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  1. Article: Pharmacological aspects of ipecac syrup (TJN-119)-induced emesis in ferrets.

    Endo, T / Nemoto, M / Ogawa, T / Tamakai, H / Hamaue, N / Hirafuji, M / Takeda, Y / Hasegawa, M / Fugii, Y / Minami, M

    Research communications in molecular pathology and pharmacology

    2000  Volume 108, Issue 3-4, Page(s) 187–200

    Abstract: In order to elucidate the precise mechanism of ipecac syrup (TJN-119) on the occurrence of vomiting, we examined the effects of ipecac syrup on the abdominal afferent nerve activity as well as on the 5-HT levels of the ileum and area postrema in ferrets. ...

    Abstract In order to elucidate the precise mechanism of ipecac syrup (TJN-119) on the occurrence of vomiting, we examined the effects of ipecac syrup on the abdominal afferent nerve activity as well as on the 5-HT levels of the ileum and area postrema in ferrets. Oral administration of TJN-119 (0.5 mg/kg) produced a significant increase in afferent abdominal vagus nerve activity which lasted approximately 1 hour. The maximum response induced by TJN-119 was estimated to be 219 +/- 18% of the pre-injection level. Cephaeline or emetine, the main alkaloids of ipecac syrup, also demonstrated similar effects on afferent vagus nerve activity. TJN-119 increased the 5-HT content in the ileum but not in the area postrema. These observations illustrate possible mechanisms that may act at peripheral sites. It was recently reported that TJN-119 has a high affinity to 5-HT4 receptors (Hasegawa et al., unpublished data). These results suggest that 5-HT4 receptors may be involved in the emetic action of TJN-119.
    MeSH term(s) Afferent Pathways/drug effects ; Animals ; Emetics/pharmacology ; Emetine/analogs & derivatives ; Emetine/pharmacology ; Ferrets ; Hydroxyindoleacetic Acid/metabolism ; Ileum/drug effects ; Ileum/metabolism ; Ipecac/pharmacology ; Medulla Oblongata/drug effects ; Medulla Oblongata/physiopathology ; Models, Biological ; Serotonin/metabolism ; Vagus Nerve/drug effects ; Vomiting/chemically induced ; Vomiting/etiology ; Vomiting/physiopathology
    Chemical Substances Emetics ; Serotonin (333DO1RDJY) ; Hydroxyindoleacetic Acid (54-16-0) ; Ipecac (8012-96-2) ; cephaelin (QA971541A1) ; Emetine (X8D5EPO80M)
    Language English
    Publishing date 2000
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1204228-6
    ISSN 1078-0297 ; 0034-5164
    ISSN 1078-0297 ; 0034-5164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Antiemetic effects of N-3389, a newly synthesized 5-HT3 and 5-HT4 receptor antagonist, in ferrets.

    Minami, M / Endo, T / Tamakai, H / Ogawa, T / Hamaue, N / Hirafuji, M / Monma, Y / Yoshioka, M / Hagihara, K

    European journal of pharmacology

    1997  Volume 321, Issue 3, Page(s) 333–342

    Abstract: The antiemetic activity of N-3389 (endo-3,9-dimethyl-3,9-diazabicyclo[3,3,1]non-7-yl-1 H-indazole-3-carboxamide dihydrochloride), a new 5-HT3 and 5-HT4 receptor antagonist, against cisplatin-, cyclophosphamide- and copper sulfate-induced emesis was ... ...

