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Article ; Online: Retroperitoneal biloma-A rare differential diagnosis of perirenal fluid accumulation.

Hanawa, Kazushi / Fukasawa, Masanari / Aoki, Tadashi / Nozawa, Munehiro / Takihana, Yoshio / Mishina, Yuji / Nakagomi, Hiroshi

IJU case reports

2024 Volume 7, Issue 3, Page(s) 270–273

Abstract: Introduction: Nontraumatic biliary rupture and retroperitoneal biloma infrequently occur. Here, we report a case of retroperitoneal biloma due to spontaneous left hepatic duct perforation, which was difficult to differentiate from a perirenal abscess.!## ...

Abstract	Introduction: Nontraumatic biliary rupture and retroperitoneal biloma infrequently occur. Here, we report a case of retroperitoneal biloma due to spontaneous left hepatic duct perforation, which was difficult to differentiate from a perirenal abscess. Case presentation: A 94-year-old female patient was hospitalized with symptoms of fatigue and right back pain that lasted for 5 days. Computed tomography revealed fluid accumulation in the retroperitoneum, and urinary extravasation and right perinephric abscess were suspected. Antimicrobial treatment and drainage with ureteral stents and urethral catheters demonstrated no symptom improvement. Ultrasound-guided puncture of the abscess revealed the presence of bile. Pigtail catheter drainage improved symptoms and inflammatory response. After diagnosis, endoscopic retrograde cholangiopancreatography revealed bile leakage, and a bile duct stent was inserted. Conclusion: Biloma can cause perirenal fluid accumulation, and they should be considered an origin of perirenal fluid accumulation when urinary tract lesions are excluded.
Language	English
Publishing date	2024-03-23
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12723
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Article ; Online: Bladder cancer with urinary diversion by a sigmoid colon conduit after transverse colon stoma.

Aoki, Tadashi / Furuya, Ryota / Fukasawa, Masanari / Nozawa, Munehiro / Takihana, Yoshio / Sudoh, Makoto / Nakagomi, Hiroshi

IJU case reports

2023 Volume 7, Issue 1, Page(s) 46–49

Abstract: Introduction: Sigmoid conduit is one of the methods for achieving urinary diversion, but it is performed less frequently than ileal conduit and ureterostomy. Herein, we report a case in which a sigmoid colon conduit was performed after nephrostomy and ... ...

Abstract	Introduction: Sigmoid conduit is one of the methods for achieving urinary diversion, but it is performed less frequently than ileal conduit and ureterostomy. Herein, we report a case in which a sigmoid colon conduit was performed after nephrostomy and transverse colostomy. Case presentation: A 70-year-old man was referred to our hospital because of a bladder tumor. Computed tomography and transurethral biopsy revealed advanced bladder cancer with ureteral and rectal invasion. Despite drug therapy, the tumor progressed. Thus, nephrostomy and transverse colostomy were performed for urinary and fecal diversion, respectively. Subsequently, chemotherapy was administered for 8 months. As nephrostomy-related complications occurred frequently during chemotherapy, a sigmoid colon conduit was performed instead of nephrostomy for urinary diversion to improve the patient's quality of life. Conclusion: In patients with advanced bladder cancer requiring a double stoma of the urinary and fecal tracts, sigmoid colon conduit may be selected as a urinary diversion method.
Language	English
Publishing date	2023-11-08
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12665
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Article: Endovascular treatment of ureteroarterial fistulas with stent-grafts.

Araki, Takuji / Nagata, Motonori / Araki, Tsutomu / Takihana, Yoshio / Takeda, Masayuki

Radiation medicine

2008 Volume 26, Issue 6, Page(s) 372–375

Abstract: Ureteroarterial fistula is a rare condition with life-threatening hematuria that should be diagnosed and treated immediately. We reported two patients of ureteroarterial fistula who underwent successful endovascular treatment by stent-grafts. They had ... ...

