LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 65

Search options

  1. Book ; Online: Personalized Medicine in the Field of Inflammatory Skin Disorders

    Tampa, Mircea / Neagu, Monica / Caruntu, Constantin / Georgescu, Simona Roxana

    2022  

    Keywords Medicine ; sea-buckthorn seed oil ; long-chain fatty acids ; skin dysplastic keratinocytes ; UVA ; CD36 ; SR-B2 ; atopic dermatitis ; eczema ; JAK inhibitors ; systematic review ; meta-analysis ; evidence-based medicine ; immune-mediated skin diseases ; target therapy ; skin conditions and systemic inflammatory diseases ; systemic sclerosis ; biomarker ; calumenin ; S100A6 ; cytohesin 2 ; cannabinoids ; inflammation ; gut-lung-skin barrier ; signaling pathways ; inflammatory biomarkers ; psoriasis vulgaris ; prevalence ; comorbidities ; risk factors ; systemic lupus erythematous ; lupus nephritis ; lipid peroxidation ; DNA oxidation ; oxidized proteins ; carbohydrate oxidation ; antioxidative stress strategies ; biomarkers ; IgY ; psoriatic dermatitis ; imiquimod ; C57 BL/6 mice ; alginate ; biomaterial ; dressing ; fibers ; hydrogel ; nanofibers ; commercially available ; wound care ; wound healing ; cutaneous melanoma ; epigenetic regulation ; drug resistance ; therapeutic targets ; epigenetic therapy ; immune response ; Sutton nevi ; halo nevi ; skin tumor ; psoriasis ; proteome analysis ; estrogen ; menopause ; cSCC ; AK ; sialylation ; sialyltransferase ; sialidase ; COVID-19 ; pyoderma gangrenosum ; immunosuppression ; cyclosporine ; corticosteroids ; autoinflammatory disease ; androgenic alopecia ; clinical trial ; hair density ; platelet-rich plasma ; n/a
    Language 0|e
    Size 1 electronic resource (262 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021608745
    ISBN 9783036535739 ; 303653573X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: A Panel of Potential Serum Markers Related to Angiogenesis, Antioxidant Defense and Hypoxia for Differentiating Cutaneous Squamous Cell Carcinomas from Actinic Keratoses.

    Georgescu, Simona Roxana / Tocut, Sandra Milena / Matei, Clara / Ene, Corina Daniela / Nicolae, Ilinca / Tampa, Mircea

    Journal of personalized medicine

    2024  Volume 14, Issue 1

    Abstract: Cutaneous squamous cell carcinoma (cSCC) arising from the malignant proliferation of epidermal keratinocytes is the second most common skin cancer. Actinic keratosis (AK), which is considered cSCC in situ, may progress into invasive tumors. Currently, ... ...

    Abstract Cutaneous squamous cell carcinoma (cSCC) arising from the malignant proliferation of epidermal keratinocytes is the second most common skin cancer. Actinic keratosis (AK), which is considered cSCC in situ, may progress into invasive tumors. Currently, there are no serum markers that can differentiate cSCC from AK. The aim of our study was to assess angiogenesis and oxidative stress in patients with cSCC and patients with AK and find reliable serum markers useful in the diagnosis of cSCC. We have determined the serum levels of a group of proangiogenic factors (MMP-2, MMP-9, VEGF, FGF2), the total antioxidative status/capacity (TAS/TAC), ImAnOx, a marker of oxidative stress, and HIF-1 alpha, an indicator of hypoxia. We have identified higher serum levels of MMP-2. MMP-9, VEGF, FGF2 and HIF-1 alpha and lower levels of ImAnOx in cSCC patients compared to AK patients and controls. There were no statistically significant differences between AK patients and controls. We have found positive correlations between proangiogenic markers and HIF-1 alpha and negative correlations between proangiogenic markers and ImAnOx. Our results suggest that MMP-2, MMP-9, VEGF, FGF2, ImAnOx and HIF-1 may be promising markers for differentiating AK from cSCC, and there is a link between angiogenesis, oxidative stress and hypoxia.
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14010103
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Psoriasis: What Is New in Markers of Disease Severity?

