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Article ; Online: Assay interference as a cause of false positive troponin T elevation in emergency department patients.

Lyons, K S / Herity, N / Lee, G / Talbot, C / McKeeman, G

2023 Volume 389, Page(s) 131165

Abstract: Background: Troponin assays are used in the diagnosis of myocardial injury and may show elevated results for a variety of reasons. However it is increasingly recognised that cardiac troponin elevation may in some cases be due to assay interference. This ...

Abstract	Background: Troponin assays are used in the diagnosis of myocardial injury and may show elevated results for a variety of reasons. However it is increasingly recognised that cardiac troponin elevation may in some cases be due to assay interference. This is of significant importance as a misdiagnosis of myocardial injury may lead to unnecessary and potentially harmful investigation and treatment for patients. We sought to confirm the accuracy of cardiac high sensitivity troponin T (chsTnT) elevation in an unselected group of patients presenting to the emergency department, by using a second confirmatory cardiac high sensitivity troponin I (chsTnI) assay. Methods: We identified patients presenting to two local emergency departments over a five-day period who had chsTnT levels measured as part of routine clinical care. All samples with elevated chsTnT levels (above the 99% centile URL) were retested for chsTnI in order to confirm true myocardial injury. Results: A total of 74 samples from 54 patients were analysed for chsTnT and chsTnI. 7 samples (9.5%) had chsTnI levels < 5 ng/L suggesting assay interference as the cause of chsTnT elevation. Conclusions: Assay interference leading to false positive troponin elevation may be more common than many physicians appreciate and can potentially lead to harmful investigation and treatment for patients. In cases where the diagnosis of myocardial injury is uncertain, a second alternative troponin assay should be performed to confirm true myocardial injury.
MeSH term(s)	Humans ; Troponin T ; Myocardial Infarction/diagnosis ; Troponin I ; Heart ; Emergency Service, Hospital ; Heart Injuries ; Biomarkers
Chemical Substances	Troponin T ; Troponin I ; Biomarkers
Language	English
Publishing date	2023-07-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131165
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Article ; Online: The validity and reproducibility of perceptually regulated exercise responses during combined arm + leg cycling.

Hill, M / Puddiford, M / Talbot, C / Price, M

European journal of applied physiology

2020 Volume 120, Issue 10, Page(s) 2203–2212

Abstract: Purpose: Rating of perceived exertion (RPE) is a reliable method of assessing exercise intensity during isolated arm and leg cycling. The aim of this study was to assess the validity and reproducibility of perceptually regulated exercise responses ... ...

Abstract	Purpose: Rating of perceived exertion (RPE) is a reliable method of assessing exercise intensity during isolated arm and leg cycling. The aim of this study was to assess the validity and reproducibility of perceptually regulated exercise responses during combined arm + leg cycling. Methods: Twelve males (age; 24.6 ± 5.3 years, height; 1.81 ± 0.7 m, mass; 83.1 ± 8.4 kg) initially undertook incremental exercise tests to volitional exhaustion for arm cycling (133 ± 14 W) and leg cycling (253 ± 32 W). On three subsequent occasions, participants undertook combined arm + leg cycling trials using two modified Monark ergometers involving three bouts of exercise at RPE 9, 13 and 17, in that order. Heart rate (HR), oxygen uptake ([Formula: see text]) and pulmonary ventilation ([Formula: see text]) were recorded continuously. Results: No significant differences were observed for HR (P = 0.086), [Formula: see text] (P = 0.525) and [Formula: see text] (P = 0.899) between trials, whilst significant differences were observed between each level of RPE (all P < 0.001). For % peak [Formula: see text], the ICC increased with successive trials for all RPE levels. For % maximal HR the ICC generally decreased with successive trials. Conclusion: RPE can be used as a reliable frame of reference for the production of exercise intensity during combined arm + leg cycling without any formal familiarisation. Since combined arm + leg cycling elicits a greater energy expenditure than arm or leg work alone, this novel mode of non-weight bearing exercise might prove effective for aerobic conditioning and weight control.
MeSH term(s)	Adult ; Arm/physiology ; Exercise ; Exercise Test/methods ; Exercise Test/standards ; Exercise Tolerance ; Heart Rate ; Humans ; Leg/physiology ; Male ; Oxygen Consumption ; Perception ; Pulmonary Ventilation ; Reproducibility of Results
Language	English
Publishing date	2020-07-24
Publishing country	Germany
Document type	Evaluation Study ; Journal Article
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-020-04444-z
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Article ; Online: Correction to: The validity and reproducibility of perceptually regulated exercise responses during combined arm + leg cycling.

