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  1. Article ; Online: Immunoglobulins or convalescent plasma to tackle COVID-19: buying time to save lives - current situation and perspectives.

    Tamburello, Adriana / Marando, Marco

    Swiss medical weekly

    2020  Volume 150, Page(s) w20264

    MeSH term(s) Betacoronavirus ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive ; Immunoglobulins/immunology ; Immunoglobulins/therapeutic use ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy
    Chemical Substances Immunoglobulins
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2020.20264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: False-Negative Nasopharyngeal Swab RT-PCR Assays in Typical COVID-19: Role of Ultra-low-dose Chest CT and Bronchoscopy in Diagnosis.

    Marando, Marco / Tamburello, Adriana / Gianella, Pietro

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 7, Page(s) 1680

    Abstract: On 11 March 2020, the WHO declared COVID-19 a pandemic and global health emergency. We describe the clinical features and role of ultra-low-dose chest computed tomography (CT) and bronchoscopy in the diagnosis of coronavirus disease (COVID-19). In our ... ...

    Abstract On 11 March 2020, the WHO declared COVID-19 a pandemic and global health emergency. We describe the clinical features and role of ultra-low-dose chest computed tomography (CT) and bronchoscopy in the diagnosis of coronavirus disease (COVID-19). In our patient, who was highly suggestive clinically and radiologically for COVID-19, we had two false-negative results for nasopharyngeal and oral swab reverse-transcriptase polymerase chain reaction (RT-PCR) assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Eventually, we confirmed the diagnosis using bronchoscopy and bronchoalveolar lavage (BAL).
    Learning points: Clinical and laboratory findings in COVID-19 are unspecific.Chest CT has a diagnostic sensitivity comparable to nasopharyngeal swab RT-PCR assay but lacks specificity.RT-PCR assays on biological specimens, particularly nasopharyngeal swabs, are considered the diagnostic gold standard.Bronchoscopy and bronchoalveolar lavage can help confirm the diagnosis and should be performed in patients in whom diagnostic-driven treatment for COVID-19, such as tocilizumab or remdesivir, is being considered.
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and Pulmonary Embolism: Not a Coincidence.

    Tamburello, Adriana / Bruno, Giovanni / Marando, Marco

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 6, Page(s) 1692

    Abstract: In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus ... ...

    Abstract In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus disease 2019). The virus is transmitted between humans and the outbreak was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. Coagulopathy is a common abnormality in patients with COVID-19 due to inflammation, hypoxia, immobilisation, endothelial damage and diffuse intravascular coagulation. However, the data on this topic are still limited. Here we report the case of a man presenting with pneumonia complicated by bilateral pulmonary embolism.
    Learning points: SARS-CoV-2 is a novel infectious agent that causes COVID-19, which can manifest in several ways, affecting endothelial cells and most organs.There is growing evidence that SARS-CoV-2-mediated endothelial damage is due to direct viral injury and the systemic inflammatory response, possibly together with a cytokine storm.As endothelial damage can manifest as thromboembolic disease, such as pulmonary thromboembolism, appropriate anti-thrombotic preventive strategies should be followed, and proper screening and treatment for thromboembolic complications should be implemented.
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immunoglobulins or convalescent plasma to tackle COVID-19

    Marando, Marco / Tamburello, Adriana

    Swiss Medical Weekly ; ISSN 1424-3997

    buying time to save lives – current situation and perspectives

    2020  

    Keywords General Medicine ; covid19
    Language English
    Publisher EMH Swiss Medical Publishers, Ltd.
    Publishing country ch
    Document type Article ; Online
    DOI 10.4414/smw.2020.20264
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Diagnostic sensitivity of RT-PCR assays on nasopharyngeal specimens for detection of SARS-CoV-2 infection: A Systematic Review and Meta-Analysis.

    Marando, Marco / Tamburello, Adriana / Gianella, Pietro / Taylor, Rebecca / Bernasconi, Enos / Fusi-Schmidhauser, Tanja

    Caspian journal of internal medicine

    2022  Volume 13, Issue Suppl 3, Page(s) 139–147

    Abstract: Background: Reverse transcription polymerase chain reaction (RT-PCR) is the current standard of reference in the diagnosis of SARS-CoV-2 infection. In outpatient clinical practice, nasopharyngeal swab RT-PCR testing is still the most common procedure. ... ...

