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Article: [Epidemiological study on cardiovascular and renal diseases in Okinawa].

Takishita, Shuichi

Nihon rinsho. Japanese journal of clinical medicine

2006 Volume 64 Suppl 6, Page(s) 126–130

MeSH term(s)	Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/epidemiology ; Hypertension/etiology ; Japan/epidemiology ; Kidney Diseases/epidemiology ; Kidney Diseases/etiology ; Longitudinal Studies ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Obesity/complications ; Obesity/epidemiology ; Proteinuria/complications ; Proteinuria/epidemiology ; Risk Factors
Language	Japanese
Publishing date	2006-08
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article: [Usefulness of long-acting Ca antagonist in hypertensive patients with metabolic syndrome].

Takishita, Shuichi

Nihon rinsho. Japanese journal of clinical medicine

2006 Volume 64 Suppl 9, Page(s) 607–610

MeSH term(s)	Antihypertensive Agents/administration & dosage ; Calcium Channel Blockers/administration & dosage ; Delayed-Action Preparations ; Humans ; Hypertension/drug therapy ; Metabolic Syndrome/complications
Chemical Substances	Antihypertensive Agents ; Calcium Channel Blockers ; Delayed-Action Preparations
Language	Japanese
Publishing date	2006-12-28
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article ; Online: Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat.

Yamazato, Masanobu / Nakamoto, Minori / Sakima, Atsushi / Yamazato, Yoriko / Takishita, Shuichi / Ohya, Yusuke

Clinical and experimental hypertension (New York, N.Y. : 1993)

2018 Volume 41, Issue 3, Page(s) 255–262

Abstract: Stimulation of α2-adrenoceptor/I1-imidazoline receptors in the rostral ventrolateral medulla decreases the blood pressure via sympathoinhibition. However, alteration of receptor responses in genetically hypertensive rats remains unclear. We examined ... ...

Abstract	Stimulation of α2-adrenoceptor/I1-imidazoline receptors in the rostral ventrolateral medulla decreases the blood pressure via sympathoinhibition. However, alteration of receptor responses in genetically hypertensive rats remains unclear. We examined cardiovascular responses of α2-adrenoceptor/I1-imidazoline receptor agonist and antagonists microinjected into the rostral ventrolateral medulla of conscious spontaneously hypertensive rats and normotensive Wistar Kyoto rats. Injection of 2-nmol clonidine-an α2-adrenoceptor/I1-imidazoline receptor agonist-unilaterally into the rostral ventrolateral medulla decreased the blood pressure, heart rate, and renal sympathetic nerve activity; the responses were significantly enhanced in spontaneously hypertensive rats than in Wistar Kyoto rats. Co-injection of 2-nmol 2-methoxyidazoxan (a selective α2-adrenoceptor antagonist) or 2-nmol efaroxan (an I1-receptor antagonist) with 2 nmol of clonidine attenuated the hypotensive and bradycardic effects of clonidine-only injection. Injection of 2-methoxyidazoxan alone increased the blood pressure and heart rate in spontaneously hypertensive rats, but not in Wistar Kyoto rats. These results suggest enhanced responsiveness of α2-adrenoceptor/I1-imidazoline receptors in the rostral ventrolateral medulla of spontaneously hypertensive rats.
MeSH term(s)	Animals ; Antihypertensive Agents/pharmacology ; Benzofurans/pharmacology ; Blood Pressure/drug effects ; Blood Pressure Determination ; Clonidine/pharmacology ; Consciousness/physiology ; Heart Rate/drug effects ; Hypertension/drug therapy ; Hypertension/physiopathology ; Idazoxan/analogs & derivatives ; Idazoxan/pharmacology ; Imidazoles/pharmacology ; Imidazoline Receptors/physiology ; Male ; Medulla Oblongata/physiology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptors, Adrenergic, alpha-2/physiology ; Sympathetic Nervous System/drug effects
Chemical Substances	Antihypertensive Agents ; Benzofurans ; Imidazoles ; Imidazoline Receptors ; Receptors, Adrenergic, alpha-2 ; imidazoline I1 receptors ; 2-methoxyidazoxan (E27LB7P0ET) ; efaroxan (G00490L21H) ; Clonidine (MN3L5RMN02) ; Idazoxan (Y310PA316B)
Language	English
Publishing date	2018-05-15
Publishing country	England
Document type	Journal Article ; Video-Audio Media
ZDB-ID	604757-9
ISSN	1525-6006 ; 0730-0077
ISSN (online)	1525-6006
ISSN	0730-0077
DOI	10.1080/10641963.2018.1469641
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Article: [Therapeutic strategy for morning blood pressure elevation in elderly hypertensives].

