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  1. Article ; Online: Laparoscopic-Assisted Total Resection and Endorectal Pull-Through Technique for Congenital Megarectum with Anorectal Malformation.

    Mitani, Yasuyuki / Kubota, Akio / Goda, Taro / Takifuji, Katsunari / Iwamoto, Ryuta / Kawai, Manabu

    Journal of pediatric surgery

    2023  Volume 58, Issue 7, Page(s) 1269–1273

    Abstract: Background/purpose: Congenital megarectum (CMR) is sometimes associated with anorectal malformations (ARM), although there is no established therapeutic strategy. This study aims to clarify the clinical features of ARM with CMR, and to demonstrate the ... ...

    Abstract Background/purpose: Congenital megarectum (CMR) is sometimes associated with anorectal malformations (ARM), although there is no established therapeutic strategy. This study aims to clarify the clinical features of ARM with CMR, and to demonstrate the effectiveness of a surgical treatment, namely laparoscopic-assisted total resection and endorectal pull-through technique.
    Methods: We conducted a review of the clinical records of the patients with ARM with CMR treated at our institution between January 2003 and December 2020.
    Results: Seven of 33 cases of ARM (21.2%) were diagnosed with CMR, four males and three females. The types of ARM were 'intermediate' in four, and 'low' in three patients. Five of the seven patients (71.4%) required resection of megarectum for intractable constipation and underwent laparoscopic-assisted total resection and endorectal pull-through technique. Bowel function was improved after resection in all five cases. All five specimens showed hypertrophy of the circular fibers, and three of them showed abnormal location of ganglion cells within the circular muscle fibers.
    Conclusions: CMR often causes intractable constipation and requires resection of the dilated rectum. Laparoscopic-assisted total resection and endorectal pull-through technique for ARM with CMR considered to be an effective, minimally invasive treatment for intractable constipation.
    Level of evidence for clinical research papers: Level Ⅳ.
    Type of study: Treatment study.
    MeSH term(s) Male ; Female ; Humans ; Anorectal Malformations/surgery ; Anorectal Malformations/complications ; Retrospective Studies ; Rectum/surgery ; Rectum/abnormalities ; Constipation/etiology ; Constipation/surgery ; Laparoscopy/methods ; Megacolon/surgery ; Anal Canal/surgery ; Anal Canal/abnormalities
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2023.01.061
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  2. Article ; Online: Endoscopic submucosal tunnel dissection versus conventional endoscopic submucosal dissection for early gastric cancers: outcomes of 799 consecutive cases in a single institution.

    Ojima, Toshiyasu / Takifuji, Katsunari / Nakamura, Masaki / Nakamori, Mikihito / Hayata, Keiji / Kitadani, Junya / Yamaue, Hiroki

    Surgical endoscopy

    2020  Volume 34, Issue 12, Page(s) 5625–5631

    Abstract: Background: Endoscopic submucosal dissection (ESD) is a standard treatment for early gastric cancers (EGCs), but because of the obscured view and difficulty in submucosal lifting it is time consuming and poses high risk of perforation and bleeding in ... ...

    Abstract Background: Endoscopic submucosal dissection (ESD) is a standard treatment for early gastric cancers (EGCs), but because of the obscured view and difficulty in submucosal lifting it is time consuming and poses high risk of perforation and bleeding in large lesions. In endoscopic submucosal tunnel dissection (ESTD) technique, good visualization of the submucosal layer can be achieved in the tunnel, it is, therefore, easy to discern the muscularis propria and visualize the vessels in the submucosal area. This study aims to evaluate the technical feasibility, efficacy, and safety of ESTD in comparison with conventional ESD (cESD) technique for treatment of EGCs.
    Methods: This is a single-center retrospective study of 799 consecutive patients with EGCs who underwent ESD. ESTD (n = 141) were performed between 2015 and 2018 and cESD (n = 658) were performed between 2003 and 2015. Using propensity scores to strictly balance the significant variables, we compared treatment outcomes.
    Results: After matching, we enrolled 444 patients (n = 111 in ESTD group, n = 333 in cESD group). The resection speeds for lesions of the ESTD were faster than those of cESD (19.3 mm
    Conclusion: ESTD technique is a safe and feasible treatment procedure for EGCs. It presents many theoretical advantages and may have definite benefits over cESD. ESTD may, therefore, be considered as the standard endoscopic treatment for EGCs.
    MeSH term(s) Aged ; Aged, 80 and over ; Dissection ; Endoscopic Mucosal Resection ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Stomach Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2020-08-03
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-020-07849-1
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  3. Article ; Online: Randomized controlled trial comparing cosmetic results of midline incision versus off-midline incision for specimen extraction in laparoscopic colectomy.

