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  1. Book ; Online: Obesity and Diabetes: Implications for Brain-Immunometabolism

    Gaspar, Joana M. / Latini, Alexandra / Talbot, Sebastien

    2020  

    Keywords Science: general issues ; Neurosciences ; obesity ; energy homeostasis ; diabetes ; neurodegeneration ; inflammation
    Size 1 electronic resource (204 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229945
    ISBN 9782889635856 ; 2889635856
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Decoding nociceptor-DC dialogues.

    Crosson, Theo / Talbot, Sebastien

    Immunity

    2023  Volume 56, Issue 5, Page(s) 906–908

    Abstract: Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al. ...

    Abstract Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al.
    MeSH term(s) Nociceptors/physiology ; Calcitonin Gene-Related Peptide ; Dendritic Cells
    Chemical Substances Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.04.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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  3. Article ; Online: Anatomical differences in nociceptor neurons sensitivity.

    Crosson, Theo / Talbot, Sebastien

    Bioelectronic medicine

    2022  Volume 8, Issue 1, Page(s) 7

    Abstract: Background: Dorsal Root Ganglia (DRG) neurons are derived from the neural crest and mainly innervate the skin, while Jugular Nodose Complex (JNC) neurons originate from the placode and innervate internal organs. These ganglia are composed of highly ... ...

    Abstract Background: Dorsal Root Ganglia (DRG) neurons are derived from the neural crest and mainly innervate the skin, while Jugular Nodose Complex (JNC) neurons originate from the placode and innervate internal organs. These ganglia are composed of highly heterogeneous groups of neurons aimed at assessing and preserving homeostasis. Among other subtypes, nociceptor neurons are specialized in sensing and responding to environmental dangers. As form typically follows function, we hypothesized that JNC and DRG neurons would be phenotypically and transcriptomically different.
    Methods: Mouse JNC and DRG neurons were cultured ex vivo. Using calcium imaging, qPCR and neurite outgrowth assay, we compared the sensitivity of JNC and DRG neurons. Using in-silico analysis of existing RNA sequencing datasets, we confronted our results to transcriptomic differences found between both ganglia.
    Results: We found drastically different expression levels of Transient Receptor Potential (TRP) channels, growth factor receptors and neuropeptides in JNC and DRG neurons. Functionally, naïve JNC neurons' TRP channels are more sensitive to thermal cues than the ones from DRG neurons. However, DRG neurons showed increased TRP channel responsiveness, neuropeptide release and neurite outgrowth when exposed to Nerve Growth Factor (NGF). In contrast, JNC neurons preferentially responded to Brain-derived neurotrophic factor (BDNF).
    Conclusion: Our data show that JNC and DRG neurons are transcriptomically and functionally unique and that pain sensitivity is different across anatomical sites. Drugs targeting NGF signaling may have limited efficacy to treat visceral pain. Bioelectronics nerve stimulation should also be adjusted to the ganglia being targeted and their different expression profile.
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-022-00088-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons.

    Wilcox, Natalie C / Taheri, Golnar / Halievski, Katherine / Talbot, Sebastien / Silva, Jaqueline R / Ghasemlou, Nader

    The Journal of allergy and clinical immunology

    2024  

    Abstract: Various immune cells in the skin contribute to its function as a first line of defense against infection and disease, and the skin's dense innervation by pain-sensing sensory neurons protects the host against injury or damage signals. Dendritic cells ( ... ...

    Abstract Various immune cells in the skin contribute to its function as a first line of defense against infection and disease, and the skin's dense innervation by pain-sensing sensory neurons protects the host against injury or damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis. Langerhans cells (LCs) are a DC subset located only in the epidermis; both populations of cells can migrate to lymph nodes to contribute to broad immune responses. Dermal DCs and LCs are found in close apposition with sensory nerve fibers in the skin and express neurotransmitter receptors, allowing them to communicate directly with the peripheral nervous system. Thus, neuroimmune signaling between DCs and/or LCs and sensory neurons can modulate physiologic and pathophysiologic pathways, including immune cell regulation, host defense, allergic response, homeostasis, and wound repair. Here, we summarize the latest discoveries on DC- and LC-neuron interaction with neurons while providing an overview of gaps and areas not previously explored. Understanding the interactions between these 2 defence systems may provide key insight into developing therapeutic targets for treating diseases such as psoriasis, neuropathic pain, and lupus.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Analysis of Airway Vagal Neurons.

