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Article: Correction: Identification of a novel nonsense NOG mutation in a patient with stapes ankylosis and symphalangism spectrum disorder.

Sonoyama, Toru / Ishino, Takashi / Ogawa, Yui / Oda, Takashi / Takeno, Sachio

Human genome variation

2023 Volume 10, Issue 1, Page(s) 28

Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Published Erratum
ISSN	2054-345X
ISSN	2054-345X
DOI	10.1038/s41439-023-00249-6
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Article: Identification of a novel nonsense NOG mutation in a patient with stapes ankylosis and symphalangism spectrum disorder.

Sonoyama, Toru / Ishino, Takashi / Ogawa, Yui / Oda, Takashi / Takeno, Sachio

Human genome variation

2023 Volume 10, Issue 1, Page(s) 12

Abstract: Multiple bone disorders due to mutations in the human noggin (NOG) causes a variety of phenotypes. Hearing impairment due to stapes ankylosis secondary to bony degeneration is also a feature of these syndromes. We describe the case of an individual in a ... ...

Abstract	Multiple bone disorders due to mutations in the human noggin (NOG) causes a variety of phenotypes. Hearing impairment due to stapes ankylosis secondary to bony degeneration is also a feature of these syndromes. We describe the case of an individual in a Japanese family with conductive hearing loss due to stapes ankylosis and hyperopia and dactylosymphysis. We revealed a novel NOG mutation, NM_005450.6:c.222 C > A / p.Tyr74*, and confirmed genetic significance.
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article
ISSN	2054-345X
ISSN	2054-345X
DOI	10.1038/s41439-023-00236-x
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Article ; Online: Artificial intelligence-based diagnosis of the depth of laryngopharyngeal cancer.

Yumii, Kohei / Ueda, Tsutomu / Kawahara, Daisuke / Chikuie, Nobuyuki / Taruya, Takayuki / Hamamoto, Takao / Takeno, Sachio

Auris, nasus, larynx

2023 Volume 51, Issue 2, Page(s) 417–424

Abstract: Objective: Transoral surgery (TOS) is a widely used treatment for laryngopharyngeal cancer. There are some difficult cases of setting the extent of resection in TOS, particularly in setting the vertical margins. However, positive vertical margins ... ...

Abstract	Objective: Transoral surgery (TOS) is a widely used treatment for laryngopharyngeal cancer. There are some difficult cases of setting the extent of resection in TOS, particularly in setting the vertical margins. However, positive vertical margins require additional treatment. Further, excessive resection should be avoided as it increases the risk of bleeding as a postoperative complication and may lead to decreased quality of life, such as dysphagia. Considering these issues, determining the extent of resection in TOS is an important consideration. In this study, we investigated the possibility of accurately diagnosing the depth of laryngopharyngeal cancer using radiomics, an image analysis method based on artificial intelligence (AI). Methods: We included esophagogastroduodenoscopic images of 95 lesions that were pathologically diagnosed as squamous cell carcinoma (SCC) and treated with transoral surgery at our institution between August 2009 and April 2020. Of the 95 lesions, 54 were SCC in situ, and 41 were SCC. Radiomics analysis was performed on 95 upper gastrointestinal endoscopic NBI images of these lesions to evaluate their diagnostic performance for the presence of subepithelial invasion. The lesions in the endoscopic images were manually delineated, and the accuracy, sensitivity, specificity, and area under the curve (AUC) were evaluated from the features obtained using least absolute shrinkage and selection operator analysis. In addition, the results were compared with the depth predictions made by skilled endoscopists. Results: In the Radiomics study, the average cross-validation was 0.833. The mean AUC for cross-validation calculated from the receiver operating characteristic curve was 0.868. These results were equivalent to those of the diagnosis made by a skilled endoscopist. Conclusion: The diagnosis of laryngopharyngeal cancer depth using radiomics analysis has potential clinical applications. We plan to use it in actual surgery in the future and prospectively study whether it can be used for diagnosis.
MeSH term(s)	Humans ; Artificial Intelligence ; Quality of Life ; ROC Curve ; Endoscopy ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/surgery ; Retrospective Studies
Language	English
Publishing date	2023-10-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604552-2
ISSN	1879-1476 ; 0385-8146
ISSN (online)	1879-1476
ISSN	0385-8146
DOI	10.1016/j.anl.2023.09.001
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Article: [Day surgery to correct chronic nasal obstruction--with a special reference to cautery of the mucosa of the inferior nasal turbinate].