Abstract	Ureteroarterial fistula is a rare condition with life-threatening hematuria that should be diagnosed and treated immediately. We reported two patients of ureteroarterial fistula who underwent successful endovascular treatment by stent-grafts. They had undergone pelvic surgery followed by placement of an indwelling ureteral stent for stricture of the ureter before sudden hematuria occurred. Routine contrast-enhanced computed tomography did not reveal extravasation or a pseudo-aneurysm. Angiograms with multiple oblique views demonstrated small pseudoaneurysms of the iliac artery overriding the ipsilateral ureter. The endovascular treatment of ureteroarterial fistula using stent-grafts was successful, and the hematuria disappeared immediately after stent-graft deployment. The hematuria did not recur up to the last follow-up visits of 3 and 19 months, respectively.
MeSH term(s)	Aged ; Aneurysm, False/etiology ; Female ; Hematuria/etiology ; Humans ; Iliac Artery ; Male ; Stents ; Ureteral Diseases/complications ; Ureteral Diseases/therapy ; Urinary Fistula/complications ; Urinary Fistula/therapy ; Vascular Fistula/complications ; Vascular Fistula/therapy
Language	English
Publishing date	2008-08-03
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	639138-2
ISSN	1862-5274 ; 0288-2043
ISSN (online)	1862-5274
ISSN	0288-2043
DOI	10.1007/s11604-008-0235-x
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Article ; Online: Differential impact of lower urinary tract symptoms on generic and disease-specific quality of life in men and women.

Araki, Isao / Tsuchida, Takayuki / Nomura, Teruhisa / Fukasawa, Mizuya / Takihana, Yoshio / Koyama, Nobuyuki / Takeda, Masayuki

Urologia internationalis

2008 Volume 81, Issue 1, Page(s) 60–65

Abstract: Introduction: We investigated how generic and disease-specific measures differ in estimating the quality of life (QoL) impact of lower urinary tract symptoms (LUTS).: Materials and methods: A total of 172 men and 67 women >or=40 years old who ... ...

Abstract	Introduction: We investigated how generic and disease-specific measures differ in estimating the quality of life (QoL) impact of lower urinary tract symptoms (LUTS). Materials and methods: A total of 172 men and 67 women >or=40 years old who attended the public lectures completed the questionnaire comprising the International Prostate Symptom Score, benign prostatic hyperplasia impact index and SF-36 Health Survey. The multiple regression analysis was performed to evaluate the QoL impact of LUTS. Results: Both storage and voiding symptoms showed significant correlations with disease-specific QoL. Among men, voiding symptom correlated more closely with disease-specific QoL than storage symptom did, and this finding was reversed among women. Storage but not voiding symptoms showed a significant correlation with generic QoL. Among men, storage symptom correlated more closely with mental health than physical health, and the reversed finding was obtained among women. Generic QoL, especially physical health, was significantly influenced by some comorbid diseases, but disease-specific QoL was not. Conclusions: The QoL impact of LUTS was differentially estimated by disease-specific and generic measures with sex differences.
MeSH term(s)	Adult ; Aged ; Female ; Health Surveys ; Humans ; Male ; Middle Aged ; Prostatic Hyperplasia/pathology ; Prostatic Hyperplasia/psychology ; Quality of Life ; Regression Analysis ; Sex Factors ; Surveys and Questionnaires ; Urinary Tract/anatomy & histology ; Urologic Diseases/diagnosis ; Urologic Diseases/pathology ; Urologic Diseases/psychology
Language	English
Publishing date	2008
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000137642
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Article: [Pharmacokinetics of paclitaxel and carboplatin in a hemodialysis patient with metastatic urothelial carcinoma--a case report].

