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  1. Article ; Online: Reduced Skin T-Cell Receptor Diversity in Large Cell Transformed Mycosis Fungoides.

    Gleason, Laura / Talasila, Sahithi / Tekmen, Volkan / Nikbakht, Neda

    The Journal of investigative dermatology

    2023  Volume 143, Issue 11, Page(s) 2318–2322.e4

    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.03.1683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Waterbirth: A Systematic Review and Meta-Analysis.

    Edwards, Sara / Angarita, Ana M / Talasila, Sahithi / Berghella, Vincenzo

    American journal of perinatology

    2023  

    Abstract: Despite patient interest, there is little evidence regarding waterbirth. This review sought to compare maternal and perinatal outcomes in waterbirth, compared with landbirth. This search was conducted using MEDLINE, Google Scholar, Web of Sciences, ... ...

    Abstract Despite patient interest, there is little evidence regarding waterbirth. This review sought to compare maternal and perinatal outcomes in waterbirth, compared with landbirth. This search was conducted using MEDLINE, Google Scholar, Web of Sciences, Scopus, ClinicalTrial.gov, OVID, and Cochrane Library from inception to November 15, 2021, with no language or geographic restrictions. Review was registered with PROSPERO under registration number: CRD42021288576. Selection criteria included randomized controlled trials of women with singleton cephalic gestations at ≥36 weeks comparing waterbirth to landbirth. The primary outcome was a perinatal composite outcome. Secondary outcomes included maternal and individual perinatal outcomes. Summary measures were reported as relative risk or mean difference with 95% confidence intervals using random effects model of DerSimonian and Laird.
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1764145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Challenges in utilizing ALK expression to distinguish primary cutaneous from systemic anaplastic large cell lymphoma.

    Gleason, Laura / Afifi, Ladan / Banner, Lauren / Talasila, Sahithi / Joffe, Daniel / Bhatti, Safiyyah / Alpdogan, Onder / Porcu, Pierluigi / Nikbakht, Neda

    Molecular and clinical oncology

    2024  Volume 20, Issue 5, Page(s) 35

    Abstract: Anaplastic large cell lymphoma (ALCL) is a ... ...

    Abstract Anaplastic large cell lymphoma (ALCL) is a CD30
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2796865-0
    ISSN 2049-9469 ; 2049-9450
    ISSN (online) 2049-9469
    ISSN 2049-9450
    DOI 10.3892/mco.2024.2733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Waterbirth: A Systematic Review and Meta-Analysis

    Edwards, Sara / Angarita, Ana M. / Talasila, Sahithi / Berghella, Vincenzo

    American Journal of Perinatology

    2023  

    Abstract: Despite patient interest, there is little evidence regarding waterbirth. This review sought to compare maternal and perinatal outcomes in waterbirth, compared with landbirth. This search was conducted using MEDLINE, Google Scholar, Web of Sciences, ... ...

    Abstract Despite patient interest, there is little evidence regarding waterbirth. This review sought to compare maternal and perinatal outcomes in waterbirth, compared with landbirth. This search was conducted using MEDLINE, Google Scholar, Web of Sciences, Scopus, ClinicalTrial.gov, OVID, and Cochrane Library from inception to November 15, 2021, with no language or geographic restrictions. Review was registered with PROSPERO under registration number: CRD42021288576. Selection criteria included randomized controlled trials of women with singleton cephalic gestations at ≥36 weeks comparing waterbirth to landbirth. The primary outcome was a perinatal composite outcome. Secondary outcomes included maternal and individual perinatal outcomes. Summary measures were reported as relative risk or mean difference with 95% confidence intervals using random effects model of DerSimonian and Laird. I 2 (Higgins I 2 ) > 0% was used to identify heterogeneity. Six trials including 706 patients were included. When reported, all patients were ≥ 37 weeks' gestation. Labor augmentation (41.7 vs. 84.7%, p  < 0.0001) and neuraxial anesthesia (10.5 vs. 72.4%, p  < 0.0001) were less common with waterbirth. Estimated blood loss, postpartum hemorrhage, perineal laceration, episiotomy, mode of delivery, and perinatal outcomes did not differ between groups. Chorioamnionitis and endometritis were not reported by any trial. Maternal satisfaction was higher ( p  = 0.01) and pain scores lower ( p  = 0.003) with waterbirth. Length of first stage ( p  < 0.00001), third stage ( p  = 0.02), and labor ( p  = 0.04) were shorter with waterbirth. The composite perinatal outcome could not be calculated due to lack of individual patient data. Compared with landbirth, waterbirth was associated with lower rates of neuraxial anesthesia and lower pain scores, with improved maternal satisfaction.
    Key Points: Data are limited regarding the safety and potential benefits of waterbirth. With waterbirth, maternal satisfaction was higher and pain scores lower. The first and third stages of labor and labor overall were shorter. No significant differences noted in other maternal outcomes, such as hemorrhage or laceration. Insufficient data are available regarding neonatal outcomes.
    Keywords waterbirth ; water ; delivery ; morbidity ; mortality
    Language English
    Publishing date 2023-02-15
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0043-1764145
    Database Thieme publisher's database