Sakima, Atsushi / Takishita, Shuichi

Nihon rinsho. Japanese journal of clinical medicine

2005 Volume 63, Issue 6, Page(s) 1086–1090

Abstract: Although the cardiovascular events such as stroke, angina pectoris and myocardial infarction can occur at any time of day, it has been known that the peak incidence of the cardiovascular events increases during the morning period. In elderly ... ...

Abstract	Although the cardiovascular events such as stroke, angina pectoris and myocardial infarction can occur at any time of day, it has been known that the peak incidence of the cardiovascular events increases during the morning period. In elderly hypertensives, a greater morning blood pressure surge is associated with an advanced silent cerebrovascular disease as well as a higher incidence of stroke. Thus, the blood pressure control of the early morning period may become an important therapeutic strategy for preventing the cardiovascular events. In this review, we focused on the recent strategy for morning blood pressure rising in the elderly hypertensives.
MeSH term(s)	Adrenergic alpha-Antagonists/administration & dosage ; Aged ; Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin-Converting Enzyme Inhibitors/administration & dosage ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Circadian Rhythm ; Clinical Trials as Topic ; Doxazosin/administration & dosage ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/etiology ; Hypertension/physiopathology ; Renin-Angiotensin System/physiology ; Risk Factors ; Stroke/etiology ; Stroke/prevention & control ; Sympathetic Nervous System/physiology
Chemical Substances	Adrenergic alpha-Antagonists ; Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Doxazosin (NW1291F1W8)
Language	Japanese
Publishing date	2005-06
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article: [Centrally-acting antihypertensive drugs].

Takishita, Shuichi / Yamazato, Masanobu

Nihon rinsho. Japanese journal of clinical medicine

2004 Volume 62 Suppl 3, Page(s) 591–595

MeSH term(s)	Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Clonidine/administration & dosage ; Clonidine/adverse effects ; Clonidine/pharmacology ; Guanabenz/administration & dosage ; Guanabenz/adverse effects ; Guanabenz/pharmacology ; Guanfacine/administration & dosage ; Guanfacine/adverse effects ; Guanfacine/pharmacology ; Humans ; Hypertension/drug therapy ; Hypertension/etiology ; Imidazoline Receptors ; Kidney/metabolism ; Methyldopa/administration & dosage ; Methyldopa/adverse effects ; Methyldopa/pharmacology ; Norepinephrine/secretion ; Pressoreceptors/physiopathology ; Receptors, Drug/agonists ; Renal Circulation/drug effects ; Sodium/metabolism ; Sympathetic Nervous System/drug effects ; Sympathetic Nervous System/physiopathology ; Sympatholytics/administration & dosage ; Sympatholytics/adverse effects ; Sympatholytics/pharmacology ; Vascular Resistance
Chemical Substances	Antihypertensive Agents ; Imidazoline Receptors ; Receptors, Drug ; Sympatholytics ; Guanfacine (30OMY4G3MK) ; Methyldopa (56LH93261Y) ; Sodium (9NEZ333N27) ; Guanabenz (GGD30112WC) ; Clonidine (MN3L5RMN02) ; Norepinephrine (X4W3ENH1CV)
Language	Japanese
Publishing date	2004-03
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article: Progression of renal failure delayed by use of losartan in a case of IgA nephropathy.

Iseki, Kunitoshi / Takishita, Shuichi

Internal medicine (Tokyo, Japan)

2002 Volume 41, Issue 12, Page(s) 1167–1170

Abstract: We report a case of IgA nephropathy with renal failure in which the deterioration of renal function was inhibited by the addition of angiotensin II receptor blocker (ARB) losartan. Before administration of losartan, the mean decline in the patient's ... ...