Takeno, Sachio

Nihon Jibiinkoka Gakkai kaiho

2011 Volume 114, Issue 2, Page(s) 72–77

MeSH term(s)	Ambulatory Surgical Procedures ; Humans ; Laser Therapy/methods ; Nasal Mucosa/surgery ; Nasal Obstruction/surgery ; Turbinates/surgery
Language	Japanese
Publishing date	2011-05-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	968067-6
ISSN	0030-6622
ISSN	0030-6622
DOI	10.3950/jibiinkoka.114.72
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Article ; Online: Association Between Subjective Voice Assessment and Psychological Distress After Thyroidectomy.

Taito, Mahoko / Hamamoto, Takao / Chikuie, Nobuyuki / Nishida, Manabu / Takeno, Sachio / Okamura, Hitoshi

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2022 Volume 37, Issue 2, Page(s) 260–263

Abstract: Purpose: This study aimed to determine the association between postoperative subjective voice function and psychological distress in patients without laryngeal nerve injury after thyroidectomy.: Design: A prospective cohort study.: Methods: We ... ...

Abstract	Purpose: This study aimed to determine the association between postoperative subjective voice function and psychological distress in patients without laryngeal nerve injury after thyroidectomy. Design: A prospective cohort study. Methods: We investigated the factors associated with subjective voice function in patients who underwent thyroidectomy without laryngeal nerve injury between October 2018 and July 2020. The Voice Handicap Index was used to assess subjective voice function, the GRBAS (grade, roughness, breathiness, asthenia, strain) scale to assess objective voice, and the Hospital Anxiety and Depression Scale to assess psychological distress. Findings: Among 39 patients who underwent thyroidectomy, 32 had no postoperative laryngeal nerve injury. Postoperative Voice Handicap Index was significantly associated with Hospital Anxiety and Depression Scale-Anxiety score after surgery (rs = 0.448, P = .010). Conclusions: In this study, an association was observed between subjective voice function and anxiety following surgery. The finding suggested that nurses and medical practitioners need to consider postoperative anxiety when evaluating patients' voice function after thyroidectomy.
MeSH term(s)	Humans ; Laryngeal Nerve Injuries ; Postoperative Period ; Prospective Studies ; Psychological Distress ; Thyroidectomy/adverse effects
Language	English
Publishing date	2022-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2021.11.012
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Article: Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy.

Hamamoto, Takao / Sato, Yuki / Yumii, Kohei / Chikuie, Nobuyuki / Taruya, Takayuki / Horibe, Yuichiro / Ishino, Takashi / Ueda, Tsutomu / Takeno, Sachio / Yoshimura, Kenichi

Journal of personalized medicine

2023 Volume 13, Issue 7

Abstract: Chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer; however, CRT may cause post-treatment dysphagia. Transcutaneous electrical sensory stimulation (TESS), developed in recent years for swallowing rehabilitation, ... ...

