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  1. AU="Tal Noy-Porat"
  2. AU="Via, Jeremy"
  3. AU="Farshad Moradi Kashkooli"
  4. AU="Doaa Ebrahim"
  5. AU="Rangarajan, Amith"
  6. AU="Alonso-Sánchez, Jesús"
  7. AU="Zhuo, J C"
  8. AU="Pazurek, Angelica" AU="Pazurek, Angelica"
  9. AU=Sundararaman T
  10. AU="Singla, Amit Kumar"
  11. AU="Shu, Ran"
  12. AU="Kim, Jiha"
  13. AU="MacDonald, Suzanne E."
  14. AU="Heather Limburg"
  15. AU="Gross, Boris"
  16. AU="Perkins, George H"
  17. AU="Jormanainen, J"
  18. AU="Pichardo-González, Priamo A"
  19. AU="Cannegieter, Suzanne"
  20. AU="Trocino, Giuseppe"
  21. AU="Emiliano, Thais Moura"
  22. AU=Sinelli Mariateresa
  23. AU="De-guo LÜ"
  24. AU="Benoit-Pilven, Clara"
  25. AU="Lanza, Stefania"
  26. AU="Chilingarian, A"
  27. AU="Baldovini, Nicolas"
  28. AU="López Rodríguez, David"
  29. AU="Alexander König"
  30. AU="Jakobsen, Henrik L"
  31. AU="Yong-Zhao Dai"
  32. AU="Tara L. Pukala"
  33. AU="Addo‐Danso, Shalom D."
  34. AU=Ficheux Q.
  35. AU="Tomoyo Sawada"
  36. AU="Mohammad Kawsar Sharif Siam"
  37. AU=Kushnareva Yulia
  38. AU="Canova, Christopher T"
  39. AU="Hasnaoui, Naoual"
  40. AU="Maradana, Jhansi"
  41. AU="Raggini, Elisa"
  42. AU="Baxter, A."
  43. AU="Jackson, Shirnae"
  44. AU="Schenzle, Lisa"
  45. AU="Veronica Phillips"
  46. AU="Braun, Jörg"
  47. AU="Cassandra E. Holbert"
  48. AU="Trevisan Alexandra"

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  1. Artikel ; Online: Characterization of antibody-antigen interactions using biolayer interferometry

    Tal Noy-Porat / Ron Alcalay / Adva Mechaly / Eldar Peretz / Efi Makdasi / Ronit Rosenfeld / Ohad Mazor

    STAR Protocols, Vol 2, Iss 4, Pp 100836- (2021)

    2021  

    Abstract: Summary: This protocol describes the use of a biolayer interferometry platform for assessing antibody-antigen interactions. The protocol focuses on affinity determination and epitope binning, although the system can be utilized for measuring any protein- ... ...

    Abstract Summary: This protocol describes the use of a biolayer interferometry platform for assessing antibody-antigen interactions. The protocol focuses on affinity determination and epitope binning, although the system can be utilized for measuring any protein-protein interaction. Readings are collected in real time, allowing the use of unlabeled molecules, and data can thus be obtained in a fast and easy manner. Experiments should be carefully designed, taking into consideration the tested interaction, available sensors, and suitable controls.For complete details on the use and execution of this protocol, please refer to Noy-Porat et al. (2021).
    Schlagwörter Immunology ; Antibody ; Protein Biochemistry ; Science (General) ; Q1-390
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant Viruses

    Yinon Levy / Ron Alcalay / Anat Zvi / Efi Makdasi / Eldar Peretz / Tal Noy-Porat / Theodor Chitlaru / Michal Mandelboim / Ohad Mazor / Ronit Rosenfeld

    Vaccines, Vol 10, Iss 251, p

    2022  Band 251

    Abstract: SARS-CoV-2 surface spike protein mediates the viral entry into the host cell and represents the primary immunological target of COVID-19 vaccines as well as post-exposure immunotherapy. Establishment of the highly immunogenic B-cell epitope profile of ... ...