    Abstract The antiemetic activity of N-3389 (endo-3,9-dimethyl-3,9-diazabicyclo[3,3,1]non-7-yl-1 H-indazole-3-carboxamide dihydrochloride), a new 5-HT3 and 5-HT4 receptor antagonist, against cisplatin-, cyclophosphamide- and copper sulfate-induced emesis was investigated using ferrets. We also examined the effects of these agents on abdominal afferent vagus nerve activity in anesthetized ferrets. Both intraperitoneal (0.1-1.0 mg/kg) and oral (0.1-1.0 mg/kg) administration of N-3389 produced dose-dependent antiemetic effects. The time-course of cisplatin (10 mg/kg, i.p.)-induced emesis in another group of ferrets paralleled the increase in abdominal afferent vagus nerve activity induced by cisplatin (10 mg/kg, i.p.) and was inhibited by pretreatment with N-3389 (1.0 mg/kg, i.v.). Furthermore, the cisplatin (10 mg/kg, i.p.)-induced increase in abdominal afferent vagus nerve activity was markedly reduced by an additional injection of N-3389 (0.1-1.0 mg/kg, i.v.) in a dose-dependent manner. The antiemetic effects exhibited by N-3389 are probably due to the inhibition of 5-HT3 and 5-HT4 receptors on the abdominal afferent vagus nerves.
    MeSH term(s) 5-Methoxytryptamine/pharmacology ; Animals ; Antiemetics/pharmacology ; Antineoplastic Agents/toxicity ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cisplatin/toxicity ; Copper Sulfate/toxicity ; Cyclophosphamide/toxicity ; Emetics/toxicity ; Ferrets ; Indazoles/pharmacology ; Male ; Receptors, Serotonin/drug effects ; Receptors, Serotonin, 5-HT3 ; Receptors, Serotonin, 5-HT4 ; Serotonin/analogs & derivatives ; Serotonin/pharmacology ; Serotonin Antagonists/pharmacology ; Vagus Nerve/drug effects ; Vagus Nerve/physiology ; Vomiting/chemically induced ; Vomiting/drug therapy
    Chemical Substances Antiemetics ; Antineoplastic Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Emetics ; Indazoles ; Receptors, Serotonin ; Receptors, Serotonin, 5-HT3 ; Serotonin Antagonists ; Receptors, Serotonin, 5-HT4 (158165-40-3) ; Serotonin (333DO1RDJY) ; 5-Methoxytryptamine (3VMW6141KC) ; 2-methyl-5-HT (78263-90-8) ; Cyclophosphamide (8N3DW7272P) ; Copper Sulfate (LRX7AJ16DT) ; N 3389 (NBN3HB12DW) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 1997-03-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/s0014-2999(96)00974-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Chemical modulation of 5-HT3 and 5-HT4 receptors affects the release of 5-hydroxytryptamine from the ferret and rat intestine.

    Minami, M / Tamakai, H / Ogawa, T / Endo, T / Hamaue, N / Hirafuji, M / Yoshioka, M / Blower, P R

    Research communications in molecular pathology and pharmacology

    1995  Volume 89, Issue 2, Page(s) 131–142

    Abstract: In species which vomit, elevated intestinal serotonin (5-hydroxytryptamine, 5-HT) may stimulate abdominal vagal afferent fibers, which in turn evoke the vomiting reflex. The release of 5-HT from intestinal enterochromaffin (EC) cells is regulated by ... ...

    Abstract In species which vomit, elevated intestinal serotonin (5-hydroxytryptamine, 5-HT) may stimulate abdominal vagal afferent fibers, which in turn evoke the vomiting reflex. The release of 5-HT from intestinal enterochromaffin (EC) cells is regulated by polymodal mechanisms. The object of this study was to evaluate the involvement of 5-HT autoreceptors in the regulation of 5-HT release from the small intestine. Functional studies were carried out using 5-HT3 receptor agonist and antagonists, and 5-HT4 receptor agonist. Ferret and rat ileal tissue were isolated and 5-HT released into the bathing solution was determined using HPLC with an electrochemical detector (ECD). We previously reported that cisplatin produced a significant increase in cumulative 5-HT release and that ondansetron, a selective 5-HT3 receptor antagonist, did not alter the 5-HT release from the ferret ileum. In this study, a selective 5-HT3 agonist, 2-methyl-5-HT, induced a dose-dependent increase of 5-HT from the rat ileum. This release of 5-HT was significantly reduced by granisetron, a selective 5-HT3 receptor antagonist. Furthermore, a selective 5-HT4 receptor agonist, 5-methoxytryptamine induced a concentration-dependent increase of 5-HT in the rat ileum. These results suggest that both 5-HT3 and 5-HT4 receptors may be involved in intestinal 5-HT release.
    MeSH term(s) 5-Methoxytryptamine/pharmacology ; Animals ; Ferrets ; Granisetron/pharmacology ; Ileum/drug effects ; Ileum/secretion ; Ileum/ultrastructure ; In Vitro Techniques ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/secretion ; Intestinal Mucosa/ultrastructure ; Male ; Rats ; Rats, Wistar ; Receptors, Serotonin/classification ; Receptors, Serotonin/drug effects ; Receptors, Serotonin/physiology ; Serotonin/analogs & derivatives ; Serotonin/pharmacology ; Serotonin/secretion ; Serotonin Antagonists/pharmacology ; Serotonin Receptor Agonists/pharmacology
    Chemical Substances Receptors, Serotonin ; Serotonin Antagonists ; Serotonin Receptor Agonists ; Serotonin (333DO1RDJY) ; 5-Methoxytryptamine (3VMW6141KC) ; 2-methyl-5-HT (78263-90-8) ; Granisetron (WZG3J2MCOL)
    Language English
    Publishing date 1995-08
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1204228-6
    ISSN 1078-0297 ; 0034-5164
    ISSN 1078-0297 ; 0034-5164
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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