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  1. Article ; Online: Intravenous iron in heart failure with reduced ejection fraction: just about right.

    Kalogeropoulos, Andreas P / Tam, Edlira

    European journal of heart failure

    2022  Volume 24, Issue 6, Page(s) 1114–1116

    MeSH term(s) Heart Failure/drug therapy ; Humans ; Iron ; Stroke Volume ; Ventricular Function, Left
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2520
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5299: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Safety and Efficacy of Anti-Hypertensive Medications in Patients with Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-analysis.

    Al-Sadawi, Mohammed / Tao, Michael / Dhaliwal, Simrat / Goldschmit, Mark / Tam, Edlira / Mann, Noel

    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

    2024  

    Abstract: Introduction: Hypertension (HTN) is a co-morbidity that is commonly associated with heart failure with preserved ejection fraction (HFpEF). However, it remains unclear whether treatment of hypertension in HFpEF patients is associated with improved ... ...

    Abstract Introduction: Hypertension (HTN) is a co-morbidity that is commonly associated with heart failure with preserved ejection fraction (HFpEF). However, it remains unclear whether treatment of hypertension in HFpEF patients is associated with improved cardiovascular outcomes.
    Aim: The purpose of this meta-analysis is to evaluate the association of anti-hypertensive medical therapy with cardiovascular outcomes in patients with HFpEF.
    Methods: We performed a database search for studies reporting on the association of anti-hypertensive medications with cardiovascular outcomes and safety endpoints in patients with HFpEF. The databases searched include OVID Medline, Web of Science, and Embase. The primary endpoint was all-cause mortality. Secondary endpoints include cardiovascular (CV) mortality, worsening heart failure (HF), CV hospitalization, composite major adverse cardiovascular events (MACE), hyperkalemia, worsening renal function, and hypotension.
    Results: A total of 12 studies with 14062 HFpEF participants (7010 treated with medical therapy versus 7052 treated with placebo) met inclusion criteria. Use of anti-hypertensive medications was not associated with lower all-cause mortality, CV mortality or CV hospitalization compared to treatment with placebo (OR 1.02, 95% CI 0.77-1.35; p = 0.9, OR 0.88, 95% CI 0.73-1.06; p = 0.19, OR 0.99, 95% CI 0.87-1.12; p = 0.83, OR 0.90, 95% CI 0.79-1.03; p = 0.11). Anti-hypertensive medications were not associated with lower risk of subsequent acute myocardial infarction (AMI) (OR 0.53, 95% CI 0.07-3.73; p = 0.5). Use of anti-hypertensive medications was associated with a statistically significant lower risk of MACE (OR 0.90, 95% CI 0.83-0.98; p = 0.02).
    Conclusions: While treatment with anti-hypertensive medications was not associated with lower risk of all-cause mortality, their use may be associated with reduce risk of adverse cardiovascular outcomes in patients with HFpEF regardless of whether they have HTN. Additional high quality studies are required to clarify this association and determine the effect based on specific classes of medications.
    Language English
    Publishing date 2024-05-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1236337-6
    ISSN 1179-1985 ; 1120-9879
    ISSN (online) 1179-1985
    ISSN 1120-9879
    DOI 10.1007/s40292-024-00646-0
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    Zs.A 4289: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Utility of native T1 mapping and myocardial extracellular volume fraction in patients with nonischemic dilated cardiomyopathy: A systematic review and meta-analysis.

    Tao, Michael / Dhaliwal, Simrat / Ghosalkar, Dhairyasheel / Sheng, Siyuan / Dianati-Maleki, Neda / Tam, Edlira / Rahman, Tahmid / Mann, Noelle / Kort, Smadar

    International journal of cardiology. Heart & vasculature

    2024  Volume 51, Page(s) 101339

    Abstract: Background: Cardiac magnetic resonance imaging (CMR) based T1 mapping and extracellular volume fraction (ECV) are powerful tools for identifying myocardial fibrosis. This systematic review and : Methods: A literature search was conducted for studies ... ...

