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Article: Dosimetric Effects of the Supine and Prone Positions in Proton Therapy for Prostate Cancer.

Kato, Takahiro / Kato, Masato / Takemasa, Kimihiro / Murakami, Masao

2023 Volume 47, Issue 4, Page(s) 331–335

Abstract: Purpose: To quantitatively evaluate how much the doses to organs at risk are affected in the prone position compared to the supine position in the proton therapy (PT) for prostate cancer.: Materials and methods: Fifteen consecutive patients with ... ...

Abstract	Purpose: To quantitatively evaluate how much the doses to organs at risk are affected in the prone position compared to the supine position in the proton therapy (PT) for prostate cancer. Materials and methods: Fifteen consecutive patients with clinically localized prostate cancer underwent treatment planning computed tomography scans in both the supine and prone positions. The clinical target volume (CTV) consisted of the prostate gland plus the seminal vesicles. The PT plans were designed using the standard lateral opposed fields with passively scattered proton beams for both treatment positions. The prescribed dose for each plan was set to 78 Gy (Relative biological effectiveness)/39 fractions to 50% of the planning target volume. Dose-volume metrics of the rectum and bladder in the two treatment positions were analyzed. Results: It was confirmed that all the parameters of D Conclusions: We confirmed that the rectal doses were significantly lower in the prone compared with the supine position in PT. Although uncertain, the prone position could be an effective method to reduce the rectal dose in PT.
Language	English
Publishing date	2023-01-10
Publishing country	India
Document type	Journal Article
ZDB-ID	1193902-3
ISSN	1998-3913 ; 0971-6203
ISSN (online)	1998-3913
ISSN	0971-6203
DOI	10.4103/jmp.jmp_85_22
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Article ; Online: Analysis of respiratory-induced motion trajectories of individual liver segments in patients with hepatocellular carcinoma.

Kato, Takahiro / Takemasa, Kimihiro / Ikeda, Tomohiro / Sakagami, Hisanori / Kato, Ryohei / Narita, Yuki / Oyama, Sho / Komori, Shinya / Yamaguchi, Hisashi / Murakami, Masao

Journal of applied clinical medical physics

2024 Volume 25, Issue 4, Page(s) e14257

Abstract: Purpose: To analyze the respiratory-induced motion trajectories of each liver segment for hepatocellular carcinoma (HCC) to derive a more accurate internal margin and optimize treatment protocol selection.: Materials and methods: Ten-phase-gated four- ...

Abstract	Purpose: To analyze the respiratory-induced motion trajectories of each liver segment for hepatocellular carcinoma (HCC) to derive a more accurate internal margin and optimize treatment protocol selection. Materials and methods: Ten-phase-gated four-dimensional computed tomography (4DCT) scans of 14 patients with HCC were analyzed. For each patient, eight representative regions of interest (ROI) were delineated on each liver segment in all 10 phases. The coordinates of the center of gravity of each ROI were obtained for each phase, and then the respiratory motion in the left-right (LR), anteroposterior (AP), and craniocaudal (CC) directions was analyzed. Two sets of motion in each direction were also compared in terms of only two extreme phases and all 10 phases. Results: Motion of less than 5 mm was detected in 12 (86%) and 10 patients (71%) in the LR and AP directions, respectively, while none in the CC direction. Motion was largest in the CC direction with a maximal value of 19.5 mm, with significant differences between liver segment 7 (S7) and other segments: S1 (p < 0.036), S2 (p < 0.041), S3 (p < 0.016), S4 (p < 0.041), and S5 (p < 0.027). Of the 112 segments, hysteresis >1 mm was observed in 4 (4%), 2 (2%), and 15 (13%) in the LR, AP, and CC directions, respectively, with a maximal value of 5.0 mm in the CC direction. Conclusion: A significant amount of respiratory motion was detected in the CC direction, especially in S7, and S8. Despite the small effect of hysteresis, it can be observed specifically in the right lobe. Therefore, caution is required when using 4DCT to determine IM using only end-inspiration and end-expiration. Understanding the respiratory motion in individual liver segments can be helpful when selecting an appropriate treatment protocol.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/pathology ; Motion ; Respiration ; Four-Dimensional Computed Tomography/methods ; Radiotherapy Planning, Computer-Assisted/methods
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.14257
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Article: Optimal Bladder Volume for Hypofractionated Proton Therapy in Each Localized Prostate Cancer Risk Group.

