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  1. Article: Incomplete bowel obstruction caused by sigmoid colon cancer in an inguinal hernia: a case report.

    Sujino, Hiroki / Gon, Hideki / Shimoda, Yota / Takishita, Chie / Enomoto, Masanobu / Tachibana, Shingo / Kasuya, Kazuhiko / Nagakawa, Yuichi

    Surgical case reports

    2024  Volume 10, Issue 1, Page(s) 99

    Abstract: Background: Most colon cancers that develop in the intestinal tract within the inguinal hernia sac are identified by incarceration. However, treatment methods for these cases vary depending on the pathology. Cases showing perforation or abscess ... ...

    Abstract Background: Most colon cancers that develop in the intestinal tract within the inguinal hernia sac are identified by incarceration. However, treatment methods for these cases vary depending on the pathology. Cases showing perforation or abscess formation require emergency surgery for infection control, while cases with no infection generally involve oncological resection, with laparoscopic surgery also being an option. We encountered a case of Incomplete bowel obstruction secondary to sigmoid colon cancer within the hernial sac. We report the process leading to the selection of the treatment method and the surgical technique, along with a review of the literature.
    Case presentation: A 79-year-old man presented to our hospital complaining of a left inguinal bulge (hernia) and pain in the same area. The patient had the hernia for more than 20 years. Using computed tomography, we diagnosed an incomplete bowel obstruction caused by a tumor of the intestinal tract within the hernial sac. Since imaging examination showed no signs of strangulation or perforation, we decided to perform elective surgery after a definitive diagnosis. After colonoscopy, we diagnosed sigmoid colon cancer with extra-serosal invasion; however, we could not insert a colorectal tube. Although we proposed sigmoid resection and temporary ileostomy, we chose the open Hartmann procedure because the patient wanted a single surgery. For the hernia, we simultaneously used the Iliopubic Tract Repair method, which does not require a mesh. Eight months after the surgery, no recurrence of cancer or hernia was observed.
    Conclusions: We report a case of advanced sigmoid colon cancer with a long-standing inguinal hernia that later became incomplete bowel obstruction. Although previous studies have used various approaches among the available surgical methods for cancer within the hernial sac, such as inguinal incision, laparotomy, and laparoscopic surgery, most hernias are repaired during the initial surgery using a non-mesh method. For patients with inguinal hernias that have become difficult to treat, the complications of malignancy should be taken into consideration and the treatment option should be chosen according to the pathophysiology.
    Language English
    Publishing date 2024-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-024-01874-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Significance of Zinc Replacement Therapy After Pancreaticoduodenectomy.

    Takishita, Chie / Nagakawa, Yuichi / Osakabe, Hiroaki / Nakagawa, Nobuhiko / Mitsuka, Yusuke / Mazaki, Junichi / Iwasaki, Kenichi / Ishizaki, Tetsuo / Kozono, Shingo

    Anticancer research

    2022  Volume 42, Issue 12, Page(s) 5833–5837

    Abstract: Background/aim: Recently, a decrease in serum zinc levels and the need for zinc preparations have been reported in the perioperative period of gastrointestinal surgery. In this study, we examined treatment outcomes among patients supplemented with zinc ... ...

    Abstract Background/aim: Recently, a decrease in serum zinc levels and the need for zinc preparations have been reported in the perioperative period of gastrointestinal surgery. In this study, we examined treatment outcomes among patients supplemented with zinc after pancreaticoduodenectomy (PD) and evaluated the significance of zinc replacement therapy.
    Patients and methods: From June 2020 to April 2021, 56 patients who received zinc acetate hydrate (50 mg/day) from postoperative day 3 after PD in our department were retrospectively reviewed. Patients' characteristics and preoperative as well as postoperative data, including serum zinc levels and surgical results at 1 month were reviewed.
    Results: Preoperative zinc deficiency was present in 86.1% (46/56) of the patients. Moreover, despite zinc supplementation, 17.8% (10/56) of patients had postoperative zinc deficiency. A comparison between the low zinc level group (Zn <80 μg/dl) and the normal zinc level group (Zn ≥80 μg/dl) after surgery showed siginificant differences among patients with malignant diseases (vs. benign diseases, p=0.044), those undergoing open surgery (vs. minimally invasive surgery, p=0.036), and those with intraoperative blood loss ≥346 ml (vs. <346 ml: p=0.041) in the univariate analysis. Multivariate analysis revealed that zinc deficiency was significantly associated with open surgery [odds ratio (OR)=15.885, 95% confidence interval (CI)=1.77-142.01, p=0.013] and intraoperative blood loss (OR=9.329, 95% CI=1.50-57.74, p=0.016).
    Conclusion: In patients undergoing open PD for pancreatic cancer, zinc preparations of 50 mg may not be sufficient and further supplementation may be necessary.
    MeSH term(s) Humans ; Pancreaticoduodenectomy/adverse effects ; Zinc/therapeutic use ; Blood Loss, Surgical ; Retrospective Studies ; Pancreatectomy ; Malnutrition
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-12-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical feasibility of endoscopic ultrasound-guided biliary drainage for preoperative management of malignant biliary obstruction (with videos).

