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Article ; Online: Cleavage-Activation of Respiratory Viruses - Half a Century of History from Sendai Virus to SARS-CoV-2.

Takeda, Makoto

2023 Volume 77, Issue 1, Page(s) 1–6

Abstract: Many viruses require the cleavage-activation of membrane fusion proteins by host proteases in the course of infection. This knowledge is based on historical studies of Sendai virus in the 1970s. From the 1970s to the 1990s, avian influenza virus and ... ...

Abstract	Many viruses require the cleavage-activation of membrane fusion proteins by host proteases in the course of infection. This knowledge is based on historical studies of Sendai virus in the 1970s. From the 1970s to the 1990s, avian influenza virus and Newcastle disease virus were studied, showing a clear link between virulence and the cleavage-activation of viral membrane fusion proteins (hemagglutinin and fusion proteins) by host proteases. In these viruses, cleavage of viral membrane fusion proteins by furin is the basis for their high virulence. Subsequently, from the 2000s to the 2010s, the importance of TMPRSS2 in activating the membrane fusion proteins of various respiratory viruses, including seasonal influenza viruses, was demonstrated. In late 2019, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) emerged and caused a pandemic. The virus continues to mutate, producing variants that have caused global pandemics. The spike protein of SARS-CoV-2 is characterized by two cleavage sites, each of which is cleaved by furin and TMPRSS2 to achieve membrane fusion. SARS-CoV-2 variants exhibit altered sensitivity to these proteases. Thus, studying the cleavage-activation of membrane fusion proteins by host proteases is critical for understanding the ongoing pandemic and developing countermeasures against it.
MeSH term(s)	Animals ; Humans ; Furin/metabolism ; SARS-CoV-2/genetics ; Sendai virus/genetics ; Sendai virus/metabolism ; COVID-19 ; Peptide Hydrolases/metabolism ; Membrane Fusion Proteins ; Virus Internalization
Chemical Substances	Furin (EC 3.4.21.75) ; Peptide Hydrolases (EC 3.4.-) ; Membrane Fusion Proteins
Language	English
Publishing date	2023-11-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1478383-6
ISSN	1884-2836 ; 1344-6304
ISSN (online)	1884-2836
ISSN	1344-6304
DOI	10.7883/yoken.JJID.2023.353
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Article ; Online: Proteolytic activation of SARS-CoV-2 spike protein.

Takeda, Makoto

Microbiology and immunology

2021 Volume 66, Issue 1, Page(s) 15–23

Abstract: Spike (S) protein cleavage is a crucial step in coronavirus infection. In this review, this process is discussed, with particular focus on the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Compared with influenza virus ... ...

Abstract	Spike (S) protein cleavage is a crucial step in coronavirus infection. In this review, this process is discussed, with particular focus on the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Compared with influenza virus and paramyxovirus membrane fusion proteins, the cleavage activation mechanism of coronavirus S protein is much more complex. The S protein has two cleavage sites (S1/S2 and S2'), and the cleavage motif for furin protease at the S1/S2 site that results from a unique four-amino acid insertion is one of the distinguishing features of SARS-CoV-2. The viral particle incorporates the S protein, which has already undergone S1/S2 cleavage by furin, and then undergoes further cleavage at the S2' site, mediated by the type II transmembrane serine protease transmembrane protease serine 2 (TMPRSS2), after binding to the receptor angiotensin-converting enzyme 2 (ACE2) to facilitate membrane fusion at the plasma membrane. In addition, SARS-CoV-2 can enter the cell by endocytosis and be proteolytically activated by cathepsin L, although this is not a major mode of SARS-CoV-2 infection. SARS-CoV-2 variants with enhanced infectivity have been emerging throughout the ongoing pandemic, and there is a close relationship between enhanced infectivity and changes in S protein cleavability. All four variants of concern carry the D614G mutation, which indirectly enhances S1/S2 cleavability by furin. The P681R mutation of the delta variant directly increases S1/S2 cleavability, enhancing membrane fusion and SARS-CoV-2 virulence. Changes in S protein cleavability can significantly impact viral infectivity, tissue tropism, and virulence. Understanding these mechanisms is critical to counteracting the coronavirus pandemic.
MeSH term(s)	COVID-19 ; Humans ; Proteolysis ; SARS-CoV-2 ; Serine Endopeptidases ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
Language	English
Publishing date	2021-10-12
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	224792-6
ISSN	1348-0421 ; 0385-5600
ISSN (online)	1348-0421
ISSN	0385-5600
DOI	10.1111/1348-0421.12945
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Article ; Online: Error analysis of Raven's Coloured Progressive Matrices in children and adolescents with cerebral palsy.

