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  1. Article ; Online: Association between Loss of Immune Checkpoint Programmed Cell Death Protein 1 and Active ANCA-Associated Renal Vasculitis.

    Hakroush, Samy / Tampe, Björn

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Immune checkpoint inhibitors (ICIs) have made an important contribution to the survival of patients with certain cancers. ICIs interrupt co-inhibitory signaling pathways mediated by programmed cell death protein 1 (PD-1), programmed cell death protein ... ...

    Abstract Immune checkpoint inhibitors (ICIs) have made an important contribution to the survival of patients with certain cancers. ICIs interrupt co-inhibitory signaling pathways mediated by programmed cell death protein 1 (PD-1), programmed cell death protein ligand 1 (PD-L1) and cytotoxic T lymphocyte-associated antigen (CTLA-4) that result in the elimination of cancer cells by stimulating the immune system. However, immune-related adverse events have also been described and attributed to an enhanced immune system activation. Recent observations have suggested a dysregulation of immune checkpoints in active antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We here analyzed intrarenal PD-1 and PD-L1 by immunostaining in a total of 15 kidney biopsies with ANCA-associated renal vasculitis in correlation with glomerular and tubulointerstitial lesions. For independent validation, publicly available datasets were analyzed for PD-1 expression (encoded by
    MeSH term(s) Humans ; Antibodies, Antineutrophil Cytoplasmic ; Programmed Cell Death 1 Receptor/genetics ; Complement Factor B ; Receptor, Anaphylatoxin C5a ; B7-H1 Antigen ; Pilot Projects ; Kidney/metabolism ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/pathology ; Kidney Diseases/pathology ; Complement C5
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Programmed Cell Death 1 Receptor ; Complement Factor B (EC 3.4.21.47) ; Receptor, Anaphylatoxin C5a ; B7-H1 Antigen ; Complement C5
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy.

    Korsten, Peter / Tampe, Björn

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Diabetic nephropathy is a common microvascular complication of diabetes mellitus. It is characterized by progressive chronic kidney disease (CKD) with decline of kidney function by hyperfiltration. On a mechanistic level, activation of the complement ... ...

    Abstract Diabetic nephropathy is a common microvascular complication of diabetes mellitus. It is characterized by progressive chronic kidney disease (CKD) with decline of kidney function by hyperfiltration. On a mechanistic level, activation of the complement system has been implicated in the pathogenesis of diabetic nephropathy. Therefore, here we pursued a transcriptome array-based approach to link intrarenal SGLT-2 and the synthesis of distinct complement components in diabetic nephropathy. Publicly available datasets for
    MeSH term(s) Humans ; Complement C5 ; Complement System Proteins/genetics ; Diabetes Mellitus ; Diabetic Nephropathies/metabolism ; Kidney Glomerulus/metabolism ; Renal Insufficiency, Chronic/complications ; Transcriptome
    Chemical Substances Complement C5 ; Complement System Proteins (9007-36-7) ; SLC5A2 protein, human
    Language English
    Publishing date 2023-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242317066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Avacopan improves patient perspective on steroid-related toxicity effects in a case with ANCA-associated vasculitis.

    Korsten, Peter / Tampe, Björn

    Rheumatology advances in practice

    2023  Volume 7, Issue 2, Page(s) rkad058

    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Case Reports
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkad058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Multidisciplinary critical care medicine - Getting things done across specialties.

    Korsten, Peter / Tampe, Björn

    Frontiers in medicine

    2023  Volume 10, Page(s) 1135003

    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1135003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Transcriptome Array-Based Approach Links Proteinuria and Distinct Molecular Signatures to Intrarenal Expression of Type I Interferon

    Korsten, Peter / Tampe, Björn

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: In systemic lupus erythematosus (SLE), the relevance of non-hematopoietic sources of type I interferon in human autoimmunity has recently been recognized. Particularly, type I interferon production precedes autoimmunity in early skin lesions related to ... ...

