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Artikel ; Online: Important Role of Endogenous Nerve Growth Factor Receptor in the Pathogenesis of Hypoxia-Induced Pulmonary Hypertension in Mice.

Goten, Chiaki / Usui, Soichiro / Takashima, Shin-Ichiro / Inoue, Oto / Yamaguchi, Kosei / Hashimuko, Daiki / Takeda, Yusuke / Nomura, Ayano / Sakata, Kenji / Kaneko, Shuichi / Takamura, Masayuki

International journal of molecular sciences

2023 Band 24, Heft 3

Abstract: Pulmonary arterial hypertension (PAH) remains a disease with poor prognosis; thus, a new mechanism for PAH treatment is necessary. Circulating nerve growth factor receptor (Ngfr)-positive cells in peripheral blood mononuclear cells are associated with ... ...

Abstract	Pulmonary arterial hypertension (PAH) remains a disease with poor prognosis; thus, a new mechanism for PAH treatment is necessary. Circulating nerve growth factor receptor (Ngfr)-positive cells in peripheral blood mononuclear cells are associated with disease severity and the prognosis of PAH patients; however, the role of Ngfr in PAH is unknown. In this study, we evaluated the function of Ngfr using Ngfr gene-deletion (Ngfr
Mesh-Begriff(e)	Animals ; Mice ; Familial Primary Pulmonary Hypertension/metabolism ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/pathology ; Hypoxia/metabolism ; Leukocytes, Mononuclear/metabolism ; Lung/pathology ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Artery/pathology ; Receptor, Nerve Growth Factor/metabolism ; Vascular Remodeling
Chemische Substanzen	Receptor, Nerve Growth Factor ; Ngfr protein, mouse
Sprache	Englisch
Erscheinungsdatum	2023-01-18
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24031868
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effect of pulmonary vein isolation on the relationship between left atrial reverse remodeling and sympathetic nerve activity in patients with atrial fibrillation.

Mukai, Yusuke / Murai, Hisayoshi / Hamaoka, Takuto / Sugimoto, Hiroyuki / Inoue, Oto / Goten, Chiaki / Kusayama, Takashi / Takashima, Shin-Ichiro / Kato, Takeshi / Usui, Soichiro / Sakata, Kenji / Takata, Shigeo / Takamura, Masayuki

Clinical autonomic research : official journal of the Clinical Autonomic Research Society

2022 Band 32, Heft 4, Seite(n) 229–235

Abstract: Purpose: Catheter ablation (CA) to isolate the pulmonary vein, which is an established treatment for atrial fibrillation (AF), is associated with left atrium reverse remodeling (LARR). The intrinsic cardiac autonomic nervous system includes the ganglion ...

Abstract	Purpose: Catheter ablation (CA) to isolate the pulmonary vein, which is an established treatment for atrial fibrillation (AF), is associated with left atrium reverse remodeling (LARR). The intrinsic cardiac autonomic nervous system includes the ganglion plexi adjacent to the pulmonary vein in the left atrium (LA). However, little is known about the effect of CA on the relationship between LARR and sympathetic nerve activity in patients with AF. Methods: This study enrolled 22 AF patients with a normal left ventricular ejection fraction (LVEF) aged 64.6 ± 12.9 years who were scheduled for CA. Sympathetic nerve activity was evaluated by direct recording of muscle sympathetic nerve activity (MSNA) before and 12 weeks after CA. Blood pressure, heart rate (HR), HR variability, and echocardiography were also measured. Results: The heart rate increased significantly after CA (63 ± 10.9 vs. 70.6 ± 7.7 beats/min, p < 0.01), but blood pressure did not change. A high frequency (HF) and low frequency (LF) of HR variability decreased significantly after ablation, but no significant change in LF/HF was observed. CA significantly decreased MSNA (38.9 ± 9.9 vs. 28 ± 9.1 bursts/min, p < 0.01). Moreover, regression analysis revealed a positive correlation between the percentage change in MSNA and the LA volume index (r = 0.442, p < 0.05). Conclusions: Our results show that CA for AF reduced MSNA and the decrease was associated with the LA volume index in AF patients with a normal LVEF. These findings suggest that LARR induced by CA for AF decrease sympathetic nerve activity.
Mesh-Begriff(e)	Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Catheter Ablation ; Heart Atria/diagnostic imaging ; Heart Atria/surgery ; Humans ; Pulmonary Veins/surgery ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left
Sprache	Englisch
Erscheinungsdatum	2022-06-23
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1080007-4
ISSN	1619-1560 ; 0959-9851
ISSN (online)	1619-1560
ISSN	0959-9851
DOI	10.1007/s10286-022-00873-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Circulating nerve growth factor receptor positive cells are associated with severity and prognosis of pulmonary arterial hypertension.

