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Article ; Online: Supramolecular nanoarchitectonics of propionylated polyrotaxanes with bulky nitrobenzyl stoppers for light-triggered drug release.

Zhang, Shunyao / Tamura, Atsushi / Yui, Nobuhiko

RSC advances

2024 Volume 14, Issue 6, Page(s) 3798–3806

Abstract: Cyclodextrin (CD)-based polyrotaxanes (PRXs) are supramolecular polymers comprising multiple CDs mechanically interlocked onto a linear polymer chain by capping the polymer ends with bulky stoppers. Among various PRX derivatives, propionylated PRXs (Pr- ... ...

Abstract	Cyclodextrin (CD)-based polyrotaxanes (PRXs) are supramolecular polymers comprising multiple CDs mechanically interlocked onto a linear polymer chain by capping the polymer ends with bulky stoppers. Among various PRX derivatives, propionylated PRXs (Pr-PRXs) composed of propionylated α-CD and high molecular-weight poly(ethylene glycol) (PEG) form self-assembled nanoparticles in aqueous solution through hydrophobic interactions. Although Pr-PRX nanoparticles can encapsulate hydrophobic drugs in their hydrophobic domains, their release rate is limited. To improve the efficiency of drug release from Pr-PRX nanoparticles, ultraviolet (UV) light-dissociable Pr-PRXs were designed using 4,5-dimethoxy 2-nitrobenzyl groups as UV-cleavable bulky stopper molecules to facilitate UV-induced drug release. Photodegradable Pr-PRX (Pr-PD-PRX) was synthesized, and its UV-induced dissociation was examined. Pr-PD-PRX was completely dissociated
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d4ra00213j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: [Intracellularly Degradable Polyrotaxanes for Therapeutic Applications].

Tamura, Atsushi

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2019 Volume 139, Issue 2, Page(s) 143–155

Abstract: Recently, the application of β-cyclodextrins (β-CDs) as therapeutic agents has received considerable attention. β-CDs have been reported to have therapeutic effects on various diseases, such as Niemann-Pick type C (NPC) disease, a family of lysosomal ... ...

Abstract	Recently, the application of β-cyclodextrins (β-CDs) as therapeutic agents has received considerable attention. β-CDs have been reported to have therapeutic effects on various diseases, such as Niemann-Pick type C (NPC) disease, a family of lysosomal storage disorders characterized by the lysosomal accumulation of cholesterol. To further improve the therapeutic efficacy of β-CDs, the use of β-CD-threaded polyrotaxanes (PRXs) has been proposed as a carrier of β-CDs for NPC disease. PRXs are supramolecular polymers composed of many CDs threaded onto a linear polymer chain and capped with bulky stopper molecules. In this review, the design of PRXs and their therapeutic applications are described. To achieve the intracellular release of threaded β-CDs from PRXs, stimuli-cleavable linkers are introduced in an axle polymer of PRXs. The stimuli-labile PRXs can dissociate into their constituent molecules by a cleavage reaction under specific stimuli, such as pH reduction in lysosomes. The release of the threaded β-CDs from acid-labile PRXs in acidic lysosomes leads to the formation of an inclusion complex with the cholesterol that has accumulated in NPC disease patient-derived fibroblasts, thus promoting the extracellular excretion of the excess cholesterol. Moreover, the administration of PRXs to a mouse model of NPC disease caused significant suppression of the tissue accumulation of cholesterol, resulting in a prolonged life span in the model mice. Additionally, the induction of autophagy by the methylated β-CD-threaded PRXs (Me-PRXs) is described. Accordingly, the stimuli-labile PRXs are expected to be effective carriers of CDs for therapeutic applications.
MeSH term(s)	Animals ; Autophagy/drug effects ; Cholesterol/metabolism ; Cyclodextrins/chemistry ; Cyclodextrins/metabolism ; Disease Models, Animal ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Drug Design ; Fibroblasts/metabolism ; Humans ; Hydrogen-Ion Concentration ; Lysosomes/metabolism ; Macromolecular Substances ; Methylation ; Mice ; Niemann-Pick Diseases/drug therapy ; Niemann-Pick Diseases/metabolism ; Poloxamer/chemistry ; Poloxamer/metabolism ; Rotaxanes/chemistry ; Rotaxanes/metabolism ; beta-Cyclodextrins/administration & dosage ; beta-Cyclodextrins/metabolism ; beta-Cyclodextrins/pharmacology
Chemical Substances	Cyclodextrins ; Drug Carriers ; Macromolecular Substances ; Rotaxanes ; beta-Cyclodextrins ; polyrotaxane ; Poloxamer (106392-12-5) ; Cholesterol (97C5T2UQ7J) ; betadex (JV039JZZ3A)
Language	Japanese
Publishing date	2019-01-16
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.18-00168-1
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Article ; Online: Enhanced Tumor Targeting and Antitumor Activity of Methylated β-Cyclodextrin-Threaded Polyrotaxanes by Conjugating Cyclic RGD Peptides.