    Abstract Background: Reverse transcription polymerase chain reaction (RT-PCR) is the current standard of reference in the diagnosis of SARS-CoV-2 infection. In outpatient clinical practice, nasopharyngeal swab RT-PCR testing is still the most common procedure. The purpose of this systematic review and meta-analysis was to evaluate the sensitivity of RT-PCR nasopharyngeal assays.
    Methods: We searched three databases, including PubMed/MEDLINE, EMBASE, and Cochrane Library, using a comprehensive strategy. Studies investigating the sensitivity of SARS-CoV-2 RT-PCR nasopharyngeal assays in adults were included. Two reviewers extracted data and assessed trial quality independently. Pooled sensitivity and its confidence interval were computed using the meta package in R.
    Results: Thirteen studies were found eligible for the inclusion in the systematic review. Out of these, 25 different sub-studies were identified and included in the meta-analysis, which reported the sensitivities of 25 different nasopharyngeal RT-PCR assays. Finally, the overall pooled sensitivity resulted 89% (95% CI, 85.4 to 91.8%).
    Conclusion: Our study suggests that RT-PCR assays on nasopharyngeal specimens have a substantial sensitivity for diagnosing SARS-CoV-2 infection.
    Language English
    Publishing date 2022-07-14
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2971933-1
    ISSN 2008-6172 ; 2008-6164
    ISSN (online) 2008-6172
    ISSN 2008-6164
    DOI 10.22088/cjim.13.0.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Detection rate of somatostatin receptor PET in patients with recurrent medullary thyroid carcinoma: a systematic review and a meta-analysis.

    Treglia, Giorgio / Tamburello, Adriana / Giovanella, Luca

    Hormones (Athens, Greece)

    2018  Volume 16, Issue 4, Page(s) 362–372

    Abstract: Purpose: Several articles have demonstrated the high diagnostic performance of somatostatin receptor positron emission tomography (PET) in patients with neuroendocrine tumours (NETs). On the other hand, only a few studies have evaluated the detection ... ...

    Abstract Purpose: Several articles have demonstrated the high diagnostic performance of somatostatin receptor positron emission tomography (PET) in patients with neuroendocrine tumours (NETs). On the other hand, only a few studies have evaluated the detection rate (DR) of this imaging method in recurrent medullary thyroid carcinoma (MTC). We aimed to perform a systematic review and a meta-analysis of the DR of somatostatin receptor PET or PET/CT in patients with recurrent MTC to add evidence-based data to this setting.
    Methods: A comprehensive computer literature search of studies published in PubMed/MEDLINE and the Cochrane Library Database through May 2017 and regarding somatostatin receptor PET or PET/CT in patients with recurrent MTC was carried out. DR was determined on a per patient-basis. A sub-analysis considering serum calcitonin (Ctn) values was also performed.
    Results: Nine studies on the diagnostic performance of somatostatin receptor PET or PET/CT in detecting recurrent MTC were discussed in the systematic review. The meta-analysis of these selected studies provided the following DR on a per patient-based analysis: 63.5% [95% confidence interval (95%CI): 49-77]. Heterogeneity among the selected studies was found. DR of somatostatin receptor PET or PET/CT increased in patients with higher serum Ctn levels (83% for Ctn >500 ng/L).
    Conclusions: In patients with recurrent MTC, somatostatin receptor PET or PET/CT demonstrated a non-optimal DR which increased in patients with higher serum Ctn values. The diagnostic performance of somatostatin receptor PET or PET/CT in recurrent MTC is lower compared to that of the same imaging method in the majority of NETs.
    MeSH term(s) Carcinoma, Neuroendocrine/diagnostic imaging ; Carcinoma, Neuroendocrine/metabolism ; Humans ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/metabolism ; Positron-Emission Tomography/standards ; Receptors, Somatostatin/metabolism ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/metabolism
    Chemical Substances Receptors, Somatostatin
    Language English
    Publishing date 2018-02-20
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2581819-3
    ISSN 2520-8721 ; 1109-3099
    ISSN (online) 2520-8721
    ISSN 1109-3099
    DOI 10.14310/horm.2002.1756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Viewpoint: "Alcohol Consumption in Late Adolescence is Associated with an Increased Risk of Severe Liver Disease Later in Life".

