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Article ; Online: Correction to: Association between urate-lowering therapy and cardiovascular events in patients with asymptomatic hyperuricemia.

Hashimoto, Hiroyuki / Takeuchi, Masato / Kawakami, Koji

2024 Volume 43, Issue 3, Page(s) 1271–1274

Language	English
Publishing date	2024-01-26
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-024-06866-y
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Article ; Online: Timing of Initiation of Xanthine Oxidase Inhibitors Based on Serum Uric Acid Level Does Not Predict Renoprognosis in Patients with Preserved Kidney Function.

Takayama, Atsushi / Fukasawa, Toshiki / Takeuchi, Masato / Kawakami, Koji

Metabolic syndrome and related disorders

2024 Volume 22, Issue 3, Page(s) 222–231

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Uric Acid ; Xanthine Oxidase ; Hyperuricemia/epidemiology ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/drug therapy ; Glomerular Filtration Rate ; Kidney
Chemical Substances	Uric Acid (268B43MJ25) ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2023.0238
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Zs.A 5950: Show issues

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Article ; Online: Effectiveness of sublingual immunotherapy in pediatric cedar pollinosis: A real-world database study.

Matsushita, Rie / Tanaka-Mizuno, Sachiko / Takeuchi, Masato / Kawakami, Koji

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2024 Volume 35, Issue 1, Page(s) e14075

Abstract: Background: Pediatric allergic rhinitis (AR), including cedar pollinosis (CP), is increasing in Japan. We investigated the effects of sublingual immunotherapy (SLIT), which has limited studies of its effectiveness in real-world settings, on children ... ...

Abstract	Background: Pediatric allergic rhinitis (AR), including cedar pollinosis (CP), is increasing in Japan. We investigated the effects of sublingual immunotherapy (SLIT), which has limited studies of its effectiveness in real-world settings, on children with CP. Methods: This retrospective cohort study used a claim database in 2018-2021. Children aged ≤15 years with CP records in 2019 were eligible and were followed up through 2021. We included 2962 CP children undergoing SLIT and 547 who were not. The medication score was used to evaluate SLIT effectiveness in the cedar pollen dispersal season each year. Adverse events and the occurrence of allergic diseases were also evaluated. Results: Medication score was higher in the SLIT group during the index period but lower in 2021 compared to the non-SLIT group (mean ± standard deviation: 5.17 ± 2.39 and 4.74 ± 2.38 in 2019, 3.13 ± 2.30 and 3.55 ± 2.48 in 2021, respectively). The adjusted mean difference between groups from 2019 to 2021 was -0.62 (95% confidence interval: -0.86 to -0.39, p < .0001), and the medication score was reduced in the SLIT group (risk ratio: 1.2: 1.1 to 1.3). The occurrence of adverse events involving abdominal disorders (adjusted odds ratio [aOR]: 0.64: 0.51 to 0.81), asthma exacerbation (aOR: 0.37: 0.24 to 0.57), and allergic diseases involving hay fever unrelated to CP (aOR: 0.60: 0.45 to 0.80) or asthma (aOR: 0.71: 0.58 to 0.86) was lower in the SLIT group. Conclusion: In children with CP, SLIT is effective, well tolerated, and could decrease the occurrence of other allergic diseases.
MeSH term(s)	Humans ; Child ; Rhinitis, Allergic, Seasonal/epidemiology ; Rhinitis, Allergic, Seasonal/therapy ; Retrospective Studies ; Sublingual Immunotherapy ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/therapy ; Asthma
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.14075
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Zs.A 3096: Show issues

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Article ; Online: Hypothetical intervention of targeted systolic blood pressure control of < 120 mmHg on renal prognosis for persons with stage 3-4 chronic kidney disease: an application of parametric g-formula using health checkup data in Japan.

Takeuchi, Masato / Shinkawa, Kanna / Yanagita, Motoko / Kawakami, Koji

Clinical and experimental nephrology

2023 Volume 27, Issue 6, Page(s) 542–547

Abstract: Background: The revised KDIGO guidelines recommend maintaining systolic blood pressure (sBP) < 120 mmHg in patients with chronic kidney disease (CKD), based on cardiovascular and survival benefits. However, the renal benefit of this strategy remains ... ...