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  5. Article: Pleomorphic dermal sarcoma of the scalp: Review of management and distinguishing features from atypical fibroxanthoma.

    Cohen, Alexa J / Talasila, Sahithi / Lazarevic, Bojan / Gleason, Laura / Patel, Viral / Nikbakht, Neda

    JAAD case reports

    2022  Volume 29, Page(s) 123–126

    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Role of FDG-PET in the Evaluation of Hidradenitis Suppurativa: A Systematic Review.

    Talasila, Sahithi / Teichner, Eric M / Subtirelu, Robert C / Xiang, David H / Ayubcha, Cyrus / Werner, Thomas / Alavi, Abass / Revheim, Mona-Elisabeth

    Journal of clinical medicine

    2023  Volume 12, Issue 17

    Abstract: Hidradenitis suppurativa (HS) is a chronic skin disorder characterized by nodules, comedones, and sinus tracts that often leave prominent scarring. In recent years, non-invasive imaging techniques have been used to assess the inflammatory activity, ... ...

    Abstract Hidradenitis suppurativa (HS) is a chronic skin disorder characterized by nodules, comedones, and sinus tracts that often leave prominent scarring. In recent years, non-invasive imaging techniques have been used to assess the inflammatory activity, vascularization, and treatment response of lesions. Specifically, fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans may aid in identifying systemic inflammation in patients with HS, improving diagnosis. Inflamed hypermetabolic tissues exhibit a greater uptake of FDG due to increased glucose uptake and vascularity. A systematic review was conducted to summarize the utility of nuclear imaging techniques in the diagnosis and treatment follow-up of HS. PubMed, Scopus, and ScienceDirect databases were utilized for relevant articles discussing the utility of PET scans in managing HS. A total of 51 citations were identified in the initial search. Following the review of titles, abstracts, and duplicates, 43 articles were excluded, leaving a total of eight articles for analysis. Data were extracted from each article, encompassing the number of patients, imaging techniques employed, and final results. An analysis of the data demonstrated that FDG-PET showed evidence of identifying subclinical lesions of the disease, improving the visualization of HS, and providing an objective method of assessing severity.
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12175491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Utility of T-cell immunosequencing in distinguishing mycosis fungoides progression from treatment related cutaneous adverse events.

    Bhatti, Safiyyah / Joffe, Daniel / Banner, Lauren / Talasila, Sahithi / Mandel, Jenna / Lee, Jason / Porcu, Pierluigi / Nikbakht, Neda

    Frontiers in medicine

    2023  Volume 10, Page(s) 1243459

    Abstract: Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin. Mogamulizumab and ... ...