Asano, D / Takeda, M / Nobusako, S / Morioka, S

Journal of intellectual disability research : JIDR

2023 Volume 67, Issue 7, Page(s) 655–667

Abstract: Background: Analysis of the errors in the Raven's Coloured Progressive Matrices (RCPM) has been previously performed for children with intellectual disabilities but has not been investigated for those with cerebral palsy (CP). This study aimed to ... ...

Abstract	Background: Analysis of the errors in the Raven's Coloured Progressive Matrices (RCPM) has been previously performed for children with intellectual disabilities but has not been investigated for those with cerebral palsy (CP). This study aimed to investigate whether the types and positions of errors made by individuals with CP differed from those made by typically developing (TD) controls. Methods: Forty-five participants with CP aged 4-18 years and 30 TD children aged 3-9 years underwent RCPM testing. We first compared the RCPM performance and error characteristics between the groups and then examined the association between RCPM and the severity of CP and receptive vocabulary in the CP group. Results: The results showed that while mean total scores in the two groups were comparable, the types and positions of errors made by individuals with CP differed from those of TD controls. The development of non-verbal intelligence in children with CP increased with age; when controlling for age, non-verbal intelligence was significantly correlated with all three functional levels of CP severity and receptive vocabulary. Conclusions: This study provides valuable insights into the problem-solving strategies employed by children with CP.
MeSH term(s)	Humans ; Child ; Adolescent ; Cerebral Palsy ; Intelligence Tests ; Intellectual Disability ; Problem Solving ; Intelligence
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1103832-9
ISSN	1365-2788 ; 0964-2633
ISSN (online)	1365-2788
ISSN	0964-2633
DOI	10.1111/jir.13034
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Article: Effect of changing temperatures from the spawning and egg stages to the emerging adult stage on the induction of reproductive diapause in females of Pseudaulacaspis pentagona (Hemiptera: Diaspididae)

Takeda, Mitsuyoshi

Applied entomology and zoology. 2022 Feb., v. 57, no. 1

2022

Abstract: Overwintering females in the third generation of Pseudaulacaspis pentagona (Targioni Tozetti) (Hemiptera: Diaspididae) entered reproductive diapause with undeveloped ovarian eggs. Ovarian development in females collected before the winter solstice was ... ...

Abstract	Overwintering females in the third generation of Pseudaulacaspis pentagona (Targioni Tozetti) (Hemiptera: Diaspididae) entered reproductive diapause with undeveloped ovarian eggs. Ovarian development in females collected before the winter solstice was retarded, but development proceeded normally thereafter. Neither length of photoperiod nor changing photoperiods affected the induction of reproductive diapause. Reproductive diapause of P. pentagona was induced when the temperature decreased to around 20 °C from the high temperature conditions of the previous generation spawning and current generation egg stages. A transfer test was conducted to elucidate temperature sensitivity, from 25 °C in the spawning and egg stages to 20 °C at various developmental stages. The sensitive stage for the induction of reproductive diapause was a few days after the emergence of females. Under natural conditions, first-generation eggs encounter temperatures below 20 °C in May and adults encounter the high temperatures in June to July and develop normally. Second-generation insects encounter temperatures of 24 °C or higher in July to August and develop normally as adults. In contrast, third-generation eggs encounter temperatures of 24 °C or higher in September and the adults encounter temperatures of 22 °C or lower in October, and reproductive diapause is induced. This paper will discuss the seasonal adaptations of P. pentagona in relation to regional climate conditions and the voltinism of two or three generations per year.
Keywords	Pseudaulacaspis pentagona ; adults ; diapause ; eggs ; entomology ; ovarian development ; overwintering ; temperature ; voltinism
Language	English
Dates of publication	2022-02
Size	p. 15-25.
Publishing place	Springer Japan
Document type	Article
ZDB-ID	820195-x
ISSN	1347-605X ; 0003-6862
ISSN (online)	1347-605X
ISSN	0003-6862
DOI	10.1007/s13355-021-00757-3
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Article: Implications of the success of EGFR-targeted therapy in advanced non-small cell lung cancer for its application to the adjuvant setting.

