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  1. AU="Talyta Ellen de Jesus dos Santos"
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  1. Article ; Online: Myelodysplastic syndrome versus idiopathic cytopenia of undetermined significance

    Talyta Ellen de Jesus dos Santos / Romelia Pinheiro Goncalves / Fernando Barroso Duarte

    Revista Brasileira de Hematologia e Hemoterapia, Vol 35, Iss 6, Pp 438-

    the role of morphology in distinguishing between these entities

    2013  Volume 439

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Hematologia e Hemoterapia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Presence of new mutations in the TP53 gene in patients with low-risk myelodysplastic syndrome

    Fernando Barroso Duarte / Romélia Pinheiro Gonçalves Lemes / Talyta Ellen de Jesus dos Santos / Maritza Cavalcante Barbosa / João Paulo Leitão de Vasconcelos / Francisco Dário Rocha-Filho / Ilana Zalcberg / Diego Coutinho / Monalisa Feliciano Figueiredo / Luciana Barros Carlos / Paulo Roberto Leitão de Vasconcelos

    Journal of Medical Case Reports, Vol 11, Iss 1, Pp 1-

    two case reports

    2017  Volume 4

    Abstract: Abstract Background Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for ... ...

    Abstract Abstract Background Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present study, two mutations in this gene are presented and discussed with the clinical evolution of the patients. Case presentation The first case is a 77-year-old Brazilian woman diagnosed as having multiple lineage dysplasia myelodysplastic syndrome according to World Health Organization 2016 and classified as very low-risk by Revised International Prognostic Scoring. The second case is an 80-year-old Brazilian man also diagnosed as having multiple lineage dysplasia myelodysplastic syndrome and classified as low risk. The mutation described in the first case was already identified in some neoplasias and it is associated with a poor prognosis, but it had never been reported before in myelodysplastic syndrome. The second mutation has never been described. Conclusions This is a novel report for the scientific community and may be very helpful as we can better understand the disease and the impact of mutations through the follow-up of these patients and others in the future. Both patients are in a good clinical condition, suggesting that these mutations may not alter the clinical course of the disease or may be associated with a good prognosis, but their role in the disease must be investigated more deeply in a larger population.
    Keywords Myelodysplastic syndromes ; TP53 mutations ; Prognosis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Tumor suppressor p53 protein expression

    Fernando Barroso Duarte / Romelia Pinheiro Gonçalves / Maritza Cavalcante Barbosa / Francisco Dário Rocha Filho / Talyta Ellen de Jesus dos Santos / Thayna Nogueira dos Santos / Paulo Roberto Leitão de Vasconcelos

    Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 3, Pp 196-

    prognostic significance in patients with low-risk myelodysplastic syndrome

    2014  Volume 201

    Abstract: BACKGROUND: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, ... ...

    Abstract BACKGROUND: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability.OBJECTIVE: To evaluate the impact of p53 protein expression at diagnosis in patients with low-risk myelodysplastic syndrome.METHODS: This study enrolled 38 patients diagnosed with low-risk myelodysplastic syndrome. Clinical data were collected by reviewing medical records, and immunohistochemical p53 staining was performed on bone marrow biopsies.RESULTS: Of the 38 participants, 13 (34.21%) showed p53 expression in their bone marrow. At diagnosis, this group of patients also presented clinical features characteristic of a poor prognosis more often than patients who did not express p53. Furthermore, patients expressing p53 had a shorter median survival time compared to those without p53 expression.CONCLUSION: This study shows that the expression of p53 at diagnosis is a useful indicator of distinct clinical characteristics and laboratory profiles found in low-risk myelodysplastic syndrome patients. These data indicate that the immunohistochemical analysis of p53 may be a prognostic tool for myelodysplastic syndrome and should be used as an auxiliary test to help determine the best therapeutic choice.
    Keywords Myelodysplastic syndromes ; Tumor suppressor protein p53 ; Prognosis ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2014-06-01T00:00:00Z
    Publisher Sociedade Brasileira de Hematologia e Hemoterapia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Methemoglobin measure in adult patients with sickle-cell anemia