Goten, Chiaki / Usui, Soichiro / Takashima, Shin-Ichiro / Inoue, Oto / Okada, Hirofumi / Shimojima, Masaya / Sakata, Kenji / Kawashiri, Masaaki / Kaneko, Shuichi / Takamura, Masayuki

Pulmonary circulation

2021 Band 11, Heft 1, Seite(n) 2045894021990525

Abstract: Pulmonary arterial hypertension (PAH) remains a disease with a poor prognosis, so early detection and treatment are very important. Sensitive and non-invasive markers for PAH are urgently required. This study was performed to identify sensitive markers ... ...

Abstract	Pulmonary arterial hypertension (PAH) remains a disease with a poor prognosis, so early detection and treatment are very important. Sensitive and non-invasive markers for PAH are urgently required. This study was performed to identify sensitive markers of the clinical severity and prognosis of PAH. Patients diagnosed with PAH (n = 30) and control participants (n = 15) were enrolled in this observational study. Major EPC and MSC markers (including CD34, CD133, VEGFR2, CD90, PDGFRα, and NGFR) in peripheral blood mononuclear cells (PBMNCs) were assessed by flow cytometry. Associations of these markers with hemodynamic parameters (e.g. mean pulmonary arterial pressure, pulmonary vascular resistance, and cardiac index) were assessed. Patients with PAH were followed up for 12 months to assess the incidence of major adverse events, defined as death or lung transplantation. Levels of circulating EPC and MSC markers in PBMNCs were higher in patients with PAH than in control participants. Among the studied markers, nerve growth factor receptor (NGFR) was significantly positively correlated with hemodynamic parameters. During the 12-month follow-up period, major-event-free survival was significantly higher in patients with PAH who had relatively low frequencies of NGFR positive cells than patients who had higher frequencies. These results suggested that the presence of circulating NGFR positive cells among PBMNCs may be a novel biomarker for the severity and prognosis of PAH.
Sprache	Englisch
Erscheinungsdatum	2021-02-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2638089-4
ISSN	2045-8940 ; 2045-8932
ISSN (online)	2045-8940
ISSN	2045-8932
DOI	10.1177/2045894021990525
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Current outlook of cardiac stem cell therapy towards a clinical application.

Takashima, Shin-Ichiro / Tempel, Dennie / Duckers, Henricus J

Heart (British Cardiac Society)

2013 Band 99, Heft 23, Seite(n) 1772–1784

Mesh-Begriff(e)	Allografts ; Autografts ; Embryonic Stem Cells/transplantation ; Heart/physiology ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/trends ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cell Transplantation/trends ; Myoblasts/transplantation ; Myocardial Infarction/therapy ; Myocytes, Cardiac/transplantation ; Pluripotent Stem Cells/transplantation ; Regeneration/physiology ; Stem Cell Transplantation/methods ; Stem Cell Transplantation/trends ; Time Factors
Sprache	Englisch
Erscheinungsdatum	2013-12
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2012-303308
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Diabetes impairs the angiogenic capacity of human adipose-derived stem cells by reducing the CD271+ subpopulation in adipose tissue

Inoue, Oto / Usui, Soichiro / Takashima, Shin-ichiro / Nomura, Ayano / Yamaguchi, Kosei / Takeda, Yusuke / Goten, Chiaki / Hamaoka, Takuto / Ootsuji, Hiroshi / Murai, Hisayoshi / Kaneko, Shuichi / Takamura, Masayuki

Biochemical and biophysical research communications. 2019 Sept. 17, v. 517, no. 2

2019

Abstract: Type 2 diabetes mellitus is an important risk factor for cardiovascular diseases (CVDs). Therapeutic angiogenesis using adipose-derived stem cells (ADSCs) is attractive for CVD therapy. However, although it would be critical for ADSC application on CVD ... ...