    Mukai, Shuntaro / Itoi, Takao / Tsuchiya, Takayoshi / Ishii, Kentaro / Tonozuka, Ryosuke / Nagakawa, Yuichi / Kozono, Shingo / Takishita, Chie / Osakabe, Hiroaki / Sofuni, Atsushi

    Journal of hepato-biliary-pancreatic sciences

    2022  Volume 30, Issue 7, Page(s) 983–992

    Abstract: Background/purpose: EUS-guided biliary drainage (EUS-BD) has recently been reported to be a useful salvage technique after ERCP fail. However, data on EUS-BD used for preoperative biliary drainage (PBD) are limited. The aim of this study was to verify ... ...

    Abstract Background/purpose: EUS-guided biliary drainage (EUS-BD) has recently been reported to be a useful salvage technique after ERCP fail. However, data on EUS-BD used for preoperative biliary drainage (PBD) are limited. The aim of this study was to verify the clinical feasibility of EUS-BD for PBD.
    Methods: PBD was performed for malignant biliary obstruction in 318 patients at our institution between July 2014 and April 2022. Fifteen (4.7%) of these patients underwent surgical resection after preoperative EUS-BD (HGS 13; HDS 1; AGS with HGS 1) and were retrospectively analyzed.
    Results: The stent was successfully placed in all 15 cases with a median procedure time of 15 min (technical success rate 100%). The median total bilirubin value decreased significantly from 3.7 before drainage to 0.9 after surgery (p < .001) and cholangitis was well managed (clinical success rate 100%). Surgery was performed at a median of 22 days after drainage, and there were no stent-related adverse events or recurrences of biliary obstruction. Severe surgery-related adverse events occurred in three cases, but none were associated with EUS-BD. The stent was removed during surgery in 12 cases.
    Conclusions: EUS-BD can be a feasible and safe alternative method of PBD for malignant biliary obstruction after ERCP fail.
    MeSH term(s) Humans ; Retrospective Studies ; Feasibility Studies ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Cholestasis/diagnostic imaging ; Cholestasis/etiology ; Cholestasis/surgery ; Drainage/methods ; Ultrasonography, Interventional ; Endosonography/methods ; Stents/adverse effects
    Language English
    Publishing date 2022-12-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2536236-7
    ISSN 1868-6982 ; 1868-6974
    ISSN (online) 1868-6982
    ISSN 1868-6974
    DOI 10.1002/jhbp.1292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prospective evaluation of common hepatic duct histopathology at the time of choledochal cyst excision ranging from children to adults.

    Nikai, Koki / Koga, Hiroyuki / Suda, Kazuto / Miyahara, Katsumi / Lane, Geoffrey J / Arakawa, Atsushi / Fukumura, Yuki / Saiura, Akio / Hayashi, Yutaka / Nagakawa, Yuichi / Okazaki, Tadaharu / Takishita, Chie / Yanai, Toshihiro / Yamataka, Atsuyuki

    Pediatric surgery international

    2023  Volume 40, Issue 1, Page(s) 15

    Abstract: Purpose: To evaluate common hepatic duct just distal to the HE anastomosis (d-CHD) prospectively for mucosal damage, inflammation, fibrosis, dysplasia, carcinoma in situ, malignant transformation, effects of serum amylase, and symptoms at presentation ... ...

