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  1. AU="Tam, Patrick Chung Kay"
  2. AU="Patrick R. H. Steinmetz"
  3. AU="Odierna, Francesco"
  4. AU="Monteiro, Valter" AU="Monteiro, Valter"
  5. AU=Konkel Alex
  6. AU="Alnakib, Yasir"
  7. AU=Tallerico Rossana
  8. AU=Scherer Kai
  9. AU="Cao, Guiyun"
  10. AU="Zarrouki, Youssef"
  11. AU="Abayomi, Akin"
  12. AU=Kpatcha Tchazou
  13. AU=Glaeser Robert M
  14. AU="Mioara Cristea"
  15. AU="Turiegano, Enrique"
  16. AU="Russcher, H"
  17. AU="Lim, Kean-Jin"
  18. AU="Spurek, Monika"
  19. AU="Giulia A. Zamboni"

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  1. Artikel: Necrotizing Soft Tissue Infections in South Australia: A 15-Year Review.

    Tam, Patrick Chung Kay / Kennedy, Brendan / Ashokan, Anushia

    Open forum infectious diseases

    2023  Band 10, Heft 4, Seite(n) ofad117

    Abstract: Necrotizing soft tissue infections (NSTIs) are associated with high morbidity and mortality. We retrospectively examined the impact of empiric antimicrobials coupled with early surgery on mortality in NSTI. Early surgery independently reduced 30-day ... ...

    Abstract Necrotizing soft tissue infections (NSTIs) are associated with high morbidity and mortality. We retrospectively examined the impact of empiric antimicrobials coupled with early surgery on mortality in NSTI. Early surgery independently reduced 30-day mortality (odds ratio, .16; 95% confidence interval, .05-.51;
    Sprache Englisch
    Erscheinungsdatum 2023-03-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad117
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The diagnostic accuracy of Gram stain on formalin-fixed paraffin-embedded sections of skin tissue in the diagnosis of bacterial skin infection.

    Stagg, Brendan / Foster-Smith, Erwin / Tam, Patrick Chung Kay

    Journal of cutaneous pathology

    2023  Band 51, Heft 3, Seite(n) 246–250

    Abstract: Background and objective: To evaluate the sensitivity, specificity, and likelihood ratios of Gram stain on formalin-fixed, paraffin-embedded (GS-FFPE) sections of skin in diagnosing bacterial skin infection.: Methods: We reviewed a retrospective ... ...

    Abstract Background and objective: To evaluate the sensitivity, specificity, and likelihood ratios of Gram stain on formalin-fixed, paraffin-embedded (GS-FFPE) sections of skin in diagnosing bacterial skin infection.
    Methods: We reviewed a retrospective series of skin specimens reported at our institution wherein histopathological assessment included Gram stain and fresh tissue was concurrently submitted for microscopy and culture. The clinicopathological correlation was the reference standard, whereby the presence of infection was deduced from the final diagnosis in each patient's case notes.
    Results: Our sample included 168 cases (105 positive for infection). GS-FFPE showed a sensitivity of 0.43 (95% confidence interval 0.29, 0.57), a specificity of 0.98 (0.95, 1.01), a positive likelihood ratio of 21.50 (19.76, 23.24), and a negative likelihood ratio of 0.58 (0.41, 0.75).
    Conclusions: GS-FFPE has poor sensitivity, and a negative result should not be used as evidence to exclude infection. In contrast, it has excellent specificity and, unless the pretest probability of infection is very low, a positive result would make infection much more likely. The value of the GS-FFPE lies in cases where sterile tissue was not submitted for microbiological studies, or sterile tissue culture was negative, and there is at least a low-to-moderate pretest probability of infection.
    Mesh-Begriff(e) Humans ; Paraffin Embedding ; Retrospective Studies ; Skin/microbiology ; Staining and Labeling ; Tissue Fixation ; Formaldehyde
    Chemische Substanzen Formaldehyde (1HG84L3525)
    Sprache Englisch
    Erscheinungsdatum 2023-11-23
    Erscheinungsland United States
    Dokumenttyp Review ; Journal Article
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.14563
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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