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Article ; Online: Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma.

Sun, Xiaoyu / Hou, Tianheng / Cheung, Edwin / Iu, Tiffany Nga-Teng / Tam, Victor Wai-Hou / Chu, Ida Miu-Ting / Tsang, Miranda Sin-Man / Chan, Paul Kay-Sheung / Lam, Christopher Wai-Kei / Wong, Chun-Kwok

Cellular & molecular immunology

2019  Volume 17, Issue 6, Page(s) 631–646

Abstract: We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly (I:C)/LyoVec or infection-related cytokine TNF-α to induce ... ...

Abstract We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly (I:C)/LyoVec or infection-related cytokine TNF-α to induce expression of cytokines/chemokines/adhesion molecules. House dust mite (HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo. IL-38 significantly inhibited induced proinflammatory IL-6, IL-1β, CCL5, and CXCL10 production, and antiviral interferon-β and intercellular adhesion molecule-1 expression in the coculture system. Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1, STAT3, p38 MAPK, ERK1/2, and NF-κB pathways, and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13. Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluid (BALF) and lung homogenates. Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia, together with reduced Th2, Th17, and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs, spleen, and lymph nodes. IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice, together with significantly decreased CCR3
MeSH term(s) Adult ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Asthma/complications ; Asthma/drug therapy ; Asthma/genetics ; Asthma/immunology ; Bronchi/pathology ; Cells, Cultured ; Cytokines/pharmacology ; Cytokines/therapeutic use ; Down-Regulation/drug effects ; Eosinophils/drug effects ; Eosinophils/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Hypersensitivity/complications ; Hypersensitivity/drug therapy ; Hypersensitivity/genetics ; Hypersensitivity/immunology ; Inflammation/complications ; Inflammation/immunology ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Injections, Intraperitoneal ; Interleukins/pharmacology ; Interleukins/therapeutic use ; Ligands ; Male ; Mice ; Mice, Inbred BALB C ; Models, Biological ; Poly I-C/pharmacology ; Pyroglyphidae/drug effects ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Signal Transduction/drug effects ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances Anti-Inflammatory Agents ; Cytokines ; IL-38 protein, human ; Inflammation Mediators ; Interleukins ; Ligands ; Recombinant Proteins ; Tumor Necrosis Factor-alpha ; Poly I-C (O84C90HH2L)
Language English
Publishing date 2019-10-23
Publishing country China
Document type Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID 2435097-7
ISSN 2042-0226 ; 1672-7681
ISSN (online) 2042-0226
ISSN 1672-7681
DOI 10.1038/s41423-019-0300-7
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Zs.A 6681: Show issues Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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