Furuya, Yasuhisa / Takihana, Yoshio / Araki, Isao / Tanabe, Nobuaki / Takeda, Masayuki

Gan to kagaku ryoho. Cancer & chemotherapy

2003 Volume 30, Issue 7, Page(s) 1017–1020

Abstract: A 69-year-old-man undergoing hemodialysis for 8 years developed metastatic urothelial carcinoma and received combination chemotherapy with paclitaxel and carboplatin. Paclitaxel 175 mg/m2 was given as a 3-hour intravenous infusion, and carboplatin was ... ...

Abstract	A 69-year-old-man undergoing hemodialysis for 8 years developed metastatic urothelial carcinoma and received combination chemotherapy with paclitaxel and carboplatin. Paclitaxel 175 mg/m2 was given as a 3-hour intravenous infusion, and carboplatin was dosed to the area under the plasma concentration-time curve (AUC) of 5 mg.min/ml calculated according to the Calvert formula as a 30-minute intravenous infusion immediately after paclitaxel. Hemodialysis was started 1 hour after carboplatin, then their pharmacokinetics was determined in the patient. The AUC of paclitaxel and carboplatin were 15.2 and 64.56 micrograms.h/ml, respectively. The metastatic tumor size was reduced by more than 20% after 3 courses of this chemotherapy. Grade 3 neutropenia and grade 1 thrombopenia were observed. This is the first report that the combination of paclitaxel and carboplatin is feasible in a patient with metastatic urothelial carcinoma undergoing hemodialysis, with low toxicity and safety.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carboplatin/administration & dosage ; Carboplatin/pharmacokinetics ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/secondary ; Drug Administration Schedule ; Drug Monitoring ; Humans ; Kidney Failure, Chronic/therapy ; Kidney Neoplasms/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/secondary ; Male ; Paclitaxel/administration & dosage ; Paclitaxel/pharmacokinetics ; Renal Dialysis ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D)
Language	Japanese
Publishing date	2003-07
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Development of nomogram to non-steroidal antiandrogen sequential alternation in prostate cancer for predictive model.

Kamiya, Naoto / Suzuki, Hiroyoshi / Nishimura, Kensaku / Fujii, Motohiro / Okegawa, Takatsugu / Matsuda, Tadashi / Morita, Tatsuo / Takihana, Yoshio / Ozono, Seiichiro / Namiki, Mikio / Matsubara, Akio / Ichikawa, Tomohiko / Miki, Tsuneharu

Japanese journal of clinical oncology

2014 Volume 44, Issue 3, Page(s) 263–269

Abstract: Objectives: To clarify clinical predictors for a prostate-specific antigen decrease ≥50% in response to alternative non-steroidal antiandrogen therapy and to develop a nomogram to predict the prostate-specific antigen decrease ≥50% in response to ... ...

