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Article ; Online: Diagnostic Performance of

Light, Alexander / Lazic, Stefan / Houghton, Kate / Bayne, Max / Connor, Martin J / Tam, Henry / Ahmed, Hashim U / Shah, Taimur T / Barwick, Tara D

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024 Volume 65, Issue 3, Page(s) 379–385

Abstract: For men with prostate cancer who develop biochemical failure after radiotherapy, European guidelines recommend reimaging ... ...

Abstract	For men with prostate cancer who develop biochemical failure after radiotherapy, European guidelines recommend reimaging with
MeSH term(s)	Male ; Humans ; Multiparametric Magnetic Resonance Imaging ; Gallium Radioisotopes ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy
Chemical Substances	PSMA-11 ; Gallium Radioisotopes
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.266527
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Article ; Online: Lessons and Applications of Omics Research in Diabetes Epidemiology.

Yu, Gechang / Tam, Henry C H / Huang, Chuiguo / Shi, Mai / Lim, Cadmon K P / Chan, Juliana C N / Ma, Ronald C W

Current diabetes reports

2024 Volume 24, Issue 3, Page(s) 27–44

Abstract: Purpose of review: Recent advances in genomic technology and molecular techniques have greatly facilitated the identification of disease biomarkers, advanced understanding of pathogenesis of different common diseases, and heralded the dawn of precision ... ...

Abstract	Purpose of review: Recent advances in genomic technology and molecular techniques have greatly facilitated the identification of disease biomarkers, advanced understanding of pathogenesis of different common diseases, and heralded the dawn of precision medicine. Much of these advances in the area of diabetes have been made possible through deep phenotyping of epidemiological cohorts, and analysis of the different omics data in relation to detailed clinical information. In this review, we aim to provide an overview on how omics research could be incorporated into the design of current and future epidemiological studies. Recent findings: We provide an up-to-date review of the current understanding in the area of genetic, epigenetic, proteomic and metabolomic markers for diabetes and related outcomes, including polygenic risk scores. We have drawn on key examples from the literature, as well as our own experience of conducting omics research using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank, as well as other cohorts, to illustrate the potential of omics research in diabetes. Recent studies highlight the opportunity, as well as potential benefit, to incorporate molecular profiling in the design and set-up of diabetes epidemiology studies, which can also advance understanding on the heterogeneity of diabetes. Learnings from these examples should facilitate other researchers to consider incorporating research on omics technologies into their work to advance the field and our understanding of diabetes and its related co-morbidities. Insights from these studies would be important for future development of precision medicine in diabetes.
MeSH term(s)	Humans ; Proteomics/methods ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/genetics ; Genomics/methods ; Metabolomics/methods ; Precision Medicine/methods
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2065167-3
ISSN	1539-0829 ; 1534-4827
ISSN (online)	1539-0829
ISSN	1534-4827
DOI	10.1007/s11892-024-01533-7
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Article: Corporate governance, ownership structure and managing earnings to meet critical thresholds among Chinese listed firms

Lai, Liona / Tam, Henry

Review of quantitative finance and accounting Vol. 48, No. 3 , p. 789-818

2017 Volume 48, Issue 3, Page(s) 789–818

Author's details	Liona Lai, Henry Tam
Keywords	Corporate governance ; Ownership structure ; Earnings management ; Earnings thresholds ; China
Language	English
Publisher	Springer
Publishing place	New York, NY
Document type	Article
ZDB-ID	1087855-5 ; 2009625-2
ISSN	1573-7179 ; 0924-865X
ISSN (online)	1573-7179
ISSN	0924-865X
Database	ECONomics Information System

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Article ; Online: Rethinking prostate cancer screening: could MRI be an alternative screening test?

Eldred-Evans, David / Tam, Henry / Sokhi, Heminder / Padhani, Anwar R / Winkler, Mathias / Ahmed, Hashim U

Nature reviews. Urology

2020 Volume 17, Issue 9, Page(s) 526–539

Abstract: In the past decade rigorous debate has taken place about population-based screening for prostate cancer. Although screening by serum PSA levels can reduce prostate cancer-specific mortality, it is unclear whether the benefits outweigh the risks of false- ... ...