Abstract	We report a case of IgA nephropathy with renal failure in which the deterioration of renal function was inhibited by the addition of angiotensin II receptor blocker (ARB) losartan. Before administration of losartan, the mean decline in the patient's glomerular filtration rate (GFR) was 0.64 ml/min/1.73 m2/month. Losartan treatment was started when serum creatinine rose above 4.0 mg/dl. With this treatment the serum creatinine level has remained stable for 3.5 years, and the mean decline in GFR was 0.06 ml/min/1.73 m2/month. We document successful retardation of renal failure with the use of losartan. Our experience suggests that dialysis therapy can be delayed significantly in patients using this drug.
MeSH term(s)	Adult ; Angiotensin Receptor Antagonists ; Antihypertensive Agents/therapeutic use ; Chronic Disease ; Creatinine/blood ; Disease Progression ; Female ; Glomerular Filtration Rate/drug effects ; Glomerulonephritis, IGA/blood ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/drug therapy ; Humans ; Losartan/therapeutic use ; Renal Insufficiency/blood ; Renal Insufficiency/drug therapy ; Renal Insufficiency/etiology
Chemical Substances	Angiotensin Receptor Antagonists ; Antihypertensive Agents ; Creatinine (AYI8EX34EU) ; Losartan (JMS50MPO89)
Language	English
Publishing date	2002-12-24
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	0918-2918 ; 0021-5120
ISSN	0918-2918 ; 0021-5120
DOI	10.2169/internalmedicine.41.1167
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Article ; Online: Differences in 24-h blood pressure profile of Japanese hypertensive patients under ARB treatment.

Kita, Toshihiro / Sakima, Atsushi / Yokota, Naoto / Tamaki, Noboru / Etoh, Takuma / Shimokubo, Toru / Nakada, Seigo / Takishita, Shuichi / Ohya, Yusuke / Kitamura, Kazuo

Clinical and experimental hypertension (New York, N.Y. : 1993)

2015 Volume 37, Issue 7, Page(s) 574–579

Abstract: Blood pressure (BP) control throughout the entire day is recommended for cardiovascular protection. Angiotensin-II receptor blockers (ARBs) are widely used in hypertensive patients because of beneficial class effects. It is uncertain, however, whether ... ...

Abstract	Blood pressure (BP) control throughout the entire day is recommended for cardiovascular protection. Angiotensin-II receptor blockers (ARBs) are widely used in hypertensive patients because of beneficial class effects. It is uncertain, however, whether are there any differences in 24-h BP profiles among ARBs. We examined ambulatory blood pressure monitoring (ABPM) among 211 Japanese hypertensive patients (age, 69.4 ± 9.6 years; female, 59.2%) under treatment with five different ARBs. Patients were divided into five groups according to ARBs prescribed. Patient backgrounds were almost identical in all the groups and there were no differences in office, 24-h and daytime BP; however, nighttime BP with olmesartan was significantly lower than with other ARBs. Office BPs with candesartan and telmisartan, but not other ARBs, correlated well with 24-h BP (p < 0.01). Also, there were higher correlations between daytime and nighttime BP with candesartan and telmisartan. In all patients, pulse pressure with office BP was significantly correlated with ambulatory arterial stiffness index (p = 0.001) and fluctuation of systolic BP on ABPM (p = 0.002). In conclusion, different ARB treatments produced meaningful differences in 24-h profiles.
MeSH term(s)	Aged ; Angiotensin Receptor Antagonists/administration & dosage ; Angiotensin Receptor Antagonists/pharmacokinetics ; Benzimidazoles/administration & dosage ; Benzimidazoles/pharmacokinetics ; Blood Pressure/drug effects ; Blood Pressure Monitoring, Ambulatory/methods ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/physiopathology ; Imidazoles/administration & dosage ; Imidazoles/pharmacokinetics ; Japan/epidemiology ; Male ; Middle Aged ; Tetrazoles/administration & dosage ; Tetrazoles/pharmacokinetics ; Therapeutic Equivalency
Chemical Substances	Angiotensin Receptor Antagonists ; Benzimidazoles ; Imidazoles ; Tetrazoles ; olmesartan (8W1IQP3U10) ; candesartan (S8Q36MD2XX)
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	604757-9
ISSN	1525-6006 ; 0730-0077
ISSN (online)	1525-6006
ISSN	0730-0077
DOI	10.3109/10641963.2015.1026042
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Article ; Online: Prevalence of anemia according to stage of chronic kidney disease in a large screening cohort of Japanese.

