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Article ; Online: Abbreviated MRI for Hepatocellular Carcinoma Surveillance: Point-Why Extracellular Contrast Agents Are Superior for This Task.

Tamandl, Dietmar / Schima, Wolfgang

2023 Volume 222, Issue 4, Page(s) e2330254

MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Contrast Media ; Magnetic Resonance Imaging/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.23.30254
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Article ; Online: Effects of short- and long-term TSH suppression on lumbar bone mineral density in both genders using PET/CT.

Einspieler, Holger / Walter, Christoph / Hacker, Marcus / Karanikas, Georgios / Tamandl, Dietmar

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22640

Abstract: Iatrogenic subclinical hyperthyroidism is induced intentionally in patients with differentiated thyroid cancer to reduce the risk of tumor recurrence. This retrospective study aimed to investigate the effect of thyroid-stimulating hormone (TSH) ... ...

Abstract	Iatrogenic subclinical hyperthyroidism is induced intentionally in patients with differentiated thyroid cancer to reduce the risk of tumor recurrence. This retrospective study aimed to investigate the effect of thyroid-stimulating hormone (TSH) suppressive therapy on bone mineral density in men and women. Two cohorts of endocrine cancer patients were compared. In cohort A, 42 patients with long-lasting suppressed serum TSH were assessed. Cohort B consisted of 41 euthyroid patients. Bone density was measured in the L1-L4 lumbar vertebrae of all patients using PET/CT scans performed for cancer staging. In 17 patients of cohort A who received a second PET/CT scan, bone density was measured again to provide longitudinal analysis. A non-significant difference in age (p = .572) and equal distribution of sex (p = .916) was determined when comparing both cohorts. A significant difference (p = .011) with a moderate effect (η
MeSH term(s)	Humans ; Female ; Male ; Bone Density ; Positron Emission Tomography Computed Tomography ; Thyroxine ; Retrospective Studies ; Thyrotropin ; Neoplasm Recurrence, Local/drug therapy ; Lumbar Vertebrae/diagnostic imaging ; Absorptiometry, Photon
Chemical Substances	Thyroxine (Q51BO43MG4) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50118-z
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Article ; Online: Management of varices but not anticoagulation is associated with improved outcome in patients with HCC and macrovascular tumour invasion.

Balcar, Lorenz / Mrekva, Arpad / Scheiner, Bernhard / Pomej, Katharina / Meischl, Tobias / Mandorfer, Mattias / Reiberger, Thomas / Trauner, Michael / Tamandl, Dietmar / Pinter, Matthias

Cancer imaging : the official publication of the International Cancer Imaging Society

2024 Volume 24, Issue 1, Page(s) 9

Abstract: Background & aims: The value of bleeding prophylaxis and anticoagulation in patients with hepatocellular carcinoma (HCC) and macrovascular tumour invasion (MVI) is unclear. We evaluated the impact of anticoagulation on thrombosis progression, bleeding ... ...

Abstract	Background & aims: The value of bleeding prophylaxis and anticoagulation in patients with hepatocellular carcinoma (HCC) and macrovascular tumour invasion (MVI) is unclear. We evaluated the impact of anticoagulation on thrombosis progression, bleeding events, and overall mortality, and assessed the efficacy of adequate management of varices as recommended for patients with cirrhosis. Methods: HCC patients with MVI who had Child-Turcotte-Pugh A-B7 were included between Q4/2002 and Q2/2022. Localization of the tumour thrombus and changes at 3-6 months were evaluated by two radiologists. Univariable and multivariable logistic/Cox regression analyses included time-dependent variables (i.e., anticoagulation, systemic therapy, non-selective beta blocker treatment). Results: Of 124 patients included (male: n = 110, 89%), MVI involved the main portal vein in 47 patients (38%), and 49 individuals (40%) had additional non-tumorous thrombus apposition. Fifty of 80 patients (63%) with available endoscopy had varices. Twenty-four individuals (19%) received therapeutic anticoagulation and 94 patients (76%) were treated with effective systemic therapies. The use of therapeutic anticoagulation did not significantly affect the course of the malignant thrombosis at 3-6 months. Systemic therapy (aHR: 0.26 [95%CI: 0.16-0.40]) but not anticoagulation was independently associated with reduced all-cause mortality. In patients with known variceal status, adequate management of varices was independently associated with reduced risk of variceal bleeding (aHR: 0.12 [95%CI: 0.02-0.71]). In the whole cohort, non-selective beta blockers were independently associated with reduced risk of variceal bleeding or death from any cause (aHR: 0.69 [95%CI: 0.50-0.96]). Conclusion: Adequate bleeding prophylaxis and systemic anti-tumour therapy but not anticoagulation were associated with improved outcomes in patients with HCC and MVI.
MeSH term(s)	Humans ; Male ; Carcinoma, Hepatocellular/drug therapy ; Esophageal and Gastric Varices/complications ; Liver Neoplasms/drug therapy ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/prevention & control ; Venous Thrombosis ; Varicose Veins/complications ; Liver Cirrhosis/complications ; Thrombosis/etiology ; Thrombosis/prevention & control ; Anticoagulants/therapeutic use
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2104862-9
ISSN	1470-7330 ; 1470-7330
ISSN (online)	1470-7330
ISSN	1470-7330
DOI	10.1186/s40644-024-00657-z
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Article ; Online: Relative Enhancement in Gadoxetate Disodium-Enhanced Liver MRI as an Imaging Biomarker in the Diagnosis of Non-Alcoholic Fatty Liver Disease in Pediatric Obesity.