    Tampa, Mircea / Mitran, Madalina Irina / Mitran, Cristina Iulia / Matei, Clara / Georgescu, Simona Roxana

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 2

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Humans ; Psoriasis ; Inflammation ; Biomarkers ; Patient Acuity ; Neoplasms
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60020337
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: A New Horizon for Atopic Dermatitis Treatments: JAK Inhibitors.

    Tampa, Mircea / Mitran, Cristina Iulia / Mitran, Madalina Irina / Georgescu, Simona Roxana

    Journal of personalized medicine

    2023  Volume 13, Issue 3

    Abstract: The article entitled "Application of Janus Kinase Inhibitors in Atopic Dermatitis: An Updated Systematic Review and Meta-Analysis of Clinical Trials" that belongs to the Special Issue, " Personalized medicine in the field of inflammatory skin diseases", ... ...

    Abstract The article entitled "Application of Janus Kinase Inhibitors in Atopic Dermatitis: An Updated Systematic Review and Meta-Analysis of Clinical Trials" that belongs to the Special Issue, " Personalized medicine in the field of inflammatory skin diseases", a collection of articles addressing the current critical issues in the pathogenesis and management of chronic inflammatory skin disorders, represents a valuable work that has contributed to elucidating the role of Janus kinase (JAK) inhibitors as a treatment option for atopic dermatitis (AD), as well as their safety profiles [...].
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13030384
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Personalized Medicine in the Field of Inflammatory Skin Disorders.

    Tampa, Mircea / Neagu, Monica / Caruntu, Constantin / Georgescu, Simona Roxana

    Journal of personalized medicine

    2022  Volume 12, Issue 3

    Abstract: Inflammatory skin diseases occur after the onset of abnormal immune cell responses and the activation of various immune signaling pathways in the skin [ ... ]. ...

    Abstract Inflammatory skin diseases occur after the onset of abnormal immune cell responses and the activation of various immune signaling pathways in the skin [...].
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12030426
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Changes in Serum IL-12 Levels following the Administration of H1-Antihistamines in Patients with Chronic Spontaneous Urticaria.

    Ene, Corina Daniela / Tocut, Milena / Tampa, Mircea / Georgescu, Simona Roxana / Matei, Clara / Leulescu, Iulia Maria Teodora / Nicolae, Ilinca / Ene, Cosmin

    Journal of personalized medicine

    2024  Volume 14, Issue 3

    Abstract: Introduction: Research regarding the role of the IL-12 cytokine family in modulating immune and inflammatory responses is continuously evolving. In this study, the contribution of the p35 and p40 subunits as monomers (noted as IL-12p35 and IL-12p40) and ...

    Abstract Introduction: Research regarding the role of the IL-12 cytokine family in modulating immune and inflammatory responses is continuously evolving. In this study, the contribution of the p35 and p40 subunits as monomers (noted as IL-12p35 and IL-12p40) and heterodimers (noted as IL-12p70 or IL-12p35/p40) was analysed in the pathophysiology and progression of chronic spontaneous urticaria (CSU).
    Materials and methods: We conducted a longitudinal, case-control study involving 42 CSU cases and 40 control cases comprising adults without associated conditions. Serial measurements were performed to assess the serum levels of IL-12p70, IL-12p35, and IL-12p40 at the onset of the disease (pre-therapy phase) and 6 weeks after the initiation of the treatment (post-therapy phase).
    Results: During the pre-therapeutic phase of CSU, elevated serum levels of IL-12 cytokine subtypes were detected compared to the control group. The relationship between IL-12 profiles and the course of CSU highlighted the pro-inflammatory role of IL-12p70 and the anti-inflammatory role of IL-12p35. Significant correlations were observed between IL-12p70 levels and the duration of the disease, as well as between IL-12 and the effectiveness of H1-antihistamines.
    Conclusions: The molecular background for the pleiotropic activities mediated by IL-12-derived cytokines in patients with CSU lies in the strict regulation of the production, signalling pathways, and cytokine-specific influences on the same pathophysiological events. The results of the present study suggest that the superficial layers of the skin serve as a cellular source of IL-12, a cytokine produced through antigenic stimulation. In patients with CSU, we identified independent, additive, or divergent functions of IL-12p70, IL-12p35, and IL-12p40, all relevant to systemic inflammation. These findings prove that the prototype programming of IL-12 is abnormal in CSU.
    Language English
    Publishing date 2024-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14030295
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Skin Inflammation-A Cornerstone in Dermatological Conditions.

