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  1. Article: [Neuropathology of Inflammatory and Autoimmune-Mediated Diseases].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2024  Volume 76, Issue 4, Page(s) 353–360

    Abstract: Herein, the author summarize the basic findings on the neuropathology of inflammatory and autoimmune central nervous system (CNS) diseases. Current knowledge on infectious, demyelinating, and autoimmune diseases have also been reported. Further, I ... ...

    Abstract Herein, the author summarize the basic findings on the neuropathology of inflammatory and autoimmune central nervous system (CNS) diseases. Current knowledge on infectious, demyelinating, and autoimmune diseases have also been reported. Further, I emphasize the importance of considering the neuropathology of meningitis, encephalitis, and abscesses as infectious diseases; multiple sclerosis and neuromyelitis optica as demyelinating diseases; and vasculitis, paraneoplastic neurological syndrome, and collagen diseases as autoimmune diseases.
    MeSH term(s) Humans ; Autoimmune Diseases ; Multiple Sclerosis ; Neuromyelitis Optica ; Autoimmune Diseases of the Nervous System ; Central Nervous System Diseases
    Language Japanese
    Publishing date 2024-04-08
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: [Eserine, in Crooked House and Curtain].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2023  Volume 75, Issue 12, Page(s) 1343–1346

    Abstract: Eserine, well-known as physostigmine, is classified as an alkaloid. It is a cholinesterase inhibitor and appears in Agatha Christie's novel entitled, Crooked House and Curtain: Poirot's Last Case. In clinical medicine, eserine was used as an ophthalmic ... ...

    Abstract Eserine, well-known as physostigmine, is classified as an alkaloid. It is a cholinesterase inhibitor and appears in Agatha Christie's novel entitled, Crooked House and Curtain: Poirot's Last Case. In clinical medicine, eserine was used as an ophthalmic treatment for glaucoma and considered as a treatment for myasthenia gravis, Alzheimer's disease, and hereditary cerebellar ataxias. Currently, it is used as a treatment for anticholinergic poisoning.
    MeSH term(s) Humans ; Physostigmine/therapeutic use ; Physostigmine/pharmacology ; Cholinesterase Inhibitors ; Myasthenia Gravis
    Chemical Substances Physostigmine (9U1VM840SP) ; Cholinesterase Inhibitors
    Language Japanese
    Publishing date 2023-12-14
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: [Psychiatric Diseases of One Flew Over the Cuckoo's Nest].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2022  Volume 74, Issue 12, Page(s) 1379–1383

    Abstract: This short article summarized of electroconvulsive therapy (ECT) and lobotomy presented in the movie One Flew Over the Cuckoo's Nest. ECT has established itself as an effective treatment despite many setbacks, and lobotomies are no longer performed. ... ...

    Abstract This short article summarized of electroconvulsive therapy (ECT) and lobotomy presented in the movie One Flew Over the Cuckoo's Nest. ECT has established itself as an effective treatment despite many setbacks, and lobotomies are no longer performed. Medical professionals have a responsibility to look ahead to the future and establish reliable treatments.
    Language Japanese
    Publishing date 2022-12-08
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: [Egon Schiele and Dystonia].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2021  Volume 73, Issue 12, Page(s) 1341–1345

    Abstract: Egon Schiele was one of the famous expressionist painters and ended his short life at the age 28 years. Based on the characteristics of his paintings, it was considered that he might have had cervical dystonia. However, the hypothesis may be wrong. The ... ...

    Abstract Egon Schiele was one of the famous expressionist painters and ended his short life at the age 28 years. Based on the characteristics of his paintings, it was considered that he might have had cervical dystonia. However, the hypothesis may be wrong. The interesting things are that he might have strongly influenced by medical materials including neuropsychiatric patients seen in Salpêtrière hospital.
    MeSH term(s) Adult ; Dystonia ; Famous Persons ; Humans ; Male ; Paintings
    Language Japanese
    Publishing date 2021-11-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [Neuro-Oncology: The Role of Neurologists in Oncology].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2021  Volume 73, Issue 10, Page(s) 1075–1078

    Abstract: Neurologists have a significant role in cancer treatment. Neuro-oncology is a novel discipline that involves the study of primary tumors and specific neurological symptoms associated with cancer and cancer treatments. Thus, neurologists must be involved ... ...

    Abstract Neurologists have a significant role in cancer treatment. Neuro-oncology is a novel discipline that involves the study of primary tumors and specific neurological symptoms associated with cancer and cancer treatments. Thus, neurologists must be involved in the treatment of cancer patients in Japan. In addition, it is necessary to educate and train neurologists as neuro-oncologists. With the increase in the number of cancer patients, its importance seems to increase further.
    MeSH term(s) Humans ; Japan ; Neurologists
    Language Japanese
    Publishing date 2021-10-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: [Neurotoxicities Associated with CAR-T Cell Therapy].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2020  Volume 73, Issue 1, Page(s) 47–58

    Abstract: Chimeric antigen receptor (CAR) T cell therapy has recently approved for CD-19-positive B-cell malignancies, such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma in Japan. CAR-T therapy may develop cytokine release syndoromes as well as ...

