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  1. AU="Takenaka, Haruka"
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  1. Article ; Online: The Soluble Lectin Families as Novel Biomarkers for COVID-19 Pneumonia.

    Takenaka, Haruka / Saito, Atsushi / Kuronuma, Koji / Moniwa, Keigo / Nishikiori, Hirotaka / Takahashi, Satoshi / Chiba, Hirofumi

    In vivo (Athens, Greece)

    2023  Volume 37, Issue 4, Page(s) 1721–1728

    Abstract: Background/aim: The lung-specific soluble lectins, SP-A and SP-D have been clinically used to diagnose interstitial lung disease, but their clinical significance in COVID-19 remains controversial. This study was undertaken to determine their association ...

    Abstract Background/aim: The lung-specific soluble lectins, SP-A and SP-D have been clinically used to diagnose interstitial lung disease, but their clinical significance in COVID-19 remains controversial. This study was undertaken to determine their association with other lectins (MBL and FCN1), disease severity, and radiographs in COVID-19 patients.
    Patients and methods: A total of 131 patients with COVID-19 admitted in the Sapporo Medical University Hospital between May 22 and September 19, 2021, were enrolled in the study. Data including demographics, medical history, symptoms, signs, laboratory findings, and radiological images were collected from the patients' medical records. Chest computed tomography (CT) scanning was performed at admission. Serum levels of surfactant protein A and D (SP-A and SP-D), mannose-binding lectin (MBL) and ficolin1 (FCN1) were measured using enzyme-linked immunosorbent assay (ELISA) kits.
    Results: Compared to the control group, the COVID-19 group had significantly higher serum SP-A and FCN1 levels on admission (SP-A: 59.60±38.89 vs. 35.61±11.22 ng/ml; p<0.01, FCN1: 542.45±506.04 vs. 250.6±161.1 ng/ml; p<0.01). The severe group in COVID-19 had significantly higher serum SP-D and lower MBL levels than the non-severe group (SP-D: 141.7±155.7 vs. 61.41±54.54 ng/ml; p<0.01, MBL: 1,670±1,240 vs. 2,170±1,140 ng/ml; p<0.05). SP-D strongly reflected the degree of imaging findings, whereas SP-A showed a significant correlation, albeit slightly weaker than SP-D. Conversely, MBL and FNC1 were not significantly correlated with imaging findings.
    Conclusion: Among soluble serum lectins, SP-A and SP-D may be more sensitive to CT findings than reported disease biomarkers such as IL-6, LDH, and CRP due to their lung-specific characteristics.
    MeSH term(s) Humans ; Lectins ; Pulmonary Surfactant-Associated Protein D/metabolism ; COVID-19/diagnosis ; Biomarkers ; Lung/diagnostic imaging ; Lung/metabolism
    Chemical Substances Lectins ; Pulmonary Surfactant-Associated Protein D ; Biomarkers
    Language English
    Publishing date 2023-06-25
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Efficacy and predictor of anti-TNFα agents in patients with intestinal Behçet's disease.

    Miyazaki, Haruka / Watanabe, Daisuke / Okamoto, Norihiro / Tokunaga, Eri / Ku, Yuna / Takenaka, Haruka / Hoshi, Namiko / Ooi, Makoto / Kodama, Yuzo

    BMC gastroenterology

    2022  Volume 22, Issue 1, Page(s) 149

    Abstract: Background: Behçet's disease (BD) is a recurrent multisystem inflammatory disease. Anti-tumor necrosis factor (TNF) α agents have been used to treat patients with intestinal BD with severe disease activity or those who are resistant to conventional ... ...

    Abstract Background: Behçet's disease (BD) is a recurrent multisystem inflammatory disease. Anti-tumor necrosis factor (TNF) α agents have been used to treat patients with intestinal BD with severe disease activity or those who are resistant to conventional treatments; however, the long-term efficacy of anti-TNFα agents in intestinal BD remains unclear. In the present study, we investigated the clinical outcomes and predictors of discontinuation of anti-TNFα agents in patients with intestinal BD.
    Methods: We reviewed the medical records of patients with intestinal BD who received first-line anti-TNFα agents between January 2009 and June 2020. The primary outcome was the percentage of patients who continued anti-TNFα therapy for 48 weeks. Secondary outcomes included the percentage of patients who achieved marked improvement, complete remission, and mucosal healing, as well as predictors of discontinuation of anti-TNFα agents.
    Results: A total of 29 patients were included in the study. Twenty-two (75.9%) patients continued anti-TNFα therapy for 48 weeks. The percentage of patients who achieved marked improvement, complete remission, and mucosal healing at week 48 was 48.3%, 37.9%, and 48.3%, respectively. At week 96, 11 (37.9%) patients achieved marked improvement, complete remission, and mucosal healing. A higher C-reactive protein level (CRP; ≥ 1 mg/dL) at baseline was a predictor of discontinuation of anti-TNFα agents.
    Conclusions: The 48-week continuation rate of anti-TNFα agents was 75.9% in bio-naïve patients with intestinal BD. However, a higher baseline CRP level (≥ 1 mg/dL) was associated with discontinuation of anti-TNFα agents.
    MeSH term(s) Behcet Syndrome/drug therapy ; Behcet Syndrome/pathology ; Humans ; Intestinal Diseases/drug therapy ; Intestines/pathology ; Remission Induction ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Tumor Necrosis Factor-alpha
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-022-02221-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Non-Alcoholic Fatty Liver Disease Is Strongly Associated with Smoking Status and Is Improved by Smoking Cessation in Japanese Males: A Retrospective Study.