Abstract	Type 2 diabetes mellitus is an important risk factor for cardiovascular diseases (CVDs). Therapeutic angiogenesis using adipose-derived stem cells (ADSCs) is attractive for CVD therapy. However, although it would be critical for ADSC application on CVD therapy, whether and how diabetes impairs human ADSC therapeutic potential is still uncertain. In this study, we aimed to investigate the impact of diabetes on the angiogenic potential of ADSCs in patients with CVDs, with special focus on stemness-related genes and cellular alteration of ADSCs. We established cultured ADSCs from diabetic (DM-ADSCs) and non-diabetic patients (nonDM-ADSCs) with CVDs. DM-ADSCs demonstrated limited proliferative capacity and reduced paracrine capacity of VEGF, with lower expression of the stemness gene SOX2. Angiogenic capacity and ADSC engraftment were assessed using xenograft experiments in a hindlimb ischemia model of athymic nude mice. Consistent with the results of in vitro assays, DM-ADSCs did not rescue limb ischemia. In contrast, nonDM-ADSCs induced neovascularization with enhanced engraftment. To elucidate the mechanism underlying these ADSC changes, we compared the surface marker profiles of freshly isolated ADSCs obtained from diabetic and non-diabetic patients by flow cytometry. Among studied subsets, the CD34+CD31−CD271+ subpopulation was reduced in the adipose tissues of diabetic patients. In addition, SOX2 expression and proliferative capacity were considerably reduced in nonDM-ADSCs derived from the stromal vascular fraction (SVF) with depletion of CD271+ cells (p < 0.01). Our observations elucidated that reduced CD271+ subpopulation is critical for the impairment of ADSCs in diabetic patients. Further investigations on the CD271+ subset of ADSCs might provide novel insights into the mechanisms and solutions for diabetes-related ADSC dysfunction in cell therapy.
Schlagwörter	adipose tissue ; angiogenesis ; flow cytometry ; genes ; hindlimbs ; humans ; ischemia ; models ; noninsulin-dependent diabetes mellitus ; research ; risk factors ; xenotransplantation
Sprache	Englisch
Erscheinungsverlauf	2019-0917
Umfang	p. 369-375.
Erscheinungsort	Elsevier Inc.
Dokumenttyp	Artikel
Anmerkung	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2019.07.081
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits.

Saito, Yoshiro / Misu, Hirofumi / Takayama, Hiroaki / Takashima, Shin-Ichiro / Usui, Soichiro / Takamura, Masayuki / Kaneko, Shuichi / Takamura, Toshinari / Noguchi, Noriko

Biological & pharmaceutical bulletin

2018 Band 41, Heft 5, Seite(n) 828–832

Abstract: Selenoprotein P (SeP) is a selenium (Se)-rich extracellular protein. SeP is identified as a hepatokine, causing insulin resistance in type 2 diabetes. Thus, the measurement of SeP in serum has received much attention, and several enzyme-linked ... ...

Abstract	Selenoprotein P (SeP) is a selenium (Se)-rich extracellular protein. SeP is identified as a hepatokine, causing insulin resistance in type 2 diabetes. Thus, the measurement of SeP in serum has received much attention, and several enzyme-linked immunosorbent assay (ELISA) kits for SeP determination are now commercially available. In the present study, we determined the serum SeP levels by our original ELISA and sol particle homogeneous immunoassay (SPIA) methods and also by commercially available kits, and these determinants were compared. We found a kit-dependent correlation of the determinants with our methods. These results suggest that the selection of kit is critical for comparison with our previous reports and for discussing the relationship between the serum SeP levels and disease condition.
Mesh-Begriff(e)	Aged ; Female ; Humans ; Immunoassay/methods ; Male ; Middle Aged ; Reproducibility of Results ; Selenoprotein P/blood
Chemische Substanzen	Selenoprotein P
Sprache	Englisch
Erscheinungsdatum	2018-04-18
Erscheinungsland	Japan
Dokumenttyp	Comparative Study ; Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b18-00046
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Renal iodine

Okabe, Yoshitaka / Murai, Hisayoshi / Tokuhisa, Hideki / Hamaoka, Takuto / Mukai, Yusuke / Sugimoto, Hiroyuki / Takashima, Shin-Ichiro / Kato, Takeshi / Matsuo, Shinro / Usui, Soichiro / Furusho, Hiroshi / Takamura, Masayuki / Kaneko, Shuichi

Autonomic neuroscience : basic & clinical

2020 Band 226, Seite(n) 102671

Abstract: Background: Renal denervation is effective for modulating augmented sympathetic nerve activity (SNA) in heart failure with reduced ejection fraction (HFrEF). We have demonstrated that renal iodine: Methods: The study population consisted of 24 HFrEF ... ...

