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Article ; Online: cAMP signaling in ovarian physiology in teleosts: A review.

Takahashi, Takayuki / Ogiwara, Katsueki

2022 Volume 101, Page(s) 110499

Abstract: Ovarian function in teleosts, like in other vertebrates, is regulated by two distinct gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Gonadotropin effects are mediated by membrane-bound G protein-coupled receptors ... ...

Abstract	Ovarian function in teleosts, like in other vertebrates, is regulated by two distinct gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Gonadotropin effects are mediated by membrane-bound G protein-coupled receptors localized on the surface of follicle cells. Gonadotropin receptor activation results in increased intracellular cAMP, the most important second cellular signaling molecule. FSH stimulation induces the production of 17β-estradiol in the cells of growing follicles to promote vitellogenesis in oocytes. In contrast, in response to LH, fully grown post-vitellogenic follicles gain the ability to synthesize maturation-inducing steroids, which induce meiotic resumption and ovulation. All these events were induced downstream of cAMP. In this review, we summarize studies addressing the role of the cAMP pathway in gonadotropin-induced processes in teleost ovarian follicles. Furthermore, we discuss future problems concerning cAMP signaling in relation to teleost ovarian function and the differences and similarities in the gonadotropin-induced cAMP signaling pathways between mammals and teleosts.
MeSH term(s)	Female ; Animals ; Follicle Stimulating Hormone/pharmacology ; Luteinizing Hormone/metabolism ; Luteinizing Hormone/pharmacology ; Ovarian Follicle/metabolism ; Ovulation ; Gonadotropins/metabolism ; Gonadotropins/pharmacology ; Mammals/metabolism
Chemical Substances	Follicle Stimulating Hormone (9002-68-0) ; Luteinizing Hormone (9002-67-9) ; Gonadotropins
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2022.110499
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Article ; Online: Signal pathway of LH-induced expression of nuclear progestin receptor in vertebrate ovulation.

Takahashi, Takayuki / Ogiwara, Katsueki

General and comparative endocrinology

2022 Volume 321-322, Page(s) 114025

Abstract: Nuclear progestin receptor (PGR), which is induced in the follicles destined to undergo ovulation, is believed to be obligatory for rupture of the follicles during ovulation in vertebrates. Studies in some mammals and teleost medaka have revealed the ... ...

Abstract	Nuclear progestin receptor (PGR), which is induced in the follicles destined to undergo ovulation, is believed to be obligatory for rupture of the follicles during ovulation in vertebrates. Studies in some mammals and teleost medaka have revealed the outline of the central signaling pathway that leads to the PGR expression in the preovulatory follicles at ovulation. In this review, we summarize the current knowledge on what signaling mediators are involved in the LH-induced follicular expression of PGR at ovulation in these animals. LH-inducibility of follicular PGR expression is conserved. In both group of animals, activation of the LH receptor on the granulosa cell surface with LH commonly results in the increase of intracellular cAMP levels, while the downstream signaling cascades activated by high level of cAMP are totally different between mice and medaka. PGR is currently presumed to be induced via PKA/CREB-mediated transactivation and ERK1/2-dependent signaling in mice, but the receptor is induced via EPAC/RAP and AKT/CREB pathways in the teleost medaka. The differences and similarities in the signaling pathways for PGR expression between them is discussed from comparative and evolutionary aspects. We also discussed questions concerning PGR expression and its regulation needed to be investigated in future.
MeSH term(s)	Animals ; Female ; Granulosa Cells/metabolism ; Mammals/metabolism ; Mice ; Oryzias/metabolism ; Ovulation/physiology ; Progesterone Congeners ; Progestins/metabolism ; Receptors, Progesterone/genetics ; Receptors, Progesterone/metabolism ; Signal Transduction ; Steroids/metabolism
Chemical Substances	Progesterone Congeners ; Progestins ; Receptors, Progesterone ; Steroids
Language	English
Publishing date	2022-03-12
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1851-x
ISSN	1095-6840 ; 0016-6480
ISSN (online)	1095-6840
ISSN	0016-6480
DOI	10.1016/j.ygcen.2022.114025
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Article ; Online: Roles of melatonin in the teleost ovary: A review of the current status.