Abstract	Chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer; however, CRT may cause post-treatment dysphagia. Transcutaneous electrical sensory stimulation (TESS), developed in recent years for swallowing rehabilitation, is used at many medical facilities. Although TESS has been used for dysphagia in several fields, its safety and efficacy in patients with head and neck cancer remain to be clarified. Therefore, this study evaluated the safety of TESS in ten patients with head and neck cancers undergoing CRT. Swallowing rehabilitation intervention and TESS implementation were performed for all patients during CRT. Non-blood-toxicity adverse events (AEs), such as dermatitis and mucositis, occurred during CRT; however, the severity was less than grade 3. No patient experienced pain due to TESS. As survival time analysis using the Kaplan-Meier method for interferential current device implementation rates revealed a feasibility of 100% for up to 60 Gy and a feasibility of 78% for up to 70 Gy, TESS may be feasible until 70 Gy. This study confirmed the feasibility and safety of TESS in the head and neck region during CRT. Although the precise mechanism of TESS on dysphagia remains unclear, its continued use has great potential for improving sensory disturbance.
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13071129
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Article ; Online: Severe Type 2 Inflammation Leads to High Platelet-Activating-Factor-Associated Pathology in Chronic Rhinosinusitis with Nasal Polyps-A Hierarchical Cluster Analysis Using Bulk RNA Barcoding and Sequencing.

Ishino, Takashi / Oda, Takashi / Kawasumi, Tomohiro / Takemoto, Kota / Nishida, Manabu / Horibe, Yuichiro / Chikuie, Nobuyuki / Taruya, Takayuki / Hamamoto, Takao / Ueda, Tsutomu / Takeno, Sachio

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Platelet-activating factor (PAF) is a phospholipid-derived inflammatory mediator that triggers various inflammatory conditions, including eosinophil activation and recruitment. This study aimed to evaluate the expressions of PAF-metabolism-associated ... ...

Abstract	Platelet-activating factor (PAF) is a phospholipid-derived inflammatory mediator that triggers various inflammatory conditions, including eosinophil activation and recruitment. This study aimed to evaluate the expressions of PAF-metabolism-associated genes, namely genes coding the enzymes involved in PAF synthesis (LPCAT1, LPCAT2, LPCAT3, and LPCAT4), PAF degradation (PAFAH1B2, PAFAH1B3, and PAFAH2), and the gene for the PAF receptor (PTAFR) in subtypes of CRSwNP classified by clinical- or hierarchal-analysis-based classifications. Transcriptomic analysis using bulk RNA barcoding and sequencing (BRB-seq) was performed with CRSwNP, including eosinophilic CRS (ECRS) (
MeSH term(s)	Humans ; Rhinitis/pathology ; Platelet Activating Factor/genetics ; Platelet Activating Factor/metabolism ; Nasal Mucosa/metabolism ; RNA/metabolism ; Nasal Polyps/pathology ; Rhinosinusitis ; Sinusitis/metabolism ; Inflammation/metabolism ; Chronic Disease ; Cluster Analysis ; Eosinophils/metabolism
Chemical Substances	Platelet Activating Factor ; RNA (63231-63-0)
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042113
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Article: Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan.

Ogawa, Yui / Kunimoto, Masaru / Takeno, Sachio / Sonoyama, Toru / Ishino, Takashi / Hamamoto, Takao / Ueda, Tsutomu

Laryngoscope investigative otolaryngology

2021 Volume 7, Issue 1, Page(s) 259–265

Abstract: Objective: Pneumococcal conjugate vaccines (PCVs) have been reported to reduce the incidence of myringotomy with tympanostomy tube insertion (MTTI) in children. However, little information is available focusing specific ages. We examined the ... ...