    Iwamoto, Hiromitsu / Matsuda, Kenji / Takifuji, Katsunari / Tamura, Koichi / Mitani, Yasuyuki / Mizumoto, Yuki / Nakamura, Yuki / Sakanaka, Toshihiro / Yokoyama, Shozo / Hotta, Tsukasa / Yamaue, Hiroki

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 281

    Abstract: Purpose: A notable advantage of laparoscopic colorectal surgery is that only a small incision at the extraction site is necessary, which is considered to be cosmetically beneficial. Meanwhile, the optimal extraction site for the resected specimen in ... ...

    Abstract Purpose: A notable advantage of laparoscopic colorectal surgery is that only a small incision at the extraction site is necessary, which is considered to be cosmetically beneficial. Meanwhile, the optimal extraction site for the resected specimen in laparoscopic colectomy is controversial in terms of cosmetic benefit. This randomized controlled trial compares midline and off-midline extraction sites in laparoscopic colectomy in patients with colon cancer, with consideration of cosmetic benefits as the primary endpoint.
    Methods: Included were patients that underwent elective laparoscopic colectomy at WMUH between October 2014 and February 2017. Patients were randomly assigned to either midline incision group or off-midline incision group. Prospectively collected data included cosmetic results (patients and observer assessment scale) and complications including incidence of incisional hernia, SSI, and pain. This trial was registered with UMIN Clinical Trials (UMIN000028943).
    Results: Finally, 98 patients with colorectal cancer were analyzed. No significant differences were found between the two groups in patient and observer assessment scales of cosmetic results (midline 8 ± 1.1 vs off-midline 11 ± 5.9 p = 0.16, midline 13.5 ± 6.6 vs off-midline 15 ± 11 p = 0.58, respectively) or in postoperative pain. However, incisional hernia occurred in four cases in the midline group (8%), which was significantly higher than that in the off-midline group (no cases, 0%).
    Conclusion: There was no significant difference in terms of cosmetic benefit, the primary endpoint, between the two groups. In this study, only the extraction site location was compared; future studies will examine differences depending on the incisional direction, including the incidence of incisional hernia.
    MeSH term(s) Humans ; Incisional Hernia/epidemiology ; Incisional Hernia/surgery ; Colectomy/adverse effects ; Colectomy/methods ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Surgical Wound Infection ; Pain, Postoperative/epidemiology ; Surgical Wound/complications
    Language English
    Publishing date 2023-07-18
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-023-03018-9
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  4. Article: Asymptomatic patent processus vaginalis is a risk for developing external inguinal hernia in adults: A prospective cohort study.

    Watanabe, Takashi / Yokoyama, Shozo / Iwahashi, Makoto / Mori, Kazunari / Yamade, Naohisa / Yamaguchi, Kazuya / Takifuji, Katsunari / Mitani, Yasuyuki / Matsuda, Kenji / Yamaue, Hiroki

    Annals of medicine and surgery (2012)

    2021  Volume 64, Page(s) 102258

    Abstract: Background: Inguinal hernia repair is common for children and adults across the world, but the mechanism behind hernia onset still requires elucidation. This prospective study aims to determine whether patent processus vaginalis (PPV) is a factor in the ...