Abstract	Background: The revised KDIGO guidelines recommend maintaining systolic blood pressure (sBP) < 120 mmHg in patients with chronic kidney disease (CKD), based on cardiovascular and survival benefits. However, the renal benefit of this strategy remains less clear. Methods: We used data of routine health checkups in Japan. Persons whose estimated glomerular filtration rate (eGFR) was < 60 mL/min/1.73 m Results: We enrolled 28,972 persons with CKD (median age: 54 years, male: 69%, baseline eGFR [median]: 56 mL/min/1.73m Conclusions: A targeted sBP control strategy maintaining < 120 mmHg may not yield a renoprotective effect for patients with stage 3-4 CKD, although it was expected to offer a cardiovascular benefit. Future research may be warranted in higher-risk populations, such as elderly people or those with more advanced kidney disease.
MeSH term(s)	Humans ; Male ; Aged ; Middle Aged ; Blood Pressure ; Japan/epidemiology ; Kidney ; Renal Insufficiency, Chronic ; Prognosis ; Glomerular Filtration Rate ; Hypertension/epidemiology
Language	English
Publishing date	2023-03-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-023-02341-1
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Zs.A 4922: Show issues

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Article ; Online: Impact of the COVID-19 pandemic on the incidence of healthcare facility-onset Clostridioides difficile infection in hospitalized patients with sepsis: Interrupted time series analysis using Japanese Diagnosis Procedure Combination data.

Endo, Koji / Mizuno, Kayoko / Takeuchi, Masato / Kawakami, Koji

Anaerobe

2023 Volume 79, Page(s) 102693

Abstract: Objectives: Healthcare facility-onset Clostridioides difficile infection (HO-CDI) is a major nosocomial infection associated with high mortality and healthcare costs. We aimed to determine if HO-CDI incidence decreased due to the COVID-19 pandemic. We ... ...

Abstract	Objectives: Healthcare facility-onset Clostridioides difficile infection (HO-CDI) is a major nosocomial infection associated with high mortality and healthcare costs. We aimed to determine if HO-CDI incidence decreased due to the COVID-19 pandemic. We hypothesized that the pandemic decreased HO-CDI as healthcare workers became more diligent in handwashing and sanitization. Methods: In this retrospective cohort study, adult patients with sepsis hospitalized in general wards from January 2018 to February 2021 were identified using a nationwide Japanese administrative database. Patients were divided into two groups according to the hospitalization date (before and after the first declaration of a state of emergency). The primary outcome was a change in the level of the HO-CDI monthly incidence ratio (per 10000 patient-days). Results: Of the 49,156 eligible hospitalizations for sepsis, 41,870 were before and 7,283 were after the first state of emergency declaration. Interrupted time-series (ITS) analysis showed no significant difference in the HO-CDI incidence ratio after Japan's first state of emergency declaration (level change -1.0, 95% confidence interval (CI) -8.6 to 6.6, p = 0.8, slope change 0.06, 95% CI -0.17 to 0.3, p = 0.6). The overall HO-CDI incidence ratio was 3.86/10000 patient-days (interquartile range 2.97-4.53); higher incidence existed in subgroups with older adults or a lower Barthel index at admission. Conclusions: No significant change in HO-CDI incidence was observed in patients with sepsis hospitalized in general wards before and after Japan's first state of emergency declaration. Our study revealed that HO-CDI in general wards in Japan had been consistently decreasing since before the COVID-19 pandemic.
MeSH term(s)	Humans ; Clostridioides difficile ; Clostridium Infections/diagnosis ; Clostridium Infections/epidemiology ; COVID-19/epidemiology ; COVID-19 Testing ; Cross Infection/epidemiology ; Delivery of Health Care ; East Asian People ; Incidence ; Interrupted Time Series Analysis ; Pandemics ; Retrospective Studies ; Sepsis/epidemiology
Language	English
Publishing date	2023-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1237621-8
ISSN	1095-8274 ; 1075-9964
ISSN (online)	1095-8274
ISSN	1075-9964
DOI	10.1016/j.anaerobe.2023.102693
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Zs.A 4318: Show issues

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Article ; Online: Effectiveness of Specific Health Check-ups in Japan for the primary prevention of obesity-related diseases: a protocol for a target trial emulation.

