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  1. AU="Tampakakis, Emmanouil"
  2. AU="Tabares, Jeffrey V"

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  1. Artikel ; Online: In search of markers of pulmonary vascular remodelling in pulmonary hypertension due to left heart disease.

    Tampakakis, Emmanouil

    European journal of heart failure

    2018  Band 20, Heft 4, Seite(n) 735–737

    Mesh-Begriff(e) Heart Diseases ; Heart Failure ; Humans ; Hypertension, Pulmonary ; Pulmonary Artery ; Vascular Remodeling
    Sprache Englisch
    Erscheinungsdatum 2018-01-15
    Erscheinungsland England
    Dokumenttyp Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.1137
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Heart generation and regeneration.

    Tampakakis, Emmanouil / Kwon, Chulan

    Seminars in cell & developmental biology

    2021  Band 118, Seite(n) 92–93

    Mesh-Begriff(e) Heart/anatomy & histology ; Heart/physiopathology ; Heart Failure/physiopathology ; Humans
    Sprache Englisch
    Erscheinungsdatum 2021-07-22
    Erscheinungsland England
    Dokumenttyp Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.07.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: COVID-19 acute respiratory distress syndrome: intriguing haemodynamics of an intriguing syndrome.

    Smith, Nick / Tampakakis, Emmanouil

    European journal of heart failure

    2021  Band 23, Heft 2, Seite(n) 208–210

    Mesh-Begriff(e) COVID-19 ; Cardiac Catheterization ; Heart Failure ; Hemodynamics ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-01-07
    Erscheinungsland England
    Dokumenttyp Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2087
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  4. Artikel ; Online: The role of hormones and neurons in cardiomyocyte maturation.

    Tampakakis, Emmanouil / Mahmoud, Ahmed I

    Seminars in cell & developmental biology

    2021  Band 118, Seite(n) 136–143

    Abstract: The heart undergoes profound morphological and functional changes as it continues to mature postnatally. However, this phase of cardiac development remains understudied. More recently, cardiac maturation research has attracted a lot of interest due to ... ...

    Abstract The heart undergoes profound morphological and functional changes as it continues to mature postnatally. However, this phase of cardiac development remains understudied. More recently, cardiac maturation research has attracted a lot of interest due to the need for more mature stem cell-derived cardiomyocytes for disease modeling, drug screening and heart regeneration. Additionally, neonatal heart injury models have been utilized to study heart regeneration, and factors regulating postnatal heart development have been associated with adult cardiac disease. Critical components of cardiac maturation are systemic and local biochemical cues. Specifically, cardiac innervation and the concentration of various metabolic hormones appear to increase perinatally and they have striking effects on cardiomyocytes. Here, we first report some of the key parameters of mature cardiomyocytes and then discuss the specific effects of neurons and hormonal cues on cardiomyocyte maturation. We focus primarily on the structural, electrophysiologic, metabolic, hypertrophic and hyperplastic effects of each factor. This review highlights the significance of underappreciated regulators of cardiac maturation and underscores the need for further research in this exciting field.
    Mesh-Begriff(e) Hormones/metabolism ; Humans ; Myocytes, Cardiac/physiology ; Neurons/metabolism
    Chemische Substanzen Hormones
    Sprache Englisch
    Erscheinungsdatum 2021-04-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.03.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice.

    Kumari, Raniki / Pascalau, Raluca / Wang, Hui / Bajpayi, Sheetal / Yurgel, Maria / Quansah, Kwaku / Hattar, Samer / Tampakakis, Emmanouil / Kuruvilla, Rejji

    Cell reports

    2024  Band 43, Heft 2, Seite(n) 113674

    Abstract: Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to ... ...

    Abstract Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to modulate noradrenergic responses, its specific roles in autonomic physiology remain under-appreciated. Here, we show that sympathetic-derived NPY is essential for metabolic and cardiovascular regulation in mice. NPY and NE are co-expressed in 90% of prevertebral sympathetic neurons and only 43% of paravertebral neurons. NPY-expressing neurons primarily innervate blood vessels in peripheral organs. Sympathetic-specific NPY deletion elicits pronounced metabolic and cardiovascular defects in mice, including reductions in insulin secretion, glucose tolerance, cold tolerance, and pupil size and elevated heart rate, while notably, however, basal blood pressure was unchanged. These findings provide insight into target tissue-specific functions of NPY derived from sympathetic neurons and imply its potential involvement in metabolic and cardiovascular diseases.
    Mesh-Begriff(e) Animals ; Mice ; Neuropeptide Y ; Blood Pressure ; Anti-Anxiety Agents ; Norepinephrine ; Homeostasis ; Glucose
    Chemische Substanzen Neuropeptide Y ; Anti-Anxiety Agents ; Norepinephrine (X4W3ENH1CV) ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113674
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Understanding Heart Field Progenitor Cells for Modeling Congenital Heart Diseases.

    Miyamoto, Matthew / Gangrade, Harshi / Tampakakis, Emmanouil

    Current cardiology reports

    2021  Band 23, Heft 5, Seite(n) 38

    Abstract: Purpose of review: Heart development is a meticulously coordinated process that involves the specification of two distinct populations of cardiac progenitor cells, namely the first and the second heart field. Disruption of heart field progenitors can ... ...

