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Abstract	Objective:
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.690726
Database	MEDical Literature Analysis and Retrieval System OnLINE

Article: Role of H

Mohiuddin Chowdhury, Abu Taiub Mohammed / Kamal, Aktar / Abbas, Md Kafil Uddin / Karim, Md Rezaul / Ali, Md Ahsan / Talukder, Shubhashis / Hamidullah Mehedi, H M / Hassan, Hamid / Shahin, Abul Hossain / Li, Yarui / He, Shuixiang

World journal of clinical cases

2022 Volume 10, Issue 23, Page(s) 8170–8185

Abstract: Background: Coronavirus disease 2019 (COVID-19) is a global pandemic putting the population at a high risk of infection-related health hazards, mortality and a potential failure of proper medical therapies. Therefore, it is necessary to evaluate the ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) is a global pandemic putting the population at a high risk of infection-related health hazards, mortality and a potential failure of proper medical therapies. Therefore, it is necessary to evaluate the potential use of the existing drugs that could be used as options for the medical management of COVID-19 patients. Aim: To evaluate the role of the H Methods: This study was done on seriously ill COVID-19 patients admitted to the intensive care unit (ICU) from different institutes in Bangladesh. Patients were divided into famotidine treatment group "A" (famotidine 40 mg to 60 mg oral formulation every 8 h with other treatment as given), and control group "B" (treatment as given). National early warning score (NEWS)-2, and sequential organ failure assessment day-1 score was calculated to evaluate the outcome. Outcomes were evaluated by the time required for clinical improvement, characterized as duration required from enrollment to the achievement of NEWS-2 of ≤ 2 maintained for 24 h; time to symptomatic recovery, defined as the duration in days (from randomization) required for the recovery of the COVID-19 symptoms; mortality rate; duration of ICU and hospital stay; total period of hospitalization; the rate of supplementary oxygen requirement; the computed tomography (CT) chest recovery (%), the time required for the viral clearance and "NEWS-2" on discharge. Results: A total of 208 patients were enrolled in this study with 104 patients in each group. The famotidine treatment group had comparatively better recovery of 75% and a low mortality of 25% than the control with a recovery of 70% and a mortality of 30%. Duration of clinical improvement (group A 9.53 d, group B 14.21 d); hospitalization period among the recovered patients (group A 13.04 d, group B 16.31 d), pulmonary improvement in chest CT (group A 21.7%, group B 13.2%), and the time for viral clearance (group A 20.7 d, group B 23.8 d) were found to be statistically significant Conclusion: According to our study, treatment with famotidine achieved a better clinical outcome compared to the control group in severe COVID-19 illness, although no significant survival benefit was found.
Language	English
Publishing date	2022-02-14
Publishing country	United States
Document type	Clinical Trial
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i23.8170
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Role of H

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