Hojreh, Azadeh / Lischka, Julia / Tamandl, Dietmar / Ramazanova, Dariga / Mulabdic, Amra / Greber-Platzer, Susanne / Ba-Ssalamah, Ahmed

Nutrients

2023 Volume 15, Issue 3

Abstract: Relative enhancement (RE) in gadoxetate disodium (Gd-EOB-DTPA)-enhanced MRI is a reliable, non-invasive method for the evaluation and differentiation between simple steatosis and non-alcoholic steatohepatitis in adults. This study evaluated the ... ...

Abstract	Relative enhancement (RE) in gadoxetate disodium (Gd-EOB-DTPA)-enhanced MRI is a reliable, non-invasive method for the evaluation and differentiation between simple steatosis and non-alcoholic steatohepatitis in adults. This study evaluated the diagnostic accuracy of RE in Gd-EOB-DTPA-enhanced liver MRI and hepatic fat fraction (HFF) in unenhanced liver MRI and ultrasound (US) for non-alcoholic fatty liver disease (NAFLD) screening in pediatric obesity. Seventy-four liver US and MRIs from 68 pediatric patients (13.07 ± 2.95 years) with obesity (BMI > BMI-for-age + 2SD) were reviewed with regard to imaging biomarkers (liver size, volume, echogenicity, HFF, and RE in Gd-EOB-DTPA-enhanced MRIs, and spleen size), blood biomarkers, and BMI. The agreement between the steatosis grade, according to HFF in MRI and the echogenicity in US, was moderate. Alanine aminotransferase correlated better with the imaging biomarkers in MRI than with those in US. BMI correlated better with liver size and volume on MRI than in US. In patients with RE < 1, blood biomarkers correlated better with RE than those in the whole sample, with a significant association between gamma-glutamyltransferase and RE (
MeSH term(s)	Child ; Humans ; Biomarkers ; Contrast Media ; Liver/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Pediatric Obesity/complications ; Pediatric Obesity/diagnostic imaging ; Adolescent
Chemical Substances	Biomarkers ; Contrast Media ; gadolinium ethoxybenzyl DTPA
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15030558
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Article ; Online: Imaging of colorectal cancer - the clue to individualized treatment.

Tamandl, Dietmar / Mang, Thomas / Ba-Ssalamah, Ahmed

Innovative surgical sciences

2018 Volume 3, Issue 1, Page(s) 3–15

Abstract: Colorectal cancer (CRC) is the most common gastrointestinal neoplasm and the second most common cause for cancer-related death in Europe. Imaging plays an important role both in the primary diagnosis, treatment evaluation, follow-up, and, to some extent, ...