    Abstract Purpose: To evaluate common hepatic duct just distal to the HE anastomosis (d-CHD) prospectively for mucosal damage, inflammation, fibrosis, dysplasia, carcinoma in situ, malignant transformation, effects of serum amylase, and symptoms at presentation in CC cases ranging from children to adults.
    Methods: Cross-sections of d-CHD obtained at cyst excision 2018-2023 from 65 CC patients; 40 children (< 15 years old), 25 adults (≥ 15) were examined with hematoxylin and eosin, Ki-67, S100P, IMP3, p53, and Masson's trichrome to determine an inflammation score (IS), fibrosis score (FS), and damaged mucosa rate (DMR; damaged mucosa expressed as a percentage of the internal circumference).
    Results: Mean age at cyst excision ("age") was 18.2 years (range: 3 months-74 years). Significant inverse correlations were found for age and DMR (p = 0.002), age and IS (p = 0.011), and age and Ki-67 (p = 0.01). FS did not correlate with age (p = 0.32) despite significantly increased IS in children. Dysplasia was identified in a 4-month-old girl with cystic CC. Serum amylase was elevated in high DMR subjects.
    Conclusions: High DMR, high IS, and evidence of dysplasia in pediatric CC suggest children are at risk for serious sequelae best managed by precise histopathology, protocolized follow-up, and awareness that premalignant histopathology can arise in infancy.
    MeSH term(s) Female ; Humans ; Adult ; Child ; Infant ; Adolescent ; Hepatic Duct, Common ; Choledochal Cyst/surgery ; Ki-67 Antigen ; Inflammation ; Fibrosis ; Amylases
    Chemical Substances Ki-67 Antigen ; Amylases (EC 3.2.1.-)
    Language English
    Publishing date 2023-11-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-023-05589-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pancreaticoduodenectomy for preservation of fat-replaced pancreatic body and tail tissue in a patient with solid pseudopapillary neoplasm: a case report.

    Sakurai, Toru / Nagakawa, Yuichi / Takishita, Chie / Osakabe, Hiroaki / Nishino, Hitoe / Akashi, Masanori / Okazaki, Naoto / Suzuki, Kenta / Katsumata, Kenji / Tsuchida, Akihiko

    Surgical case reports

    2020  Volume 6, Issue 1, Page(s) 134

    Abstract: Background: There is no standard surgical method for treating pancreatic head tumors with fat replacement of the pancreatic body and tail. Total pancreatectomy procedures are usually performed to excise pancreatic head tumors and lead to endocrine ... ...

    Abstract Background: There is no standard surgical method for treating pancreatic head tumors with fat replacement of the pancreatic body and tail. Total pancreatectomy procedures are usually performed to excise pancreatic head tumors and lead to endocrine function loss and subsequent development of diabetes. We present a rare case where the adipose tissue was preserved during pancreaticoduodenectomy in a patient with a solid pseudopapillary neoplasm and fat-replaced pancreatic body and tail.
    Case presentation: Contrast-enhanced computed tomography scans of a 43-year-old man revealed a tumor measuring approximately 3 cm in size with calcification in the pancreatic head. Magnetic resonance cholangiopancreatography showed that the pancreatic ducts in the body and tail were completely disrupted. Furthermore, endoscopic ultrasonography showed no pancreatic parenchyma in the body and tail of the pancreas, with disruption in the main pancreatic duct. Endoscopic ultrasonography-guided fine-needle aspiration led to the final pathological diagnosis of a solid pseudopapillary neoplasm, and laparoscopic total pancreatectomy was performed. However, intraoperative findings indicated that the tumor was located in the pancreatic head. Pancreatic parenchyma was not observed in the pancreatic body or tail, as it had been completely replaced with adipose tissue. Nevertheless, the shape of the pancreas was identifiable. Therefore, pancreaticoduodenectomy was performed to transect parenchyma at the pancreatic neck, while preserving the adipose tissue present in the pancreatic body. The main pancreatic duct could not be identified at the cut surface. Therefore, we performed modified Blumgart-style pancreaticojejunostomy to cover the cut end instead of reconstructing the pancreatic duct. The patient was discharged on postoperative day 12 without complications and is being followed-up as an outpatient. His fasting blood sugar and hemoglobin A1c levels according to the National Glycohemoglobin Standardization Program reports were within normal limits, indicating that the endocrine function (insulin secretion ability) was preserved during the 1.5 years following surgery.
    Conclusions: In patients with pancreatic head tumors, pancreaticoduodenectomy that preserves fat-replaced pancreatic body and tail tissues can preserve postoperative endocrine function.
    Language English
    Publishing date 2020-06-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-020-00894-x
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  6. Article ; Online: Safe exposure of the left renal vein during laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: anatomical variations and pitfalls.