Kohagura, Kentaro / Tomiyama, Nozomi / Kinjo, Kozen / Takishita, Shuichi / Iseki, Kunitoshi

Clinical and experimental nephrology

2009 Volume 13, Issue 6, Page(s) 614–620

Abstract: Background: The prevalence of chronic kidney disease (CKD) is high in developed countries, including Japan. However, little is known about the prevalence of anemia according to the estimated glomerular filtration rate (eGFR) among Japanese.: Methods: ...

Abstract	Background: The prevalence of chronic kidney disease (CKD) is high in developed countries, including Japan. However, little is known about the prevalence of anemia according to the estimated glomerular filtration rate (eGFR) among Japanese. Methods: We studied screenees on the Okinawa General Health Maintenance Association (OGHMA) registry in 1993 (N = 94,602; 54,848 women and 39,754 men) who had both serum creatinine and hematocrit data. Anemia was defined as follows: hematocrit level <40% in men, <32% in women aged <50 years, and <35% in women aged >or=50 years. GFR was estimated using a new Japanese equation: eGFR (ml/min per 1.73 m(2)) = 194 x serum creatinine(1.094) x age(0.287) x 0.739 (if female). Results: The prevalence of anemia clearly increased as CKD progressed below an eGFR of 60 ml/min per 1.73 m(2) in both genders. Logistic analysis adjusted with body mass index and older age (>or=70 years) revealed that the odds ratio for complications of anemia was significantly increased below an eGFR of 45 ml/min per 1.73 m(2) in women and 90 ml/min per 1.73 m(2) in men. The association of lower kidney function with anemia was found to be more prevalent: adjusted odds ratio >or=2.0, from approximately 50 ml/min per 1.73 m(2). Conclusion: The present study suggested that there might be as many as 1,000,000 people with CKD stage 3-5 complicated with anemia in Japan.
MeSH term(s)	Adult ; Aged ; Anemia/complications ; Anemia/epidemiology ; Asian Continental Ancestry Group ; Body Mass Index ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Humans ; Japan/epidemiology ; Kidney Failure, Chronic/epidemiology ; Male ; Mass Screening ; Middle Aged ; Prevalence ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology
Language	English
Publishing date	2009-06-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-009-0197-z
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Zs.A 4922: Show issues

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Article ; Online: Dietary intervention with Okinawan vegetables increased circulating endothelial progenitor cells in healthy young women.

Mano, Rieko / Ishida, Akio / Ohya, Yusuke / Todoriki, Hidemi / Takishita, Shuichi

Atherosclerosis

2009 Volume 204, Issue 2, Page(s) 544–548

Abstract: Objective: Circulating endothelial progenitor cells (EPCs) play a critical role in maintaining the integrity of vascular vessels. The number of EPCs inversely correlates with the number of atherosclerotic risk factors. Although nonpharmacological ... ...