Hill, M / Puddiford, M / Talbot, C / Price, M

European journal of applied physiology

2020 Volume 120, Issue 12, Page(s) 2847

Abstract: The original version of this article unfortunately contained a mistake. ...

Abstract	The original version of this article unfortunately contained a mistake.
Language	English
Publishing date	2020-10-06
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-020-04497-0
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Article: Early evaluation of a DBT-informed online intervention for people with eating disorders.

Vuillier, Laura / Greville-Harris, M / Talbot, C V / May, L / Moseley, R L

Journal of eating disorders

2024 Volume 12, Issue 1, Page(s) 9

Abstract: Objectives: Eating disorders (EDs) have a worldwide prevalence of 7.8%, with towering mortality rates and high healthcare costs. The current recommended treatment for EDs principally works by directly targeting ED thoughts and behaviours, but recovery ... ...

Abstract	Objectives: Eating disorders (EDs) have a worldwide prevalence of 7.8%, with towering mortality rates and high healthcare costs. The current recommended treatment for EDs principally works by directly targeting ED thoughts and behaviours, but recovery rates are low. A multifaceted link between difficulties with emotions and EDs is now widely established, and newer third-wave therapies that aim to address these underlying emotion difficulties are promising. The current study piloted an online emotion self-help intervention which was co-developed with clinicians and people with lived experienced of EDs. The intervention aimed to specifically address difficulties with emotion identification and regulation, as well as unhelpful beliefs about emotions, which are believed to give rise to and maintain ED thoughts and behaviours. Method: We recruited 39 people with self-reported EDs to test this intervention over a one-week period. Our participants were asked to complete a series of questionnaires measuring emotion processes and psychopathology on Day 1 (T1) before being given access to the intervention. Participants were then asked to practice the newly acquired skills for seven days, before taking the same questionnaires on Day 9 (T2). We also asked participants to qualitatively report on their experience of the intervention. Results: We found significant improvements in ED psychopathology (ED-15), depression (PHQ-9), and anxiety (GAD-7) pre- to post-intervention, with medium to large effect sizes. All our emotion variables namely alexithymia (TAS-20), difficulties regulating emotions (DERS-SF), and unhelpful beliefs about emotions (EBQ) also showed significant changes post-intervention with medium to large effect sizes. Most importantly, changes in emotion regulation processes were linked to improved eating psychopathology. The qualitative analysis corroborated this finding, highlighting how the intervention helped them form new beliefs about emotions, which helped them reduce ED behaviours. Discussion: Significant improvements in emotion processing and regulations, as well as psychopathology, along with positive qualitative feedback, suggest that the intervention effectively met its aims of increasing awareness of the link between emotions and eating psychopathology, providing help to identify and regulate emotions, and normalising emotional experiences. While our results are promising, further research is required to assess its effectiveness longer term and in clinical settings.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-024-00974-5
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Thesis ; Online: Directing Virtual Humans Using Play-Scripts and Spatio-Temporal Reasoning

Talbot, Christine

2018

Abstract: Historically, most virtual human character research focuses on realism/emotions, interaction with humans, and discourse. The majority of the spatial positioning of characters has focused on one-on-one conversations with humans or placing virtual ... ...

Abstract	Historically, most virtual human character research focuses on realism/emotions, interaction with humans, and discourse. The majority of the spatial positioning of characters has focused on one-on-one conversations with humans or placing virtual characters side-by-side when talking. These rely on conversation space as the main driver (if any) for character placement. Movies and games rely on motion capture (mocap) files and hard-coded functions to perform spatial movements. These require extensive technical knowledge just to have a character move from one place to another. Other methods involve the use of Behavior Markup Language (BML), a form of XML, which describes character behaviors. BML Realizers take this BML and perform the requested behavior(s) on the character(s). Also, there are waypoint and other spatial navigation schemes, but they primarily focus on traversals and not correct positioning. Each of these require a fair amount of low-level detail and knowledge to write, plus BML realizers are still in their early stages of development. Theatre, movies, and television all utilize a form of play-scripts, which provide detailed information on what the actor must do spatially, and when for a particular scene (that is spatio-temporal direction). These involve annotations, in addition to the speech, which identify scene setups, character movements, and entrances /exits. Humans have the ability to take these play-scripts and easily perform a believable scene. This research focuses on utilizing play-scripts to provide spatio-temporal direction to virtual characters within a scene. Because of the simplicity of creating a playscript, and our algorithms to interpret the scripts, we are able to provide a quick method of blocking scenes with virtual characters. We focus on not only an all-virtual cast of characters, but also human-controlled characters intermixing with the virtual characters for the scene. The key here is that human-controlled characters introduce a dynamic spatial component that affects how the virtual characters should perform the scene to ensure continuity, cohesion, and inclusion with the human-controlled character. The algorithms to accomplish the blocking of a scene from a standard play-script are the core research contribution. These techniques include some part of speech tagging, named entity recognition, a rules engine, and strategically designed force-directed graphs. With these methods, we are able to similarly map any play-script’s spatial positioning of characters to a human-performed version of the same playscript. Also, human-based evaluations indicate these methods provide a qualitatively good performance. Potential applications include: a rehearsal tool for actors; a director tool to help create a play-script; a controller for virtual human characters in games or virtual environments; or a planning tool for positioning people in an industrial environment.
Keywords	Artificial intelligence\|Computer science
Subject code	004
Language	ENG
Publishing date	2018-01-01 00:00:01.0
Publisher	The University of North Carolina at Charlotte
Publishing country	us
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dimitrios Zambakis' Scientific Hypothesis on the Transmission of Leprosy.