    Wang, Jo-Chiao / Crosson, Theo / Talbot, Sebastien

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2506, Page(s) 297–314

    Abstract: Internal organs, including the airway, are innervated by neurons of the autonomic and sensory nervous systems. The airway-innervating sensory neurons primarily originate from the vagus nerve, whose cell bodies are found, in rodents, in the jugular and ... ...

    Abstract Internal organs, including the airway, are innervated by neurons of the autonomic and sensory nervous systems. The airway-innervating sensory neurons primarily originate from the vagus nerve, whose cell bodies are found, in rodents, in the jugular and nodose ganglia complex (JNC). About half of these sensory neurons expressed the heat-sensing ion channel TRPV1 and evolved to limit tissue damage by detecting chemical, mechanical, or thermal threats and to initiate protective airway reflexes such as coughing and bronchoconstriction. They also help monitor the host homeostasis by sensing nutrients, pressure, and O
    MeSH term(s) Nociceptors ; Nodose Ganglion ; Sensory Receptor Cells/physiology ; Transcriptome ; Vagus Nerve
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2364-0_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Neuro-Immunity Controls Obesity-Induced Pain.

    Eichwald, Tuany / Talbot, Sebastien

    Frontiers in human neuroscience

    2020  Volume 14, Page(s) 181

    Abstract: The prevalence of obesity skyrocketed over the past decades to become a significant public health problem. Obesity is recognized as a low-grade inflammatory disease and is linked with several comorbidities such as diabetes, circulatory disease, common ... ...

    Abstract The prevalence of obesity skyrocketed over the past decades to become a significant public health problem. Obesity is recognized as a low-grade inflammatory disease and is linked with several comorbidities such as diabetes, circulatory disease, common neurodegenerative diseases, as well as chronic pain. Adipocytes are a major neuroendocrine organ that continually, and systemically, releases pro-inflammatory factors. While the exact mechanisms driving obesity-induced pain remain poorly defined, nociceptor hypersensitivity may result from the systemic state of inflammation characteristic of obesity as well as weight surplus-induced mechanical stress. Obesity and pain also share various genetic mutations, lifestyle risk factors, and metabolic pathways. For instance, fat pads are often found hyper-innervated and rich in immune cell types of multiple origins. These immunocytes release cytokines, amplifying nociceptor function, which, in turn, via locally released neuropeptides, sustain immunocytes' function. Here, we posit that along with mechanical stress stemming from extra weight, the local neuro-immune interplay occurring within the fat pads maintains the state of chronic low-grade inflammation and heightens sensory hypersensitivity. Overall, stopping such harmful neuro-immune crosstalk may constitute a novel pathway to prevent obesity-associated comorbidities, including neuronal hypersensitivity.
    Language English
    Publishing date 2020-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2020.00181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Down-regulation of MCH II molecules by ubiquitination is required for the accumulation of CD206+ monocyte-derived DCs in lymph nodes

    Majdoubi, Abdelilah / Lee, Jun Seong / Balood, Mohammad / Talbot, Sébastien / Cheong, Cheolho / Thibodeau, Jacques

    Molecular immunology. 2022 Oct., v. 150

    2022  

    Abstract: Migratory DCs play a critical role in skin immunity. A subset of these cells infiltrate skin come from the extravasation of blood monocytes (P1) that continuously differentiate into an intermediate stage (P2) before becoming fully functional DCs (P3), ... ...

    Abstract Migratory DCs play a critical role in skin immunity. A subset of these cells infiltrate skin come from the extravasation of blood monocytes (P1) that continuously differentiate into an intermediate stage (P2) before becoming fully functional DCs (P3), which can migrate to skin draining lymph nodes (sdLNs). During their development into monocyte-derived DCs (moDCs), in parallel with the downregulation of Ly-6C, P1-P2-P3 progressively upregulate MHC class II molecules (MHCII) and the mannose receptor (CD206). To study the role of MHCII expression in the biology of migratory DCs. We studied by flow cytometry the development and migration of skin moDCs using four transgenic mouse models expressing different MHCII levels. Using CD206 as a surrogate marker for MHCII to identify P1, P2 and P3, we found that variations in the levels of MHCII did not affect the development of skin moDCs. However, tempering with ubiquitination of I-A resulted in the over-expression of MHCII, a decrease in the expression of IRF4 and CCR7, and prevented migration of skin moDCs to sdLNs. Interestingly, mice overexpressing MHCII developed larger tumors in B16-mel-anoma model. However, a GM-CSF-producing B16 variant increased the expression of IRF4 in tumor moDCs and restored their migration to sdLNs. The data show that although not required for their development in the skin, the down-regulation of MHCII by ubiquitination is crucial for IRF4\CCR7 dependent migration of CD206+DCs to the sdLN in homeostasis and during inflammation.
    Keywords flow cytometry ; genetically modified organisms ; homeostasis ; immunity ; inflammation ; lymph ; mannose ; mice ; migratory behavior ; models ; monocytes ; neoplasms ; ubiquitination
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2022.05.082
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 166: Show issues Location:
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  8. Article: Editorial: Obesity and Diabetes: Implications for Brain-Immunometabolism.

