: A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson's disease.

Koh, Jinsoo / Takahashi, Maiko / Ohmae, Yasuhiko / Taruya, Junko / Sakata, Mayumi / Yasui, Masaaki / Terada, Masaki / Ito, Hidefumi

PloS one

2022 Volume 17, Issue 4, Page(s) e0266354

Abstract: Background: Impulse control disorders are detrimental neuropsychiatric symptoms of Parkinson's disease. Increased impulsivity is a predisposing factor for impulse control disorders and should therefore be controlled. Recently, mindfulness meditation as ... ...

Abstract	Background: Impulse control disorders are detrimental neuropsychiatric symptoms of Parkinson's disease. Increased impulsivity is a predisposing factor for impulse control disorders and should therefore be controlled. Recently, mindfulness meditation as a non-drug therapy has been reported to be useful in improving neuropsychiatric symptoms, such as impulsivity. Methods: We performed a prospective single-arm, open-label pilot trial to investigate the effectiveness of mindfulness meditation to control impulsivity in patients with Parkinson's disease (UMIN clinical trials registry: UMIN000037779). Results: Twenty patients with Parkinson's disease were enrolled in an 8-week mindfulness meditation program. As a primary outcome, we investigated whether the score of the Barratt Impulsiveness Scale (BIS-11) was significantly reduced after the intervention. As an exploratory examination, functional connectivity changes were also assessed by resting-state functional magnetic resonance imaging. After the intervention, the BIS-11 score was decreased from 59.5 [55.6, 63.3] (mean [95% confidence interval]) to 55.2 [50.3, 60.1] (ΔBIS-11: -4.2, [-7.5, -0.9]). Functional connectivity was increased in the default mode network (DMN) at a cluster including the precuneus, posterior cingulate gyrus, and left posterior lobe (false discovery rate-adjusted p [FDR-p] = 0.046) and in the right frontoparietal network (FPN) at the medial frontal lobe (FDR-p = 0.039). Conclusions: This open-label, single-arm pilot study provided preliminary data for mindfulness meditation to control the impulsivity of patients with PD. A brief mindfulness meditation program may be effective in controlling impulsivity in PD and may change the functional connectivity of the DMN and right FPN.
MeSH term(s)	Humans ; Impulsive Behavior ; Magnetic Resonance Imaging ; Meditation/psychology ; Mindfulness/methods ; Parkinson Disease/therapy ; Pilot Projects ; Prospective Studies
Language	English
Publishing date	2022-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266354
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Article ; Online: Feasibility study on collecting patient-reported outcomes from breast cancer patients using the LINE-ePRO system.

Hayashida, Tetsu / Nagayama, Aiko / Seki, Tomoko / Takahashi, Maiko / Matsumoto, Akiko / Kubota, Anna / Jinno, Hiromitsu / Miyata, Hiroaki / Kitagawa, Yuko

Cancer science

2022 Volume 113, Issue 5, Page(s) 1722–1730

Abstract: Due to the increasing complexity of cancer treatment, ensuring safety and maintaining the quality of life during treatment are important issues. Patient-reported outcomes (PROs) in oncology are essential for assessing patient symptoms. A feasibility ... ...

Abstract	Due to the increasing complexity of cancer treatment, ensuring safety and maintaining the quality of life during treatment are important issues. Patient-reported outcomes (PROs) in oncology are essential for assessing patient symptoms. A feasibility study was undertaken on breast cancer patients by building a PRO data collection system based on LINE, one of the most popular social network service applications in Japan. In this study, one or more predefined PRO questions for each breast cancer patient's clinical situation were sent to the patient's LINE application daily. The patient selected a predefined answer by tapping the screen, but no free-text answers were allowed. Seventy-three patients were enrolled. The median observation period was 435 days (84-656 days), and the total number of PROs collected was 16,417, with a mean of 224.9 reports per patient. Patients on adjuvant endocrine therapy were notified of 2.5 questions per week, and the median number of responses per week and response rate were 2.387 (1.687-11.627) and 95.5%, respectively. Analyzing the results by age group, the number of responses from those aged 60 and above was equal to or higher than that of the younger age group. It was also possible to track each patient's PROs accurately. These results suggested that the design of the system, based on an application used daily, instead of using specifically prepared applications for collecting electronic PROs, was the reason for the favorable acceptance from patients and the satisfactory response rate from all age groups, including the elderly.
MeSH term(s)	Aged ; Breast Neoplasms/therapy ; Feasibility Studies ; Female ; Humans ; Patient Reported Outcome Measures ; Quality of Life ; Software
Language	English
Publishing date	2022-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15329
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