LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2598

Search options

  1. Article: [Challenges and Prospects of a Specific Clinical Study].

    Takano, Tadao

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 51, Issue 1, Page(s) 1–6

    Abstract: The term"clinical trials"as used in the Clinical Trials Act refers to research aimed at determining the efficacy or safety of pharmaceuticals by administering them to humans. The term"specified clinical trials"as defined in this Act encompasses clinical ... ...

    Abstract The term"clinical trials"as used in the Clinical Trials Act refers to research aimed at determining the efficacy or safety of pharmaceuticals by administering them to humans. The term"specified clinical trials"as defined in this Act encompasses clinical trials that meet either of the following criteria:(i)Clinical trials funded or supported by a manufacturer with marketing approval for the pharmaceuticals or(ii)Clinical trials involving unapproved or off-label pharmaceuticals. Such research must comply with the standards established by the Clinical Research Act. The Clinical Research Subcommittee is deliberating strategies to bolster the conduct of clinical research in alignment with international standards. Discussions encompass establishing sponsors for multi-institutional collaborative research, utilizing collected data for drug application submissions, re- evaluating the legal parameters of observational studies, defining the extent of off-label use research, assessing the applicability of laws to medical devices, digitizing and simplifying notification and amendment processes, and introducing various modifications and strategies to uphold research quality. The objective is to refine the clinical research framework and enhance access to pertinent information.
    MeSH term(s) Humans ; Data Collection ; Marketing ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language Japanese
    Publishing date 2024-01-22
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Cardiometabolic Effects of Antipsychotics in Challenging Behavior and Neuropsychiatric Symptoms in Patients With Intellectual Disability.

    Takano, Tomoyuki

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48088

    Abstract: Introduction Despite the well-established association between antipsychotics and metabolic adverse effects in psychiatric disorders, the variable influence of long-term and off-label antipsychotic medication on behavioral disorders has not been ... ...

    Abstract Introduction Despite the well-established association between antipsychotics and metabolic adverse effects in psychiatric disorders, the variable influence of long-term and off-label antipsychotic medication on behavioral disorders has not been investigated in detail. Objective To clarify the impact of antipsychotic use on challenging behavior (CB) and neuropsychiatric symptoms (NPS), we evaluated the clinical findings and cardiometabolic effects in individuals with intellectual disability (ID) hospitalized in our residential facility for profoundly disabled patients. Patients and methods A total of 130 individuals hospitalized in our residential facility were retrospectively investigated and divided into two groups - individuals with and without CB and NPS. Antipsychotics (first- and second-generation antipsychotics) are prescribed to all individuals in the CB and NPS-positive ID group. Conversely, antipsychotics were not prescribed to any individuals in the CB- and NPS-negative ID groups. To investigate the cardiometabolic effects of antipsychotics, the following metabolic parameters were measured: body weight (BW), total calorie intake per day, body mass index (BMI), blood pressure, serum lipid levels (total cholesterol, high-density lipoprotein cholesterol, and triglyceride), and corrected QT interval (QTc) of electrocardiogram (ECG). The etiology of disabilities, level of ID, severity of motor disability, and presence or absence of epilepsy were also examined. Results Two main results were derived: (1) Autism spectrum disorder was the most predominant etiology in individuals with CB and NPS who were prescribed antipsychotics, and (2) the mean values of metabolic parameters were all normal in both medicated and nonmedicated individuals, but the total calorie intake was significantly higher in individuals who were prescribed antipsychotics. Conclusions Our investigation demonstrated that in individuals with an adequate energy intake, most metabolic parameters can be maintained within normal limits. We suggest that body weight control is the primary step in avoiding the cardiometabolic adverse effects of antipsychotics in intellectually disabled individuals with CB and NPS.
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48088
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Pacing intracellular Ca

    Yule, David I / Takano, Takahiro

    The Journal of physiology

    2024  

    Abstract: An increase in intracellular [ ... ...

    Abstract An increase in intracellular [Ca
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284755
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: [Ⅲ. Clinical Trials of Trastuzumab Deruxtecan for HER2-Low Advanced Breast Cancer].