    Abstract In systemic lupus erythematosus (SLE), the relevance of non-hematopoietic sources of type I interferon in human autoimmunity has recently been recognized. Particularly, type I interferon production precedes autoimmunity in early skin lesions related to SLE. However, the relevance of intrarenal type I interferon expression has not been shown in lupus nephritis. From transcriptome array datasets, median-centered log
    MeSH term(s) Humans ; Male ; Female ; Lupus Nephritis ; Transcriptome ; Ligands ; Receptors, G-Protein-Coupled/genetics ; Lupus Erythematosus, Systemic ; Proteinuria/genetics ; Interferon Type I/genetics ; Interferon-alpha/genetics
    Chemical Substances Ligands ; Receptors, G-Protein-Coupled ; Interferon Type I ; IFNA13 protein, human ; Interferon-alpha
    Language English
    Publishing date 2023-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Relevance of histopathological findings for predictive scoring of short-term treatment response to plasma exchange in severe ANCA-associated renal vasculitides.

    Hakroush, Samy / Korsten, Peter / Ströbel, Philipp / Tampe, Björn

    Frontiers in immunology

    2024  Volume 15, Page(s) 1340999

    Abstract: Introduction: Rapidly progressive glomerulonephritis (RPGN) is characterized by a rapid loss of kidney function, affecting both renal and overall patient survival. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel ... ...

    Abstract Introduction: Rapidly progressive glomerulonephritis (RPGN) is characterized by a rapid loss of kidney function, affecting both renal and overall patient survival. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis affecting multiple organ systems including the kidney, and among most frequent causes of RPGN. We here aimed to validate a recently described scoring system for short-term treatment response to therapeutic plasma exchange (PLEX) in a well-characterized and independent cohort of severe renal AAV presenting with RPGN. Furthermore, we compared this scoring with established classification systems in renal AAV including histopathological findings.
    Methods: We here directly compare the scoring system with retrospective data about PLEX treatment in our own clinical practice and according to current recommendations in a cohort of 53 patients with severe AAV presenting with RPGN confirmed by kidney biopsy.
    Results: We here confirm that PLEX scoring is capable to identify patients at risk for short-term poor outcome in severe AAV presenting with RPGN (
    Conclusion: Our observations underscore the relevance of performing a kidney biopsy in this patient population that is often challenged in the setting of intensive care treatment, requirement of KRT with need for anticoagulation and bleeding risk. Therefore, validation of our observations and this recent scoring system for treatment response to PLEX in independent cohorts would be of great clinical relevance in the treatment of patients with severe AAV presenting with RPGN.
    MeSH term(s) Humans ; Antibodies, Antineutrophil Cytoplasmic ; Plasma Exchange ; Glomerulonephritis ; Retrospective Studies ; Kidney/pathology ; Nephritis/pathology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1340999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tailored Use of Avacopan in a Case With Refractory Antineutrophil Cytoplasmic Antibody-Associated Renal Vasculitis and Concominant Complement System Activation.

    Hakroush, Samy / Tampe, Björn

    Kidney international reports

    2022  Volume 8, Issue 2, Page(s) 376–378

    Language English
    Publishing date 2022-11-25
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.10.033
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  8. Article: Determinants of Tunneled Hemodialysis Catheter Implantation Time by Ultrasound Guidance: A Single-Center Cross-Sectional Study.

    Tampe, Désirée / Tampe, Björn

    Journal of clinical medicine

    2022  Volume 11, Issue 12

    Abstract: Background: We have previously reported that the ultrasound (US)-guided tip positioning is an accurate and safe procedure for placement of retrograde- and antegrade-tunneled hemodialysis catheters (HDCs). However, determinants of tunneled hemodialysis ... ...

    Abstract Background: We have previously reported that the ultrasound (US)-guided tip positioning is an accurate and safe procedure for placement of retrograde- and antegrade-tunneled hemodialysis catheters (HDCs). However, determinants of tunneled hemodialysis catheter implantation time by using US guidance have not been described yet. Therefore, we here report a comparative analysis to identify determinants of implantation time for retrograde- and antegrade-tunneled HDCs placement by US guidance.
    Methods: We performed a cross-sectional study to compare implantation time for US-guided tip positioning of retrograde- and antegrade-tunneled HDCs. We included a total number of 47 tunneled HDC insertions, including 23 retrograde tunneled and 24 antegrade-tunneled HDCs in patients requiring placement of an HDC for the temporary or permanent treatment of end-stage kidney disease (ESKD) in a single-center, cross-sectional pilot study.
    Results: We show that clinical and laboratory parameters did not differ between retrograde- and antegrade-tunneled HDC implantations. There was a tendency for shorter implantation time in antegrade-tunneled HDCs, although not statistically significant. Finally, we identified an independent inverse association between body weight (BW) and platelet counts with HDC implantation time specifically in antegrade-tunneled HDCs.
    Conclusion: In this study, we identified determinants for tunneled HDC implantation time that might be relevant for patients and interventionists.
    Language English
    Publishing date 2022-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11123526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Serum sodium levels associate with recovery of kidney function in immune checkpoint inhibitor nephrotoxicity.