Abstract	Objectives: To clarify clinical predictors for a prostate-specific antigen decrease ≥50% in response to alternative non-steroidal antiandrogen therapy and to develop a nomogram to predict the prostate-specific antigen decrease ≥50% in response to alternative non-steroidal antiandrogen therapy in patients with advanced prostate cancer that relapsed after initial combined androgen blockade. We previously reported that combined androgen blockade with an alternative non-steroidal antiandrogen is effective for advanced prostate cancer that has relapsed after initial combined androgen blockade. Methods: We enrolled 161 patients from 14 medical institutions with histologically confirmed prostate cancer who had been treated with combination therapy and in whom cancer progressed after first-line combined androgen blockade therapy. A nomogram for the prostate-specific antigen decrease ≥50% from baseline prostate-specific antigen in response to alternative non-steroidal antiandrogen therapy was developed based on the final logistic regression model. Results: Overall prostate-specific antigen decreased ≥50% in 75 of 161 patients (46.6%) in response to alternative non-steroidal antiandrogen therapy. Using five independent risk factors (initial serum level of prostate-specific antigen, hemoglobin, C-reactive protein, prostate-specific antigen nadir to second hormone therapy and Gleason sum), a nomogram was developed for the prediction of prostate-specific antigen decrease ≥50% in response to alternative non-steroidal antiandrogen therapy. The receiver operating characteristic curve showed that the accuracy of the predicted probability was 72.5% for the model. Conclusions: This predictive nomogram could predict the prostate-specific antigen decrease ≥50% in response to alternative non-steroidal antiandrogen therapy and might be of benefit to determine the sequential treatment strategy in patients with relapse after first combined androgen blockade.
MeSH term(s)	Androgen Antagonists/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Biomarkers, Tumor/blood ; C-Reactive Protein/metabolism ; Cohort Studies ; Disease Progression ; Drug Administration Schedule ; Goserelin/administration & dosage ; Humans ; Kaplan-Meier Estimate ; Leuprolide/administration & dosage ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local/drug therapy ; Nomograms ; Predictive Value of Tests ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; ROC Curve ; Reproducibility of Results ; Retrospective Studies
Chemical Substances	Androgen Antagonists ; Biomarkers, Tumor ; Goserelin (0F65R8P09N) ; C-Reactive Protein (9007-41-4) ; Prostate-Specific Antigen (EC 3.4.21.77) ; Leuprolide (EFY6W0M8TG)
Language	English
Publishing date	2014-03
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyt230
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Article: Real-time quantitative analysis for human telomerase reverse transcriptase mRNA and human telomerase RNA component mRNA expressions as markers for clinicopathologic parameters in urinary bladder cancer.

Takihana, Yoshio / Tsuchida, Takayuki / Fukasawa, Mizuya / Araki, Isao / Tanabe, Nobuaki / Takeda, Masayuki

International journal of urology : official journal of the Japanese Urological Association

2006 Volume 13, Issue 4, Page(s) 401–408

Abstract: Aim: The expression of the telomerase subunits such as human telomerase reverse transcriptase (hTERT) and human telomerase RNA component (hTR) may be associated with tumor development and progression. We evaluated the relationship between mRNA ... ...

Abstract	Aim: The expression of the telomerase subunits such as human telomerase reverse transcriptase (hTERT) and human telomerase RNA component (hTR) may be associated with tumor development and progression. We evaluated the relationship between mRNA quantification of both hTERT and hTR and clinicopathologic parameters in bladder cancer. Methods: We examined the mRNA expression of hTERT and hTR in 29 specimens with bladder cancer (Grade: Grade I, 9 cases; Grade II, 13 cases and Grade III, 7 cases. Stage: pTa-pT1, 18 cases; pT2-T4, 11 cases). We immediately froze all of specimens obtained during TUR-Bt and isolated the total RNA from each specimen. We measured the quantity of hTERT, hTR and GAPDH mRNA by a real-time reverse transcription-polymerase chain reaction method based on TaqMan technology. Results: The hTERT/GAPDH mRNA ratio and hTERT mRNA/total RNA in superficial bladder tumor was significantly lower than in invasive bladder tumor. The hTR/GAPDH mRNA ratio and hTR mRNA/total RNA in superficial tumor were significantly lower than in invasive bladder tumor. The hTERT mRNA expression significantly correlated with tumor grade, but the hTR mRNA expression did not correlate with tumor grade. There was no significant difference in the hTERT/GAPDH mRNA ratio and hTR mRNA/total RNA according to multiplicity of bladder tumor. Conclusions: Our results demonstrated that the expression of hTERT mRNA correlated with the progression of stage and grade in bladder cancer. The quantitative analysis of hTERT and hTR mRNA might be a marker for clinicopathologic parameters in bladder cancer.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Catalytic Domain ; DNA-Binding Proteins/genetics ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; RNA/genetics ; RNA, Messenger/genetics ; RNA, Neoplasm/genetics ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Spectrophotometry ; Telomerase/genetics ; Urinary Bladder Neoplasms/enzymology ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology
Chemical Substances	DNA-Binding Proteins ; RNA, Messenger ; RNA, Neoplasm ; telomerase RNA ; RNA (63231-63-0) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2006-04
Publishing country	Australia
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328401-0
ISSN	0919-8172
ISSN	0919-8172
DOI	10.1111/j.1442-2042.2006.01300.x
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 278: Show issues

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Article: Decreased expression of G protein-coupled receptor kinases in the detrusor smooth muscle of human urinary bladder with outlet obstruction.