    Abstract Background: Inguinal hernia repair is common for children and adults across the world, but the mechanism behind hernia onset still requires elucidation. This prospective study aims to determine whether patent processus vaginalis (PPV) is a factor in the development of external inguinal hernias.
    Method: We enrolled 1008 patients who underwent laparoscopic surgery and in whom the inguinal region was observed. If processus vaginalis existed, we measured the diameter and length. Patients were followed for three years after surgery to investigate the incidence of external inguinal hernias.
    Result: No significant differences were found between age groups. Furthermore, no difference could be recognized in length or opening diameter of the PPVs between age groups. Three-year follow up was possible for 765 of 1008 patients enrolled in this study (76%), eight of whom, all male, developed external inguinal hernia during this period. Multivariate analysis for onset of inguinal hernia onset in male patients showed that PPV and length of the right PPV were independent risk factors for development of external inguinal hernia.
    Conclusion: The patency rate, length, and diameter of the processus vaginalis do not differ according to age. The patency of the processus vaginalis in male patients is an independent risk factor for development of external inguinal hernia in adults.
    Language English
    Publishing date 2021-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2021.102258
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  5. Article ; Online: Laparoscopic anterior resection with or without transanal tube for rectal cancer patients - A multicenter randomized controlled trial.

    Tamura, Koichi / Matsuda, Kenji / Horiuchi, Tetsuya / Noguchi, Kohei / Hotta, Tsukasa / Takifuji, Katsunari / Iwahashi, Makoto / Iwamoto, Hiromitsu / Mizumoto, Yuki / Yamaue, Hiroki

    American journal of surgery

    2021  Volume 222, Issue 3, Page(s) 606–612

    Abstract: Background: In rectal cancer surgery, insertion of transanal tube has been shown to have efficacy to prevent anastomotic leakage. This randomized controlled study aims to clarify the incidence of anastomotic leakage with or without transanal tube in ... ...

    Abstract Background: In rectal cancer surgery, insertion of transanal tube has been shown to have efficacy to prevent anastomotic leakage. This randomized controlled study aims to clarify the incidence of anastomotic leakage with or without transanal tube in patients with rectal cancer.
    Methods: Patients who underwent elective low anterior resection were randomly allocated to either have transanal tube insertion or not for five days after surgery. We examined the incidence of anastomotic leakage, postoperative 30-day morbidity and mortality.
    Results: 157 patients were randomized to the transanal tube group or the no-transanal tube group. Symptomatic anastomotic leakage occurred in six patients (7.6%) of the former group and eight patients (10.3%) in the latter group, without significant difference (p = 0.559). There was also no significant difference in morbidity between groups (p = 0.633) and no mortality was detected.
    Conclusions: Transanal tube insertion had no significant benefit towards prevention of anastomotic leakage in rectal cancer surgery.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anastomotic Leak/epidemiology ; Anastomotic Leak/mortality ; Anastomotic Leak/prevention & control ; Elective Surgical Procedures/instrumentation ; Elective Surgical Procedures/methods ; Elective Surgical Procedures/mortality ; Female ; Humans ; Incidence ; Intubation/instrumentation ; Intubation/methods ; Laparoscopy/methods ; Male ; Middle Aged ; Prospective Studies ; Rectal Neoplasms/mortality ; Rectal Neoplasms/surgery ; Rectum
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2020.12.054
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  6. Article ; Online: New diagnostic strategy using narrow-band imaging (NBI) during laparoscopic surgery for patients with colorectal cancer.

    Takei, Yoh / Hotta, Tsukasa / Takifuji, Katsunari / Yokoyama, Shozo / Matsuda, Kenji / Watanabe, Takashi / Tamura, Koichi / Mitani, Yasuyuki / Ieda, Junji / Iwamoto, Hiromitsu / Mizumoto, Yuki / Iwahashi, Yoshifumi / Yamaue, Hiroki

    Surgical endoscopy

    2022  Volume 36, Issue 12, Page(s) 8843–8855

    Abstract: Background: Accurate tumor stage diagnosis during laparoscopic surgery remains difficult. We clarify the impact of new diagnostic strategy using narrow-band imaging (NBI) during laparoscopic surgery for colorectal cancer compared with other strategies.!# ...

