Article ; Online: Elevated luminal inorganic phosphate suppresses intestinal Zn absorption in 5/6 nephrectomized rats.
American journal of physiology. Renal physiology
2024 Volume 326, Issue 3, Page(s) F411–F419
Abstract: Zinc (Zn) is an essential trace element in various biological processes. Chronic kidney disease (CKD) often leads to hypozincemia, resulting in further progression of CKD. In CKD, intestinal Zn absorption, the main regulator of systemic Zn metabolism, is ...
| Abstract | Zinc (Zn) is an essential trace element in various biological processes. Chronic kidney disease (CKD) often leads to hypozincemia, resulting in further progression of CKD. In CKD, intestinal Zn absorption, the main regulator of systemic Zn metabolism, is often impaired; however, the mechanism underlying Zn malabsorption remains unclear. Here, we evaluated intestinal Zn absorption capacity in a rat model of CKD induced by 5/6 nephrectomy (5/6 Nx). Rats were given Zn and the incremental area under the plasma Zn concentration-time curve (iAUC) was measured as well as the expression of ZIP4, an intestinal Zn transporter. We found that 5/6 Nx rats showed lower iAUC than sham-operated rats, but expression of ZIP4 protein was upregulated. We therefore focused on other Zn absorption regulators to explore the mechanism by which Zn absorption was substantially decreased. Because some phosphate compounds inhibit Zn absorption by coprecipitation and hyperphosphatemia is a common symptom in advanced CKD, we measured inorganic phosphate (P |
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| MeSH term(s) | Humans ; Rats ; Animals ; Phosphates/metabolism ; Hyperphosphatemia/drug therapy ; Zinc ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/complications ; Nephrectomy/adverse effects ; Intestinal Absorption | |||||
| Chemical Substances | Phosphates ; Zinc (J41CSQ7QDS) | |||||
| Language | English | |||||
| Publishing date | 2024-01-18 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 603837-2 | |||||
| ISSN | 1522-1466 ; 0363-6127 | |||||
| ISSN (online) | 1522-1466 | |||||
| ISSN | 0363-6127 | |||||
| DOI | 10.1152/ajprenal.00310.2023 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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