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  1. Article ; Online: Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia.

    Ennis, Sarah / Conforte, Alessandra / O'Reilly, Eimear / Takanlu, Javid Sabour / Cichocka, Tatiana / Dhami, Sukhraj Pal / Nicholson, Pamela / Krebs, Philippe / Ó Broin, Pilib / Szegezdi, Eva

    iScience

    2023  Volume 26, Issue 6, Page(s) 106943

    Abstract: The bone marrow (BM) is a complex microenvironment, coordinating the production of billions of blood cells every day. Despite its essential role and its relevance to hematopoietic diseases, this environment remains poorly characterized. Here we present a ...

    Abstract The bone marrow (BM) is a complex microenvironment, coordinating the production of billions of blood cells every day. Despite its essential role and its relevance to hematopoietic diseases, this environment remains poorly characterized. Here we present a high-resolution characterization of the niche in health and acute myeloid leukemia (AML) by establishing a single-cell gene expression database of 339,381 BM cells. We found significant changes in cell type proportions and gene expression in AML, indicating that the entire niche is disrupted. We then predicted interactions between hematopoietic stem and progenitor cells (HSPCs) and other BM cell types, revealing a remarkable expansion of predicted interactions in AML that promote HSPC-cell adhesion, immunosuppression, and cytokine signaling. In particular, predicted interactions involving transforming growth factor β1 (TGFB1) become widespread, and we show that this can drive AML cell quiescence
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Microvesicles of osteoblasts modulate bone marrow mesenchymal stem cell-induced apoptosis to curcumin in myeloid leukemia cells.

    Zahedpanah, Mahdi / Takanlu, Javid Sabour / Nikbakht, Mohsen / Rad, Fariba / Farhid, Fatemeh / Mousavi, Seyed Asadollah / Rad, Soroush / Fumani, Hosein Kamranzadeh / Hosseini Rad, Seyed Mohammad Ali / Mohammadi, Saeed

    Journal of cellular physiology

    2019  Volume 234, Issue 10, Page(s) 18707–18719

    Abstract: Microvesicles (MVs) derived from bone marrow niche components have an important role in genetic reprogramming and subsequent drugs induce apoptosis in leukemic cells. Here, we have found that undertreatment of curcumin or daunorubicin, the cross-talk ... ...

    Abstract Microvesicles (MVs) derived from bone marrow niche components have an important role in genetic reprogramming and subsequent drugs induce apoptosis in leukemic cells. Here, we have found that undertreatment of curcumin or daunorubicin, the cross-talk through MVs of KG-1-bone marrow mesenchymal stem cells (BMSCs), significantly downregulates the expression of the survival gene osteopontin (OPN), CXCL-12, IL-6 (interleukin-6), STAT-3, and VCAM-1 (vascular cell adhesion molecule 1) in treated-KG-1 cells as well as exclusively upregulates CXCL-12 in BMSCs. Drug treated-cell populations' MVs of both single cultured osteoblasts (OBs) and cocultured KG-1 + BMSCs + OBs similarly upregulate survival mediators' OPN, CXCL-12, IL-6, STAT-3, and VCAM-1 in treated-KG-1 cells. Likewise, isolated MVs from KG-1 cells or communication between KG-1, BMSCs, and OBs treated by drugs increase the expression of genes OPN, CXCL-12, IL-6, STAT3, and VCAM-1 by OBs. MVs derived from KG-1 + BMSCs + OBs reduce drug-induced apoptosis in KG-1 cells. This suggests MVs-mediated information transfer is a procedure whereby OBs could overcome BMSCs-induced apoptosis in drug-treated-KG-1 cells.
    MeSH term(s) Apoptosis/drug effects ; Cell Communication/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell-Derived Microparticles/metabolism ; Cell-Derived Microparticles/ultrastructure ; Curcumin/pharmacology ; Down-Regulation/drug effects ; Dynamic Light Scattering ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Leukemia, Myeloid/genetics ; Leukemia, Myeloid/pathology ; Mesenchymal Stem Cells/cytology ; Osteoblasts/drug effects ; Osteoblasts/metabolism
    Chemical Substances Curcumin (IT942ZTH98)
    Language English
    Publishing date 2019-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.28511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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