Abstract	Colorectal cancer (CRC) is the most common gastrointestinal neoplasm and the second most common cause for cancer-related death in Europe. Imaging plays an important role both in the primary diagnosis, treatment evaluation, follow-up, and, to some extent, also in prevention. Like in the clinical setting, colon and rectal cancer have to be distinguished as two quite separate entities with different goals of imaging and, consequently, also different technical requirements. Over the past decade, there have been improvements in both more robust imaging techniques and new data and guidelines that help to use the optimal imaging modality for each scenario. For colon cancer, the continued research on computed tomography (CT) colonography (CTC) has led to high-level evidence that puts this technique on eye height to optical colonoscopy in terms of detection of cancer and polyps ≥10 mm. However, also for smaller polyps and thus for screening purposes, CTC seems to be an optimal tool. In rectal cancer, the technical requirements to perform state-of-the art imaging have recently been defined. Evaluation of T-stage, mesorectal fascia infiltration and extramural vascular invasion are the most important prognostic factors that can be identified on MRI. With this information, risk stratification both for local and distal failure is possible, enabling the clinician to tailor the optimal therapeutic approach in non-metastatic rectal cancer. Imaging of metastatic CRC is also covered, although the complex ramifications of treatment options in the metastatic setting are beyond the scope of this article. In this review, the most important recent developments in the imaging of colon and rectal cancer will be highlighted. If used in an interdisciplinary setting, this can lead to an individualized treatment concept for each patient.
Language	English
Publishing date	2018-03-13
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2364-7485
ISSN (online)	2364-7485
DOI	10.1515/iss-2017-0049
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Article ; Online: Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury.

Reiterer, Christian / Taschner, Alexander / Luf, Florian / Hecking, Manfred / Tamandl, Dietmar / Zotti, Oliver / Reiberger, Thomas / Starlinger, Patrick / Mandorfer, Mattias / Fleischmann, Edith

BMC nephrology

2022 Volume 23, Issue 1, Page(s) 21

Abstract: Background: The impact of changes in portal pressure before and after liver resection (defined as ΔHVPG) on postoperative kidney function remains unknown. Therefore, we investigated the effect of ΔHVPG on (i) the incidence of postoperative AKI and (ii) ... ...

Abstract	Background: The impact of changes in portal pressure before and after liver resection (defined as ΔHVPG) on postoperative kidney function remains unknown. Therefore, we investigated the effect of ΔHVPG on (i) the incidence of postoperative AKI and (ii) the renin-angiotensin system (RAAS) and sympathetic nervous system (SNS) activity. Methods: We included 30 patients undergoing partial liver resection. Our primary outcome was postoperative AKI according to KDIGO criteria. For our secondary outcome we assessed the plasma renin, aldosterone, noradrenaline, adrenaline, dopamine and vasopressin concentrations prior and 2 h after induction of anaesthesia, on the first and fifth postoperative day. HVPG was measured prior and immediately after liver resection. Results: ΔHVPG could be measured in 21 patients with 12 patients HVPG showing increases in HVPG (∆HVPG≥1 mmHg) while 9 patients remained stable. AKI developed in 7/12 of patients with increasing HVPG, but only in 2/9 of patients with stable ΔHVPG (p = 0.302). Noradrenalin levels were significantly higher in patients with increasing ΔHVPG than in patients with stable ΔHVPG. (p = 0.009). Biomarkers reflecting RAAS and SNS activity remained similar in patients with increasing vs. stable ΔHVPG. Conclusions: Patients with increased HVPG had higher postoperative creatinine concentrations, however, the incidence of AKI was similar between patients with increased versus stable HVPG.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Hepatectomy/methods ; Humans ; Incidence ; Male ; Middle Aged ; Portal Pressure ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Renin-Angiotensin System/physiology ; Retrospective Studies ; Sympathetic Nervous System/physiopathology ; Young Adult
Language	English
Publishing date	2022-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-021-02658-7
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Article ; Online: Influence of age on gadoxetic acid disodium-induced transient respiratory motion artifacts in pediatric liver MRI.

Hojreh, Azadeh / Ba-Ssalamah, Ahmed / Lang, Christian / Poetter-Lang, Sarah / Huber, Wolf-Dietrich / Tamandl, Dietmar

PloS one

2022 Volume 17, Issue 3, Page(s) e0264069

Abstract: Purpose: Gd-EOB-DTPA-enhanced liver MRI is frequently compromised by transient severe motion artifacts (TSM) in the arterial phase, which limits image interpretation for the detection and differentiation of focal liver lesions and for the recognition of ...