Chen, Kyra / Talbot, Christopher / Mammis, Antonios

Journal of medical biography

2022 Volume 31, Issue 3, Page(s) 146–148

Abstract: Dimitrios Zambakis was an acclaimed physician at his time, most recognized for his work on leprosy. He theorized that leprosy was a hereditary disease, receiving many awards for his work including the Cholera Medal of Honour (1854), Château-Villard Prize ...

Abstract	Dimitrios Zambakis was an acclaimed physician at his time, most recognized for his work on leprosy. He theorized that leprosy was a hereditary disease, receiving many awards for his work including the Cholera Medal of Honour (1854), Château-Villard Prize from the Faculty of Medicine in Paris (1898), The Montyon Prize, and the title of Pasha. However, his theory was routinely argued against and was later proven to be invalid. Leprosy is regarded as a contagious disease spread by contact and is not hereditary. The last name appears to be spelled in various ways (Zambakis, Zambaco). For this paper, "Dimitrios Zambakis" will be used.
MeSH term(s)	Male ; Humans ; History, 20th Century ; Leprosy ; Medicine ; Paris ; Physicians ; Faculty
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	1159267-9
ISSN	1758-1087 ; 0967-7720
ISSN (online)	1758-1087
ISSN	0967-7720
DOI	10.1177/09677720221079833
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Zs.A 3995: Show issues

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Article ; Online: Gene expression profiling suggests severe, extensive central centrifugal cicatricial alopecia may be both clinically and biologically distinct from limited disease subtypes.

Jamerson, Taylor A / Conover Talbot, C / Dina, Yemisi / Kwatra, Shawn G / Garza, Luis A / Aguh, Crystal

Experimental dermatology

2022 Volume 31, Issue 5, Page(s) 789–793

Abstract: The natural history of central centrifugal cicatricial alopecia (CCCA) is widely variable. Some patients experience rapid progression to extensive, end-stage disease while others never approach extensive involvement over decades, suggesting heterogeneity ...

Abstract	The natural history of central centrifugal cicatricial alopecia (CCCA) is widely variable. Some patients experience rapid progression to extensive, end-stage disease while others never approach extensive involvement over decades, suggesting heterogeneity in CCCA disease phenotype. To better characterize clinically severe disease in CCCA, tissue samples were obtained from the peripheral, hair-bearing lesional scalp of women with clinically focal, limited and extensive CCCA disease involvement. A microarray analysis was conducted to identify differential expression of genes previously identified to be preferentially expressed in the lesional scalp vs. non-lesional scalp of CCCA patients. Clinically extensive, severe CCCA was characterized by increased expression of MMP9, SFRP4 and MSR1 when directly compared with focal and limited disease. These biomarkers correspond to dysregulated pathways of fibrosis, Wnt signalling and macrophage-mediated inflammatory processes respectively. These findings hold significance for both possible targets for future study of prognostic markers of disease severity and new potential therapeutic targets. In summary, this study suggests clinically extensive, severe CCCA may have a differential gene expression pattern in the lesional scalp of affected patients, in addition to its clinical distinction.
MeSH term(s)	Alopecia/genetics ; Alopecia/pathology ; Cicatrix/genetics ; Cicatrix/pathology ; Dermatitis/pathology ; Female ; Gene Expression Profiling ; Hair/pathology ; Humans ; Microarray Analysis ; Scalp/pathology
Language	English
Publishing date	2022-01-20
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.14524
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Zs.A 3508: Show issues

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Article ; Online: Transcriptomic study of anastasis for reversal of ethanol-induced apoptosis in mouse primary liver cells.