    Tamburello, Adriana / Marando, Marco / Bellentani, Stefano

    Annals of hepatology

    2018  Volume 17, Issue 3, Page(s) 343–344

    Abstract: Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk of ... ...

    Abstract Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk of severe liver disease. No threshold level emerged for liver damage and this is a warning for all the sociologists and politics. New legiferation and educational campaigns addressed to young people, with particular attention to the access to alcohol, prices and advertising are necessary.
    MeSH term(s) Adolescent ; Adult ; Alcohol Drinking ; Humans ; Liver Diseases ; Male ; Prospective Studies
    Language English
    Publishing date 2018-04-09
    Publishing country Mexico
    Document type Journal Article ; Comment
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.5604/01.3001.0011.7379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: COVID-19 and pulmonary embolism: Not a coincidence

    Tamburello, Adriana / Bruno, Giovanni / Marando, Marco

    Eur. J. Case Rep. Intern. Med.

    Abstract: In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus ... ...

    Abstract In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus disease 2019). The virus is transmitted between humans and the outbreak was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. Coagulopathy is a common abnormality in patients with COVID‐19 due to inflammation, hypoxia, immobilisation, endothelial damage and diffuse intravascular coagulation. However, the data on this topic are still limited. Here we report the case of a man presenting with pneumonia complicated by bilateral pulmonary embolism.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #854668
    Database COVID19

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  10. Article ; Online: Contemporary adequacy of thromboprophylaxis in acutely ill medical patients in Switzerland: a bi-centric prospective cohort.

    Marando, Marco / Blondon, Katherine / Darbellay Farhoumand, Pauline / Nendaz, Mathieu / Grauser, Damien / Sallet, Alain / Tamburello, Adriana / Pons, Marco / Righini, Marc / Gianella, Pietro / Blondon, Marc

    Swiss medical weekly

    2023  Volume 153, Page(s) 40117

    Abstract: Background: Venous thromboembolism is a dreaded complication of hospitalised patients, with associated morbidity, mortality and increased healthcare costs. Previous studies have shown that pharmacological thromboprophylaxis, though effective, is ... ...

    Abstract Background: Venous thromboembolism is a dreaded complication of hospitalised patients, with associated morbidity, mortality and increased healthcare costs. Previous studies have shown that pharmacological thromboprophylaxis, though effective, is inadequately administered in a large proportion of medical inpatients.
    Study aims: Our primary aim was to evaluate the contemporary adequacy of thromboprophylaxis in medical inpatients admitted to two Swiss hospitals (a university hospital and a regional hospital). The secondary aim was to estimate the 90-day incidence of relevant thrombotic and bleeding events.
    Methods: In this prospective cohort, patients were recruited at the University Hospital of Geneva and the Regional Hospital of Lugano between September 2020 and February 2021 and followed for 90 days for venous thromboembolism and bleeding events. The adequacy of thromboprophylaxis (pharmacological and/or mechanical) at 24h after hospital admission was evaluated according to the simplified Geneva risk score for hospital-associated venous thromboembolism.
    Results: Among 200 participants (100 at each site, mean age of 65 years), 57.5% were deemed at high risk of venous thromboembolism at admission. Thromboprophylaxis was adequate in 59.5% (95% CI 52.3-66.4%). Among high-risk and low-risk inpatients, thromboprophylaxis was adequate in 71.3% and 43.5%, respectively, with differences between sites. At 90 days, risks of adjudicated venous thromboembolism, major bleeding and mortality were 1.5%, 1.5% and 6.0%, respectively.
    Conclusion: Despite the extensive literature on thromboprophylaxis, the adequacy of thromboprophylaxis has not improved and remains insufficient among medical inpatients. Implementation and evaluation of clinical decision support systems are critically needed in this field.
    Clinicaltrials: gov number: NCT05306821.
    MeSH term(s) Humans ; Aged ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/epidemiology ; Anticoagulants/therapeutic use ; Switzerland ; Prospective Studies ; Risk Factors ; Hemorrhage/chemically induced ; Hemorrhage/drug therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.57187/smw.2023.40117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.152: Show issues Location:
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