Narita, Yuki / Kato, Takahiro / Ishikawa, Yojiro / Takemasa, Kimihiro / Yamaguchi, Hisashi / Murakami, Masao

Cureus

2023 Volume 15, Issue 11, Page(s) e48723

Abstract: Background This study aimed to determine the optimal bladder volume (BV) for hypofractionated proton therapy in prostate cancer (PC). Materials and methods Two hundred patients with PC were enrolled in this study and classified into low-, intermediate-, ... ...

Abstract	Background This study aimed to determine the optimal bladder volume (BV) for hypofractionated proton therapy in prostate cancer (PC). Materials and methods Two hundred patients with PC were enrolled in this study and classified into low-, intermediate-, and high-risk groups. Treatment planning was performed by assuming a hypofractionated schedule of 63 Gy (relative biological effectiveness) in 21 fractions. The dose indices of the bladder (V
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.48723
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Article: Taiei Miura and Franco-Japanese friendship in psychiatry.

Takemasa, K

The Keio journal of medicine

2001 Volume 50, Issue 1, Page(s) 8–12

Abstract: Japanese medicine enthusiastically adopted many aspects of Western medicine, especially German, during and after Japan's modernization. After the war, the policy giving priority to German medicine changed greatly, and American medicine replaced German ... ...

Abstract	Japanese medicine enthusiastically adopted many aspects of Western medicine, especially German, during and after Japan's modernization. After the war, the policy giving priority to German medicine changed greatly, and American medicine replaced German medicine in postwar days. Some people, however, question whether it is proper to get medical information one-sidedly from a single country. Faced with the situation of whether German or American medicine should occupy the dominant position in Japan, some doctors chose to establish ties with French medicine. Professor Taiei Miura (1901-1995) re-established an intimate relationship, broken off during the war, in the medical field between Japan and France. Much information was to be learned from French medicine, particularly in clinical neurology and psychiatry. In this essay, we relate the details of how Miura became interested in French medicine, went to study in France, then contributed greatly to Franco-Japanese friendship.
MeSH term(s)	France ; History, 20th Century ; International Cooperation/history ; Japan ; Psychiatry/history
Language	English
Publishing date	2001-08-03
Publishing country	Japan
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	390981-5
ISSN	1880-1293 ; 0022-9717
ISSN (online)	1880-1293
ISSN	0022-9717
DOI	10.2302/kjm.50.8
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Article: [Diagnosis of and therapy for schizophrenia].

Takemasa, Kenichi

Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica

2009 Volume 111, Issue 3, Page(s) 347–351

MeSH term(s)	Humans ; Japan/epidemiology ; Prevalence ; Schizophrenia/diagnosis ; Schizophrenia/epidemiology ; Schizophrenia/therapy ; Schizophrenic Psychology
Language	Japanese
Publishing date	2009
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	604306-9
ISSN	0033-2658
ISSN	0033-2658
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Article ; Online: Safety of hydrogel spacers for rectal wall protection in patients with prostate cancer: A retrospective analysis of 200 consecutive cases.

Yamaguchi, Hisashi / Kato, Takahiro / Ishikawa, Yojiro / Takemasa, Kimihiro / Narita, Yuki / Takagawa, Yoshiaki / Seto, Ichiro / Machida, Masanori / Dai, Yuntao / Azami, Yusuke / Tominaga, Takuya / Takayama, Kanako / Suzuki, Motohisa / Kikuchi, Yasuhiro / Murakami, Masao

International journal of urology : official journal of the Japanese Urological Association

2023 Volume 30, Issue 4, Page(s) 401–407

Abstract: Objective: To evaluate the safety and complications of hydrogel spacer implantation.: Methods: This single-center historical cohort study retrospectively analyzed cases of hydrogel spacer implantation between October 2018 and March 2022. The survey ... ...