Takeda, Masayuki

Journal of thoracic disease

2020 Volume 12, Issue 8, Page(s) 4553–4555

Language	English
Publishing date	2020-09-09
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-2020-46
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Article: [Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2].

Takeda, Makoto

Uirusu

2020 Volume 69, Issue 1, Page(s) 61–72

Abstract: The distribution pattern of host proteases and their cleavage specificity for viral fusion glycoproteins are key determinants for viral tissue tropism and pathogenicity. The discovery of this protease-dependent virus tropism and pathogenicity has been ... ...

Abstract	The distribution pattern of host proteases and their cleavage specificity for viral fusion glycoproteins are key determinants for viral tissue tropism and pathogenicity. The discovery of this protease-dependent virus tropism and pathogenicity has been triggered by the leading studies of the host-induced or -controlled modification of viruses by Homma et al. in 1970s. With the introduction of advanced protein analysis method, the observations by Homma et al. have been clearly explained by the cleavage activation of viral fusion glycoproteins by proteases. The molecular biological features of viruses, which show distinct protease specificity or dependency, have been also revealed by newly introduced nucleotide and molecular analysis method. Highly pathogenic avian influenza viruses (HPAIVs) have multi-basic cleavage motif in the hemagglutinin (HA) protein and are activated proteolytically by furin. Furin is ubiquitously expressed in eukaryotic cells and thereby HPAIVs have the potential to cause a systemic infection in infected animals. On the other hand, the HA cleavage site of low pathogenic avian influenza viruses (LPAIVs) and seasonal human influenza viruses is mono-basic and thus not recognized by furin. They are likely cleaved by protease(s) localized in specific organs or tissues. However, the protease(s), which cleaves mono-basic HA in vivo, has long been undetermined, although many proteases have been shown as candidates. Finally, recent studies using gene knocked out mice revealed that TMPRSS2, a member of type II transmembrane serine proteases, is responsible for the cleavage of influenza viruses with a mono-basic HA in vivo. A subsequent study further demonstrated that TMPRSS2 contributes to replication and pathology of emerging SARS- and MERS coronaviruses in vivo.
Keywords	covid19
Language	Japanese
Publishing date	2020-09-09
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	603272-2
ISSN	0042-6857
ISSN	0042-6857
DOI	10.2222/jsv.69.61
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Article ; Online: Editorial Comment to OnabotulinumtoxinA (botulinum toxin type A) for the treatment of Japanese patients with overactive bladder and urinary incontinence: Results of single-dose treatment from a phase III, randomized, double-blind, placebo-controlled trial (interim analysis).

Takeda, Masayuki

International journal of urology : official journal of the Japanese Urological Association

2020 Volume 27, Issue 3, Page(s) 234–235

MeSH term(s)	Botulinum Toxins, Type A ; Double-Blind Method ; Humans ; Japan ; Urinary Bladder, Overactive ; Urinary Incontinence
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2020-03-13
Publishing country	Australia
Document type	Journal Article ; Comment
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.14226
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Book ; Conference proceedings: Molecular neurobiology of Alzheimer disease and related disorders

Takeda, Masatoshi

[...selected papers presented at the ... International Symposium on Neurobiology of Alzheimer's Disease and Related Disorders in October 2002, Osaka] ; 18 tab