Furuya, Yasuhisa / Araki, Isao / Kamiyama, Manabu / Zakoji, Hidenori / Takihana, Yoshio / Takeda, Masayuki

International journal of urology : official journal of the Japanese Urological Association

2006 Volume 13, Issue 9, Page(s) 1226–1232

Abstract: Aim: We examine the expression of mRNA of G protein-coupled receptor kinase (GRK) subtypes and muscarinic acetylcholine receptor (M) subtypes in the detrusor smooth muscle of the human urinary bladder. Furthermore, we confirm the presence and the ... ...

Abstract	Aim: We examine the expression of mRNA of G protein-coupled receptor kinase (GRK) subtypes and muscarinic acetylcholine receptor (M) subtypes in the detrusor smooth muscle of the human urinary bladder. Furthermore, we confirm the presence and the localization of GRK proteins in the detrusor smooth muscle of the obstructed bladder in comparison with the control bladder. Methods: Detrusor smooth muscle tissues of the human urinary bladder were obtained from 12 male patients; 6 patients did not have bladder outlet obstruction, and the other 6 patients had bladder outlet obstruction. Portions of the dome or anterior wall of the urinary bladder were used for the present study. Reverse transcription/polymerase chain reaction for GRK2, M2 and M3 was performed using total RNA extracted from human urinary bladder detrusor. Antibodies to GRK2, GRK3 and GRK4 were used to confirm the presence of the protein product in the human urinary bladder using immunohistochemical staining and the western blotting technique. Results: All complementary DNA (cDNA) transcribed from three different mRNA (M2, M3 and GRK2) were successfully amplified and size-fractionated. The expression of GRK2 protein was strong in the human bladder detrusor, but was significantly weakened by western blotting in obstructed bladder in comparison with control bladder. Conclusions: Failure in desensitization mechanisms of muscarinic acetylcholine receptors might be related to storage symptom elicited by overactivity in obstructed bladder with benign prostatic hyperplasia.
MeSH term(s)	Blotting, Western ; G-Protein-Coupled Receptor Kinase 2 ; G-Protein-Coupled Receptor Kinase 3 ; G-Protein-Coupled Receptor Kinase 4 ; Humans ; Immunoenzyme Techniques ; Male ; Muscle, Smooth/cytology ; Muscle, Smooth/enzymology ; Prostatic Hyperplasia/enzymology ; Prostatic Hyperplasia/pathology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, Muscarinic M2/genetics ; Receptor, Muscarinic M2/metabolism ; Receptor, Muscarinic M3/genetics ; Receptor, Muscarinic M3/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Urinary Bladder/cytology ; Urinary Bladder/enzymology ; Urinary Bladder Neck Obstruction/enzymology ; Urinary Bladder Neck Obstruction/pathology ; beta-Adrenergic Receptor Kinases/genetics ; beta-Adrenergic Receptor Kinases/metabolism
Chemical Substances	RNA, Messenger ; Receptor, Muscarinic M2 ; Receptor, Muscarinic M3 ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; G-Protein-Coupled Receptor Kinase 3 (EC 2.7.11.15) ; GRK2 protein, human (EC 2.7.11.15) ; GRK3 protein, human (EC 2.7.11.15) ; beta-Adrenergic Receptor Kinases (EC 2.7.11.15) ; G-Protein-Coupled Receptor Kinase 2 (EC 2.7.11.16) ; G-Protein-Coupled Receptor Kinase 4 (EC 2.7.11.16) ; GRK4 protein, human (EC 2.7.11.16)
Language	English
Publishing date	2006-09-18
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328401-0
ISSN	0919-8172
ISSN	0919-8172
DOI	10.1111/j.1442-2042.2006.01497.x
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Zs.MO 278: Show issues

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Article: Modified endoscopic live donor nephrectomy: retroperitoneoscopy followed by hand-assistance.