Tang, Ho Man / Talbot, C Conover / Fung, Ming Chiu / Tang, Ho Lam

Scientific data

2022 Volume 9, Issue 1, Page(s) 418

Abstract: Anastasis is a cell recovery mechanism that rescues dying cells from the brink of death. Reversal of apoptosis is the first example of anastasis. Here, we describe a comprehensive dataset containing time-course mRNA expression profiles for reversal of ... ...

Abstract	Anastasis is a cell recovery mechanism that rescues dying cells from the brink of death. Reversal of apoptosis is the first example of anastasis. Here, we describe a comprehensive dataset containing time-course mRNA expression profiles for reversal of ethanol-induced apoptosis in mouse primary liver cells in νitro. This transcriptome dataset includes the conditions of the untreated cells, cells undergoing apoptosis triggered by incubating with cell death inducer of 4.5% ethanol for 5 hours, and apoptosis reversal of ethanol-induced cells at the early (3
MeSH term(s)	Animals ; Apoptosis ; Cell Death Reversal ; Ethanol/pharmacology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Mice ; Transcriptome
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Dataset ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-022-01470-8
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Article ; Online: Management of haemarthrosis induced anterior shoulder dislocation with arthroscopic washout and haemostasis.

Sorial, Ayman / Talbot, Charles

Trauma case reports

2019 Volume 21, Page(s) 100171

Abstract: Spontaneous heamarthrosis is a known and previously described complication of anticoagulant therapy. The knee and the shoulder joints are amongst the most commonly affected joints [1,2]. Subsequent dislocation/subluxation of the shoulder is also ... ...

Abstract	Spontaneous heamarthrosis is a known and previously described complication of anticoagulant therapy. The knee and the shoulder joints are amongst the most commonly affected joints [1,2]. Subsequent dislocation/subluxation of the shoulder is also previously described reporting acute anterior shoulder dislocation complicating a non-traumatic haemarthrosis [3], and a further report of a severely subluxed glenohumeral joint that was initially mis-diagnosed as anterior atraumatic dislocation [4]. Both cases were treated by aspiration of the joint, with supplementary manipulation required in the former. Here we report the additional use of shoulder arthroscopy and haemostasis to achieve concentric reduction of an atraumatic shoulder dislocation secondary to heamarthrosis, in a patient on warfarin.
Language	English
Publishing date	2019-04-09
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2835433-3
ISSN	2352-6440 ; 2352-6440
ISSN (online)	2352-6440
ISSN	2352-6440
DOI	10.1016/j.tcr.2019.100171
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Article ; Online: Cannabinoids for the treatment of refractory neuropathic pruritus in amyotrophic lateral sclerosis: A case report.

Lou, Kelvin / Murphy, Shane / Talbot, Clair

Palliative medicine

2021 Volume 36, Issue 1, Page(s) 208–211

Abstract: Background: Neuropathic symptoms have a wide variety of manifestations, ranging from pain to pruritus. Neuropathic pruritus is a type of chronic pruritus related to damaged small fibers. Cannabinoids have evidence to manage neuropathic symptoms. We ... ...

Abstract	Background: Neuropathic symptoms have a wide variety of manifestations, ranging from pain to pruritus. Neuropathic pruritus is a type of chronic pruritus related to damaged small fibers. Cannabinoids have evidence to manage neuropathic symptoms. We present a case of refractory neuropathic pruritus that was successfully managed with the use of oral cannabinoids. Case presentation: A 60-year-old male with amyotrophic lateral sclerosis with ongoing pruritus despite the use of standard neuropathic therapies. Possible course of action: Sodium channel and Formulation of a plan: A balanced oral cannabinoid from a licensed producer was preferred as it has evidence for neuropathic symptoms and is generally well tolerated. Outcome: The patient showed improvement to his pruritus score from 7/10 to 3/10. There was initial increased sedation but tolerance developed quickly. Lessons learned from case: Cannabinoids are possibly safe and effective in management of neuropathic pruritus. View on research problems: Additional research is needed to establish efficacy and safety.
MeSH term(s)	Amyotrophic Lateral Sclerosis/complications ; Cannabinoids/therapeutic use ; Dronabinol/therapeutic use ; Humans ; Middle Aged ; Pain/drug therapy ; Pruritus/drug therapy ; Pruritus/etiology
Chemical Substances	Cannabinoids ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2021-09-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	639247-7
ISSN	1477-030X ; 0269-2163
ISSN (online)	1477-030X
ISSN	0269-2163
DOI	10.1177/02692163211045314
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