Abstract	Objective: To evaluate the safety and complications of hydrogel spacer implantation. Methods: This single-center historical cohort study retrospectively analyzed cases of hydrogel spacer implantation between October 2018 and March 2022. The survey items were the rates of possible hydrogel injection implementation, the success rate of hydrogel implantation including asymmetry, higher position, rectal wall infiltration, subcapsular injection, and other adverse events, and width created by the spacer. To investigate the learning curve, 1, 2, and 3 points were assigned to adverse event grades G1, G2, and G3, respectively. Spacer effectiveness obstruction, such as asymmetry was assigned 3 points. A Mann-Whitney U test was performed to assess statistically significant differences. Results: The study included a total of 200 patients with a median (range) age of 70 (44-85) years. In 10 (5%) patients, hydrogel injection implementation was not possible. Of 190 patients who underwent hydrogel spacer placement, 168 (88%) received a satisfactory placement. The median (range) width of hydrogel spacers was 13.1 (4.4-18.7) mm. Spacer asymmetry, higher position, rectal wall infiltration, and prostate subcapsular infiltration occurred in 7 (3.7%), 5 (2.6%), 12 (6.3%), and 1 (0.5%) patients, respectively. G1 and G3 adverse events occurred in 13 (7%) and 4 (2%) patients, respectively. Practitioner #1 who performed the highest number of procedures had significantly (p = 0.04) lower total scores in group B. Conclusion: Spacer implantation yielded favorable outcomes with a high percentage of appropriate spacer implantation, and few major complications.
MeSH term(s)	Male ; Humans ; Aged ; Aged, 80 and over ; Hydrogels/adverse effects ; Retrospective Studies ; Cohort Studies ; Organs at Risk ; Rectum/surgery ; Prostatic Neoplasms ; Radiotherapy Dosage ; Hydrogel, Polyethylene Glycol Dimethacrylate/adverse effects
Chemical Substances	Hydrogels ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5)
Language	English
Publishing date	2023-01-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.15140
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Article ; Online: The impact of different setup methods on the dose distribution in proton therapy for hepatocellular carcinoma.

Takemasa, Kimihiro / Kato, Takahiro / Narita, Yuki / Kato, Masato / Yamazaki, Yuhei / Ouchi, Hisao / Oyama, Sho / Yamaguchi, Hisashi / Wada, Hitoshi / Murakami, Masao

Journal of applied clinical medical physics

2021 Volume 22, Issue 3, Page(s) 63–71

Abstract: Purpose: To investigate the impact of different setup methods, vertebral body matching (VM), diaphragm matching (DM), and marker matching (MM), on the dose distribution in proton therapy (PT) for hepatocellular carcinoma (HCC).: Materials and methods!# ...

Abstract	Purpose: To investigate the impact of different setup methods, vertebral body matching (VM), diaphragm matching (DM), and marker matching (MM), on the dose distribution in proton therapy (PT) for hepatocellular carcinoma (HCC). Materials and methods: Thirty-eight HCC lesions were studied retrospectively to assess changes in the dose distribution on two computed tomography (CT) scans. One was for treatment planning (1st-CT), and the other was for dose confirmation acquired during the course of PT (2nd-CT). The dose coverage of the clinical target volume (CTV-D Results: For CTV-D Conclusion: Although MM is obviously the most effective method, it is suggested that DM may be particularly effective in cases where the distance from right diaphragm top to COM of CTV of 90 mm or less.
MeSH term(s)	Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/radiotherapy ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Proton Therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Retrospective Studies
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.13178
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Article ; Online: Dosimetric impact of simulated changes in large bowel content during proton therapy with simultaneous integrated boost for locally advanced pancreatic cancer.

Narita, Yuki / Kato, Takahiro / Takemasa, Kimihiro / Sato, Hiroki / Ikeda, Tomohiro / Harada, Takaomi / Oyama, Sho / Murakami, Masao

Journal of applied clinical medical physics

2021 Volume 22, Issue 11, Page(s) 90–98

Abstract: Purpose: To investigate the dosimetric impact of changes in the large bowel content during proton therapy (PT) with simultaneous integrated boost (SIB) for locally advanced pancreatic cancer (LAPC).: Materials and methods: Fifteen patients with LAPC ... ...

Abstract	Purpose: To investigate the dosimetric impact of changes in the large bowel content during proton therapy (PT) with simultaneous integrated boost (SIB) for locally advanced pancreatic cancer (LAPC). Materials and methods: Fifteen patients with LAPC were included in this study. The SIB method was performed using five fields according to our standard protocol. A total dose of 67.5 Gy(relative biological effectiveness [RBE]) was prescribed in 25 fractions using the SIB method. A dose of 45 Gy(RBE) was prescribed for the entire planning target volume (PTV) by using four main fields. The remaining 22.5 Gy(RBE) was prescribed to the PTV excluding for the gastrointestinal tract using one subfield. Five simulated doses were obtained by the forward dose calculations with the Hounsfield units (HU) override to the large bowel to 50, 0, -100, -500, and -1000, respectively. The dose-volume indices in each plan were compared using the 50 HU plan as a reference. Results: At D Conclusion: Density change in the large bowel was revealed to significantly affect the doses of the CTV and spinal cord during PT with SIB for LAPC. For beam arrangement, it is important to select a gantry angle that prevents the large bowel from passing as much as possible. If this is unavoidable, it is important to carefully observe the gas image on the beam path during daily image guidance and to provide adaptive re-planning as needed.
MeSH term(s)	Humans ; Organs at Risk ; Pancreatic Neoplasms/radiotherapy ; Proton Therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated
Language	English
Publishing date	2021-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.13429
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Article ; Online: Trend analysis of the dosimetric impact of anatomical changes during proton therapy for maxillary sinus carcinoma.