    Abstract Background: Cardiac magnetic resonance imaging (CMR) based T1 mapping and extracellular volume fraction (ECV) are powerful tools for identifying myocardial fibrosis. This systematic review and
    Methods: A literature search was conducted for studies reporting on use of CMR-based native T1 mapping and ECV measurement in NICM patients and their association with major adverse cardiac events (MACE), ventricular arrhythmias (VAs), and left ventricular reverse remodeling (LVRR). Databases searched included: Ovid MEDLINE, EMBASE, Web of Science, and Google Scholar. The search was not restricted to time or publication status.
    Results: Native T1 and ECV were significantly higher in NICM patients compared to controls (MD 78.80, 95 % CI 50.00, 107.59; p < 0.01; MD 5.86, 95 % CI 4.55, 7.16; p < 0.01). NICM patients who experienced MACE had higher native T1 and ECV (MD 52.87, 95 % CI 26.59, 79.15; p < 0.01; MD 6.03, 95 % CI 3.79, 8.26; p < 0.01). There was a non-statistically significant trend toward higher native T1 time in NICM patients who experienced VAs. NICM patients who were poor treatment responders had higher baseline native T1 and ECV (MD 40.58, 95 % CI 12.90, 68.25; p < 0.01; MD 3.29, 95 % CI 2.25, 4.33; p < 0.01).
    Conclusions: CMR-based native T1 and ECV quantification may be useful tools for risk stratification of patients with NICM. They may provide additional diagnostic utility in combination with LGE, which poorly characterizes fibrosis in patients with diffuse myocardial involvement.
    Language English
    Publishing date 2024-02-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2024.101339
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  4. Article ; Online: Utility of Fractional Flow Reserve Computed Tomography Angiography in Patients With Stable Coronary Artery Disease.

    Tao, Michael / Gier, Chad / Al-Sadawi, Mohammed / Dhaliwal, Simrat / Masson, Ravi / Rahman, Tahmid / Gavalas, Michael / Tam, Edlira / Mann, Noelle

    The American journal of cardiology

    2023  Volume 208, Page(s) 31–36

    Abstract: Coronary computed tomography angiography is a modality with high negative predictive value for evaluation of coronary artery disease (CAD). However, its diagnostic accuracy for obstructive CAD is limited by multiple factors. Fractional flow reserve (FFR) ...

    Abstract Coronary computed tomography angiography is a modality with high negative predictive value for evaluation of coronary artery disease (CAD). However, its diagnostic accuracy for obstructive CAD is limited by multiple factors. Fractional flow reserve (FFR) computed tomography (FFR
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Fractional Flow Reserve, Myocardial ; Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Tomography, X-Ray Computed ; Myocardial Infarction ; Coronary Vessels ; Predictive Value of Tests ; Coronary Stenosis
    Language English
    Publishing date 2023-10-07
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.07.080
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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.73: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Utility of coronary revascularization in patients with ischemic left ventricular dysfunction.

    Al-Sadawi, Mohammed / Tao, Michael / Dhaliwal, Simrat / Radakrishnan, Archanna / Liu, Yang / Gier, Chad / Masson, Ravi / Rahman, Tahmid / Tam, Edlira / Mann, Noelle

    Cardiovascular revascularization medicine : including molecular interventions

    2024  

    Abstract: Background: Revascularization in patients with left ventricular (LV) dysfunction has been a subject of ongoing uncertainty and conflicting results. This is further complicated by factors including viability, severity of LV dysfunction, and method of ... ...

    Abstract Background: Revascularization in patients with left ventricular (LV) dysfunction has been a subject of ongoing uncertainty and conflicting results. This is further complicated by factors including viability, severity of LV dysfunction, and method of revascularization using percutaneous coronary intervention (PCI) versus coronary-artery bypass grafting (CABG).
    Objectives: The purpose of this meta-analysis is to evaluate the association of coronary revascularization with outcomes in patients with ischemic LV dysfunction.
    Methods: A literature search was conducted for studies reporting on cardiovascular outcomes after revascularization compared to optimal medical therapy (OMT) in patients with ischemic LV dysfunction.
    Results: A total of 23 studies with 10,110 participants met inclusion criteria. Revascularization was significantly associated with lower all-cause mortality and CV mortality compared to OMT. The association was statistically significant regardless of severity of LV dysfunction or method of revascularization. Subgroup analysis demonstrated that revascularization was significantly associated with lower all-cause and CV mortality compared to OMT for patients with viable myocardium and mixed cohorts with variable viability, but not patients without viable myocardium. Revascularization was not associated with a significant difference in risk of heart failure (HF) hospitalization or acute myocardial infarction (AMI) compared to OMT.
    Conclusions: Revascularization in patients with ischemic LV dysfunction is associated with lower risk of all-cause and CV mortality independent of severity of LV dysfunction or method of revascularization. Revascularization is not associated with lower risk of mortality in patients without evidence of viable myocardium and is not associated with lower risk of AMI or HF hospitalization.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2024.02.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5562: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Race and Ethnicity in Heart Failure: JACC Focus Seminar 8/9.