Takahashi, Takayuki / Ogiwara, Katsueki

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

2021 Volume 254, Page(s) 110907

Abstract: Melatonin, the neurohormone mainly synthesized in and secreted from the pineal gland of vertebrates following a circadian rhythm, is an important factor regulating various physiological processes, including reproduction. Recent data indicate that ... ...

Abstract	Melatonin, the neurohormone mainly synthesized in and secreted from the pineal gland of vertebrates following a circadian rhythm, is an important factor regulating various physiological processes, including reproduction. Recent data indicate that melatonin is also synthesized in the ovary and that it acts directly at the level of the ovary to modulate ovarian physiology. In some teleosts, melatonin is reported to affect ovarian steroidogenesis. The direct action of melatonin on the ovary could be a possible factor promoting oocyte maturation in teleosts. A role for melatonin in follicle rupture during ovulation in the teleost medaka has recently emerged. In addition, melatonin is suggested to affect oocyte maturation by its antioxidant activity. However, the molecular mechanisms underlying these direct effects of melatonin are largely unknown.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Circadian Rhythm/physiology ; Female ; Fishes/metabolism ; Fishes/physiology ; Melatonin/metabolism ; Melatonin/physiology ; Neurotransmitter Agents/metabolism ; Oocytes/cytology ; Oogenesis ; Ovarian Follicle/metabolism ; Ovary/metabolism ; Ovary/physiology ; Pineal Gland/physiology ; Reactive Oxygen Species ; Steroids/metabolism
Chemical Substances	Antioxidants ; Neurotransmitter Agents ; Reactive Oxygen Species ; Steroids ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2021-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	121246-1
ISSN	1531-4332 ; 0300-9629 ; 1095-6433
ISSN (online)	1531-4332
ISSN	0300-9629 ; 1095-6433
DOI	10.1016/j.cbpa.2021.110907
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Article: Roles of melatonin in the teleost ovary: A review of the current status

Takahashi, Takayuki / Ogiwara, Katsueki

Comparative biochemistry and physiology. 2021 Apr., v. 254

2021

Abstract	Melatonin, the neurohormone mainly synthesized in and secreted from the pineal gland of vertebrates following a circadian rhythm, is an important factor regulating various physiological processes, including reproduction. Recent data indicate that melatonin is also synthesized in the ovary and that it acts directly at the level of the ovary to modulate ovarian physiology. In some teleosts, melatonin is reported to affect ovarian steroidogenesis. The direct action of melatonin on the ovary could be a possible factor promoting oocyte maturation in teleosts. A role for melatonin in follicle rupture during ovulation in the teleost medaka has recently emerged. In addition, melatonin is suggested to affect oocyte maturation by its antioxidant activity. However, the molecular mechanisms underlying these direct effects of melatonin are largely unknown.
Keywords	antioxidant activity ; circadian rhythm ; melatonin ; oocytes ; ovulation ; pineal body ; steroidogenesis
Language	English
Dates of publication	2021-04
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	121246-1
ISSN	1531-4332 ; 0300-9629 ; 1095-6433
ISSN (online)	1531-4332
ISSN	0300-9629 ; 1095-6433
DOI	10.1016/j.cbpa.2021.110907
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Article: Spatiotemporally varying inter-relationships between mainstem riverbed elevation and tributary sediment supply since the last interglacial in the upper Ara River, central Japan

Takahashi, Takayuki / Sugai, Toshihiko

Geomorphology. 2021 June 15, v. 383

2021

Abstract: The dynamics of sediment transport processes over millennial time scales in mountain river valleys remain poorly understood, limiting our overall understanding of sediment routing through river basins. Here, we reconstruct changes of the mainstem ... ...