Takeuchi, Masato / Shinozaki, Tomohiro / Kawakami, Koji

BMJ open

2023 Volume 13, Issue 7, Page(s) e070417

Abstract: Introduction: Concerns about public health threats have shifted towards obesity-related, non-communicable diseases in both developed and developing countries. Since 2008, Japan has adopted a nationwide universal screening programme called Specific ... ...

Abstract	Introduction: Concerns about public health threats have shifted towards obesity-related, non-communicable diseases in both developed and developing countries. Since 2008, Japan has adopted a nationwide universal screening programme called Specific Health check-ups (SHC) for the primary prevention of obesity-related, non-communicable diseases, namely, diabetes, hypertension and hyperlipidaemia. The effectiveness of SHC has not been systemically evaluated to date. Methods and analysis: We will use the employment-based health insurance database, which includes both records of receipt versus non-receipt of SHC and healthcare claims. The study design adopts the target trial emulation framework to minimise the bias inherent to the observational study (eg, time-related bias and its consequences). The key components of trial emulation-eligibility criteria, treatment strategy, assignment procedure, follow-up period, outcome, causal contrast of interest and analysis plan-are detailed, along with the ideal target trial protocol. Briefly, we will conduct the nested-trial emulation approach that allows multiple trial entries. Persons aged 40-74 years will be eligible if they do not have a documented diagnosis of hypertension and diabetes and a history of receiving SHC at baseline. Participants will be classified according to the receipt or non-receipt of SHC service and followed for a maximum of 10 years until the withdrawal from the insurance plan, the outcome occurrence or the administrative censoring (the end of the available data, expected to be March 2022), whichever comes first. The 10-year incidence of diabetes/hypertension will be compared between SHC recipients and non-recipients using pooled logistic regression with adjustments for baseline confounders. Five sensitivity analyses are employed, including per-protocol analysis, changing eligibility criteria and negative outcome control analysis. Ethics and dissemination: This protocol obtained the approval from Kyoto University Graduate School and Faculty of Medicine, Ethics Committee (R2448). The findings will be disseminated to academic conferences, and published in a peer-reviewed journal.
MeSH term(s)	Humans ; Japan/epidemiology ; Noncommunicable Diseases ; Obesity/complications ; Obesity/epidemiology ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/prevention & control ; Primary Prevention ; Observational Studies as Topic
Language	English
Publishing date	2023-07-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-070417
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Article ; Online: Association between dose reduction of renin-angiotensin-aldosterone system inhibitors before coronary artery angiography and acute kidney injury: a propensity score-matched study.

Hashimoto, Hiroyuki / Takeuchi, Masato / Kawakami, Koji

Current medical research and opinion

2023 Volume 39, Issue 6, Page(s) 893–899

Abstract: Objective: The aim of this study was to investigate the association between dose reduction of renin-angiotensin-aldosterone system inhibitors (RAASis) and Acute kidney injury (AKI). AKI, which is commonly observed in hospitalized patients, increases ... ...

Abstract	Objective: The aim of this study was to investigate the association between dose reduction of renin-angiotensin-aldosterone system inhibitors (RAASis) and Acute kidney injury (AKI). AKI, which is commonly observed in hospitalized patients, increases mortality. Although RAASis and coronary artery angiography (CAG) are reported to be risk factors for AKI, whether dose reduction of RAASis can prevent AKI after CAG remains unknown. Methods: In this retrospective propensity score (PS)-matched cohort from the RWD database, which includes 20 million patients from 190 hospitals in Japan, we examined the impact of dose reduction of RAASis on the development of AKI after CAG. The subjects were patients with an estimated glomerular filtration rate (eGFR) of 15-60 mL/min/1.73 m Results: We identified 3329 patients who were prescribed RAASis at least one month before admission and underwent CAG. Six hundred seventy-four patients had a dose reduction 3 days prior to undergoing CAG, and 2655 patients did not. AKI was observed in 34 (5.0%) patients in the reduction group and 137 (5.2%) patients in the control group. There was no significant difference in the primary outcome between the two groups in the PS-matched cohort (OR: 1.08, 95% CI: 0.70-1.66). Conclusions: A reduction in the dose of RAASis did not prevent the development of AKI among patients undergoing CAG.
MeSH term(s)	Humans ; Contrast Media/adverse effects ; Renin-Angiotensin System ; Retrospective Studies ; Propensity Score ; Coronary Vessels ; Drug Tapering ; Coronary Angiography/adverse effects ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/prevention & control ; Risk Factors
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2023.2205794
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Zs.A 955: Show issues