    Marilia Rocha Laurentino / Teresa Maria de Jesus Ponte Carvalho / Talyta Ellen de Jesus dos Santos / Maritza Cavalcante Barbosa / Thayna Nogueira dos Santos / Romélia Pinheiro Gonçalves

    Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 50, Iss 3, Pp 184-

    influence of hydroxyurea therapy

    2014  Volume 188

    Abstract: Introduction: Hemoglobin S (HbS) is unstable hemoglobin that easily oxidizes, causing methemoglobin (MetHb) increased production in patients with sickle-cell anemia (SCA). Objectives: To determine MetHb levels and the influence of hydroxyurea (HU) ... ...

    Abstract Introduction: Hemoglobin S (HbS) is unstable hemoglobin that easily oxidizes, causing methemoglobin (MetHb) increased production in patients with sickle-cell anemia (SCA). Objectives: To determine MetHb levels and the influence of hydroxyurea (HU) therapy on this marker in patients with SCA. Materials and methods: Blood samples from 53 patients with SCA at the steady-state, with and without HU therapy, and 30 healthy individuals were collected to evaluate MetHb levels. The MetHb measurement was performed by spectrophotometry. Complete blood count, HU measurements, and fetal hemoglobin (HbF) and HbS concentrations were taken from medical records. Results: MetHb levels were statically higher in patients with SCA when compared to control group (p < 0.001). There was no statistical difference in MetHb level between SCA patients, either using or not HU. We obtained a positive correlation between MetHb measurements and HbS concentration (r = 0.2557; p = 0.0323). Conclusion: HbS presence favored hemoglobin breaking down, and consequently increased MetHb production. Treatment with HU, however, did not influence the levels of this marker.
    Keywords anemia falciforme ; metemoglobina ; hidroxiureia ; Pathology ; RB1-214 ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2014-06-01T00:00:00Z
    Publisher Sociedade Brasileira de Patologia Clínica
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Prolonged response to recombinant human erythropoietin treatment in patients with myelodysplastic syndrome at a single referral centre in Brazil

    Anna Thawanny Gadelha Moura / Fernando Barroso Duarte / Maritza Cavalcante Barbosa / Talyta Ellen de Jesus dos Santos / Romélia Pinheiro Gonçalves Lemes

    Clinics, Vol 74

    Abstract: OBJECTIVES: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil. ...

    Abstract OBJECTIVES: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil. METHODS: This was a retrospective cohort study of 36 patients diagnosed with MDS and treated with EPO alfa at 30,000 to 60,000 IU per week. Clinical data were collected from medical records. The events assessed were non-response to treatment and progression to acute myeloid leukaemia (AML). Statistical analyses were performed using GraphPad Prism 7 and SPSS 24 software. RESULTS: The overall survival of patients who received EPO alfa treatment was 51.64%, with a median of 65 months of treatment, and the overall survival of this group was 100% during the first 24 months. We detected a 43.5-month median event-free survival, with a response rate of 80.5%. We observed responses from 25 to 175 months. Patients with transfusion dependence and those with a high-risk stratification, as determined by the International Prognostic Scoring System (IPSS), the Revised International Prognostic Scoring System (IPSS-R), the WHO classification-based Prognostic Scoring System (WPSS) and the WHO 2016, had a lower event-free survival than other patients. CONCLUSIONS: Despite the wide use of EPO alfa in the treatment of anaemia in patients with MDS, the median response duration is approximately only 24 months. Our data provide encouraging results concerning the benefits of using EPO alfa for the improvement of the quality of life, as patients treated with EPO showed higher overall survival, event-free survival rates and longer response durations than have been previously described in the literature.
    Keywords Myelodysplastic Syndrome ; Recombinant Human Erythropoietin ; Erythropoietin ; Epoetin Alfa ; EPO ; EPO Alfa ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Relevance of prognostic factors in the decision-making of stem cell transplantation in Myelodysplastic Syndromes

    Fernando Barroso Duarte / Talyta Ellen de Jesus dos Santos / Maritza Cavalcante Barbosa / Jacques Kaufman / João Paulo de Vasconcelos / Romélia Pinheiro Gonçalves Lemes / Francisco Dário Rocha / Diego Ferreira Coutinho / Ilana Zalcberg / Paulo Roberto Leitão de Vasconcelos

    Revista da Associação Médica Brasileira, Vol 62, Iss suppl 1, Pp 25-28

    Abstract: ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of ... ...