    Takenaka, Haruka / Fujita, Tsuyoshi / Masuda, Atsuhiro / Yano, Yoshihiko / Watanabe, Akihiko / Kodama, Yuzo

    The Kobe journal of medical sciences

    2020  Volume 66, Issue 3, Page(s) E102–E112

    Abstract: Background: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking ... ...

    Abstract Background: Cigarette smoking is known to be a significant risk factor associated with non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between smoking status and the severity of fatty liver with regard to sex and smoking cessation.
    Methods: In total, 13,466 subjects (6,642 males and 6,824 females) who had undergone abdominal ultrasonography for health check-up, multivariable logistic regression analysis was retrospectively conducted to assess the association between smoking status and the prevalence of NAFLD stratified by sex after adjusting for other potential confounders.
    Results: Male sex (odds ratio [OR] 3.27, 95% confidence interval [CI] 3.00-3.57) and smoking history (former smoker: OR 1.23, 95% CI 1.10-1.38, current smoker: OR 1.31, 95% CI 1.17-1.47) were significantly associated with NAFLD. In males with a smoking history, an increased pack-year was strongly associated with the prevalence and severity of NAFLD (prevalence of moderate to severe fatty liver: Pack-year from 0.01 to 9.99, 21.3%; Pack-year from 10.00 to 19.99, 27.2%; Pack-year ≥20.00, 33.7%; P<0.0001), although the prevalence of moderate to severe fatty liver was inversely associated with the duration of smoking cessation (more than 10 years vs. within 5 years, OR 0.71, 95% CI 0.53-0.96). In female subjects, light current smoking was negatively associated with NAFLD (current smoker with a pack-year from 0.01 to 9.99 vs. never smoker, OR 0.41, 95% CI 0.19-0.76).
    Conclusions: Smoking status and pack-year were strongly associated with the prevalence and severity of NAFLD, especially in Japanese males. However, smoking cessation improved NAFLD in this population.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cigarette Smoking/adverse effects ; Cross-Sectional Studies ; Female ; Humans ; Japan/epidemiology ; Logistic Models ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/prevention & control ; Non-alcoholic Fatty Liver Disease/therapy ; Prevalence ; Protective Factors ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Sex Factors ; Smoking Cessation
    Language English
    Publishing date 2020-11-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 840671-6
    ISSN 1883-0498 ; 0023-2513
    ISSN (online) 1883-0498
    ISSN 0023-2513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 193: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Occult Thyroid Follicular Carcinoma Diagnosed as Metastasis to the Chest Wall.

    Saijo, Hiroshi / Kitamura, Yasuo / Takenaka, Haruka / Kudo, Sayaka / Yokoo, Keiki / Hirohashi, Yoshihiko / Takahashi, Hiroki

    Internal medicine (Tokyo, Japan)

    2017  Volume 56, Issue 15, Page(s) 2033–2037

    Abstract: Chest wall tumors are relatively rare, and hematogenous metastasis to the chest wall is very rare. We herein describe a rare case of occult thyroid carcinoma as metastasis to the chest wall in an 80-year-old woman. The patient received detailed ... ...

    Abstract Chest wall tumors are relatively rare, and hematogenous metastasis to the chest wall is very rare. We herein describe a rare case of occult thyroid carcinoma as metastasis to the chest wall in an 80-year-old woman. The patient received detailed examinations of the chest wall tumor, and the results suggested that she had occult thyroid carcinoma. Surgery was then performed to remove all of her thyroid. As a result, she was diagnosed with follicular carcinoma of the thyroid. We report an extremely rare case of occult thyroid carcinoma diagnosed as hematogenous metastasis to the chest wall.
    Language English
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.56.8340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 240: Show issues Location:
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  5. Article: A case of autoimmune enteropathy with CTLA4 haploinsufficiency.