Abstract	In the past decade rigorous debate has taken place about population-based screening for prostate cancer. Although screening by serum PSA levels can reduce prostate cancer-specific mortality, it is unclear whether the benefits outweigh the risks of false-positive results and overdiagnosis of insignificant prostate cancer, and it is not recommended for population-based screening. MRI screening for prostate cancer has the potential to be analogous to mammography for breast cancer or low-dose CT for lung cancer. A number of potential barriers and technical challenges need to be overcome in order to implement such a programme. We discuss different approaches to MRI screening that could address these challenges, including abbreviated MRI protocols, targeted MRI screening, longer rescreening intervals and a multi-modal screening pathway. These approaches need further investigation, and we propose a phased stepwise research framework to ensure proper evaluation of the use of a fast MRI examination as a screening test for prostate cancer.
MeSH term(s)	Decision Trees ; Early Detection of Cancer/methods ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms/diagnostic imaging
Language	English
Publishing date	2020-07-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2493737-X
ISSN	1759-4820 ; 1759-4812
ISSN (online)	1759-4820
ISSN	1759-4812
DOI	10.1038/s41585-020-0356-2
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Article ; Online: Use of Imaging to Optimise Prostate Cancer Tumour Volume Assessment for Focal Therapy Planning.

Eldred-Evans, David / Tam, Henry / Smith, Andrew P T / Winkler, Mathias / Ahmed, Hashim U

Current urology reports

2020 Volume 21, Issue 10, Page(s) 38

Abstract: Purpose of review: Rapid advances in imaging of the prostate have facilitated the development of focal therapy and provided a non-invasive method of estimating tumour volume. Focal therapy relies on an accurate estimate of tumour volume for patient ... ...

Abstract	Purpose of review: Rapid advances in imaging of the prostate have facilitated the development of focal therapy and provided a non-invasive method of estimating tumour volume. Focal therapy relies on an accurate estimate of tumour volume for patient selection and treatment planning so that the optimal energy dose can be delivered to the target area(s) of the prostate while minimising toxicity to surrounding structures. This review provides an overview of different imaging modalities which may be used to optimise tumour volume assessment and critically evaluates the published evidence for each modality. Recent findings: Multi-parametric MRI (mp-MRI) has become the standard tool for patient selection and guiding focal therapy treatment. The current evidence suggests that mp-MRI may underestimate tumour volume, although there is a large variability in results. There remain significant methodological challenges associated with pathological processing and accurate co-registration of histopathological data with mp-MRI. Advances in different ultrasound modalities are showing promise but there has been limited research into tumour volume estimation. The role of PSMA PET/CT is still evolving and further investigation is needed to establish if this is a viable technique for prostate tumour volumetric assessment. mp-MRI provides the necessary tumour volume information required for selecting patients and guiding focal therapy treatment. The potential for underestimation of tumour volume should be taken into account and an additional margin applied to ensure adequate treatment coverage. At present, there are no other viable image-based alternatives although advances in new technologies may refine volume estimations in the future.
MeSH term(s)	Humans ; Male ; Multiparametric Magnetic Resonance Imaging ; Neoplasm Staging ; Patient Care Planning ; Patient Selection ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Tumor Burden
Language	English
Publishing date	2020-08-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057354-6
ISSN	1534-6285 ; 1527-2737
ISSN (online)	1534-6285
ISSN	1527-2737
DOI	10.1007/s11934-020-00987-y
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Zs.A 5528: Show issues

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Article ; Online: An Evaluation of Screening Pathways Using a Combination of Magnetic Resonance Imaging and Prostate-specific Antigen: Results from the IP1-PROSTAGRAM Study.

Eldred-Evans, David / Tam, Henry / Sokhi, Heminder / Padhani, Anwar R / Connor, Martin / Price, Derek / Gammon, Martin / Klimowska-Nassar, Natalia / Burak, Paula / Day, Emily / Winkler, Mathias / Fiorentino, Francesca / Ahmed, Hashim U

European urology oncology

2023 Volume 6, Issue 3, Page(s) 295–302

Abstract: Background: The use of prostate-specific antigen (PSA) testing to screen for prostate cancer has been fraught with under- and overdiagnosis. Short, noncontrast magnetic resonance imaging (MRI) might detect more grade group ≥2 cancers with similar rates ... ...

