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  1. Article ; Online: Anti-varicella-zoster virus antibody titers and seroprotection status from before the first dose of varicella vaccination to before entering elementary school in one region in Japan.

    Ozaki, Takao / Nishimura, Naoko / Gotoh, Kensei / Takemoto, Koji

    Vaccine

    2023  Volume 41, Issue 6, Page(s) 1274–1279

    Abstract: Objective: We aimed to examine changes in anti-varicella-zoster virus (VZV) antibody titers and seroprotection status from before the first dose of vaccination to before 7 years old entering elementary school in children who received the routine two- ... ...

    Abstract Objective: We aimed to examine changes in anti-varicella-zoster virus (VZV) antibody titers and seroprotection status from before the first dose of vaccination to before 7 years old entering elementary school in children who received the routine two-dose varicella vaccination.
    Methods: Participants were 37 healthy children who received the routine two-dose varicella vaccination at our hospital. A total of five serum samples per child were collected immediately before and 4-6 weeks after each dose of the vaccination and in the year before entry to elementary school. We measured anti-VZV antibody titers by immune adherence hemagglutination (IAHA) method and glycoprotein-based enzyme-linked immunosorbent assay (gpELISA). A positive antibody titer and the seroprotection level were set as ≥2-fold and ≥16-fold, respectively, for IAHA antibody and as ≥50 units and ≥105 units, respectively, for gpELISA-IgG antibody.
    Results: The rates of IAHA antibody positivity in the five samples (in order of collection) were 0%, 65%, 38%, 100%, and 59%, and the rates of seroprotection were 0%, 43%, 8%, 100%, and 43%. The rates of gpELISA-IgG antibody positivity were 8%, 81%, 89%, 100%, and 100%, and the rates of seroprotection were 5%, 54%, 70%, 100%, and 89%. The mean IAHA antibody titer and mean gpELISA-IgG antibody titer before entering elementary school were both lower than the respective titers obtained after the second vaccination (both p < 0.01).
    Conclusions: Routine two-dose varicella vaccination leads to good antibody production, but titers of acquired antibodies decrease before children enter elementary school.
    MeSH term(s) Child ; Humans ; Japan ; Vaccination ; Herpesvirus 3, Human ; Antibodies, Viral ; Schools ; Immunoglobulin G ; Herpes Zoster ; Chickenpox/prevention & control ; Chickenpox Vaccine
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Chickenpox Vaccine
    Language English
    Publishing date 2023-01-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.01.010
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  2. Article: A Prospective Observational Study on Gastric Endoscopic Submucosal Dissection under Continuous Administration of Antithrombotic Agents.

    Kawai, Daisuke / Iwamuro, Masaya / Takenaka, Ryuta / Obata, Taisuke / Yamamoto, Takashi / Hirata, Shoichiro / Miura, Ko / Takemoto, Koji / Tsugeno, Hirofumi / Fujiki, Shigeatsu

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13071886
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  3. Article ; Online: Efficacy of liposomal amphotericin B against four species of Candida biofilms in an experimental mouse model of intravascular catheter infection.

    Fujimoto, Koichi / Takemoto, Koji

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2018  Volume 24, Issue 12, Page(s) 958–964

    Abstract: The formation of Candida biofilms on implanted medical devices is crucial to the development of infections and an important clinical problem because of elevated resistance to antifungals. The aim of this study was to compare the in vitro activity of ... ...