    Abstract Purpose of review: Heart development is a meticulously coordinated process that involves the specification of two distinct populations of cardiac progenitor cells, namely the first and the second heart field. Disruption of heart field progenitors can result in congenital heart defects. In this review, we aim to describe the signaling pathways and transcription factors that link heart field development and congenital heart disease.
    Recent findings: Single-cell transcriptomics, lineage-tracing mouse models, and stem cell-based in vitro modeling of cardiogenesis have significantly improved the spatiotemporal characterization of cardiac progenitors. Additionally, novel functional genomic studies have now linked more genetic variants with congenital heart disease. Dysregulation of cardiac progenitor cells causes malformations that can be lethal. Ongoing research will continue to shed light on cardiac morphogenesis and help us better understand and treat patients with congenital heart disease.
    Mesh-Begriff(e) Animals ; Heart ; Heart Defects, Congenital ; Humans ; Mice ; Myocardium ; Signal Transduction ; Stem Cells
    Sprache Englisch
    Erscheinungsdatum 2021-03-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-021-01468-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: The role of noncoding genetic variants in cardiomyopathy.

    Htet, Myo / Lei, Shunyao / Bajpayi, Sheetal / Zoitou, Asimina / Chamakioti, Myrsini / Tampakakis, Emmanouil

    Frontiers in cardiovascular medicine

    2023  Band 10, Seite(n) 1116925

    Abstract: Cardiomyopathies remain one of the leading causes of morbidity and mortality worldwide. Environmental risk factors and genetic predisposition account for most cardiomyopathy cases. As with all complex diseases, there are significant challenges in the ... ...

    Abstract Cardiomyopathies remain one of the leading causes of morbidity and mortality worldwide. Environmental risk factors and genetic predisposition account for most cardiomyopathy cases. As with all complex diseases, there are significant challenges in the interpretation of the molecular mechanisms underlying cardiomyopathy-associated genetic variants. Given the technical improvements and reduced costs of DNA sequence technologies, an increasing number of patients are now undergoing genetic testing, resulting in a continuously expanding list of novel mutations. However, many patients carry noncoding genetic variants, and although emerging evidence supports their contribution to cardiac disease, their role in cardiomyopathies remains largely understudied. In this review, we summarize published studies reporting on the association of different types of noncoding variants with various types of cardiomyopathies. We focus on variants within transcriptional enhancers, promoters, intronic sites, and untranslated regions that are likely associated with cardiac disease. Given the broad nature of this topic, we provide an overview of studies that are relatively recent and have sufficient evidence to support a significant degree of causality. We believe that more research with additional validation of noncoding genetic variants will provide further mechanistic insights on the development of cardiac disease, and noncoding variants will be increasingly incorporated in future genetic screening tests.
    Sprache Englisch
    Erscheinungsdatum 2023-05-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1116925
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice.

    Kumari, Raniki / Pascalau, Raluca / Wang, Hui / Bajpayi, Sheetal / Yurgel, Maria / Quansah, Kwaku / Hattar, Samer / Tampakakis, Emmanouil / Kuruvilla, Rejji

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with Norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to ... ...

    Abstract Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with Norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to modulate noradrenergic responses, its specific roles in autonomic physiology remain under-appreciated. Here, we show that sympathetic-derived NPY is essential for metabolic and cardiovascular regulation in mice. NPY and NE are co-expressed in 90% of prevertebral sympathetic neurons and only 43% of paravertebral neurons. NPY-expressing neurons primarily innervate blood vessels in peripheral organs. Sympathetic-specific deletion of NPY elicits pronounced metabolic and cardiovascular defects in mice, including reductions in insulin secretion, glucose tolerance, cold tolerance, pupil size, and an elevation in heart rate, while notably, however, basal blood pressure was unchanged. These findings provide new knowledge about target tissue-specific functions of NPY derived from sympathetic neurons and imply its potential involvement in metabolic and cardiovascular diseases.
    Sprache Englisch
    Erscheinungsdatum 2023-07-26
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.07.24.550381
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Balancing the positives and negatives of the diastolic pulmonary gradient.

    Tampakakis, Emmanouil / Tedford, Ryan J

    European journal of heart failure

    2017  Band 19, Heft 1, Seite(n) 98–100

    Sprache Englisch
    Erscheinungsdatum 2017-01
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.704
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  10. Artikel: In vitro generation of mouse heart field-specific cardiac progenitor cells

    Tampakakis, Emmanouil / Kwon, Chulan / Miyamoto, Matthew

    Journal of visualized experiments. 2019 July 03, , no. 149

    2019  

    Abstract: Pluripotent stem cells offer great potential for understanding heart development and disease and for regenerative medicine. While recent advances in developmental cardiology have led to generating cardiac cells from pluripotent stem cells, it is unclear ... ...

    Abstract Pluripotent stem cells offer great potential for understanding heart development and disease and for regenerative medicine. While recent advances in developmental cardiology have led to generating cardiac cells from pluripotent stem cells, it is unclear if the two cardiac fields - the first and second heart fields (FHF and SHF) — are induced in pluripotent stem cells systems. To address this, we generated a protocol for in vitro specification and isolation of heart field-specific cardiac progenitor cells. We used embryonic stem cells lines carrying Hcn4-GFP and Tbx1-Cre; Rosa-RFP reporters of the FHF and the SHF, respectively, and live cell immunostaining of the cell membrane protein Cxcr4, a SHF marker. With this approach, we generated progenitor cells which recapitulate the functional properties and transcriptome of their in vivo counterparts. Our protocol can be utilized to study early specification and segregation of the two heart fields and to generate chamber-specific cardiac cells for heart disease modelling. Since this is an in vitro organoid system, it may not provide precise anatomical information. However, this system overcomes the poor accessibility of gastrulation-stage embryos and can be upscaled for high-throughput screens.
    Schlagwörter embryonic stem cells ; functional properties ; heart ; heart diseases ; medicine ; membrane proteins ; mice ; models ; transcriptome
    Sprache Englisch
    Erscheinungsverlauf 2019-0703
    Umfang p. e59826.
    Erscheinungsort Journal of Visualized Experiments
    Dokumenttyp Artikel
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/59826
    Datenquelle NAL Katalog (AGRICOLA)

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