Abstract	The dynamics of sediment transport processes over millennial time scales in mountain river valleys remain poorly understood, limiting our overall understanding of sediment routing through river basins. Here, we reconstruct changes of the mainstem riverbed elevation, tributary sediment supply processes, and their inter-relationships since the last interglacial in the upper Ara River valley, central Japan. Aggradation of the mainstem river valley began before 100–95 ka and terminated by 41–40 ka. Then, the elevation of the mainstem floodplain remained stable until ~15 ka. Lateral erosion by the mainstem river, and intermittent periods of incision, continued until 5 ka, after which the mainstem river began actively incising. Aggradation of the mainstem riverbed before 41–40 ka elevated tributary junctions, decreasing the slopes of tributaries. Using reconstructed slope changes, and assuming sediment transport by debris flow in tributaries with slopes steeper than 8% and by traction in shallower tributaries, we classified the tributaries into three types: Type-A, with sediment supply by debris flow since the last interglacial; Type-B, with sediment supply by traction during the last glacial period and afterwards by debris flow; and Type-C, with sediment supply by traction since the last interglacial. Based on the relation between relief ratio and drainage area, we subdivided Type-C tributaries into those that plotted along (Type-C1) or markedly below (Type-C2) the regression line of the mainstem river and Type-A and -B tributaries. During aggradation of the mainstem river, sediments supplied by debris flow from Type-A and -B tributaries accumulated around junctions, interfingering with mainstem deposits. During this period, the junctions of Type-C1 tributaries were elevated almost synchronously with mainstem aggradation, while the junctions of Type-C2 tributaries were blocked by mainstem river deposits, forming blocked-valley lakes. Around 30 ka, Type-A and -B tributaries formed fans around their junctions that were subsequently truncated by lateral erosion by the mainstem river during the late glacial period and early Holocene, forming toe-cut terraces. Tributary deposits that had accumulated around the junctions were then reworked while maintaining a dynamic equilibrium state with the mainstem river. We infer that the responses of tributary landforms and sediment supply processes to the changing elevation of the mainstem riverbed during glacial and interglacial cycles varied depending on the drainage area and relief of each tributary. Considering the river basin as a whole, however, tributary deposits stabilized the elevation of the mainstem floodplain.
Keywords	Holocene epoch ; Japan ; drainage ; floodplains ; mass movement ; river valleys ; rivers ; sediment transport ; sediments ; stream channels ; watersheds
Language	English
Dates of publication	2021-0615
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	58028-4
ISSN	0169-555X
ISSN	0169-555X
DOI	10.1016/j.geomorph.2021.107697
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Article ; Online: The PGE

Ogiwara, Katsueki / Fujimori, Chika / Takahashi, Takayuki

Molecular and cellular endocrinology

2022 Volume 560, Page(s) 111816

Abstract: We have previously shown that the prostaglandin ... ...

Abstract	We have previously shown that the prostaglandin E
MeSH term(s)	Female ; Animals ; Oryzias ; Dinoprostone ; Ovulation/physiology ; Granulosa Cells ; Actin Cytoskeleton ; rho-Associated Kinases
Chemical Substances	N-(2-(4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo(f)isoindol-2-yl)phenyl)acetyl)benzene sulphonamide ; Dinoprostone (K7Q1JQR04M) ; rho-Associated Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-11-19
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2022.111816
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Article: Dual fungal infection with

Sugiura, Yoshitsugu / Sugimoto, Naoshi / Takahashi, Takayuki / Matsumoto, Tadahiko

Clinical case reports

2021 Volume 9, Issue 3, Page(s) 1383–1386

Abstract: A 44-year-old male Japanese was admitted for further post-remission treatments for acute myeloid leukemia. He developed a right orbital abscess. An isolate ... ...