    Abstract The formation of Candida biofilms on implanted medical devices is crucial to the development of infections and an important clinical problem because of elevated resistance to antifungals. The aim of this study was to compare the in vitro activity of liposomal amphotericin B (L-AMB) and micafungin (MCFG) against four species of Candida biofilms, and the efficacy of systemic plus lock therapy with L-AMB and MCFG in a Candida biofilm-associated catheter infection model. An XTT-reduction assay was used to measure the metabolic activity of the biofilms to evaluation of in vitro antibiofilm activity. MCFG had better in vitro activity than L-AMB against Candida glabrata biofilms, whereas L-AMB had better activity than MCFG against Candida albicans and Candida tropicalis biofilms. L-AMB and MCFG had comparable efficacy against Candida parapsilosis biofilms. In an in vitro lock therapy model, 2 mg/ml L-AMB, unlike 2 mg/ml MCFG, significantly reduced the metabolic activity of all the strains of biofilms by >96%. Systemic and intraluminal lock treatment with L-AMB for 3-days resulted in more than about 2 log
    MeSH term(s) Amphotericin B/administration & dosage ; Amphotericin B/pharmacology ; Amphotericin B/therapeutic use ; Animals ; Antifungal Agents/administration & dosage ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Biofilms/drug effects ; Candida albicans/drug effects ; Candida albicans/physiology ; Candida glabrata/drug effects ; Candida glabrata/physiology ; Candida parapsilosis/drug effects ; Candida parapsilosis/physiology ; Candida tropicalis/drug effects ; Candida tropicalis/physiology ; Catheter-Related Infections/drug therapy ; Disease Models, Animal ; Humans ; Male ; Micafungin/administration & dosage ; Micafungin/therapeutic use ; Mice ; Mice, Inbred Strains ; Treatment Outcome
    Chemical Substances Antifungal Agents ; liposomal amphotericin B ; Amphotericin B (7XU7A7DROE) ; Micafungin (R10H71BSWG)
    Language English
    Publishing date 2018-09-09
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2018.08.011
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  4. Article ; Online: AmBisome: relationship between the pharmacokinetic characteristics acquired by liposomal formulation and safety/efficacy.

    Takemoto, Koji / Kanazawa, Katsunori

    Journal of liposome research

    2017  Volume 27, Issue 3, Page(s) 186–194

    Abstract: Amphotericin B (AMPH-B) is a polyene antifungal agent with a superior and broad fungicidal spectrum, but its administration at a dose sufficient for treatment is difficult because of dose- and duration-dependent nephrotoxicity. To solve this dilemma, a ... ...

    Abstract Amphotericin B (AMPH-B) is a polyene antifungal agent with a superior and broad fungicidal spectrum, but its administration at a dose sufficient for treatment is difficult because of dose- and duration-dependent nephrotoxicity. To solve this dilemma, a liposomal formation of AMPH-B that achieved reduction of adverse effects while maintaining the efficacy, AmBisome® (L-AMB), was developed. In L-AMB, AMPH-B molecules are stabilized by phospholipids and cholesterol in the liposomal lipid bilayer, reducing the cytotoxicity for animal cells compared with that of the free-form AMPH-B. In addition, extravascular permeation of L-AMB is limited in normal tissue because of the liposome particle size (particle diameter: 100 nm or smaller), a high blood level is maintained and the distribution in organs, including the kidney is reduced, contributing to the improvement of the safety. On the other hand, vascular permeation increases due to inflammation and damage by fungal invasion, which increases L-AMB transfer from the circulation to lesions and its antifungal activity. Furthermore, since the parameter most closely correlated with the in vivo outcome of L-AMB is C
    MeSH term(s) Amphotericin B/adverse effects ; Amphotericin B/pharmacokinetics ; Animals ; Antifungal Agents/adverse effects ; Antifungal Agents/pharmacokinetics ; Biological Transport ; Chemistry, Pharmaceutical/methods ; Humans ; Lipid Bilayers ; Liposomes
    Chemical Substances Antifungal Agents ; Lipid Bilayers ; Liposomes ; liposomal amphotericin B ; Amphotericin B (7XU7A7DROE)
    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 645173-1
    ISSN 1532-2394 ; 0898-2104
    ISSN (online) 1532-2394
    ISSN 0898-2104
    DOI 10.1080/08982104.2016.1205087
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  5. Article ; Online: In vitro

    Takemoto, Koji / Nakayama, Ryo / Fujimoto, Koichi / Suzuki, Yumiko / Takarabe, Yukiko / Honsho, Masako / Kitahara, Sachiko / Noguchi, Yoshihiko / Matsui, Hidehito / Hirose, Tomoyasu / Asami, Yukihiro / Hidaka, Jun / Sunazuka, Toshiaki / Hanaki, Hideaki

    Antimicrobial agents and chemotherapy

    2024  , Page(s) e0160223

    Abstract: KSP-1007 is a novel bicyclic boronate-based broad-spectrum β-lactamase inhibitor and is being developed in combination with meropenem (MEM) for the treatment of infections caused by carbapenem-resistant Gram-negative bacteria, a global health concern, ... ...