Abstract	Background: Renal denervation is effective for modulating augmented sympathetic nerve activity (SNA) in heart failure with reduced ejection fraction (HFrEF). We have demonstrated that renal iodine Methods: The study population consisted of 24 HFrEF patients and 11 healthy subjects as controls. Patients with HFrEF underwent Results: LVEFs were 35% ± 11% in patients with HFrEF and 63% ± 10% in the controls (p < 0.01). The WR of cardiac Conclusions: The WR of renal
Mesh-Begriff(e)	3-Iodobenzylguanidine ; Aged ; Echocardiography ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Humans ; Iodine Radioisotopes ; Kidney/diagnostic imaging ; Male ; Middle Aged ; Muscles/physiopathology ; Radionuclide Imaging ; Radiopharmaceuticals ; Sympathetic Nervous System/physiopathology ; Ventricular Function, Left/physiology
Chemische Substanzen	Iodine Radioisotopes ; Radiopharmaceuticals ; 3-Iodobenzylguanidine (35MRW7B4AD)
Sprache	Englisch
Erscheinungsdatum	2020-03-31
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2020.102671
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Different prognosis between severe and very severe obstructive sleep apnea patients; Five year outcomes.

Hamaoka, Takuto / Murai, Hisayoshi / Takata, Shigeo / Hirai, Tadayuki / Sugimoto, Hiroyuki / Mukai, Yusuke / Okabe, Yoshitaka / Tokuhisa, Hideki / Takashima, Shin-Ichiro / Usui, Soichiro / Sakata, Kenji / Kawashiri, Masa-Aki / Sugiyama, Yu / Nakatsumi, Yasuto / Takamura, Masayuki

Journal of cardiology

2020 Band 76, Heft 6, Seite(n) 573–579

Abstract: Background: Obstructive sleep apnea (OSA) is characterized by augmented sympathetic nerve activity. In our previous study, patients with OSA and an apnea-hyperpnea index (AHI)>55events/h showed increased single-unit muscle sympathetic nerve activity ... ...

Abstract	Background: Obstructive sleep apnea (OSA) is characterized by augmented sympathetic nerve activity. In our previous study, patients with OSA and an apnea-hyperpnea index (AHI)>55events/h showed increased single-unit muscle sympathetic nerve activity compared to patients with OSA and AHI of 30-55events/h. However, the prognostic impact in these patients remains unclear. Methods: Ninety-one OSA patients were included. All patients who had indication for continuous positive airway pressure (CPAP) were treated with CPAP. Patients were divided into three groups: mild/moderate OSA (S), AHI<30events/h (n=44); severe OSA (SS), AHI 30-55events/h (n=29); and very severe OSA (VSS), AHI>55events/h (n=18). The primary endpoint was a composite outcome composed of death, cardiovascular events, stroke, and heart failure with hospitalization. Results: In the 5-year follow-up, the primary event rate in the SS group [3 events (7%)] was the same as that in the S group [3 events (10%)]. However, the VSS group showed a significantly higher primary event rate among the three groups [6 events (33%), p<0.05]. In Cox regression analysis, the VSS group had the highest hazard ratio compared to other risk factors. Conclusions: CPAP was effective for preventing cardiovascular disease in patients with severe OSA, however patients with very severe OSA still had a high event rate, indicating that CPAP treatment might be insufficient to reduce the OSA-related risk burden in patients with very severe OSA. Additional systemic medical treatment for CPAP might be needed in patients with very severe OSA.
Mesh-Begriff(e)	Adult ; Aged ; Continuous Positive Airway Pressure ; Coronary Artery Disease/mortality ; Female ; Heart Failure/mortality ; Hospitalization ; Humans ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Severity of Illness Index ; Sleep Apnea, Obstructive/mortality ; Sleep Apnea, Obstructive/therapy ; Stroke/mortality
Sprache	Englisch
Erscheinungsdatum	2020-06-30
Erscheinungsland	Netherlands
Dokumenttyp	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2020.06.010
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A case of pulmonary arterial hypertension with chronic hepatitis that resulted in hepatosplenomegaly after administration of prostaglandin I2.

Goten, Chiaki / Usui, Soichiro / Hamaoka, Takuto / Harada, Tomoya / Inoue, Oto / Okada, Hirofumi / Takashima, Shin-Ichiro / Kato, Takeshi / Murai, Hisayoshi / Sakata, Kenji / Furusho, Hiroshi / Kawashiri, Masa-Aki / Takamura, Masayuki

Journal of cardiology cases

2020 Band 21, Heft 5, Seite(n) 182–185

Abstract: The prognosis of pulmonary arterial hypertension (PAH) has significantly improved over the past two decades due to advances in medications, including pulmonary vasodilators. However, the side effects of these drugs remain problematic in some patients. A ... ...