Zhang, Shunyao / Tamura, Atsushi / Yui, Nobuhiko

Biomolecules

2024 Volume 14, Issue 2

Abstract: We previously reported that acid-degradable methylated β-cyclodextrins (Me-β-CDs)-threaded polyrotaxanes (Me-PRXs) can induce autophagic cell death through endoplasmic reticulum (ER) stress-related autophagy, even in apoptosis-resistant cells. Hence, Me- ... ...

Abstract	We previously reported that acid-degradable methylated β-cyclodextrins (Me-β-CDs)-threaded polyrotaxanes (Me-PRXs) can induce autophagic cell death through endoplasmic reticulum (ER) stress-related autophagy, even in apoptosis-resistant cells. Hence, Me-PRXs show great potential as anticancer therapeutics. In this study, peptide-supermolecule conjugates were designed to achieve the targeted delivery of Me-PRX to malignant tumors. Arg-Gly-Asp peptides are well-known binding motifs of integrin α
MeSH term(s)	Humans ; Rotaxanes/pharmacology ; Rotaxanes/chemistry ; Rotaxanes/metabolism ; beta-Cyclodextrins/chemistry ; Oligopeptides/chemistry ; Neoplasms/drug therapy ; Integrins ; Peptides, Cyclic
Chemical Substances	arginyl-glycyl-aspartic acid (78VO7F77PN) ; cyclic arginine-glycine-aspartic acid peptide ; Rotaxanes ; beta-Cyclodextrins ; Oligopeptides ; Integrins ; Peptides, Cyclic
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14020223
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Article: [Partial Arch Repair for Reruptured Aortic Arch Aneurysm due to Endoleak After 2-debranching Thoracic Endovascular Aortic Repair:Report of a Case].

Hori, Mariko / Yoshizaki, Takamichi / Tamura, Atsushi

Kyobu geka. The Japanese journal of thoracic surgery

2024 Volume 77, Issue 2, Page(s) 136–139

Abstract: A 67-year-old male was admitted to our hospital for sudden onset chest pain and hoarseness. He underwent 2-debranching thoracic endovascular aortic repair for a ruptured aortic arch aneurysm four years prior. However, computed tomography (CT) revealed an ...