    Kizawa, Rika / Takano, Toshimi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 50, Issue 12, Page(s) 1278–1281

    MeSH term(s) Female ; Humans ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Camptothecin ; Immunoconjugates ; Trastuzumab/therapeutic use ; Genes, erbB-2
    Chemical Substances Camptothecin (XT3Z54Z28A) ; Immunoconjugates ; Trastuzumab (P188ANX8CK) ; trastuzumab deruxtecan (5384HK7574)
    Language Japanese
    Publishing date 2024-01-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: In Reply.

    Takano, Toru

    Archives of pathology & laboratory medicine

    2021  Volume 144, Issue 7, Page(s) 797–798

    MeSH term(s) Child ; Humans ; Medical Overuse ; Thyroid Neoplasms
    Language English
    Publishing date 2021-03-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2019-0683-LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: [Medical ethics and research ethics].

    Takano, Tadao

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2021  Volume 62, Issue 8, Page(s) 1343–1348

    Abstract: Medical ethics are important for medical professionals and can be classified into two subcategories, which are: "Research Ethics," referring to the norms that researchers should follow when engaging in research activities, and "Clinical Ethics," which ... ...

    Abstract Medical ethics are important for medical professionals and can be classified into two subcategories, which are: "Research Ethics," referring to the norms that researchers should follow when engaging in research activities, and "Clinical Ethics," which are mainly norms that should be followed in routine clinical practice. Rules are the basic component of ethics and are an agreement that is enacted after the fact. On the other hand, the development of new medical care strategies requires novelty and originality. Research includes unknown and unpracticed topics; therefore, new problems arise, which are often not possible to deal with by simply following the established rules. Medical professionals need to be ethical so that they can anticipate new problems and make decisions without the rules. This can be done by understanding the background against which the rules have been formed and its preamble.
    MeSH term(s) Ethics, Medical ; Ethics, Research ; Humans
    Language Japanese
    Publishing date 2021-09-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.62.1343
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 535: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Self-injury as a predominant challenging behavior in epilepsy: A study in a residential facility for profoundly disabled patients.

    Takano, Tomoyuki

    Research in developmental disabilities

    2021  Volume 120, Page(s) 104149

    Abstract: Background: The association between challenging behavior (CB) and epilepsy in people with intellectual disability (ID) remains largely controversial.: Aim: To clarify the correlation between CB and epilepsy, we investigated the clinical ... ...

    Abstract Background: The association between challenging behavior (CB) and epilepsy in people with intellectual disability (ID) remains largely controversial.
    Aim: To clarify the correlation between CB and epilepsy, we investigated the clinical characteristics of CB in both people with and without epilepsy among individuals with ID hospitalized in our residential facility.
    Methods and procedures: A total of 63 individuals with CB was retrospectively investigated using the Behavior Problems Inventory, and the following items were collected from the medical records: sex, age, hospitalization period, etiology and risk factors, level of ID, type of CB, administration of psychotropic drugs, presence or absence of epilepsy and clinical features of epilepsy.
    Outcomes and results: Almost all individuals with CB showed profound ID. There was no significant difference in the rate of CB between people with and without epilepsy. A type analysis of CB revealed that self-injurious behavior was observed more frequently in epilepsy cases (66.7 %) than in cases without epilepsy (36.4 %) (p =  0.015), and self-injurious behavior was the predominant clinical form in people with epilepsy among the three subgroups of CB (self-injurious, aggressive and self-injurious and aggressive behavior).
    Conclusions and implications: The high incidence of self-injurious behavior in epilepsy with profound disabilities may imply the presence of common pathological basis of self-injurious behavior and epilepsy.
    MeSH term(s) Epilepsy/epidemiology ; Humans ; Intellectual Disability/epidemiology ; Residential Facilities ; Retrospective Studies ; Self-Injurious Behavior/epidemiology
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639175-8
    ISSN 1873-3379 ; 0891-4222
    ISSN (online) 1873-3379
    ISSN 0891-4222
    DOI 10.1016/j.ridd.2021.104149
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2592: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The era of meta-analyses-based recommendations: how were the Japanese Breast Cancer Society Clinical Practice Guidelines for Systemic Treatment of Breast Cancer established?