Abstract	A 44-year-old male Japanese was admitted for further post-remission treatments for acute myeloid leukemia. He developed a right orbital abscess. An isolate of
Language	English
Publishing date	2021-01-18
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.3775
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Article ; Online: A central role for cAMP/EPAC/RAP/PI3K/AKT/CREB signaling in LH-induced follicular Pgr expression at medaka ovulation†.

Ogiwara, Katsueki / Hoyagi, Miyuki / Takahashi, Takayuki

Biology of reproduction

2021 Volume 105, Issue 2, Page(s) 413–426

Abstract: Nuclear progestin receptor (PGR) is a ligand-activated transcription factor that has been identified as a pivotal mediator of many processes associated with ovarian and uterine function, and aberrant control of PGR activity causes infertility and disease ...

Abstract	Nuclear progestin receptor (PGR) is a ligand-activated transcription factor that has been identified as a pivotal mediator of many processes associated with ovarian and uterine function, and aberrant control of PGR activity causes infertility and disease including cancer. The essential role of PGR in vertebrate ovulation is well recognized, but the mechanisms by which PGR is rapidly and transiently induced in preovulatory follicles after the ovulatory LH surge are not known in lower vertebrates. To address this issue, we utilized the small freshwater teleost medaka Oryzias latipes, which serves as a good model system for studying vertebrate ovulation. In the in vitro ovulation system using preovulatory follicles dissected from the fish ovaries, we found that inhibitors of EPAC (brefeldin A), RAP (GGTI298), PI3K (Wortmannin), AKT (AKT inhibitor IV), and CREB (KG-501) inhibited LH-induced follicle ovulation, while the PKA inhibitor H-89 had no effect on follicle ovulation. The inhibitors capable of inhibiting follicle ovulation also inhibited follicular expression of Pgr and matrix metalloproteinase-15 (Mmp15), the latter of which was previously shown to not only be a downstream effector of Pgr but also a proteolytic enzyme indispensable for follicle rupture in medaka ovulation. Further detailed analysis revealed for the first time that the cAMP/EPAC/RAP/PI3K/AKT/CREB signaling pathway mediates the LH signal to induce Pgr expression in preovulatory follicles. Our data also showed that phosphorylated Creb1 is a transcription factor essential for pgr expression and that Creb1 phosphorylated by Akt1, rather than PKA, may be preferably used to induce pgr expression.
MeSH term(s)	Animals ; Female ; Fish Proteins/antagonists & inhibitors ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Gene Expression ; Luteinizing Hormone/metabolism ; Oryzias/genetics ; Oryzias/physiology ; Ovulation/genetics ; Signal Transduction
Chemical Substances	Fish Proteins ; Luteinizing Hormone (9002-67-9)
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioab077
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Article: Protective effects of coenzyme Q

Mine, Yukitoshi / Takahashi, Takayuki / Okamoto, Tadashi

Journal of clinical biochemistry and nutrition

2021 Volume 69, Issue 3, Page(s) 247–255

Abstract: Cellular senescence is an intricate and multifactorial phenomenon, which is characterized by an irreversible cellular growth arrest, it is caused in response to irretrievably DNA damage, telomere shorting, activation of oncogene, and oxidative stress. ... ...

Abstract	Cellular senescence is an intricate and multifactorial phenomenon, which is characterized by an irreversible cellular growth arrest, it is caused in response to irretrievably DNA damage, telomere shorting, activation of oncogene, and oxidative stress. Human diploid fibroblasts are a well-established experimental model for premature senescence-related studies, and exposure of fibroblasts to H
Language	English
Publishing date	2021-05-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.20-185
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Article: Stimulatory effects of collagen production induced by coenzyme Q

Mine, Yukitoshi / Takahashi, Takayuki / Okamoto, Tadashi

Journal of clinical biochemistry and nutrition

2021 Volume 71, Issue 1, Page(s) 29–33

Abstract: ... Coenzyme ... ...

Abstract	Coenzyme Q
Language	English
Publishing date	2021-11-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.20-187
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