2004

Event/congress	International Symposium on Neurobiology of Alzheimer's Disease and Related Disorders (2002, Osaka)
Author's details	eds: Masatoshi Takeda
Keywords	Alzheimer Disease / metabolism ; Alzheimer Disease / physiopatholog ; Alzheimer Disease / genetics ; Neurobiology ; Alzheimerkrankheit ; Neurobiologie ; Molekularbiologie
Subject	Molekulare Biologie ; Alzheimer-Krankheit ; Alzheimersche Krankheit ; Alzheimer-Demenz ; Morbus Alzheimer ; Greisenblödsinn ; Alzheimer's Disease
Language	English
Size	XIV, 297 S. : Ill., graph. Darst., 245 mm x 175 mm
Publisher	Karger
Publishing place	Basel (u.a.
Publishing country	Germany
Document type	Book ; Conference proceedings
HBZ-ID	HT014021035
ISBN	3-8055-7603-X ; 978-3-8055-7603-1
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Hand Selection in Dribbling Phases: An Analysis of Non-Dominant Hand Usage and Dribble Change in Basketball.

Onodera, Keisuke / Takeda, Masaki

Sports (Basel, Switzerland)

2023 Volume 11, Issue 11

Abstract: This study investigates the influence of different dribbling phases on hand selection among basketball players across various categories. A total of 33 guard players, including 11 from high school, college, and NBA teams each, were observed. Video data ... ...

Abstract	This study investigates the influence of different dribbling phases on hand selection among basketball players across various categories. A total of 33 guard players, including 11 from high school, college, and NBA teams each, were observed. Video data analysis was utilized to determine the frequency of players using their dominant hands (DHs) and non-dominant hands (NDHs) during in-game dribbling phases. The dribbling phases were classified into three categories: First (the initiation of the dribble), Middle (during the dribble but not in First and Last), and Last (the completion of the dribble). Percentage, means, and standard deviations were computed for each category within the First, Middle, and Last measurements. A two-factor analysis of variance (ANOVA) was conducted, considering player category and dribbling phase as factors. The ANOVA revealed significant main effects of player category (
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704239-X
ISSN	2075-4663 ; 2075-4663
ISSN (online)	2075-4663
ISSN	2075-4663
DOI	10.3390/sports11110226
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Article ; Online: Effects of bathing in different hot spring types on Japanese gut microbiota.

Takeda, Midori / Choi, Jungmi / Maeda, Toyoki / Managi, Shunsuke

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2316

Abstract: Hot springs have been used for a variety of purposes, including the treatment and amelioration of illness and recreation. Japan has ten different types of therapeutic springs (described here as spa types), which are traditionally believed to have ... ...

Abstract	Hot springs have been used for a variety of purposes, including the treatment and amelioration of illness and recreation. Japan has ten different types of therapeutic springs (described here as spa types), which are traditionally believed to have different efficacy. However, more research must be conducted to determine how they affect healthy people. Therefore, this study focused on the gut microbiota and aimed to investigate changes in the gut microbiota in healthy people after bathing in different spa types. Using Beppu's hot springs (simple, chloride, bicarbonate, sulfur, and sulfate types), 136 healthy Japanese adults living in the Kyushu area participated in the study and bathed in the same hot spring for seven days. Fecal samples were collected before and after the 7-day bathing period, and the relative abundance of the gut microbiota was determined by 16S rRNA sequencing. The results showed that the relative abundance of Bifidobacterium bifidum increased significantly after seven consecutive days of bathing in the bicarbonate spring. Significant increases in other gut microbiota were also observed after bathing in simple, bicarbonate, and sulfur springs. These results suggest that bathing in different hot springs may affect the gut microbiota in healthy individuals differently.
MeSH term(s)	Adult ; Humans ; Gastrointestinal Microbiome ; Hot Springs ; Japan ; RNA, Ribosomal, 16S/genetics ; Bicarbonates/pharmacology ; Sulfur/pharmacology
Chemical Substances	RNA, Ribosomal, 16S ; Bicarbonates ; Sulfur (70FD1KFU70)
Language	English
Publishing date	2024-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52895-7
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