    Abstract KSP-1007 is a novel bicyclic boronate-based broad-spectrum β-lactamase inhibitor and is being developed in combination with meropenem (MEM) for the treatment of infections caused by carbapenem-resistant Gram-negative bacteria, a global health concern, and here, we describe its characteristics. KSP-1007 exhibited low apparent inhibition constant (
    Language English
    Publishing date 2024-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01602-23
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  6. Article: A Case of Eosinophilic Pustular Folliculitis since Birth.

    Yoshida, Satoshi / Yatsuzuka, Kazuki / Chigyo, Kenji / Kuroo, Yuta / Takemoto, Koji / Sayama, Koji

    Children (Basel, Switzerland)

    2021  Volume 8, Issue 1

    Abstract: A newborn male infant presented with multiple pustules and erosions with erythema involving his scalp and forehead at birth. One week after birth, new pustules continued to appear, forming crusted, ring-shaped plaques with pigmentation. Tests for ... ...

    Abstract A newborn male infant presented with multiple pustules and erosions with erythema involving his scalp and forehead at birth. One week after birth, new pustules continued to appear, forming crusted, ring-shaped plaques with pigmentation. Tests for possible pathogens were negative. Tzanck smear and skin biopsy revealed pustules beneath the stratum corneum at sites corresponding to hair follicles, which contained eosinophils and neutrophils. Taken together, a diagnosis of eosinophilic pustular folliculitis (EPF) was made. The pustules on the head disappeared rapidly with topical corticosteroid treatment, although new eruptions were still observed on the trunk about one month after birth. To our knowledge, only two cases of EPF since birth have been reported to date. Here, we also discuss the differential diagnosis of noninfectious pustular diseases at birth, including erythema toxicum neonatorum and transient neonatal pustular melanosis. These diseases, and EPF, may present with very similar clinical symptoms at birth, and the Tzanck test or biopsy may be required for differential diagnosis.
    Language English
    Publishing date 2021-01-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children8010030
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  7. Article ; Online: Response to Galán-Puchades and Fuentes.

    Hamada, Kenta / Takemoto, Koji / Takei, Kensuke / Yamasaki, Yasushi / Fujiwara, Yoshiro

    The American journal of gastroenterology

    2019  Volume 114, Issue 2, Page(s) 357

    MeSH term(s) Animals ; Capsule Endoscopy ; Taenia saginata ; Taeniasis
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000118
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  8. Article ; Online: Total Hydrocortisone Dosage in the Neonatal Period May Be Related to Low Developmental Quotient in Extremely Low Birth Weight Infants: A Retrospective Cohort Study.

    Taniguchi, Akinobu / Nishida, Kazuki / Suzuki, Toshihiko / Kataoka, Erina / Fujishiro, Naozumi / Kato, Eiko / Yamamoto, Hikaru / Takemoto, Koji / Ito, Miharu / Hayashi, Seiji / Sugiyama, Yuichiro / Maeda, Takashi / Takahashi, Yoshiyuki / Sato, Yoshiaki

    Neonatology

    2023  Volume 121, Issue 2, Page(s) 195–202

    Abstract: Introduction: The effects of hydrocortisone (HDC) administration to extremely low birth weight (ELBW) infants on later development remain unclear. This study examined the association between HDC dosage during neonatal period and neurodevelopmental ... ...

    Abstract Introduction: The effects of hydrocortisone (HDC) administration to extremely low birth weight (ELBW) infants on later development remain unclear. This study examined the association between HDC dosage during neonatal period and neurodevelopmental outcomes in ELBW infants.
    Methods: This study was a retrospective cohort study conducted in eight centers in Japan. The subjects of this study were ELBW infants born between April 2015 and March 2017. The association between postnatal total HDC dosage up to 36 weeks postmenstrual age and the developmental quotient (DQ) at 3 years of age was examined. Multiple linear regression evaluated the association, adjusting for weeks of gestation, birth weight, and the presence of bronchopulmonary dysplasia, late-onset circulatory collapse, intracranial hemorrhage, necrotizing enterocolitis, and sepsis.
    Results: This study included 218 ELBW infants, of whom 144 underwent a developmental test at 3 years of age. Simple linear regression analysis revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: -2.65, 95% CI: -3.73, -1.57). Multiple linear regression analysis adjusted for the presence of bronchopulmonary dysplasia and late-onset circulatory collapse also revealed a significant association between total HDC dosage and DQ at 3 years of age (coefficients: -2.66, 95% CI: -3.89, -1.42).
    Conclusion: Higher total HDC dosage up to 36 weeks postmenstrual age in ELBW infants was associated with impaired neurodevelopmental outcomes. Although HDC is often needed in the treatment of ELBW infants, clinicians should be aware that an increased dose of HDC may be associated with impaired neurodevelopmental outcomes.
    MeSH term(s) Infant ; Humans ; Infant, Newborn ; Infant, Extremely Low Birth Weight ; Hydrocortisone ; Bronchopulmonary Dysplasia ; Retrospective Studies ; Shock
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000534934
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  9. Article ; Online: Taenia saginata Infection Diagnosed Based on the Number of Uterine Branches Observed During Capsule Endoscopy.