    Miyazaki, Haruka / Hoshi, Namiko / Kohashi, Michitaka / Tokunaga, Eri / Ku, Yuna / Takenaka, Haruka / Ooi, Makoto / Yamamoto, Nobuyuki / Uemura, Suguru / Nishimura, Noriyuki / Iijima, Kazumoto / Jimbo, Keisuke / Okano, Tsubasa / Hoshino, Akihiro / Imai, Kohsuke / Kanegane, Hirokazu / Kobayashi, Ichiro / Kodama, Yuzo

    Intestinal research

    2021  Volume 20, Issue 1, Page(s) 144–149

    Abstract: Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked ...

    Abstract Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and mutations in FOXP3, which is a master gene of regulatory T cells (Tregs), are major causes of AIE. Recent studies have demonstrated that mutations in other Treg-associated genes, such as CD25 and CTLA4, show an IPEX-like phenotype. We present the case of a 13-year-old girl with CTLA4 haploinsufficiency, suffering from recurrent immune thrombocytopenic purpura and intractable diarrhea. We detected an autoantibody to the AIE-related 75 kDa antigen (AIE-75), a hallmark of the IPEX syndrome, in her serum. She responded well to a medium dose of prednisolone and a controlled dose of 6-mercaptopurine (6-MP), even after the cessation of prednisolone administration. Serum levels of the soluble interleukin-2 receptor and immunoglobulin G (IgG) were useful in monitoring disease activity during 6-MP therapy. In conclusion, autoimmune-mediated mechanisms, similar to the IPEX syndrome, may be involved in the development of enteropathy in CTLA4 haploinsufficiency. Treatment with 6-MP and monitoring of disease activity using serum levels of soluble interleukin-2 receptor and IgG is suggested for such cases.
    Language English
    Publishing date 2021-01-22
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 3018469-1
    ISSN 2288-1956 ; 1598-9100
    ISSN (online) 2288-1956
    ISSN 1598-9100
    DOI 10.5217/ir.2020.00041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effect of Daikenchuto On Spontaneous Intestinal Tumors in Apc

    Kong, Lingling / Hoshi, Namiko / Watanabe, Daisuke / Yamada, Yasutaka / Yasutomi, Eiichiro / Adachi, Soichiro / Ooi, Makoto / Sui, Yunlong / Yoshida, Ryutaro / Sekimoto, Ryohei / Tokunaga, Eri / Miyazaki, Haruka / Ku, Yuna / Takenaka, Haruka / Kunihiro, Tadao / Inoue, Jun / Tian, Zibin / Kodama, Yuzo

    The Kobe journal of medical sciences

    2021  Volume 66, Issue 4, Page(s) E139–E148

    Abstract: Daikenchuto (TU-100) is herbal medicine which predominantly contains ginger, Japanese pepper, and ginseng. We investigated whether TU-100 can affect the composition of gut flora and intestinal tumor development using ... ...

    Abstract Daikenchuto (TU-100) is herbal medicine which predominantly contains ginger, Japanese pepper, and ginseng. We investigated whether TU-100 can affect the composition of gut flora and intestinal tumor development using Apc
    MeSH term(s) Animals ; Feces ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/genetics ; Herbal Medicine ; Intestinal Mucosa/drug effects ; Intestinal Neoplasms/drug therapy ; Intestinal Neoplasms/pathology ; Mice ; Microbiota ; Plant Extracts/pharmacology ; RNA, Ribosomal, 16S ; Real-Time Polymerase Chain Reaction
    Chemical Substances Plant Extracts ; RNA, Ribosomal, 16S ; dai-kenchu-to
    Language English
    Publishing date 2021-01-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 840671-6
    ISSN 1883-0498 ; 0023-2513
    ISSN (online) 1883-0498
    ISSN 0023-2513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 193: Show issues Location:
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  7. Article: [Q & A. A tumor of the uncinate process of the pancreas with skin lesions].

    Shiomi, Hideyuki / Takenaka, Haruka / Shiomi, Yuki / Hayakumo, Takanobu / Kutsumi, Hiromu

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2012  Volume 109, Issue 4, Page(s) 644–5, 548–9

    MeSH term(s) Female ; Gastrointestinal Neoplasms/complications ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Stromal Tumors/complications ; Gastrointestinal Stromal Tumors/pathology ; Humans ; Middle Aged ; Neurofibromatosis 1/complications
    Language Japanese
    Publishing date 2012-07-10
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 477: Show issues

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