Abstract	A 67-year-old male was admitted to our hospital for sudden onset chest pain and hoarseness. He underwent 2-debranching thoracic endovascular aortic repair for a ruptured aortic arch aneurysm four years prior. However, computed tomography (CT) revealed an aneurysmal rerupture due to a typeⅠa endoleak. We performed partial arch replacement with uncovered stent removal under intermittent hypothermic circulatory arrest. We needed to be more careful than usual open heart surgery because a non-anatomical bypass procedure was performed. The surgery was successful without any major complications, and the patient was discharged on the 23th postoperative day. Reinterventions post-endovascular repair are sometimes difficult;thus, open surgery could be useful for arch replacement.
MeSH term(s)	Male ; Humans ; Aged ; Endoleak/diagnostic imaging ; Endoleak/etiology ; Endoleak/surgery ; Endovascular Aneurysm Repair ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/surgery ; Aortic Aneurysm, Thoracic/complications ; Blood Vessel Prosthesis Implantation/adverse effects ; Stents/adverse effects ; Aneurysm, Aortic Arch ; Treatment Outcome ; Endovascular Procedures ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Blood Vessel Prosthesis/adverse effects ; Retrospective Studies
Language	Japanese
Publishing date	2024-03-11
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	603899-2
ISSN	0021-5252
ISSN	0021-5252
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Article ; Online: Potential for soil seed banks to drive vegetation changes in windswept Sasa grasslands in eastern Japan

Tamura, Atsushi

Journal of Forest Research. 2021 Jan. 02, v. 26, no. 1 p.75-80

2021

Abstract: Windswept Sasa grasslands are stable communities but may have the potential to change into other vegetation such as forests through germination of the soil seed bank. I investigated the compositions of the vegetation and soil seed banks in two windswept ... ...

Abstract	Windswept Sasa grasslands are stable communities but may have the potential to change into other vegetation such as forests through germination of the soil seed bank. I investigated the compositions of the vegetation and soil seed banks in two windswept Sasa grasslands in the Tanzawa Mountains, eastern Japan: Ryugababa (RGB) and Fudonomine (FDM). Tall tree and sub-tall tree seedlings were present in both grasslands but were below a dense cover of Sasa hayatae. The number of buried viable seeds was estimated as 2831 seeds m⁻² comprising 39 species at RGB and 5786 seeds m⁻² comprising 58 species at FDM, 70% of which were graminoids and 5−23% of which were sub-tall trees at both sites. Most sub-tall tree seeds were Weigela decora, which forms windswept scrub forests around Sasa grasslands. No seedlings of S. hayatae germinated from any of the soil seed bank samples. A habitat type analysis of the soil seed banks showed that the “other” type (species that are infrequent or do not belong to a particular plant association) had the highest relative dominance (approximately 70%), followed by windswept scrub forest (13−25%) at both sites. Sørensen’s similarity index between the vegetation and soil seed bank was low (39.6% in RGB and 47.1% in FDM), possibly because the dense Sasa cover prevents seedlings from germinating and growing. These results suggest that the soil seed banks in windswept Sasa grasslands have different species compositions from the vegetation and consequently have the potential to cause a shift to W. decora scrub forest.
Keywords	Japan ; Sasa ; Weigela ; buried seeds ; forests ; germination ; graminoids ; habitats ; research ; shrublands ; soil ; trees ; Graminoid ; Scrub forest ; Sørensen’s similarity index ; Sub-tall tree ; Vegetation
Language	English
Dates of publication	2021-0102
Size	p. 75-80.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2104467-3
ISSN	1610-7403 ; 1341-6979
ISSN (online)	1610-7403
ISSN	1341-6979
DOI	10.1080/13416979.2020.1844941
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Article ; Online: Supermolecule-Drug Conjugates Based on Acid-Degradable Polyrotaxanes for pH-Dependent Intracellular Release of Doxorubicin.

Tamura, Atsushi / Osawa, Mamoru / Yui, Nobuhiko

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 6

Abstract: Doxorubicin (DOX)-conjugated acid-degradable polyrotaxanes (PRXs) were designed as supramolecular drug carriers capable of releasing drugs in acidic cellular environments. Acid-degradable PRXs composed of α-cyclodextrin (α-CD) as a cyclic molecule, poly( ... ...