    Hamada, Kenta / Takemoto, Koji / Takei, Kensuke / Yamasaki, Yasushi / Fujiwara, Yoshiro

    The American journal of gastroenterology

    2018  Volume 113, Issue 3, Page(s) 327

    MeSH term(s) Adult ; Animals ; Anthelmintics/therapeutic use ; Capsule Endoscopy ; Female ; Humans ; Praziquantel/therapeutic use ; Taenia saginata/anatomy & histology ; Taeniasis/diagnosis ; Taeniasis/drug therapy
    Chemical Substances Anthelmintics ; Praziquantel (6490C9U457)
    Language English
    Publishing date 2018-03-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/ajg.2017.444
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  10. Article ; Online: Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers after endoscopic submucossal dissection: a randomized, open-label trial.

    Kawai, Daisuke / Takenaka, Ryuta / Ishiguro, Mikako / Okanoue, Shotaro / Gotoda, Tatsuhiro / Kono, Yoshiyasu / Takemoto, Koji / Tsugeno, Hirofumi / Fujiki, Shigeatsu

    BMC gastroenterology

    2021  Volume 21, Issue 1, Page(s) 236

    Abstract: Background: Vonoprazan is more potent and longer acting than traditional proton pump inhibitor. Although vonoprazan is expected to be superior to proton pump inhibitor, its efficacy in the treatment of gastric ulcers following endoscopic submucosal ... ...

    Abstract Background: Vonoprazan is more potent and longer acting than traditional proton pump inhibitor. Although vonoprazan is expected to be superior to proton pump inhibitor, its efficacy in the treatment of gastric ulcers following endoscopic submucosal dissection (ESD) is not fully understood. The aim of this study was to evaluate the effectiveness of vonoprazan in artificial ulcer healing following ESD.
    Methods: Patients with gastric tumors were randomly assigned to the vonoprazan group (group V) or lansoprazole group (group L) after ESD. Patients received intravenous lansoprazole (30 mg) twice on the day of ESD. Thereafter, patients were treated with vonoprazan (20 mg/day) in group V or lansoprazole (30 mg/day) in group L. Esophagogastroduodenoscopy was performed 4 and 8 weeks after the ESD.
    Results: A total of 168 patients were analyzed. The 4-week healing rate for artificial ulcer was not significantly higher in group V versus group L (17/85, 20.0% vs. 14/83, 16.9%, respectively). In addition, there were no significant differences between the 4-week shrinkage rates between the two groups. Postoperative bleeding occurred in none of the patients in group V and three in group L. One patient in group V presented delayed perforation 2 days after ESD.
    Conclusions: Vonoprazan might not be superior to lansoprazole in the healing of artificial gastric ulcer after ESD.
    Trial registration: University hospital Medical Information Network (registration number: UMIN000016642), Registered 27 February 2015, https://www.umin.ac.jp/ctr/index-j.htm.
    MeSH term(s) Dissection ; Endoscopic Mucosal Resection ; Humans ; Lansoprazole/therapeutic use ; Prospective Studies ; Proton Pump Inhibitors/adverse effects ; Pyrroles ; Stomach Neoplasms ; Stomach Ulcer/drug therapy ; Stomach Ulcer/etiology ; Sulfonamides
    Chemical Substances 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Proton Pump Inhibitors ; Pyrroles ; Sulfonamides ; Lansoprazole (0K5C5T2QPG)
    Language English
    Publishing date 2021-05-22
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ISSN 1471-230X
    ISSN (online) 1471-230X
    DOI 10.1186/s12876-021-01822-5
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