Abstract	The prognosis of pulmonary arterial hypertension (PAH) has significantly improved over the past two decades due to advances in medications, including pulmonary vasodilators. However, the side effects of these drugs remain problematic in some patients. A 51-year-old woman with chronic hepatitis C was diagnosed with PAH 7 years before presenting to our hospital. She was unable to continue her treatment with pulmonary vasodilators due to various side effects. She had a World Health Organization functional class of IV and was started on continuous infusion of prostaglandin I2 (PGI2). This therapy improved her symptoms, including dyspnea and fatigue. However, she began to complain of abdominal distension after 4 months of PGI2 therapy. Computed tomography showed significant hepatosplenomegaly. Her abdominal distension improved slightly after decreasing PGI2 treatment, but her dyspnea on exertion was exacerbated. She died 12 years after diagnosis of PAH due to uncontrollable heart failure. Here, we describe a rare case of PAH with hepatosplenomegaly after administration of PGI2. <
Sprache	Englisch
Erscheinungsdatum	2020-02-19
Erscheinungsland	Japan
Dokumenttyp	Case Reports
ISSN	1878-5409
ISSN (online)	1878-5409
DOI	10.1016/j.jccase.2020.01.001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Coronary sinus catheter placement via left cubital vein for phrenic nerve stimulation during pulmonary vein isolation.

Chikata, Akio / Kato, Takeshi / Usuda, Kazuo / Fujita, Shuhei / Maruyama, Michiro / Otowa, Kan-Ichi / Takashima, Shin-Ichiro / Murai, Hisayoshi / Usui, Soichiro / Furusho, Hiroshi / Kaneko, Shuichi / Takamura, Masayuki

Heart and vessels

2019 Band 34, Heft 10, Seite(n) 1710–1716

Abstract: Phrenic nerve (PN) stimulation is essential for the elimination of PN palsy during balloon-based pulmonary vein isolation (PVI). Although ultrasound-guided vascular access is safe, insertion of a PN stimulation catheter via central venous access carries ... ...

Abstract	Phrenic nerve (PN) stimulation is essential for the elimination of PN palsy during balloon-based pulmonary vein isolation (PVI). Although ultrasound-guided vascular access is safe, insertion of a PN stimulation catheter via central venous access carries a potential risk of the development of mechanical complications. We evaluated the safety of a left cubital vein approach for positioning a 20-electrode atrial cardioversion (BeeAT) catheter in the coronary sinus (CS), and the feasibility of right PN pacing from the superior vena cava (SVC) using proximal electrodes of the BeeAT catheter. In total, 106 consecutive patients who underwent balloon-based PVI with a left cubital vein approach for BeeAT catheter positioning were retrospectively assessed. The left cubital approach was successful in 105 patients (99.1%), and catheter insertion into the CS was possible for 104 patients (99.0%). Among these patients, constant right PN pacing from the SVC was obtained for 89 patients (89/104, 85.6%). In five patients, transient loss of right PN capture occurred during right pulmonary vein ablation. No persistent right PN palsy was observed. Small subcutaneous hemorrhage was observed in eight patients (7.5%). Neuropathy, pseudoaneurysm, arteriovenous fistula, and perforations associated with the left cubital approach were not detected. Body mass index was significantly higher in the right PN pacing failure group than in the right PN pacing success group (26.2 ± 3.2 vs. 23.8 ± 3.8; P = 0.025). CS catheter placement with a left cubital vein approach for right PN stimulation was found to be safe and feasible. Right PN pacing from the SVC using a BeeAT catheter was successfully achieved in the majority of the patients. This approach may prove to be preferable for non-obese patients.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Atrial Fibrillation/surgery ; Cardiac Pacing, Artificial/methods ; Catheter Ablation/adverse effects ; Coronary Sinus/surgery ; Female ; Humans ; Japan ; Male ; Middle Aged ; Peripheral Nerve Injuries/etiology ; Peripheral Nerve Injuries/prevention & control ; Phrenic Nerve/injuries ; Pulmonary Veins/surgery ; Retrospective Studies ; Vena Cava, Superior/surgery
Sprache	Englisch
Erscheinungsdatum	2019-04-10
Erscheinungsland	Japan
Dokumenttyp	Journal Article
ZDB-ID	89678-0
ISSN	1615-2573 ; 0910-8327 ; 0935-736X
ISSN (online)	1615-2573
ISSN	0910-8327 ; 0935-736X
DOI	10.1007/s00380-019-01402-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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