    Abstract Background: Accurate tumor stage diagnosis during laparoscopic surgery remains difficult. We clarify the impact of new diagnostic strategy using narrow-band imaging (NBI) during laparoscopic surgery for colorectal cancer compared with other strategies.
    Methods: We defined angiogenesis (Ag) and fibrosis (Fib) grades using NBI laparoscopy (lap-NBI), and assessed the clinicopathological features associated with these grades for 67 patients with colorectal cancer who underwent surgery. We assessed vessel density and gray scale with computer software.
    Results: NBI-Ag-grade and NBI-Fib-grade of the serosal surface of cancer lesions and peritoneal nodules correlated with vessel density and gray scale of those assessed by Image J computer software. NBI-Fib-grades of liver nodules also correlated with gray scale. NBI-Ag- grade and Fib-grade of the serosal surface of cancer lesions correlated with pathological depth of invasion. These NBI grades of pathological metastatic peritoneal nodules were higher than those of pathologically benign peritoneal nodules. NBI- Fib grades of pathological metastatic liver nodules were higher than those of pathologically benign liver nodules. In multivariate analysis, lap-NBI was associated with different diagnosis for T3, T4 and non-T3, and non-T4. Moreover, lap-NBI was associated with different diagnosis for T4 and non-T4. Predictive value for T4 by lap-NBI showed high sensitivity (85%) specificity (87%), positive predictive value (74%), negative predictive value (93%), and overall accuracy (87%). Sensitivity and overall accuracy of lap-NBI was superior to that of other diagnostic modalities.
    Conclusion: We clarified the usefulness of the new diagnostic strategy using lap-NBI during laparoscopic surgery for colorectal cancer in comparison with other strategies.
    MeSH term(s) Humans ; Narrow Band Imaging/methods ; Laparoscopy/methods ; Predictive Value of Tests ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/surgery ; Sensitivity and Specificity
    Language English
    Publishing date 2022-05-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09313-8
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  7. Article ; Online: Laparoscopic and Endoscopic Cooperative Surgery Versus Endoscopic Submucosal Dissection for the Treatment of Low-Risk Tumors of the Duodenum.

    Ojima, Toshiyasu / Nakamori, Mikihito / Nakamura, Masaki / Hayata, Keiji / Katsuda, Masahiro / Takifuji, Katsunari / Yamaue, Hiroki

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2018  Volume 22, Issue 5, Page(s) 935–940

    Abstract: Background: There have been no comparative studies of endoscopic submucosal dissection (ESD) and laparoscopic and endoscopic cooperative surgery (LECS) for patients with duodenal tumors regarding surgical outcomes. The aim of this study is to compare ... ...