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Article ; Online: Efficacy of Daikenchuto in the prevention of bowel obstruction in patients with colorectal cancer undergoing laparoscopic surgery: An observational study using a Japanese administrative claims database.

Kunitomi, Yuji / Nakashima, Masayuki / Takeuchi, Masato / Kawakami, Koji

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2023 Volume 31, Issue 2, Page(s) 133

Abstract: Purpose: Daikenchuto is an herbal medicine widely used in Japan without clear evidence to prevent bowel obstruction after abdominal surgery. We evaluated the efficacy of Daikenchuto in laparoscopic surgery for colorectal cancer (CRC).: Methods: We ... ...

Abstract	Purpose: Daikenchuto is an herbal medicine widely used in Japan without clear evidence to prevent bowel obstruction after abdominal surgery. We evaluated the efficacy of Daikenchuto in laparoscopic surgery for colorectal cancer (CRC). Methods: We included patients from the medical claims databases diagnosed with CRC between January 2012 and December 2019 and treated with laparoscopic surgery. We compared the Daikenchuto and control groups to evaluate early bowel obstruction (EBO) events for 1 year. The Daikenchuto group included patients prescribed Daikenchuto on postoperative day (POD) 0 or 1. An EBO event was defined as the use of a nasogastric tube, transnasal ileus tube, endoscopic balloon dilatation, or the requirement of reoperation for bowel obstruction from PODs 1 to 364. Results: In total, 46,458 patients met the eligibility criteria; 2407 and 44,051 patients were included in the Daikenchuto and control groups, respectively. Some of the patient's characteristics were significantly different between the groups. The frequencies of EBO events in the Daikenchuto and control groups were 5.7% (95% confidence interval: 4.8-6.7) and 4.6% (4.4-4.8), respectively. The most frequent events were nasogastric tube (3.1%, 2.9%) and transnasal ileus tube insertions (1.4%, 0.8%) in the Daikenchuto and control groups, respectively. The hospital stay was significantly shorter in the Daikenchuto group than in the control; this trend was confirmed in the sensitivity analysis. Conclusions: Daikenchuto did not demonstrate efficacy for EBO. It might be adequate for shortening patient's hospital stay. Further studies are warranted.
MeSH term(s)	Humans ; East Asian People ; Intestinal Obstruction/etiology ; Intestinal Obstruction/prevention & control ; Plant Extracts ; Ileus/prevention & control ; Laparoscopy ; Colorectal Neoplasms/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control
Chemical Substances	dai-kenchu-to ; Plant Extracts
Language	English
Publishing date	2023-01-26
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-07599-5
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Zs.A 3697: Show issues

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Article ; Online: Association between sedation during spinal anesthesia and mortality in older patients undergoing hip fracture surgery: A nationwide retrospective cohort study in Japan.

Nabatame, Maki / Takeuchi, Masato / Takeda, Chikashi / Kawakami, Koji

Journal of clinical anesthesia

2023 Volume 92, Page(s) 111322

Abstract: Study objective: Intraoperative sedation plays an important role in the management of regional anesthesia. Few studies have investigated the association of sedation during spinal anesthesia with postoperative mortality in older patients as a primary ... ...