    Abstract ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to discuss the factors that can guide the decision-making on referring or not a patient to HSCT. Three cases of MDS, two of which were submitted to HSCT are presented. We intend to report the difficulties in referring patients with MDS to transplant and the prognostic factors that contribute to define eligibility.
    Keywords Síndrome Mielodisplásica ; Transplante de Células-Tronco Hematopoéticas ; Prognóstico ; Medicine (General) ; R5-920
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Wernicke's encephalopathy in a patient with non-Hodgkin's lymphoma post-Autologous HSCT

    João Paulo de Vasconcelos Leitão / Romélia Pinheiro Gonçalves Lemes / Maritza Cavalcante Barbosa / Beatriz Stela Gomes de Souza Pitombeira Araújo / Karine Sampaio Nunes Barroso / Jacques Kaufman / Talyta Ellen de Jesus dos Santos / Anna Thawanny Gadelha Moura / André Rodrigues Façanha Barreto / Fernando Barroso Duarte

    Revista da Associação Médica Brasileira, Vol 64, Iss 10, Pp 882-884

    Abstract: SUMMARY Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is ... ...

    Abstract SUMMARY Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely considered in patients submitted to this procedure. Considering that, the manuscript reports the clinical characteristics and the possible factors that predisposed the occurrence of WE in a patient with non-Hodgkin's lymphoma post-Autologous HSCT. We conclude that WE should be considered in patients submitted to autologous HSCT associated with prolonged use of TPN and malnutrition.
    Keywords Wernicke's encephalopathy ; non-hodgkin's lymphoma ; autologous hsct ; thiamine deficiency ; Medicine (General) ; R5-920
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation

    Thayna Nogueira dos Santos / Fernando Barroso Duarte / Pedro Aurio Maia Filho / Talyta Ellen de Jesus dos Santos / Maritza Cavalcante Barbosa / Tarcísio Paulo de Almeida Filho / Bruno Coelho Cavalcanti / Paulo Roberto Leitão de Vasconcelos / Luana Leticia Dutra / Germison Silva Lopes / Franciclea Oliveira Costa / João Paulo Vasconcelos Leitão / Jacques KauFman / Beatriz Stella Pitombeira AraúJo / Karine Sampaio Nunes Barroso / Romélia Pinheiro Gonçalves Lemes

    Revista da Associação Médica Brasileira, Vol 62, Iss suppl 1, Pp 39-43

    Abstract: ABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to ... ...

    Abstract ABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were performed at baseline (pre-CR) of the disease and during the conditioning regimen (CR), one day after the HSCT, ten days after HSCT and twenty days after HSCT, as well as in the control group consisting of 30 healthy individuals. The outcomes showed that both groups of patients had an hyperoxidative state with high DI when compared to baseline and to the control group and that the CR exacerbated this condition. However, after the follow-up period of the study, this picture was re-established to the baseline levels of each pathology. The study patients with MM showed a mean grafting time of 10.75 days (8 to 13 days), with 10.15 days (8 to 15 days) for the lymphoma patients. In patients with MM, there was a negative correlation between the grafting time and the basal levels of GPx (r = -0.54; p = 0.034), indicating that lower levels of this important enzyme are associated with a longer grafting time. For the DI, the correlation was a positive one (r = 0.529; p = 0.030). In the group with lymphoma, it was observed that the basal levels of NOx were positively correlated with grafting time (r = 0.4664, p = 0.032). The data indicate the potential of these biomarkers as predictors of toxicity and grafting time in patients with MM and Lymphomas submitted to autologous HSCT.
    Keywords Transplante autólogo de células-tronco hematopoéticas ; Estresse oxidativo ; Dano ao DNA ; Mieloma múltiplo ; Linfoma ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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