Abstract	Doxorubicin (DOX)-conjugated acid-degradable polyrotaxanes (PRXs) were designed as supramolecular drug carriers capable of releasing drugs in acidic cellular environments. Acid-degradable PRXs composed of α-cyclodextrin (α-CD) as a cyclic molecule, poly(ethylene glycol) (PEG) as a polymer axis, and
MeSH term(s)	Rotaxanes/chemistry ; Doxorubicin/chemistry ; Polyethylene Glycols/chemistry ; Drug Carriers/chemistry ; Acids ; Hydrogen-Ion Concentration
Chemical Substances	Rotaxanes ; Doxorubicin (80168379AG) ; Polyethylene Glycols (3WJQ0SDW1A) ; Drug Carriers ; Acids
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28062517
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Article: Transcutaneous electrical nerve stimulation effects on patients with subacute vertebral fracture: a case report using an ABAB study design.

Ikeda, Naoto / Morishita, Katsuyuki / Tamura, Atsushi

Journal of physical therapy science

2023 Volume 35, Issue 2, Page(s) 151–155

Abstract: Purpose] This study investigated the effects of transcutaneous electrical nerve stimulation on trunk extension muscle strength, walking ability, and the Japanese Orthopedic Association Back Pain Evaluation Questionnaire items of gait disturbance in one ... ...

Abstract	[Purpose] This study investigated the effects of transcutaneous electrical nerve stimulation on trunk extension muscle strength, walking ability, and the Japanese Orthopedic Association Back Pain Evaluation Questionnaire items of gait disturbance in one case of a subacute osteoporotic vertebral fracture. [Participant and Methods] An 88-year-old female with the first and third lumbar vertebral fractures underwent standard physical therapy (A1 and A2 phases) and transcutaneous electrical nerve stimulation to the sclerotome region of the fractured vertebra (B1 and B2 phases). Assessments were performed before the A1 phase and the day after each phase. Assessment items included the Visual Analog Scale scores for pain during rest, getting up, standing up, and walking; isometric trunk extension muscle strength; walking ability (10-meter walking, continuous walking distance); and the Japanese Orthopedic Association Back Pain Evaluation Questionnaire items. [Results] Even though the pain intensity did not change, isometric trunk extension muscle strength, continuous walking distance, and the Japanese Orthopedic Association Back Pain Evaluation Questionnaire items of gait disturbance were improved in phase B compared to phase A. [Conclusion] Standard physical therapy and transcutaneous electrical nerve stimulation to the sclerotome area may improve trunk extension muscle strength, walking ability, and the Japanese Orthopedic Association Back Pain Evaluation Questionnaire items of gait disturbance in patients with subacute osteoporotic vertebral fractures.
Language	English
Publishing date	2023-02-01
Publishing country	Japan
Document type	Case Reports
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.35.151
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Article ; Online: Exploring Receptor Binding Affinities and Hepatic Cell Association of

Ohashi, Moe / Tamura, Atsushi / Yui, Nobuhiko

Biomacromolecules

2023 Volume 24, Issue 5, Page(s) 2327–2341

Abstract: Acid-degradable polyrotaxanes (PRXs) containing threading β-cyclodextrins (β-CDs) are promising candidates for therapeutic applications of β-CDs in metabolic diseases with cholesterol overload or imbalance. To improve cellular uptake specificity and ... ...

Abstract	Acid-degradable polyrotaxanes (PRXs) containing threading β-cyclodextrins (β-CDs) are promising candidates for therapeutic applications of β-CDs in metabolic diseases with cholesterol overload or imbalance. To improve cellular uptake specificity and efficiency of PRXs in hepatocytes,
MeSH term(s)	Rotaxanes/chemistry ; Acetylgalactosamine ; Galactosamine ; beta-Cyclodextrins/chemistry ; Hepatocytes/metabolism ; Liver/metabolism ; Acids ; Asialoglycoprotein Receptor ; Cholesterol/metabolism
Chemical Substances	Rotaxanes ; Acetylgalactosamine (KM15WK8O5T) ; Galactosamine (7535-00-4) ; beta-Cyclodextrins ; Acids ; Asialoglycoprotein Receptor ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c00194
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Potential of soil seed banks for vegetation recovery following deer exclusions under different periods of chronic herbivory in a beech forest in eastern Japan