    Nishino, Hitoe / Nagakawa, Yuichi / Takishita, Chie / Kozono, Shingo / Osakabe, Hiroaki / Nakagawa, Naoya / Suzuki, Kenta / Katsumata, Kenji / Tsuchida, Akihiko

    Surgery today

    2020  Volume 50, Issue 12, Page(s) 1664–1671

    Abstract: Purpose: The left renal vein is technically difficult to expose during laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma despite being an important landmark for posterior dissection. We hereby propose a novel technique to safely ... ...

    Abstract Purpose: The left renal vein is technically difficult to expose during laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma despite being an important landmark for posterior dissection. We hereby propose a novel technique to safely expose the left renal vein while avoiding the associated anatomical pitfalls.
    Methods: The anatomy of the left renal artery and vein was analyzed using multidetector computed tomography. We initially exposed the left renal vein on the left posterior side of the superior mesenteric artery followed by exposure toward the left kidney. We retrospectively examined the perioperative results of this technique in 33 patients who underwent laparoscopic distal pancreatectomy.
    Results: 15.7% of the patients had an accessory left renal artery coursing cranial to the vein. In 43.1%, the left renal arterial branch ventrally traversed the vein at the renal hilum, thereby posing a risk for arterial injury. The location of the left renal vein varies cranial (17.6%) or caudal (82.4%) to the pancreas. The left renal vein was exposed without any vascular injury using this technique. The median operative time was 259 min, blood loss was 18 mL, and R0 resection rate was 97.0%.
    Conclusions: The initial exposure of the left renal vein should, therefore, be on the left posterior side of the superior mesenteric artery.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anatomic Variation ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/surgery ; Female ; Humans ; Laparoscopy/methods ; Male ; Mesenteric Artery, Superior/anatomy & histology ; Middle Aged ; Multidetector Computed Tomography ; Pancreas/blood supply ; Pancreas/surgery ; Pancreatectomy/methods ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/surgery ; Renal Artery/anatomy & histology ; Renal Artery/diagnostic imaging ; Renal Veins/anatomy & histology ; Renal Veins/diagnostic imaging ; Retrospective Studies ; Safety
    Language English
    Publishing date 2020-06-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1115435-4
    ISSN 1436-2813 ; 0941-1291
    ISSN (online) 1436-2813
    ISSN 0941-1291
    DOI 10.1007/s00595-020-02053-z
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  7. Article ; Online: Preoperative cholangitis is associated with increased surgical site infection following pancreaticoduodenectomy.

    Akashi, Masanori / Nagakawa, Yuichi / Hosokawa, Yuichi / Takishita, Chie / Osakabe, Hiroaki / Nishino, Hitoe / Katsumata, Kenji / Akagi, Yoshito / Itoi, Takao / Tsuchida, Akihiko

    Journal of hepato-biliary-pancreatic sciences

    2020  Volume 27, Issue 9, Page(s) 640–647

    Abstract: Background: Few reports describe the relationship between preoperative cholangitis and surgical site infections (SSIs) after pancreaticoduodenectomy (PD). We aimed to determine the association between the incidence of preoperative cholangitis and ... ...