    Piña, Ileana L / Jimenez, Shirin / Lewis, Eldrin F / Morris, Alanna A / Onwuanyi, Anekwe / Tam, Edlira / Ventura, Hector O

    Journal of the American College of Cardiology

    2021  Volume 78, Issue 25, Page(s) 2589–2598

    Abstract: Heart failure (HF) affects >6 million Americans, with variations in incidence, prevalence, and clinical outcomes by race/ethnicity. Black adults have the highest risk for HF, with earlier age of onset and the highest risk of death and hospitalizations. ... ...

    Abstract Heart failure (HF) affects >6 million Americans, with variations in incidence, prevalence, and clinical outcomes by race/ethnicity. Black adults have the highest risk for HF, with earlier age of onset and the highest risk of death and hospitalizations. The risk of hospitalizations for Hispanic patients is higher than White patients. Data on HF in Asian individuals are more limited. However, the higher burden of traditional cardiovascular risk factors, particularly among South Asian adults, is associated with increased risk of HF. The role of environmental, socioeconomic, and other social determinants of health, more likely for Black and Hispanic patients, are increasingly recognized as independent risk factors for HF and worse outcomes. Structural racism and implicit bias are drivers of health care disparities in the United States. This paper will review the clinical, physiological, and social determinants of HF risk, unique for race/ethnic minorities, and offer solutions to address systems of inequality that need to be recognized and dismantled/eradicated.
    MeSH term(s) Health Policy ; Healthcare Disparities ; Heart Disease Risk Factors ; Heart Failure/ethnology ; Heart Failure/therapy ; Humans ; Practice Guidelines as Topic ; Social Determinants of Health ; Systemic Racism
    Language English
    Publishing date 2021-12-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.06.058
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

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  7. Article ; Online: Graphical Instructions for Administration and Scoring the Mini-Cog: Results of a Randomized Clinical Trial.

    Tam, Edlira / Gandesbery, Benjamin T / Young, Laura / Borson, Soo / Gorodeski, Eiran Z

    Journal of the American Geriatrics Society

    2018  Volume 66, Issue 5, Page(s) 987–991

    Abstract: Objectives: To develop a novel set of graphical Mini-Cog instructions designed to aid clinicians previously untrained on the Mini-Cog in accurate administration and scoring and to determine whether use of these graphical instructions improved the speed ... ...

    Abstract Objectives: To develop a novel set of graphical Mini-Cog instructions designed to aid clinicians previously untrained on the Mini-Cog in accurate administration and scoring and to determine whether use of these graphical instructions improved the speed and accuracy of deployment of this tool.
    Design: Randomized clinical trial.
    Setting: Testing was conducted in a simulated environment with a mock patient.
    Participants: Registered nurses working in inpatient or outpatient settings at a large academic medical center who had no prior exposure to or training with the Mini-Cog (N=92).
    Measurements: Our primary outcome was the composite proportion of nurses who made errors in administration or scoring of the Mini-Cog.
    Results: None of the nurses in the graphical instruction group and 28 (61%) in the standardized instructions group (15 (33%) made administration errors, 22 (48%) made scoring errors) made errors. Nurses randomly assigned to the graphical group were able to read (median 36 vs 54 seconds, P<.001), administer (46 vs 62 seconds, P<.001), and score (15 vs 84 seconds, P<.001) the Mini-Cog more quickly than those in the standardized instructions group.
    Conclusion: Graphical instructions increase the accuracy and speed of test administration in nurses without prior training in Mini-Cog administration. Further research is necessary to confirm these findings and evaluate the use of this method in other healthcare professionals and settings.
    MeSH term(s) Adult ; Cognition Disorders ; Female ; Humans ; Male ; Mental Status and Dementia Tests/standards ; Neuropsychological Tests/standards ; Nurses/statistics & numerical data
    Language English
    Publishing date 2018-02-23
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.15313
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