    Tampe, Désirée / Baier, Eva / Hakroush, Samy / Tampe, Björn

    Frontiers in medicine

    2023  Volume 10, Page(s) 1020691

    Abstract: Background: Immune checkpoint inhibitors (ICIs) are novel drugs targeting programmed cell death protein 1-ligand 1 (PD-L1) or its receptor (PD-1). Enhancing the immune system has also been associated with a wide range of immune-related adverse events ( ... ...

    Abstract Background: Immune checkpoint inhibitors (ICIs) are novel drugs targeting programmed cell death protein 1-ligand 1 (PD-L1) or its receptor (PD-1). Enhancing the immune system has also been associated with a wide range of immune-related adverse events (irAE). Among them, acute interstitial nephritis (AIN) is a rare but deleterious irAE in the kidney. However, determinants of recovery and long-term kidney function after ICI withdrawal and steroid therapy thereafter remain elusive. Therefore, we here aimed to identify parameters associated with recovery of kidney function in this previous established cohort of AIN in the context of ICI therapy.
    Methods: We here monitored kidney function over a mean follow-up time of 812 days in comparison with clinical, histopathological and laboratory parameters associated with recovery of kidney function after AIN related to ICI nephrotoxicity.
    Results: Abundance of intrarenal PD-L1/PD-1 did not correlate with recovery of kidney function. Furthermore, cumulative steroid dose that was initiated for treatment of AIN related to ICI nephrotoxicity was also not associated with improvement of kidney function. Finally, chronic lesions in the kidney including glomerular sclerosis and interstitial fibrosis/tubular atrophy (IF/TA) did not correlate with eGFR change during the follow-up time. However, we here identified that lower levels of serum sodium at time of kidney biopsy were the strongest independent predictor of renal recovery in ICI-related nephrotoxicity.
    Conclusion: Because low serum sodium levels associated with better improvement of kidney function, these observations might contribute to novel approaches to enhance recovery after AIN related to ICI nephrotoxicity.
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1020691
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  10. Article ; Online: C-Reactive Protein Levels Are Associated with Complement C4 Deposits and Interstitial Arteritis in ANCA-Associated Renal Vasculitis.

    Korsten, Peter / Baier, Eva / Hakroush, Samy / Tampe, Björn

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially life-threatening systemic small-vessel vasculitis that is characterized by pauci-immune glomerulonephritis in case of kidney involvement, representing a major ... ...

    Abstract Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially life-threatening systemic small-vessel vasculitis that is characterized by pauci-immune glomerulonephritis in case of kidney involvement, representing a major denominator of AAV mortality. Innate immunity with complement system activation is increasingly recognized in the pathogenesis of AAV and as an attractive therapeutic target. Although C-reactive protein (CRP) was thought to be a passive, nonspecific marker of inflammation, recent studies indicate that CRP plays a key role in the innate immune system by recognizing pathogens and altered self-determinants. Elevated baseline CRP at disease onset of AAV has already been described as a determinant of poor long-term outcomes. However, its clinical implications at disease onset of AAV, with respect to vasculitis manifestations and complement system activation that might also affect long-term outcomes, remain elusive. CRP levels were retrospectively analyzed in 53 kidney-biopsy-confirmed cases of ANCA-associated renal vasculitis; a total of 138 disease controls were also evaluated. Univariate and multivariate regression analysis was performed on clinicopathological parameters associated with CRP levels in ANCA-associated renal vasculitis. Results: Compared to disease controls, CRP elevation was common in ANCA-associated renal vasculitis and associated with de novo disease (
    MeSH term(s) Humans ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/pathology ; Antibodies, Antineutrophil Cytoplasmic ; Arteritis/complications ; Arteritis/pathology ; C-Reactive Protein ; Complement C4 ; Kidney/pathology ; Peroxidase ; Retrospective Studies
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; C-Reactive Protein (9007-41-4) ; Complement C4 ; Peroxidase (EC 1.11.1.7) ; CRP protein, human
    Language English
    Publishing date 2023-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043072
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