    Abstract Background: Few reports describe the relationship between preoperative cholangitis and surgical site infections (SSIs) after pancreaticoduodenectomy (PD). We aimed to determine the association between the incidence of preoperative cholangitis and surgical site infection following PD.
    Methods: The surgical outcomes of 359 patients who underwent PD were compared between patients with (n = 92) and without (n = 267) preoperative cholangitis. Bacterial cultures from the postoperative drainage fluid were examined. Risk factors for postoperative infectious complication were evaluated.
    Results: The incidence of postoperative infectious complications including grade B/C postoperative pancreatic fistula was high among patients with preoperative cholangitis (P < .01). The positive rate of bacterial culture in the drainage fluid until postoperative day 3 (P < .01) and the detection rate of Enterococcus species (P < .01) were higher in the preoperative cholangitis group. The most common cause of preoperative cholangitis was drainage device dysfunction mainly with plastic stent occlusion. In the multivariate analysis, preoperative cholangitis (odds ratio 2.04, 95% confidence interval 1.13 to 3.69; P = .02) was an independent risk factor for postoperative infectious complications.
    Conclusions: Preoperative cholangitis significantly increased ascitic bacterial contamination and the incidence of postoperative infectious complications. after PD. Appropriate preoperative biliary drainage for the prevention of preoperative cholangitis is important for improving outcomes after PD.
    MeSH term(s) Cholangitis/epidemiology ; Cholangitis/etiology ; Drainage ; Humans ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Preoperative Care ; Retrospective Studies ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology
    Language English
    Publishing date 2020-07-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2536236-7
    ISSN 1868-6982 ; 1868-6974
    ISSN (online) 1868-6982
    ISSN 1868-6974
    DOI 10.1002/jhbp.783
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  8. Article ; Online: Clinical impact of pancreaticoduodenectomy for pancreatic cancer with resection of the secondary or later branches of the superior mesenteric vein.

    Honda, Masayuki / Nagakawa, Yuichi / Akashi, Masanori / Hosokawa, Yuichi / Osakabe, Hiroaki / Takishita, Chie / Nishino, Hitoe / Tsuchida, Akihiko

    Journal of hepato-biliary-pancreatic sciences

    2020  Volume 27, Issue 10, Page(s) 731–738

    Abstract: Purpose: To evaluate the feasibility of pancreaticoduodenectomy with resection of the second jejunal vein (J2V) for pancreatic ductal adenocarcinoma (PDAC).: Methods: Among 114 patients with PDAC undergoing pancreaticoduodenectomy with portal- ... ...

    Abstract Purpose: To evaluate the feasibility of pancreaticoduodenectomy with resection of the second jejunal vein (J2V) for pancreatic ductal adenocarcinoma (PDAC).
    Methods: Among 114 patients with PDAC undergoing pancreaticoduodenectomy with portal-superior mesenteric vein resection (PVR), surgical outcomes, and prognoses of 10 patients with resection of J2V or later branches of the superior mesenteric vein (J2VR) were compared to 104 patients with PVR above J2V (standard PVR). The reconstruction methods in the J2VR group were reviewed.
    Results: There were no significant differences in the operative time (470 vs 435 min), morbidity (30% vs 27%), presence of portal vein stenosis (10% vs 5%) or thrombosis (10% vs 1%), and induction of adjuvant therapy (80% vs 88%) between the J2VR and standard PVR groups, although blood loss was higher in the J2VR group (1184 vs 494 ml; P = .002). R0 proportion and 2-year survival rates were not significantly worse in the J2VR group compared to the standard PVR group (90 and 88%; 67 and 45%, respectively). At least one branch of the superior mesenteric vein was reconstructed in the J2VR group.
    Conclusion: Pancreaticoduodenectomy with J2VR for PDAC can be safely performed with a satisfactory overall survival rate.
    MeSH term(s) Adenocarcinoma/surgery ; Humans ; Mesenteric Veins/surgery ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy ; Portal Vein/surgery ; Treatment Outcome
    Language English
    Publishing date 2020-07-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2536236-7
    ISSN 1868-6982 ; 1868-6974
    ISSN (online) 1868-6982
    ISSN 1868-6974
    DOI 10.1002/jhbp.789
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  9. Article ; Online: Neuroendocrine carcinoma of the common bile duct associated with congenital bile duct dilatation: a case report.