Tamura, Atsushi

Ecological research. 2019 Jan., v. 34, no. 1

2019

Abstract: This study aimed to evaluate the potential for vegetation recovery from buried seed banks following exclusion of deer after different periods of chronic herbivory in a beech forest. Using the seedling emergence method, I surveyed the floor vegetation, ... ...

Abstract	This study aimed to evaluate the potential for vegetation recovery from buried seed banks following exclusion of deer after different periods of chronic herbivory in a beech forest. Using the seedling emergence method, I surveyed the floor vegetation, buried seed banks and compared survey results with that of past flora. The study areas were an area within two deer exclosure fences, one established in 1997 and the other in 2003, and the area outside the fences. With regard to floor vegetation, species diversity and dominance of vulnerable (VUL) species were higher in F1997 than in F2003, and species frequency was different among the three plots. In the soil seed banks, species richness, seed density and life form composition were different among the three plots. However, when I excluded Rubus illecebrosus, which is a VUL shrub species, seed density of VUL species was not greatly different among the plots. In addition, the species composition of soil seed banks compared with that of past flora was similar among the plots. This may be because almost no VUL herb species formed the buried seed banks. In contrast, invulnerable (INV) species formed numerous seed banks. These results demonstrate that chronic deer herbivory causes a negative effect on the composition of floor vegetation through VUL herb species, and a positive effect on the seed density of soil seed banks through INV species. Conservation measures are needed while there are still plant organs remaining aboveground.
Keywords	Fagus ; Japan ; Rubus ; buried seeds ; deer ; flora ; forests ; herbivores ; research ; seedling emergence ; shrubs ; soil ; species richness ; surveys
Language	English
Dates of publication	2019-01
Size	p. 160-170.
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	233459-8
ISSN	1440-1703 ; 0912-3814
ISSN (online)	1440-1703
ISSN	0912-3814
DOI	10.1111/1440-1703.1060
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Article: [Total Aortic Arch Replacement for TypeⅠEndoleak after Thoracic Endovascular Aortic Repair using the Chimney Graft Technique:Report of a Case].

Tamura, Atsushi / Kazuno, Kei / Yoshizaki, Takamichi / Hori, Mariko

Kyobu geka. The Japanese journal of thoracic surgery

2022 Volume 75, Issue 5, Page(s) 377–381

Abstract: Here we report a case of total aortic arch replacement for typeⅠendoleak after thoracic endovascular aortic repair( TEVAR) using the concomitant chimney graft technique. An 81-year-old man was admitted with sudden back pain. Six years prior, he had ... ...

Abstract	Here we report a case of total aortic arch replacement for typeⅠendoleak after thoracic endovascular aortic repair( TEVAR) using the concomitant chimney graft technique. An 81-year-old man was admitted with sudden back pain. Six years prior, he had undergone TEVAR for treatment of a distal aortic arch aneurysm. Preoperative computed tomography revealed an 80-mm-diameter arch aneurysm and typeⅠendoleak. The back pain was caused by impending aneurysmal rupture;therefore, urgent total arch replacement was performed. One stent was cut from the main endograft and anastomosed to its distal side. The bare metal stent in the left common carotid artery was removed and reconstructed at a healthy distal artery. Postoperative computed tomography revealed no endoleak of the aneurysm, and the patient's postoperative course was uneventful.
MeSH term(s)	Aged, 80 and over ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/methods ; Endovascular Procedures/methods ; Humans ; Male ; Treatment Outcome
Language	Japanese
Publishing date	2022-04-26
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	603899-2
ISSN	0021-5252
ISSN	0021-5252
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