Abstract	Study objective: Intraoperative sedation plays an important role in the management of regional anesthesia. Few studies have investigated the association of sedation during spinal anesthesia with postoperative mortality in older patients as a primary outcome. This study aimed to test the hypothesis that sedation during spinal anesthesia increases postoperative mortality in older patients undergoing hip fracture surgery. Design: Retrospective, cohort study. Setting: Acute and subacute care hospitals in Japan. Patients: Patients aged 65 years and older who received hip fracture surgery under spinal anesthesia between April 2014 and May 2022. Exposure: Sedation during spinal anesthesia. Measurements: Postoperative in-hospital all-cause mortality within 30 days. Main results: In total, 25,554 eligible patients were identified. Propensity score matching created 4735 pairs, and baseline patient characteristics were acceptably balanced between the sedation and non-sedation groups. There was no significant difference in 30-day postoperative mortality between the two groups (hazard ratio [95% CIs]: 0.92 [0.59-1.44]). Conclusions: There was no association between sedation during hip fracture surgery in older patients under spinal anesthesia and postoperative mortality. However, these results are limited to our population, and further prospective studies are needed to determine the safety of sedation.
MeSH term(s)	Humans ; Aged ; Anesthesia, Spinal/adverse effects ; Retrospective Studies ; Cohort Studies ; Japan/epidemiology ; Anesthesia, General/adverse effects ; Postoperative Complications/etiology ; Hip Fractures/surgery
Language	English
Publishing date	2023-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2023.111322
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Zs.A 2622: Show issues

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Article ; Online: Association between urate-lowering therapy and cardiovascular events in patients with asymptomatic hyperuricemia.

Hashimoto, Hiroyuki / Takeuchi, Masato / Kawakami, Koji

Clinical rheumatology

2023 Volume 42, Issue 11, Page(s) 3075–3082

Abstract: Introduction/objectives: To investigate the role of urate-lowering therapy (ULT) in the prevention of cardiovascular disease (CVD) in patients with asymptomatic hyperuricemia using the Japanese healthcare record database.: Methods: This retrospective ...

Abstract	Introduction/objectives: To investigate the role of urate-lowering therapy (ULT) in the prevention of cardiovascular disease (CVD) in patients with asymptomatic hyperuricemia using the Japanese healthcare record database. Methods: This retrospective cohort study used data from the JMDC Claims Database, which includes records of medical check-ups and Japanese health insurance claims. Subjects aged at least 18 years with a serum uric acid (sUA) level ≥ 7.0 mg/dL and at least one medical check-up from January 2007 to August 2021 were included in this study. The exposure was any ULT prescription, and the primary outcome included composite CVD outcomes, including coronary artery disease, stroke, and atrial fibrillation. Analysis was performed with a new-user design and overlap weighting to balance the baseline characteristics of the subjects. Cox proportional hazards models were used to investigate the association between ULT and the development of CVD. Results: In total, 152,166 patients were included in the main analysis before overlap weighting in this retrospective cohort study. The number of subjects in the ULT group was 5,270, and there were 146,896 subjects in the control group. Composite CVD outcomes were observed in a total of 7,703 patients. The risk of developing composite CVD outcomes was not different between the ULT group and the control group (HR: 1.01, 95% CI: 0.89 to 1.13). Conclusions: ULT for patients with asymptomatic hyperuricemia did not prevent the development of CVD based on the Japanese claims database. Key points • Among subjects with asymptomatic hyperuricemia, ULT was not associated with a lower risk of CVD • There was no appropriate cutoff for initiating ULT in patients with asymptomatic hyperuricemia • There was no appropriate cutoff as the therapeutic goal of ULT in patients with asymptomatic hyperuricemia.
MeSH term(s)	Humans ; Adolescent ; Adult ; Hyperuricemia/complications ; Hyperuricemia/drug therapy ; Uric Acid ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Retrospective Studies ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/epidemiology ; Allopurinol/therapeutic use ; Febuxostat/therapeutic use
Chemical Substances	Uric Acid (268B43MJ25) ; Gout Suppressants ; Allopurinol (63CZ7GJN5I) ; Febuxostat (101V0R1N2E)
Language	English
Publishing date	2023-07-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-023-06710-9
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