    Kiya, Yoshitaka / Nagakawa, Yuichi / Takishita, Chie / Osakabe, Hiroaki / Nishino, Hitoe / Akashi, Masanori / Yamaguchi, Hiroshi / Nagao, Toshitaka / Oono, Ryo / Katsumata, Kenji / Tsuchida, Akihiko

    BMC gastroenterology

    2021  Volume 21, Issue 1, Page(s) 257

    Abstract: Background: Cholangiocarcinoma is frequently observed in patients with congenital bile duct dilatation (CBDD). Most cholangiocarcinomas are adenocarcinomas. Other types, especially neuroendocrine carcinomas (NECs), are rare. To the best of our knowledge, ...

    Abstract Background: Cholangiocarcinoma is frequently observed in patients with congenital bile duct dilatation (CBDD). Most cholangiocarcinomas are adenocarcinomas. Other types, especially neuroendocrine carcinomas (NECs), are rare. To the best of our knowledge, this is the third reported case of an NEC of the common bile duct associated with CBDD and the first to receive adjuvant chemotherapy for advanced disease.
    Case presentation: A 29-year-old woman presented with upper abdominal pain. Preoperative imaging indicated marked dilatation of the common bile duct and a tumor in the middle portion of the common bile duct. She was suspected of having distal cholangiocarcinoma associated with CBDD and underwent pylorus-preserving pancreaticoduodenectomy. Pathological and immunohistological findings led to a final diagnosis of large-cell NEC (pT3aN1M0 pStageIIB). The postoperative course was uneventful, and she was administered cisplatin and irinotecan every 4 weeks (four cycles) as adjuvant chemotherapy. She has remained recurrence-free for 16 months.
    Conclusions: NEC might be a differential diagnosis in cases of cholangial tumor associated with congenital bile duct dilatation. This presentation is rare and valuable, and to establish better treatment for NEC, further reports are necessary.
    MeSH term(s) Adult ; Bile Duct Neoplasms/surgery ; Bile Ducts, Extrahepatic ; Bile Ducts, Intrahepatic ; Carcinoma, Neuroendocrine/diagnostic imaging ; Carcinoma, Neuroendocrine/surgery ; Common Bile Duct/diagnostic imaging ; Common Bile Duct/surgery ; Dilatation ; Female ; Humans ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2021-06-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-230X
    ISSN (online) 1471-230X
    DOI 10.1186/s12876-021-01777-7
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  10. Article: Reconsideration of the Appropriate Dissection Range Based on Japanese Anatomical Classification for Resectable Pancreatic Head Cancer in the Era of Multimodal Treatment.

    Nagakawa, Yuichi / Nakagawa, Naoya / Takishita, Chie / Uyama, Ichiro / Kozono, Shingo / Osakabe, Hiroaki / Suzuki, Kenta / Nakagawa, Nobuhiko / Hosokawa, Yuichi / Shirota, Tomoki / Honda, Masayuki / Yamada, Tesshi / Katsumata, Kenji / Tsuchida, Akihiko

    Cancers

    2021  Volume 13, Issue 14

    Abstract: Patients with resectable pancreatic cancer are considered to already have micro-distant metastasis, because most of the recurrence patterns postoperatively are distant metastases. Multimodal treatment dramatically improves prognosis; thus, micro-distant ... ...

    Abstract Patients with resectable pancreatic cancer are considered to already have micro-distant metastasis, because most of the recurrence patterns postoperatively are distant metastases. Multimodal treatment dramatically improves prognosis; thus, micro-distant metastasis is considered to be controlled by chemotherapy. The survival benefit of "regional lymph node dissection" for pancreatic head cancer remains unclear. We reviewed the literature that could be helpful in determining the appropriate resection range. Regional lymph nodes with no suspected metastases on preoperative imaging may become areas treated with preoperative and postoperative adjuvant chemotherapy. Many studies have reported that the R0 resection rate is associated with prognosis. Thus, "dissection to achieve R0 resection" is required. The recent development of high-quality computed tomography has made it possible to evaluate the extent of cancer infiltration. Therefore, it is possible to simulate the dissection range to achieve R0 resection preoperatively. However, it is often difficult to distinguish between areas of inflammatory changes and cancer infiltration during resection. Even if the "dissection to achieve R0 resection" range is simulated based on the computed tomography evaluation, it is difficult to identify the range intraoperatively. It is necessary to be aware of anatomical landmarks to determine the appropriate dissection range during surgery.
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13143605
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