    Tampa, Mircea / Neagu, Monica / Caruntu, Constantin / Constantin, Carolina / Georgescu, Simona Roxana

    Journal of personalized medicine

    2022  Volume 12, Issue 9

    Abstract: The skin provides more than a simple mechanical barrier against external aggressors; it is an array of effector cells and molecules that constitute the skin's immune system, as defined by Bos and Kapsenberg in 1986 [ ... ]. ...

    Abstract The skin provides more than a simple mechanical barrier against external aggressors; it is an array of effector cells and molecules that constitute the skin's immune system, as defined by Bos and Kapsenberg in 1986 [...].
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12091370
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: A Meta-Analysis on the Effectiveness of Sertaconazole 2% Cream Compared with Other Topical Therapies for Seborrheic Dermatitis.

    Georgescu, Simona Roxana / Mitran, Cristina Iulia / Mitran, Madalina Irina / Amuzescu, Andreea / Matei, Clara / Tampa, Mircea

    Journal of personalized medicine

    2022  Volume 12, Issue 9

    Abstract: Seborrheic dermatitis (SD) is a relapsing inflammatory skin disorder that affects the seborrheic areas of the body. Its etiology is not completely elucidated; however, the link between disease exacerbations and the proliferation ... ...

    Abstract Seborrheic dermatitis (SD) is a relapsing inflammatory skin disorder that affects the seborrheic areas of the body. Its etiology is not completely elucidated; however, the link between disease exacerbations and the proliferation of
    Language English
    Publishing date 2022-09-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12091540
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Editorial: Recent advances in keratinocyte carcinomas: From molecular mechanisms to clinical perspectives.

    Caruntu, Constantin / Tsatsakis, Aristidis M / Tampa, Mircea / Georgescu, Simona-Roxana / Gonzalez, Salvador

    Frontiers in medicine

    2022  Volume 9, Page(s) 1078020

    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1078020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Ischemia-Modified Albumin-A Potential New Marker of Oxidative Stress in Dermatological Diseases.

    Tampa, Mircea / Mitran, Cristina Iulia / Mitran, Madalina Irina / Amuzescu, Andreea / Matei, Clara / Georgescu, Simona Roxana

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 5

    Abstract: There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. ... ...

    Abstract There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia, but also a marker of oxidative stress. We have conducted a narrative review to evaluate the role of IMA in dermatological diseases. We have identified 24 original articles that evaluated IMA in skin disorders (psoriasis, acne vulgaris, hidradenitis suppurativa, urticaria, vitiligo and Behcet's disease) and hair disorders (alopecia areata, androgenetic alopecia and telogen effluvium). The results of the studies analyzed reveal that IMA may be considered a new marker of oxidative stress in dermatological diseases and offer new insights into the pathogenesis of these disorders and the theoretical basis for the development of new, effective, targeted therapies. To the best of our knowledge, this is the first review that gathers up data on the role of IMA in dermatological diseases.
    MeSH term(s) Biomarkers/blood ; Hair Diseases/blood ; Hair Diseases/diagnosis ; Humans ; Oxidative Stress ; Serum Albumin, Human ; Skin Diseases/blood ; Skin Diseases/diagnosis
    Chemical Substances Biomarkers ; ischemia-modified albumin ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58050669
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top