    Abstract Chimeric antigen receptor (CAR) T cell therapy has recently approved for CD-19-positive B-cell malignancies, such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma in Japan. CAR-T therapy may develop cytokine release syndoromes as well as central nervous system complications (CRES/ICANS), including encephalopathy, consciousness distrubence, apahsia, seizure, motor weakness, and cerebral edema. Although the pathomechanism of CRES/ICANS remains unsolved, an appropriate intervention is important for patients. In addition, several chemotherapeutic agenets used before CAR-T cell therapy may also lead to the development of central nervous system disorders. Therefore, neurologists must be familiar with the complications of newly developed chemotherapies.
    MeSH term(s) Cell- and Tissue-Based Therapy ; Humans ; Immunotherapy, Adoptive ; Japan ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Receptors, Chimeric Antigen
    Chemical Substances Receptors, Chimeric Antigen
    Language Japanese
    Publishing date 2020-12-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: [Important and Unresolved Aspects of Neuropathologic Analyses of COVID-19 Individuals].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2020  Volume 72, Issue 10, Page(s) 1061–1065

    Abstract: The pathomechanisms of central nervous system disorders associated with COVID-19 remain unsolved. It is therefore imperative to carry out pathologic, virologic, and molecular analyses of the human brain tissue to understand the neurological ... ...

    Abstract The pathomechanisms of central nervous system disorders associated with COVID-19 remain unsolved. It is therefore imperative to carry out pathologic, virologic, and molecular analyses of the human brain tissue to understand the neurological manifestations of COVID-19. However, autopsy of COVID-19 poses challenges in terms of infection control. In this short review, the neuropathologic findings of individuals with COVID-19 were summerised and a possible autopsy methodologies to investigate these further were proposed.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Nervous System Diseases/etiology ; Neuropathology ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language Japanese
    Publishing date 2020-10-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: [Dementia of the Oldest-Old].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2020  Volume 72, Issue 12, Page(s) 1353–1359

    Abstract: It is important to have a wide perspective to provide appropriate medical care for the oldest-old individuals. In terms of daily clinical practice, polypharmacy is an important factor that affects cognitive decline in older adults. The neuropathologic ... ...

    Abstract It is important to have a wide perspective to provide appropriate medical care for the oldest-old individuals. In terms of daily clinical practice, polypharmacy is an important factor that affects cognitive decline in older adults. The neuropathologic changes of dementia in the oldest-old individuals are associated with Alzheimer's disease, Lewy body disease, cerebrovascular disease, primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), and aging-related tau astrogliopathy (ARTAG).
    MeSH term(s) Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Humans ; Lewy Body Disease/diagnosis ; Tauopathies
    Language Japanese
    Publishing date 2020-12-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: [Neurosarcoidosis (Brain)].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2020  Volume 72, Issue 8, Page(s) 833–844

    Abstract: This review focuses on neurosarcoidosis with pathological alterations in the brain. Patients with neurosarcoidosis develop several symptoms such as cranial nerve palsies, headache, consciousness disturbance, and seizures. It may be difficult to reach a ... ...

    Abstract This review focuses on neurosarcoidosis with pathological alterations in the brain. Patients with neurosarcoidosis develop several symptoms such as cranial nerve palsies, headache, consciousness disturbance, and seizures. It may be difficult to reach a definite diagnosis and carry out differential diagnosis. Sarcoidosis is characterized by noncaseating granuloma that may be seen at the dura, leptomeninges, brain (including the cranial nerves), spinal cord, and peripheral nerves. Epithelioid histocytes and multinucleated giant cells, including Langhans cells, are characteristic microscopic features. In some instances, an asteroid body and a Schaumann body may be seen. In particular, infectious diseases including tuberculosis and mycosis must be ruled out. Therefore, the pathologic diagnosis of brain lesions is the gold standard for diagnosing neurosarcoidosis. In addition to prednisolone therapy, infliximab, a monoclonal antibody against tumor necrosis factor-α, has received much attention for treating neurosarcoidosis.
    MeSH term(s) Brain ; Central Nervous System Diseases ; Humans ; Sarcoidosis ; Spinal Cord
    Language Japanese
    Publishing date 2020-07-23
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: [Neuropathology of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)].

    Takao, Masaki

    Brain and nerve = Shinkei kenkyu no shinpo

    2019  Volume 71, Issue 5, Page(s) 483–491

    Abstract: Neuropathologic alterations of neuropsychiatric systemic lupus erythematosus (NPSLE) are characterized by small vessel changes such as endothelial proliferation, fibrosis, hyalinization, fibrinoid necrosis, and thrombus formation. Pathologic ischemic and ...

    Abstract Neuropathologic alterations of neuropsychiatric systemic lupus erythematosus (NPSLE) are characterized by small vessel changes such as endothelial proliferation, fibrosis, hyalinization, fibrinoid necrosis, and thrombus formation. Pathologic ischemic and hemorrhagic changes. In some instances, vasculitis and perivascular infiltration of inflammatory cells are seen. In the spinal cord, degenerative changes of entire margin of the spinal cord may also be present.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/pathology ; Lupus Vasculitis, Central Nervous System/pathology ; Neuropathology
    Language Japanese
    Publishing date 2019-05-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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