Abstract	Background: The use of prostate-specific antigen (PSA) testing to screen for prostate cancer has been fraught with under- and overdiagnosis. Short, noncontrast magnetic resonance imaging (MRI) might detect more grade group ≥2 cancers with similar rates of biopsy. Objective: To evaluate strategies that combined PSA and MRI to select men based in the community for a prostate biopsy. Design, setting, and participants: IP1-PROSTAGRAM was a prospective, population-based, paired cohort study of 408 men aged 50-69 yr conducted at seven UK primary care practice and two imaging centres (from October 10, 2018 to May 15, 2019). Intervention: All participants underwent screening with a PSA test, MRI (T2-weighted and diffusion), and transrectal ultrasound (b-mode and elastography). If any test was screen positive, a systematic 12-core biopsy was performed. Additional image-fusion targeted biopsies were taken if the MRI or ultrasound was positive. Outcome measurements and statistical analysis: We conducted an analysis, set out in the statistical plan a priori, comparing 13 different pathways including PSA-alone, MRI-alone, and a range of PSA thresholds and MRI scores. The performance of each pathway was evaluated focusing on the trade-offs between biopsy referral rates and detection of grade group ≥2 cancers. A targeted biopsy was performed only where the PROSTAGRAM MRI showed a lesion score of 3, 4, or 5. Results and limitations: The standard PSA pathway (PSA ≥3 ng/ml + systematic biopsy) would lead to 10% of men being referred for a biopsy and a 1.0% detection rate of grade group ≥2 cancers. Pathways that relied on MRI alone set at a threshold score of 3 for a biopsy led to higher biopsy rates, but with benefit of high cancer detection rates. The pathway that combined an initial low PSA threshold (≥1.0 ng/ml) and MRI score ≥4 accurately identified a high rate of grade group ≥2 cancers (2.5%, 95% confidence interval 1.3-4.6) while recommending fewer patients for a biopsy (7.1%, 95% confidence interval 4.9-10.2). The results are pertinent to only one screening round, the impact of repeat screening rounds is not evaluated, and the required MRI capacity is currently lacking. Conclusions: Our results highlight the trade-off that exists between reducing excessive numbers of biopsies and maintaining grade group ≥2 cancer detection rates. A pathway that combines PSA ≥1 ng/ml and MRI score ≥4 maintains the detection of grade group ≥2 cancers while recommending fewer men for biopsies and would be the preferred strategy to evaluate in future studies at the first screening round. Patient summary: The IP1-PROSTAGRAM study shows that PROSTAGRAM magnetic resonance imaging in men with a prostate-specific antigen level of ≥1.0 ng/ml could be a promising pathway to evaluate in future screening trials.
MeSH term(s)	Male ; Humans ; Prostate-Specific Antigen ; Cohort Studies ; Prospective Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Image-Guided Biopsy/methods ; Magnetic Resonance Imaging/methods
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-04-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2023.03.009
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Article ; Online: Perceived patient burden and acceptability of MRI in comparison to PSA and ultrasound: results from the IP1-PROSTAGRAM study.

Eldred-Evans, David / Winkler, Mathias / Klimowska-Nassar, Natalia / Burak, Paula / Connor, Martin J / Fiorentino, Francesca / Day, Emily / Price, Derek / Gammon, Martin / Tam, Henry / Sokhi, Heminder / Padhani, Anwar R / Ahmed, Hashim U

Prostate cancer and prostatic diseases

2023 Volume 26, Issue 3, Page(s) 531–537

Abstract: Background: The IP1-PROSTAGRAM study showed that a short, non-contrast MRI detected more significant cancers with similar rates of biopsy compared to PSA. Herein, we compare the expected and perceived burden of PSA, MRI and ultrasound as screening tests. ...