    Gaspar, Joana M / Talbot, Sebastien / Latini, Alexandra

    Frontiers in neuroscience

    2020  Volume 14, Page(s) 56

    Language English
    Publishing date 2020-02-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.00056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: LIST: A Newly Developed Laser-assisted Cell Bioprinting Technology.

    Roversi, Katiane / Orimi, Hamid Ebrahimi / Erfanian, Mahyar / Talbot, Sebastien / Boutopoulos, Christos

    Bio-protocol

    2022  Volume 12, Issue 19

    Abstract: Cell bioprinting technologies aim to fabricate tissue-like constructs by delivering biomaterials layer-by-layer. Bioprinted constructs can reduce the use of animals in drug development and hold promise for addressing the shortage of organs for ... ...

    Abstract Cell bioprinting technologies aim to fabricate tissue-like constructs by delivering biomaterials layer-by-layer. Bioprinted constructs can reduce the use of animals in drug development and hold promise for addressing the shortage of organs for transplants. We recently introduced a laser-assisted drop-on-demand bioprinting technology termed Laser Induced Side Transfer (LIST). This technology can print delicate cell types, including primary neurons. This bioprinting protocol includes the following key steps: cell harvesting, bio-ink preparation, laser setup priming, printing, and post-printing analysis. This protocol includes a detailed description of the laser setup, which is a rather unusual setup for a biology lab. This should allow easy reproduction by readers with basic knowledge of optics. Although we have focused on neuron bioprinting, interested readers will be able to adapt the protocol to bioprint virtually any cell type.
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons.

    Ahmadi, Ali / Balood, Mohammad / Roversi, Katiane / Ahmadi, Maryam / Rafei, Moutih / Talbot, Sebastien

    Journal of visualized experiments : JoVE

    2022  , Issue 184

    Abstract: Somatosensory neurons have evolved to detect noxious stimuli and activate defensive reflexes. By sharing means of communication, nociceptor neurons also tune host defenses by controlling the activity of the immune system. The communication between these ... ...

    Abstract Somatosensory neurons have evolved to detect noxious stimuli and activate defensive reflexes. By sharing means of communication, nociceptor neurons also tune host defenses by controlling the activity of the immune system. The communication between these systems is mostly adaptive, helping to protect homeostasis, it can also lead to, or promote, the onset of chronic diseases. Both systems co-evolved to allow for such local interaction, as found in primary and secondary lymphoid tissues and mucosa. Recent studies have demonstrated that nociceptors directly detect and respond to foreign antigens, immune cell-derived cytokines, and microbes. Nociceptor activation not only results in pain hypersensitivity and itching, but lowers the nociceptor firing threshold, leading to the local release of neuropeptides. The peptides that are produced by, and released from, the peripheral terminals of nociceptors can block the chemotaxis and polarization of lymphocytes, controlling the localization, duration, and type of inflammation. Recent evidence shows that sensory neurons interact with innate immune cells via cell-cell contact, for example, engaging group 2D (NKG2D) receptors on natural killer (NK) cells. Given that NK cells express the cognate receptors for various nociceptor-produced mediators, it is conceivable that nociceptors use neuropeptides to control the activity of NK cells. Here, we devise a co-culture method to study nociceptor neuron-NK cell interactions in a dish. Using this approach, we found that lumbar nociceptor neurons decrease NK cell cytokine expression. Overall, such a reductionist method could be useful to study how tumor-innervating neurons control the anticancer function of NK cells and how NK cells control the elimination of injured neurons.
    MeSH term(s) Cytokines/metabolism ; Humans ; Killer Cells, Natural ; Neuropeptides/metabolism ; Nociceptors/metabolism ; Pain ; Sensory Receptor Cells/metabolism
    Chemical Substances Cytokines ; Neuropeptides
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/63800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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