    Abstract SARS-CoV-2 surface spike protein mediates the viral entry into the host cell and represents the primary immunological target of COVID-19 vaccines as well as post-exposure immunotherapy. Establishment of the highly immunogenic B-cell epitope profile of SARS-CoV-2 proteins in general, and that of the spike protein in particular, may contribute to the development of sensitive diagnostic tools and identification of vaccine` candidate targets. In the current study, the anti-viral antibody response in transgenic K18-hACE-2 mice was examined by implementing an immunodominant epitope mapping approach of the SARS-CoV-2 spike. Serum samples for probing an epitope array covering the entire spike protein were collected from mice following infection with the original SARS-CoV-2 strain as well as the B.1.1.7 Alpha and B.1.351 Beta genetic variants of concern. The analysis resulted in distinction of six linear epitopes common to the humoral response against all virus variants inspected at a frequency of more than 20% of the serum samples. Finally, the universality of the response was probed by cross-protective in vitro experiments using plaque-reducing neutralization tests. The data presented here has important implications for prediction of the efficacy of immune countermeasures against emerging SARS-CoV-2 variants.
    Schlagwörter COVID-19 ; SARS-CoV-2 ; epitope mapping ; linear epitopes ; K18-hACE2 ; Medicine ; R
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Novel Phage Display-Derived Anti-Abrin Antibodies Confer Post-Exposure Protection against Abrin Intoxication

    Adva Mechaly / Ron Alcalay / Tal Noy-Porat / Eyal Epstein / Yoav Gal / Ohad Mazor

    Toxins, Vol 10, Iss 2, p

    2018  Band 80

    Abstract: Abrin toxin is a type 2 ribosome inactivating glycoprotein isolated from the seeds of Abrus precatorius (jequirity pea). Owing to its high toxicity, relative ease of purification and accessibility, it is considered a biological threat agent. To date, ... ...

    Abstract Abrin toxin is a type 2 ribosome inactivating glycoprotein isolated from the seeds of Abrus precatorius (jequirity pea). Owing to its high toxicity, relative ease of purification and accessibility, it is considered a biological threat agent. To date, there is no effective post-exposure treatment for abrin poisoning and passive immunization remains the most effective therapy. However, the effectiveness of anti-abrin monoclonal antibodies for post-exposure therapy following abrin intoxication has not been demonstrated. The aim of this study was to isolate high affinity anti-abrin antibodies that possess potent toxin-neutralization capabilities. An immune scFv phage-display library was constructed from an abrin-immunized rabbit and a panel of antibodies (six directed against the A subunit of abrin and four against the B subunit) was isolated and expressed as scFv-Fc antibodies. By pair-wise analysis, we found that these antibodies target five distinct epitopes on the surface of abrin and that antibodies against all these sites can bind the toxin simultaneously. Several of these antibodies (namely, RB9, RB10, RB28 and RB30) conferred high protection against pulmonary intoxication of mice, when administered six hours post exposure to a lethal dose of abrin. The data presented in this study demonstrate for the first time the efficacy of monoclonal antibodies in treatment of mice after pulmonary intoxication with abrin and promote the use of these antibodies, one or several, for post-exposure treatment of abrin intoxication.
    Schlagwörter abrin ; monoclonal antibodies ; phage-display ; rabbit ; recombinant antibodies ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Life cycle and reproductive botany of Scilla hyacinthoides, a Mediterranean geophyte

    Shtein, Ilana / Amram Eshel / Tal Noy-Porat

    Scientia horticulturae. 2016 Mar. 30, v. 201

    2016  

    Abstract: The Mediterranean region is abundant with geophyte species, many of which have been developed as ornamentals. In recent years attempts were made to grow Scilla hyacinthoides L. (Asparagaceae, subfamily Scilloideae) commercially, both as a cut flower and ... ...

    Abstract The Mediterranean region is abundant with geophyte species, many of which have been developed as ornamentals. In recent years attempts were made to grow Scilla hyacinthoides L. (Asparagaceae, subfamily Scilloideae) commercially, both as a cut flower and as a water-saving ornamental geophyte. Optimizing commercial production of S. hyacinthoides requires the study of growth and development of the vegetative plant, as well as the control of flower bud initiation and development.Like most Mediterranean plants, S. hyacinthoides life cycle is attuned to the annual rhythm which alternates between hot and dry summer, and cool and rainy winter. Plants are dormant during summer. In autumn the apical meristem becomes active and either begins producing leaves for the next season, or initiates inflorescence development. After the onset of inflorescence development, a new apical meristem is formed at the axil of the youngest leaf. Frequently, two apices are formed; one of them becomes a daughter bulb. Intrabulb development of the inflorescence was studied by histology and electron microscopy. The flowering occurs in spring. Floral initiation is temperature-dependent and is inhibited by low temperatures, but inflorescence differentiation and elongation is inhibited by high temperatures. Flowers are self-incompatible and exhibit several polymorphic traits, probably important in pollinator attraction. In summary, current research provides a basis for future studies on the florogenesis and ecophysiology in Scilla, as well as enabling future fine tuning of cultivation protocols for the flower industry.
    Schlagwörter apical meristems ; autumn ; bud initiation ; bulbs ; cut flowers ; ecophysiology ; electron microscopy ; flowering ; flowers ; geophytes ; growth and development ; histology ; industry ; leaves ; ornamental plants ; pollinators ; Scilla hyacinthoides ; spring ; summer ; temperature ; water conservation ; winter ; Mediterranean region
    Sprache Englisch
    Erscheinungsverlauf 2016-0330
    Umfang p. 167-174.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 185557-8
    ISSN 0304-4238
    ISSN 0304-4238
    DOI 10.1016/j.scienta.2016.01.043
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates

    Tal Noy-Porat / Ronit Rosenfeld / Naomi Ariel / Eyal Epstein / Ron Alcalay / Anat Zvi / Chanoch Kronman / Arie Ordentlich / Ohad Mazor

    Toxins, Vol 8, Iss 3, p

    2016  Band 64

    Abstract: Ricin, derived from the castor bean plant Ricinus communis, is one of the most potent and lethal toxins known, against which there is no available antidote. To date, the use of neutralizing antibodies is the most promising post-exposure treatment for ... ...

    Abstract Ricin, derived from the castor bean plant Ricinus communis, is one of the most potent and lethal toxins known, against which there is no available antidote. To date, the use of neutralizing antibodies is the most promising post-exposure treatment for ricin intoxication. The aim of this study was to isolate high affinity anti-ricin antibodies that possess potent toxin-neutralization capabilities. Two non-human primates were immunized with either a ricin-holotoxin- or subunit-based vaccine, to ensure the elicitation of diverse high affinity antibodies. By using a comprehensive set of primers, immune scFv phage-displayed libraries were constructed and panned. A panel of 10 antibodies (five directed against the A subunit of ricin and five against the B subunit) was isolated and reformatted into a full-length chimeric IgG. All of these antibodies were found to neutralize ricin in vitro, and several conferred full protection to ricin-intoxicated mice when given six hours after exposure. Six antibodies were found to possess exceptionally high affinity toward the toxin, with KD values below pM (koff < 1 × 10−7 s−1) that were well correlated with their ability to neutralize ricin. These antibodies, alone or in combination, could be used for the development of a highly-effective therapeutic preparation for post-exposure treatment of ricin intoxication.
    Schlagwörter ricin ; antibody ; neutralization ; affinity ; immunization ; non-human primates ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2016-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

    Ronit Rosenfeld / Tal Noy-Porat / Adva Mechaly / Efi Makdasi / Yinon Levy / Ron Alcalay / Reut Falach / Moshe Aftalion / Eyal Epstein / David Gur / Theodor Chitlaru / Einat B. Vitner / Sharon Melamed / Boaz Politi / Ayelet Zauberman / Shirley Lazar / Adi Beth-Din / Yentl Evgy / Shmuel Yitzhaki /
    Shmuel C. Shapira / Tomer Israely / Ohad Mazor

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 9

    Abstract: Here, using the K18-hACE2 transgenic mice model, the authors report the in vivo efficacy of a fully human neutralizing antibody against SARS-CoV-2 and show that when administered before or up to 3 days post infection, treated mice do not exhibit disease ... ...

    Abstract Here, using the K18-hACE2 transgenic mice model, the authors report the in vivo efficacy of a fully human neutralizing antibody against SARS-CoV-2 and show that when administered before or up to 3 days post infection, treated mice do not exhibit disease symptoms while 80% of control animals succumb to the infection.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

    Tal Noy-Porat / Adva Mechaly / Yinon Levy / Efi Makdasi / Ron Alcalay / David Gur / Moshe Aftalion / Reut Falach / Shani Leviatan Ben-Arye / Shirley Lazar / Ayelet Zauberman / Eyal Epstein / Theodor Chitlaru / Shay Weiss / Hagit Achdout / Jonathan D. Edgeworth / Raghavendra Kikkeri / Hai Yu / Xi Chen /
    Shmuel Yitzhaki / Shmuel C. Shapira / Vered Padler-Karavani / Ohad Mazor / Ronit Rosenfeld

    iScience, Vol 24, Iss 5, Pp 102479- (2021)

    2021  

    Abstract: Summary: Neutralizing antibodies represent a valuable therapeutic approach to countermeasure the current COVID-19 pandemic. Emergence of SARS-CoV-2 variants emphasizes the notion that antibody treatments need to rely on highly neutralizing monoclonal ... ...