Abstract	Background: The IP1-PROSTAGRAM study showed that a short, non-contrast MRI detected more significant cancers with similar rates of biopsy compared to PSA. Herein, we compare the expected and perceived burden of PSA, MRI and ultrasound as screening tests. Methods: IP1-PROSTAGRAM was a prospective, population-based, paired screening study of 408 men conducted at seven UK primary care practices and two imaging centres. The screening tests were serum PSA, non-contrast MRI and ultrasound. If any test was screen-positive, a prostate biopsy was performed. Participants completed an Expected Burden Questionnaire (EBQ) and Perceived Burden Questionnaire (PBQ) before and after each screening test. Results: The overall level of burden for MRI and PSA was minimal. Few men reported high levels of anxiety, burden, embarrassment or pain following either MRI or PSA. Participants indicated an overall preference for MRI after completing all screening tests. Of 408 participants, 194 (47.5%) had no preference, 106 (26.0%) preferred MRI and 79 (19.4%) preferred PSA. This indicates that prior to screening, participants preferred MRI compared to PSA (+6.6%, 95% CI 4.4-8.4, p = 0.02) and after completing screening, the preference for MRI was higher (+21.1%, 95% CI 14.9-27.1, p < 0.001). The proportion of participants who strongly agreed with repeating the test was 50.5% for ultrasound, 65% for MRI and 68% for PSA. A larger proportion of participants found ultrasound anxiety-inducing, burdensome, embarrassing and painful compared to both MRI and PSA. Conclusions: Prostagram MRI and PSA are both acceptable as screening tests among men aged 50-69 years. Both tests were associated with minimal amounts of anxiety, burden, embarrassment and pain. The majority of participants preferred MRI over PSA and ultrasound. Registration: This study was registered on clinicaltrials.gov at https://clinicaltrials.gov/ct2/show/NCT03702439 .
MeSH term(s)	Male ; Humans ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prospective Studies ; Biopsy ; Magnetic Resonance Imaging
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-023-00662-6
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Article: An economic or political Kuznets curve?

Tam, Henry

Public choice Vol. 134, No. 3/4 , p. 367-389

2008 Volume 134, Issue 3, Page(s) 367–389

Author's details	Henry Tam
Keywords	Kuznets-Kurve ; Einkommensverteilung ; Demokratisierung ; Entwicklung ; Welt
Language	English
Size	graph. Darst.
Publisher	Springer
Publishing place	Dordrecht
Document type	Article
ZDB-ID	207597-0
Database	ECONomics Information System

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Article ; Online: Ossification centres in a radiograph of a child's elbow.

Chen, Ying / Tam, Henry H

BMJ (Clinical research ed.)

2012 Volume 345, Page(s) e6965

MeSH term(s)	Child ; Elbow Joint/diagnostic imaging ; Humans ; Humerus/diagnostic imaging ; Osteogenesis/physiology ; Radiography ; Radius/diagnostic imaging
Language	English
Publishing date	2012-10-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.e6965
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Article ; Online: Bench to Bedside Development of [

Challapalli, Amarnath / Barwick, Tara D / Dubash, Suraiya R / Inglese, Marianna / Grech-Sollars, Matthew / Kozlowski, Kasia / Tam, Henry / Patel, Neva H / Winkler, Mathias / Flohr, Penny / Saleem, Azeem / Bahl, Amit / Falconer, Alison / De Bono, Johann S / Aboagye, Eric O / Mangar, Stephen

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 24

Abstract: Malignant transformation is characterised by aberrant phospholipid metabolism of cancers, associated with the upregulation of choline kinase alpha (CHKα). Due to the metabolic instability of choline radiotracers and the increasing use of late-imaging ... ...

Abstract	Malignant transformation is characterised by aberrant phospholipid metabolism of cancers, associated with the upregulation of choline kinase alpha (CHKα). Due to the metabolic instability of choline radiotracers and the increasing use of late-imaging protocols, we developed a more stable choline radiotracer, [
MeSH term(s)	Male ; Humans ; Choline/metabolism ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Prostatic Neoplasms/pathology ; Radiometry
Chemical Substances	Choline (N91BDP6H0X)
Language	English
Publishing date	2023-12-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28248018
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