Furuya, Yasuhisa / Araki, Isao / Zakoji, Hidenori / Takihana, Yoshio / Tanabe, Nobuaki / Takeda, Masayuki

International journal of urology : official journal of the Japanese Urological Association

2005 Volume 12, Issue 6, Page(s) 603–606

Abstract: We have developed a novel modification of previous approaches to donor nephrectomy and herein review our original operative procedure. First, the posterior aspect of the kidney was dissected retroperitoneoscopically and dissection of the renal artery, ... ...

Abstract	We have developed a novel modification of previous approaches to donor nephrectomy and herein review our original operative procedure. First, the posterior aspect of the kidney was dissected retroperitoneoscopically and dissection of the renal artery, ureter and gonadal vein was almost completed. Second, the anterior aspect of the kidney was dissected with transperitoneal hand-assistance, and dissection of the renal pedicle from the anterior surface was accomplished easily and safely. This operative procedure was successfully performed for two donors with no intraoperative or postoperative complications. Our modified endoscopic donor nephrectomy is feasible as a minimally invasive procedure because of its safety, and its ability to preserve renal function and establish an excellent operative field for both posterior and anterior aspects of the kidney.
MeSH term(s)	Feasibility Studies ; Humans ; Kidney Transplantation ; Laparoscopy ; Living Donors ; Minimally Invasive Surgical Procedures ; Nephrectomy/methods ; Retroperitoneal Space/surgery
Language	English
Publishing date	2005-06
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	0919-8172
ISSN	0919-8172
DOI	10.1111/j.1442-2042.2005.01099.x
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Article: Differential Impact of Lower Urinary Tract Symptoms on Generic and Disease-Specific Quality of Life in Men and Women

Araki, Isao / Tsuchida, Takayuki / Nomura, Teruhisa / Fukasawa, Mizuya / Takihana, Yoshio / Koyama, Nobuyuki / Takeda, Masayuki

Urologia Internationalis

2008 Volume 81, Issue 1, Page(s) 60–65

Abstract: Introduction: We investigated how generic and disease-specific measures differ in estimating the quality of life (QoL) impact of lower urinary tract symptoms (LUTS). Materials and Methods: A total of 172 men and 67 women ≧40 years old who attended the ... ...

Institution	Department of Urology, Faculty of Medicine, University of Yamanashi, Chuo, and Clinical Pharmacology and Biostatistics Department, Sankyo Co. LTD., Tokyo, Japan
Abstract	Introduction: We investigated how generic and disease-specific measures differ in estimating the quality of life (QoL) impact of lower urinary tract symptoms (LUTS). Materials and Methods: A total of 172 men and 67 women ≧40 years old who attended the public lectures completed the questionnaire comprising the International Prostate Symptom Score, benign prostatic hyperplasia impact index and SF-36 Health Survey. The multiple regression analysis was performed to evaluate the QoL impact of LUTS. Results: Both storage and voiding symptoms showed significant correlations with disease-specific QoL. Among men, voiding symptom correlated more closely with disease-specific QoL than storage symptom did, and this finding was reversed among women. Storage but not voiding symptoms showed a significant correlation with generic QoL. Among men, storage symptom correlated more closely with mental health than physical health, and the reversed finding was obtained among women. Generic QoL, especially physical health, was significantly influenced by some comorbid diseases, but disease-specific QoL was not. Conclusions: The QoL impact of LUTS was differentially estimated by disease-specific and generic measures with sex differences.
Keywords	Lower urinary tract symptoms ; Quality of life ; Questionnaire
Language	English
Publishing date	2008-07-16
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Paper
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000137642
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