    Abstract Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin. Mogamulizumab and mechlorethamine gel are approved treatments for MF, both of which can cause treatment related cutaneous adverse events. It can often be challenging to distinguish mogamulizumab associated rash (MAR) and mechlorethamine gel associated hypersensitivity dermatitis from MF progression both clinically and histologically. High-throughput sequencing (HTS) of the T-cell receptor (TCR), also known as immunosequencing, can be used to assess T-cell clonality to support a diagnosis of MF. After identification of the malignant TCR clone at baseline, immunosequencing can track the established malignant TCR sequence and its frequency over time with high sensitivity. As a result, immunosequencing clone tracking can aid in distinguishing disease progression from treatment side effects. Here, we present a case series to demonstrate how monitoring of the malignant T-cell frequency by immunosequencing can aid in diagnosis of mogamulizumab and mechlorethamine gel cutaneous adverse events.
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1243459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids.

    Cohen, Alexa J / Talasila, Sahithi / Lazarevic, Bojan / Banner, Lauren / Gleason, Laura / Malkani, Kabir / Uitto, Jouni / Nikbakht, Neda

    Journal of cosmetic dermatology

    2022  Volume 22, Issue 3, Page(s) 932–936

    Abstract: Background: Keloids are common and have significant negative effects on quality of life. There is a need for more effective treatment approaches for keloids.: Aims: We investigated treatment outcomes of intralesional triamcinolone acetonide (IL TAC) ... ...

    Abstract Background: Keloids are common and have significant negative effects on quality of life. There is a need for more effective treatment approaches for keloids.
    Aims: We investigated treatment outcomes of intralesional triamcinolone acetonide (IL TAC) compared with combination IL TAC and cryotherapy, including changes in pruritus, pain, and keloid size.
    Patients/methods: We performed a prospective study of patients referred to one provider who treated patients with combination therapy and compared them to a historic control cohort treated with IL TAC alone. All patients were seen at Thomas Jefferson University between 2019 and 2021. Patient demographics, location of keloids, and inciting events were recorded. Pruritus and pain scores were self-reported by patients using a 10-point Likert scale administered as standard of care. Changes in keloid size were denoted as "No change," "up to 50% decrease," "more than 50% decrease," and "completely flattened."
    Results: While both treatments produced a significant reduction in mean pruritus and pain scores, there was no difference between the two treatment groups (p = 0.3933 and p = 0.2123, respectively). A greater percentage of keloids in the combination therapy group had a post-treatment size difference greater than 50% compared with those in the IL TAC only treatment group (p = 0.0021). In the subgroup of pubic keloids, all lesions treated with combination IL TAC and cryotherapy responded remarkably well to treatment.
    Conclusions: While both IL TAC and IL TAC with cryotherapy were effective at reducing pruritus and pain, combination therapy was more effective in reducing keloid size, specifically for pubic keloids.
    MeSH term(s) Humans ; Keloid/drug therapy ; Quality of Life ; Prospective Studies ; Cryotherapy ; Triamcinolone Acetonide ; Adrenal Cortex Hormones ; Treatment Outcome ; Pain ; Pruritus ; Injections, Intralesional
    Chemical Substances Triamcinolone Acetonide (F446C597KA) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Advancements in dendritic cell vaccination: enhancing efficacy and optimizing combinatorial strategies for the treatment of glioblastoma.

    Subtirelu, Robert C / Teichner, Eric M / Ashok, Arjun / Parikh, Chitra / Talasila, Sahithi / Matache, Irina-Mihaela / Alnemri, Ahab G / Anderson, Victoria / Shahid, Osmaan / Mannam, Sricharvi / Lee, Andrew / Werner, Thomas / Revheim, Mona-Elisabeth / Alavi, Abass

    Frontiers in neurology

    2023  Volume 14, Page(s) 1271822

    Abstract: Glioblastomas (GBM) are highly invasive, malignant primary brain tumors. The overall prognosis is poor, and management of GBMs remains a formidable challenge, necessitating novel therapeutic strategies such as dendritic cell vaccinations (DCVs). While ... ...

    Abstract Glioblastomas (GBM) are highly invasive, malignant primary brain tumors. The overall prognosis is poor, and management of GBMs remains a formidable challenge, necessitating novel therapeutic strategies such as dendritic cell vaccinations (DCVs). While many early clinical trials demonstrate an induction of an antitumoral immune response, outcomes are mixed and dependent on numerous factors that vary between trials. Optimization of DCVs is essential; the selection of GBM-specific antigens and the utilization of
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1271822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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