    Abstract Background: There have been no comparative studies of endoscopic submucosal dissection (ESD) and laparoscopic and endoscopic cooperative surgery (LECS) for patients with duodenal tumors regarding surgical outcomes. The aim of this study is to compare the safety and feasibility of short-term surgical outcomes of ESD and LECS for patients with low-risk tumors of the duodenum.
    Methods: This was a single-center retrospective study of 68 consecutive patients with low-risk tumors of the duodenum who received surgical treatments. ESD (n = 50) was performed between 2000 and 2013 and LECS (n = 18) was performed between 2014 and 2017.
    Results: The overall incidence of perioperative complications was significantly higher in the ESD group (28%) than in the LECS group (0%) (P = 0.014). In the ESD group, eight patients with intraoperative perforation of duodenum (16%) were repaired with metal clips. Postoperative duodenal hemorrhage occurred in three patients (6%). Postoperative duodenal stricture requiring endoscopically guided balloon dilation was observed in two patients (4%). Postoperative bile leakage was found in one patient (2%). The size of resected lesion was significantly larger in the LECS group (26.5 mm) than in the ESD group (14.5 mm) (P = 0.003). In LECS group, all 18 patients underwent curative resection; however, the curative resection rate was 52% in ESD group (P = 0.001).
    Conclusion: LECS for patients with low-risk tumors of the duodenum is a safe, feasible, and ideal alternative to ESD with regard to short-term surgical outcomes.
    Trial registration: UMIN000021200 ( http://www.umin.ac.jp/ctr/ ).
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Constriction, Pathologic/etiology ; Constriction, Pathologic/therapy ; Duodenal Neoplasms/pathology ; Duodenal Neoplasms/surgery ; Duodenum/pathology ; Endoscopic Mucosal Resection/adverse effects ; Female ; Gastrointestinal Hemorrhage/etiology ; Humans ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Intraoperative Complications/etiology ; Intraoperative Complications/surgery ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Male ; Middle Aged ; Operative Time ; Postoperative Hemorrhage/etiology ; Postoperative Period ; Retrospective Studies ; Treatment Outcome ; Tumor Burden
    Language English
    Publishing date 2018-01-19
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-018-3680-6
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  8. Article ; Online: Long-term Survival of Patients With Endoscopic Submucosal Dissection for Remnant Gastric Cancers.

    Ojima, Toshiyasu / Takifuji, Katsunari / Nakamura, Masaki / Nakamori, Mikihito / Yamaue, Hiroki

    Surgical laparoscopy, endoscopy & percutaneous techniques

    2016  Volume 26, Issue 1, Page(s) 78–81

    Abstract: Purpose: The aim of this study was to compare the oncologic results of endoscopic submucosal dissection (ESD) for early gastric cancers (EGC) in remnant stomachs (RS) with results of ESD for EGC in normal stomachs (NS).: Methods: From 2002 to 2013, ... ...

    Abstract Purpose: The aim of this study was to compare the oncologic results of endoscopic submucosal dissection (ESD) for early gastric cancers (EGC) in remnant stomachs (RS) with results of ESD for EGC in normal stomachs (NS).
    Methods: From 2002 to 2013, ESD was performed for 583 EGC lesions. ESD of the RS was performed for 34 lesions.
    Results: Two patients with EGC in the NS and 1 patient with EGC in the RS died from these gastric cancers. In all patients, the ESD treatments were considered outside of indications according to the pathologic results. The 5-year cause-specific survival rate was 99.5% for EGC patients with NS and 96.2% for EGC patients with RS. The 5-year overall survival rates were 88.4% for patients with NS and 58.4% for patients with RS.
    Conclusions: On the basis of the favorable long-term oncologic outcomes, ESD for EGC in the RS can be considered feasible in clinical practice.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Dissection/methods ; Dissection/mortality ; Female ; Gastrectomy/methods ; Gastric Stump/surgery ; Gastroscopy/methods ; Gastroscopy/mortality ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/surgery ; Reoperation/mortality ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1475108-2
    ISSN 1534-4908 ; 1530-4515 ; 1051-7200
    ISSN (online) 1534-4908
    ISSN 1530-4515 ; 1051-7200
    DOI 10.1097/SLE.0000000000000233
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  9. Article ; Online: Feasibility of Endoscopic Submucosal Dissection for Submucosal-invasive Gastric Cancer and the Predictors of Residual or Recurrent Cancer.

    Ojima, Toshiyasu / Takifuji, Katsunari / Nakamura, Masaki / Nakamori, Mikihito / Yamaue, Hiroki

    Surgical laparoscopy, endoscopy & percutaneous techniques

    2016  Volume 26, Issue 5, Page(s) 401–405

    Abstract: Purpose of the study: The purpose of this study was to determine the feasibility of the endoscopic submucosal dissection (ESD) for submucosal-invasive gastric cancer (SMGC) by assessing the therapeutic outcomes in patients treated with ESD.: Materials ...