Abstract	Objective: Circulating endothelial progenitor cells (EPCs) play a critical role in maintaining the integrity of vascular vessels. The number of EPCs inversely correlates with the number of atherosclerotic risk factors. Although nonpharmacological treatment represents the first approach to the primary prevention of atherosclerotic diseases, little is known about the effects of diet on EPCs. We investigated the effect of a dietary intervention with vegetables that are commonly eaten in Okinawa on the number of EPCs. Methods and results: Forty-five healthy young women were employed and randomized to a dietary intervention group (n=24) or a control group (n=21). Subjects in the intervention group received typical Okinawan vegetables through home-parcel delivery for 2 weeks. After the dietary intervention, urinary potassium and magnesium excretion increased only in the intervention group and changes were greater than in the control group (p=0.007, 0.010, respectively). The consumption of total vegetables correlated with changes in both urinary potassium and magnesium excretion. Serum folic acid increased and plasma homocysteine decreased in both groups but the change was significant only in the intervention group. The EPCs number significantly increased in the intervention group but did not in the control group. An inverse correlation was observed between EPC number and plasma homocysteine level (r=-0.272, p=0.016). Changes in the EPC number inversely correlated with changes in both serum total cholesterol and low-density lipoprotein cholesterol level (r=-0.555, p=0.0002; r=-0.626, p<0.0001, respectively). Conclusions: The consumption of vegetables increased the number of circulating EPCs; this change might be associated with a homocysteine-lowering effect.
MeSH term(s)	Adult ; Biomarkers/blood ; Biomarkers/urine ; Cell Count ; Cholesterol/blood ; Cholesterol, LDL/blood ; Diet ; Endothelial Cells/physiology ; Female ; Folic Acid/blood ; Homocysteine/blood ; Humans ; Japan ; Magnesium/urine ; Potassium/urine ; Reactive Oxygen Species/blood ; Stem Cells/physiology ; Vegetables ; Young Adult
Chemical Substances	Biomarkers ; Cholesterol, LDL ; Reactive Oxygen Species ; Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8) ; Cholesterol (97C5T2UQ7J) ; Magnesium (I38ZP9992A) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2009-06
Publishing country	Ireland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2008.09.035
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Article: A randomised controlled trial for the evaluation of risk for type 2 diabetes in hypertensive patients receiving thiazide diuretics: Diuretics In the Management of Essential hypertension (DIME) study.

Ueda, Shinichiro / Morimoto, Takeshi / Ando, Shin-Ichi / Takishita, Shu-Ichi / Kawano, Yuhei / Shimamoto, Kazuaki / Ogihara, Toshio / Saruta, Takao

BMJ open

2014 Volume 4, Issue 7, Page(s) e004576

Abstract: Objectives: Thiazide diuretics are one of the first choice antihypertensives but not optimally utilised because of concerns regarding their adverse effects on glucose metabolism. The Diuretics In the Management of Essential hypertension (DIME) study was ...

Abstract	Objectives: Thiazide diuretics are one of the first choice antihypertensives but not optimally utilised because of concerns regarding their adverse effects on glucose metabolism. The Diuretics In the Management of Essential hypertension (DIME) study was designed, for the first time, to assess the risk for type 2 diabetes mellitus in patients with essential hypertension during antihypertensive treatment with low-dose thiazide diuretics compared to those not treated with diuretics. Design: Multicentre, unblinded, pragmatic, randomised, controlled trial with blinded assessment of end points and intention-to-treat analysis that was started in 2004 and finished in 2012. Setting: Hypertension clinics at 106 sites in Japan, including general practitioners' offices and teaching hospitals. Participants: Non-diabetic patients with essential hypertension. Interventions: Antihypertensive treatment with low-dose thiazide diuretics at 12.5 mg/day of hydrochlorothiazide or equivalent (Diuretics group) or that without thiazide diuretics (No-diuretics group). Main outcome: The primary outcome was new onset of type 2 diabetes diagnosed according to WHO criteria and the criteria of Japanese Society of Diabetes. Results: 1130 patients were allocated to Diuretics (n=544) or No-diuretics group (n=586). Complete end point information was collected for 1049 participants after a median follow-up of 4.4 years. Diabetes developed in 25 (4.6%) participants in the Diuretics group, as compared with 29 (4.9%) in the No-diuretics group (HR 0.93; 95% CI 0.55 to 1.58; p=0.800). Conclusions: Antihypertensive treatment with thiazide diuretics at low doses may not be associated with an increased risk for new onset of type 2 diabetes. This result might suggest safety of use of low doses of thiazide diuretics. Trial registration number: ClinicalTrials.gov NCT00131846.
MeSH term(s)	Adult ; Aged ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Dose-Response Relationship, Drug ; Essential Hypertension ; Female ; Follow-Up Studies ; Humans ; Hypertension/blood ; Hypertension/complications ; Hypertension/drug therapy ; Japan/epidemiology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Assessment/methods ; Single-Blind Method ; Sodium Chloride Symporter Inhibitors/administration & dosage ; Time Factors
Chemical Substances	Blood Glucose ; Sodium Chloride Symporter Inhibitors
Language	English
Publishing date	2014-07-16
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2013-004576
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