Abstract	Purpose: Gd-EOB-DTPA-enhanced liver MRI is frequently compromised by transient severe motion artifacts (TSM) in the arterial phase, which limits image interpretation for the detection and differentiation of focal liver lesions and for the recognition of the arterial vasculature before and after liver transplantation. The purpose of this study was to investigate which patient factors affect TSM in children who undergo Gd-EOB-DTPA-enhanced liver MRI and whether younger children are affected as much as adolescents. Methods: One hundred and forty-eight patients (65 female, 83 male, 0.1-18.9 years old), who underwent 226 Gd-EOB-DTPA-enhanced MRIs were included retrospectively in this single-center study. The occurrence of TSM was assessed by three readers using a four-point Likert scale. The relation to age, gender, body mass index, indication for MRI, requirement for sedation, and MR repetition was investigated using uni- and multivariate logistic regression analysis. Results: In Gd-EOB-DTPA-enhanced MRIs, TSM occurred in 24 examinations (10.6%). Patients with TSM were significantly older than patients without TSM (median 14.3 years; range 10.1-18.1 vs. 12.4 years; range 0.1-18.9, p<0.001). TSM never appeared under sedation. Thirty of 50 scans in patients younger than 10 years were without sedation. TSM were not observed in non-sedated patients younger than 10 years of age (p = 0.028). In a logistic regression analysis, age remained the only cofactor independently associated with the occurrence of TSM (hazard ratio 9.152, p = 0.049). Conclusion: TSM in Gd-EOB-DTPA-enhanced liver MRI do not appear in children under the age of 10 years.
MeSH term(s)	Gadolinium DTPA
Chemical Substances	gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0264069
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Article ; Online: Circulating caspase-cleaved cytokeratin 18 correlates with tumour burden and response to therapy in patients with colorectal cancer liver metastasis.

Singh Bhangu, Jagdeep / Macher-Beer, Andrea / Schimek, Vanessa / Garmroudi, Bastian / Tamandl, Dietmar / Unger, Lukas W / Bachleitner-Hofmann, Thomas / Oehler, Rudolf

Clinica chimica acta; international journal of clinical chemistry

2022 Volume 538, Page(s) 53–59

Abstract: Background and aims: Systemic chemotherapy followed by hepatic resection is the treatment of choice for patients with colorectal cancer liver metastasis (CRCLM) but reliable biomarkers predicting response to therapy are needed. Spontaneous apoptosis of ... ...

Abstract	Background and aims: Systemic chemotherapy followed by hepatic resection is the treatment of choice for patients with colorectal cancer liver metastasis (CRCLM) but reliable biomarkers predicting response to therapy are needed. Spontaneous apoptosis of single tumour cells is common in CRCLM. We explored the potential of circulating apoptosis markers to predict treatment response. Materials and methods: Fifty-eight patients with CRCLM or hepatocellular carcinoma (HCC) were included in this study. Tumour tissue and blood samples were obtained before and after initiation of chemotherapy. Immunohistochemistry and ELISA assays were utilized to quantify the apoptosis marker caspase-cleaved cytokeratin 18 (M30) in tissue and circulation. Results: CRCLM tissues showed more apoptotic tumour cells than HCC, or healthy liver. This was associated with elevated levels of circulating M30 (median = 244 U/l vs. 37 U/l in healthy controls, p = 0.009) which correlated with tumour volume (r Conclusions: Apoptotic tumour cells release cellular debris into the circulation, which provides information about tumour size and vitality.
Language	English
Publishing date	2022-11-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2022.11.009
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Article ; Online: Correction: Sarcopenia and sarcopenic obesity are independent adverse prognostic factors in resectable pancreatic ductal adenocarcinoma.

Gruber, Elisabeth S / Jomrich, Gerd / Tamandl, Dietmar / Gnant, Michael / Schindl, Martin / Sahora, Klaus

PloS one

2020 Volume 15, Issue 12, Page(s) e0244896

Abstract: This corrects the article DOI: 10.1371/journal.pone.0215915.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0215915.].
Language	English
Publishing date	2020-12-29
Publishing country	United States
Document type	Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0244896
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Article ; Conference proceedings: Prediction of response to atezolizumab/bevacizumab in advanced hepatocellular carcinoma through radiomic features in pretreatment MRI

Rodriguez, Isaac / Venerito, Marino / Tamandl, Dietmar / Pinter, Matthias / Ebert, Matthias / Chang, De-Hua / Dill, Michael / Müller, Lukas / Weinmann, Arndt / Seidensticker, Maximilian / Munker, Stefan / Frölich, Matthias / Teufel, Andreas

Zeitschrift für Gastroenterologie

2024 Volume 62, Issue 01

Event/congress	40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26
Language	German
Publishing date	2024-01-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/s-0043-1777615
Database	Thieme publisher's database

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