Narita, Yuki / Kato, Takahiro / Ono, Takashi / Oyama, Sho / Yamazaki, Yuhei / Ouchi, Hisao / Takemasa, Kimihiro / Murakami, Masao

Journal of applied clinical medical physics

2021 Volume 22, Issue 9, Page(s) 298–306

Abstract: Purpose: Anatomical changes, such as shrinkage and aeration, can affect dose distribution in proton therapy (PT) for maxillary sinus carcinoma (MSC). These changes can affect the dose to the target and organs at risk (OARs); however, when these changes ... ...

Abstract	Purpose: Anatomical changes, such as shrinkage and aeration, can affect dose distribution in proton therapy (PT) for maxillary sinus carcinoma (MSC). These changes can affect the dose to the target and organs at risk (OARs); however, when these changes occur during PT is unclear. This study aimed to investigate the dosimetric impact of anatomical changes during PT. Materials and methods: Fifteen patients with MSC were enrolled in this study. Initial PT plans were generated based on initial computed tomography (CT) images. Several repeat CT images were obtained to confirm anatomical changes during PT. Evaluation PT plans were generated by copying initial PT plans to repeat CT images. The dose differences of the target and OARs were evaluated by comparing both the plans. Results: At 3-4 weeks after the initiation of PT, the target volume reduced by approximately 10% as compared with the initial volume. Consequently, the target volumes gradually varied until the end of treatment. The value of V Conclusion: The trend analysis in this study showed that anatomical changes appeared 3-4 weeks after the start of PT, and the dose to the OARs tended to increase. Therefore, it is recommended to check the status of tumor 3-4 weeks after the start of treatment to avoid the deterioration of dose distribution due to these changes.
MeSH term(s)	Carcinoma ; Humans ; Maxillary Sinus/diagnostic imaging ; Proton Therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted
Language	English
Publishing date	2021-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.13391
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Article: [Effect of growth rate of monolayer cells on survival after fractionated irradiation].

Takemasa, K

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica

1992 Volume 52, Issue 7, Page(s) 1007–1015

Abstract: This study was performed to determine the effect of the growth rate of monolayer cells on survival following fractionated irradiation. HeLa and RMUG cells that had different radiosensitivities and growth rates (Do value: 2.3 vs 1.5 Gy, doubling time: 17 ... ...

Abstract	This study was performed to determine the effect of the growth rate of monolayer cells on survival following fractionated irradiation. HeLa and RMUG cells that had different radiosensitivities and growth rates (Do value: 2.3 vs 1.5 Gy, doubling time: 17 vs 46 hours) were irradiated with 2 Gy every day. The fractions surviving after fractionated irradiation were compared with those given single doses. The dose modifying factor for fractionated irradiation was larger in RMUG than HeLa: 1.7 and 1.2, respectively. Two clones from ADGU cells that had the same radiosensitivity but different growth rates were also given fractionated irradiation, but there was no difference in surviving fractions. When recovery following two split doses was determined in each type of cell, the results of the fractions surviving after fractionated irradiation were correlated only with recovery between split doses. These suggest that the growth rates of monolayer cells may not modify the fractions surviving after fractionated irradiation, and the monolayer cell system is not suitable for determining the effect of growth rates on survival following fractionated irradiation.
MeSH term(s)	Cell Division/radiation effects ; Cell Survival/radiation effects ; HeLa Cells/radiation effects ; Humans ; Radiation Dosage ; Radiation Tolerance ; Tumor Cells, Cultured
Language	Japanese
Publishing date	1992-07-25
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604105-x
ISSN	1347-7951 ; 0048-0428
ISSN (online)	1347-7951
ISSN	0048-0428
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