    Abstract Summary: Neutralizing antibodies represent a valuable therapeutic approach to countermeasure the current COVID-19 pandemic. Emergence of SARS-CoV-2 variants emphasizes the notion that antibody treatments need to rely on highly neutralizing monoclonal antibodies (mAbs), targeting several distinct epitopes for circumventing therapy escape mutants. Previously, we reported efficient human therapeutic mAbs recognizing epitopes on the spike receptor-binding domain (RBD) of SARS-CoV-2. Here we report the isolation, characterization, and recombinant production of 12 neutralizing human mAbs, targeting three distinct epitopes on the spike N-terminal domain of the virus. Neutralization mechanism of these antibodies involves receptors other than the canonical hACE2 on target cells, relying both on amino acid and N-glycan epitope recognition, suggesting alternative viral cellular portals. Two selected mAbs demonstrated full protection of K18-hACE2 transgenic mice when administered at low doses and late post-exposure, demonstrating the high potential of the mAbs for therapy of SARS-CoV-2 infection.
    Schlagwörter Molecular biology ; Immunology ; Virology ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Rapid assessment of antibody-induced ricin neutralization by employing a novel functional cell-based assay

    Gal, Yoav / Chanoch Kronman / Eyal Epstein / Ohad Mazor / Ron Alcalay / Tal Noy-Porat / Tamar Sabo

    Journal of Immunological Methods. 2015 Sept., v. 424

    2015  

    Abstract: Ricin is one of the most potent and lethal toxins known against which there is no available antidote. Currently, the most promising countermeasures against the toxin are based on neutralizing antibodies elicited by active vaccination or administered ... ...

    Abstract Ricin is one of the most potent and lethal toxins known against which there is no available antidote. Currently, the most promising countermeasures against the toxin are based on neutralizing antibodies elicited by active vaccination or administered passively. A cell-based assay is widely applied for the primary screening and evaluation of anti-ricin antibodies, yet such assays are usually time-consuming (18–72h). Here, we report of a novel assay to monitor ricin activity, based on HeLa cells that stably express the rapidly-degraded ubiquitin-luciferase (Ub-FL, half-life of 2min). Ricin-induced arrest of protein synthesis could be quantified within 3 to 6h post intoxication (IC90 of 300 and 100ng/ml, respectively). Furthermore, by stabilizing the intracellular levels of Ub-FL in the last hour of the assay, a 3-fold increase in the assay sensitivity was attained. We applied this assay to monitor the efficacy of a ricin holotoxin-based vaccine by measuring the formation of neutralizing antibodies throughout the immunization course. The potency of anti-ricin monoclonal antibodies (directed to either subunit of the toxin) could also be easily and accurately measured in this assay format. Owing to its simplicity, this assay may be implemented for high-throughput screening of ricin-neutralizing antibodies and for identification of small-molecule inhibitors of the toxin, as well as other ribosome-inactivating toxins.
    Schlagwörter antidotes ; half life ; monoclonal antibodies ; neutralization ; neutralizing antibodies ; poisoning ; protein synthesis ; rapid methods ; ricin ; screening ; toxins ; vaccination ; vaccines
    Sprache Englisch
    Erscheinungsverlauf 2015-09
    Umfang p. 136-139.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2015.05.005
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

    Tal Noy-Porat / Efi Makdasi / Ron Alcalay / Adva Mechaly / Yinon Levy / Adi Bercovich-Kinori / Ayelet Zauberman / Hadas Tamir / Yfat Yahalom-Ronen / Ma’ayan Israeli / Eyal Epstein / Hagit Achdout / Sharon Melamed / Theodor Chitlaru / Shay Weiss / Eldar Peretz / Osnat Rosen / Nir Paran / Shmuel Yitzhaki /
    Shmuel C. Shapira / Tomer Israely / Ohad Mazor / Ronit Rosenfeld

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 7

    Abstract: Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, ... ...

    Abstract Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, which show efficient neutralizing activities against authentic virus in vitro.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

    Tal Noy-Porat / Efi Makdasi / Ron Alcalay / Adva Mechaly / Yinon Levy / Adi Bercovich-Kinori / Ayelet Zauberman / Hadas Tamir / Yfat Yahalom-Ronen / Ma’ayan Israeli / Eyal Epstein / Hagit Achdout / Sharon Melamed / Theodor Chitlaru / Shay Weiss / Eldar Peretz / Osnat Rosen / Nir Paran / Shmuel Yitzhaki /
    Shmuel C. Shapira / Tomer Israely / Ohad Mazor / Ronit Rosenfeld

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 7

    Abstract: Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, ... ...

    Abstract Here, Noy-Porat, Makdasi et al. report the isolation of a panel of neutralizing mAbs selected against SARS-CoV-2 receptor-binding domain (RBD) from a phage display library constructed based on patient samples collected in the acute phase of the disease, which show efficient neutralizing activities against authentic virus in vitro.
    Schlagwörter Science ; Q ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
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