    Abstract Purpose of the study: The purpose of this study was to determine the feasibility of the endoscopic submucosal dissection (ESD) for submucosal-invasive gastric cancer (SMGC) by assessing the therapeutic outcomes in patients treated with ESD.
    Materials and methods: From 2002 to 2013, ESD was performed for 597 lesions with early gastric cancer at our institute. ESD of the SMGC was performed for 85 patients.
    Results: Among these 85 patients, 35 patients underwent additional gastrectomy. Residual or recurrent cancer occurred in 12 patients treated through ESD method. The 5-year disease-specific survival rates were 94.9% for all 85 patients and 97.2% for 49 patients with follow-up examinations after ESD. The multivariate logistic regression analysis indicated that residual or recurrent cancer in the patients with SMGC was significantly associated with a tumor width in submucosa (P=0.0152).
    Conclusions: ESD for SMGC can be considered feasible in clinical practice in terms of the favorable long-term oncologic outcomes.
    MeSH term(s) Aftercare ; Aged ; Aged, 80 and over ; Endoscopic Mucosal Resection/methods ; Endoscopic Mucosal Resection/mortality ; Feasibility Studies ; Female ; Gastrectomy/methods ; Gastrectomy/mortality ; Gastroscopy/methods ; Gastroscopy/mortality ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/mortality ; Neoplasm, Residual/etiology ; Neoplasm, Residual/mortality ; Retrospective Studies ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 1475108-2
    ISSN 1534-4908 ; 1530-4515 ; 1051-7200
    ISSN (online) 1534-4908
    ISSN 1530-4515 ; 1051-7200
    DOI 10.1097/SLE.0000000000000315
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  10. Article ; Online: Randomized clinical trial of defaecatory function after anterior resection for rectal cancer with high versus low ligation of the inferior mesenteric artery.

    Matsuda, K / Hotta, T / Takifuji, K / Yokoyama, S / Oku, Y / Watanabe, T / Mitani, Y / Ieda, J / Mizumoto, Y / Yamaue, H

    The British journal of surgery

    2015  Volume 102, Issue 5, Page(s) 501–508

    Abstract: Background: Defaecatory function is often poor after anterior resection. Denervation of the neorectum following high ligation of the inferior mesenteric artery (IMA) is a possible cause of impaired defaecatory function. The purpose of this randomized ... ...

    Abstract Background: Defaecatory function is often poor after anterior resection. Denervation of the neorectum following high ligation of the inferior mesenteric artery (IMA) is a possible cause of impaired defaecatory function. The purpose of this randomized clinical trial was to clarify whether the level of ligation of the IMA in patients with rectal cancer affects defaecatory function.
    Methods: Between 2008 and 2011, patients who underwent anterior resection for rectal cancer were randomized to receive either high or low ligation of the IMA. The primary endpoint was to demonstrate the superiority of low ligation in terms of defaecatory function.
    Results: One hundred patients were enrolled in the study; 51 were randomized to high ligation of the IMA and 49 to low ligation. There were no differences between the groups in terms of clinical data, except tumour stage, which was more advanced in the high-ligation group (P = 0·046). Nor were there any differences in defaecatory function, self-assessment of defaecation, Faecal Incontinence Quality of Life scale or continence score between groups at 3 months and 1 year. The number of harvested lymph nodes was similar. The rate of symptomatic anastomotic leakage was 16 per cent in the high-ligation group and 10 per cent in the low-ligation group (P = 0·415).
    Conclusion: The level of ligation of the IMA in patients with rectal cancer did not affect defaecatory function or the incidence of postoperative complications.
    Registration number: NCT00701012 (http://www.clinicaltrials.gov).
    MeSH term(s) Aged ; Aged, 80 and over ; Defecation/physiology ; Fecal Incontinence/etiology ; Fecal Incontinence/physiopathology ; Female ; Humans ; Ligation/methods ; Lymphatic Metastasis ; Male ; Mesenteric Artery, Inferior/surgery ; Middle Aged ; Neoplasm Staging ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Rectal Neoplasms/pathology ; Rectal Neoplasms/physiopathology ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.9739
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