Abstract	Objective: Pneumococcal conjugate vaccines (PCVs) have been reported to reduce the incidence of myringotomy with tympanostomy tube insertion (MTTI) in children. However, little information is available focusing specific ages. We examined the prophylactic efficacy of PCVs on the onset of complex otitis media (ComOM) that requires MTTI. Method: From 2011, the public support for PCV7 started with the usual four-dose schedule and an emergency schedule for 2- to 4-year-old children in Japan. PCV7 was replaced with PCV13 in 2013. We reviewed the nationwide database obtained from the JMDC Claims Database (https://www.jmdc.co.jp/en/) to examine the MTTI incidence during the era before and after PCV introduction (from 2008 to 2010 and from 2011 to 2017, respectively). Subjects were analyzed by stratified age groups (from 0 to 8 years old) and in subdivided groups of 6 months (from 0 to 35 months old). We compared the MTTI incidence between the groups for each age as well as between those for each calendar year. Results: A significant reduction in the MTTI incidence was detected in the 1-year-old children of the PCV era compared to those of the pre-PCV era. The reduction rates were more prominent in the 12-17 months group as compared to the 18-23 months group (PCV7 Conclusions: The introduction of both PCV7 and PCV13 reduced MTTI incidences in children around 1 year old, and the effects were more prominent during the early half-periods. Our results support etiological evidence that pneumococcal infection in children aged 1 year and younger might play roles in the pathogenesis of ComOM that requires MTTI.
Language	English
Publishing date	2021-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.710
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Article ; Online: Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma.

Chikuie, Nobuyuki / Urabe, Yuji / Ueda, Tsutomu / Hamamoto, Takao / Taruya, Takayuki / Kono, Takashi / Yumii, Kohei / Takeno, Sachio

Scientific reports

2022 Volume 12, Issue 1, Page(s) 9316

Abstract: Early recurrence detection of head and neck squamous cell carcinoma (HNSCC) is important for improving prognosis. Recently, circulating tumor DNA (ctDNA) has been reported to be useful in early detection or treatment response determination in various ... ...

Abstract	Early recurrence detection of head and neck squamous cell carcinoma (HNSCC) is important for improving prognosis. Recently, circulating tumor DNA (ctDNA) has been reported to be useful in early detection or treatment response determination in various carcinomas. This study aimed to identify the utility of ctDNA for predicting recurrent metastasis in patients with HNSCC. We collected pre-treatment tissues (malignant and normal tissues) and multiple plasma samples before and after treatment for 20 cases of HNSCC treated with radical therapy. ctDNA was detected in pre-treatment plasma in 10 cases; however, there were no significant associations with tumor recurrence and staging. During follow-up, ctDNA was detected in 5 of the 7 plasma samples of recurrent cases but not in the 13 recurrence-free cases. Moreover, there was a significant difference in post-treatment relapse-free survival time between the groups with and without detected ctDNA (20.6 ± 7.7 vs. 9.6 ± 9.1 months, respectively; log-rank test, p < 0.01). Moreover, for two of the five cases with ctDNA detected after treatment, ctDNA detection was a more sensitive predictor of recurrence than imaging studies. ctDNA detection during treatment follow-up was useful in patients with HNSCC for predicting the response to treatment and recurrent metastasis.
MeSH term(s)	Biomarkers, Tumor/genetics ; Circulating Tumor DNA/genetics ; DNA, Neoplasm/genetics ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/genetics ; Humans ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/genetics
Chemical Substances	Biomarkers, Tumor ; Circulating Tumor DNA ; DNA, Neoplasm
Language	English
Publishing date	2022-06-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-13417-5
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Article: A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor.

Kono, Takashi / Monden, Nobuya / Chikuie, Nobuyuki / Taruya, Takayuki / Hamamoto, Takao / Ishino, Takashi / Ueda, Tsutomu / Takeno, Sachio

Acta medica Okayama

2022 Volume 76, Issue 2, Page(s) 229–233

Abstract: We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is ... ...

Abstract	We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy.
MeSH term(s)	Bone Neoplasms/pathology ; Chemotherapy, Adjuvant ; Female ; Humans ; Mandible/pathology ; Osteosarcoma/drug therapy ; Osteosarcoma/surgery ; Prognosis
Language	English
Publishing date	2022-05-03
Publishing country	Japan
Document type	Case Reports
ZDB-ID	188415-3
ISSN	0386-300X ; 0001-6152
ISSN	0386-300X ; 0001-6152
DOI	10.18926/AMO/63428
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