    Takano, Toshimi

    Breast cancer (Tokyo, Japan)

    2020  Volume 27, Issue 3, Page(s) 332–333

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/standards ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Chemotherapy, Adjuvant/methods ; Chemotherapy, Adjuvant/standards ; Evidence-Based Medicine/methods ; Evidence-Based Medicine/standards ; Female ; Humans ; Japan ; Mastectomy ; Medical Oncology/methods ; Medical Oncology/standards ; Meta-Analysis as Topic ; Practice Guidelines as Topic ; Societies, Medical/standards
    Language English
    Publishing date 2020-04-22
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2052429-8
    ISSN 1880-4233 ; 1340-6868
    ISSN (online) 1880-4233
    ISSN 1340-6868
    DOI 10.1007/s12282-020-01099-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5536: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Monitoring of Rho GTPase Activity in Podocytes.

    Matsuda, Jun / Takano, Tomoko

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2664, Page(s) 343–349

    Abstract: The glomerulus is the filtration unit of the kidney, where the first step of urine formation occurs. Podocytes are characterized by their actin-based projections called foot processes. Podocyte foot processes play a critical role in the permselective ... ...

    Abstract The glomerulus is the filtration unit of the kidney, where the first step of urine formation occurs. Podocytes are characterized by their actin-based projections called foot processes. Podocyte foot processes play a critical role in the permselective filtration barrier, along with fenestrated endothelial cells and the glomerular basement membrane. The Rho family of small GTPases (Rho GTPases) is the master regulators of the actin cytoskeleton and functions as molecular switches. Recent studies have shown that disruption of Rho GTPase activity and subsequent changes in foot process structure cause proteinuria. Here, we describe an effector pull-down assay using GST-fusion proteins to monitor the activity of RhoA, Rac1, and Cdc42, which are prototypical Rho GTPases in podocytes.
    MeSH term(s) Podocytes/metabolism ; rho GTP-Binding Proteins/metabolism ; Endothelial Cells/metabolism ; Kidney Glomerulus/metabolism ; Actin Cytoskeleton/metabolism ; rac1 GTP-Binding Protein/metabolism
    Chemical Substances rho GTP-Binding Proteins (EC 3.6.5.2) ; rac1 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3179-9_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Hypodense cerebral venous sinus thrombosis on unenhanced CT: Time-dependent change of CT attenuation in intravenous thrombus.

    Takano, Taiga / Matsuki, Mitsuru

    Radiology case reports

    2023  Volume 19, Issue 1, Page(s) 370–373

    Abstract: Cerebral venous sinus thrombosis (CVST) is an important cause of stroke, which accounts for 0.5%-1% of all strokes. CVST is principally manifested as headaches, papilledema, psychiatric symptoms, impaired consciousness and seizure disorders, with or ... ...

    Abstract Cerebral venous sinus thrombosis (CVST) is an important cause of stroke, which accounts for 0.5%-1% of all strokes. CVST is principally manifested as headaches, papilledema, psychiatric symptoms, impaired consciousness and seizure disorders, with or without neurological defects. We encountered a case of CVST after subacute phase, revealing a hypodense thrombus in the superior sagittal sinus (SSS) on unenhanced CT. Retrospective observation of the serial unenhanced CT images taken at another hospital showed that the SSS thrombus changed from high to low attenuation for 10 days. RBCs dominant CVST at acute phase shows high attenuation on unenhanced CT and is effective for heparin therapy, whereas CVST after subacute phase shows low attenuation on unenhanced CT by the thrombus contents of fibrin, hemosiderin and collagen, and may be ineffective to heparin therapy. Therefore, it is important to accurately identify high attenuation of the CVST at acute phase on unenhanced CT and treat with heparin as early as possible.
    Language English
    Publishing date 2023-11-10
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2023.09.057
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top