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Article: Clinical prediction model based on 18F-FDG PET/CT plus contrast-enhanced MRI for axillary lymph node macrometastasis.

Kawaguchi, Shun / Tamura, Nobuko / Tanaka, Kiyo / Kobayashi, Yoko / Sato, Junichiro / Kinowaki, Keiichi / Shiiba, Masato / Ishihara, Makiko / Kawabata, Hidetaka

Frontiers in oncology

2022 Volume 12, Page(s) 989650

Abstract: Purpose: Positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) are useful for detecting axillary lymph node (ALN) metastasis in invasive ductal breast cancer (IDC); however, there is limited clinical evidence to ... ...

Abstract	Purpose: Positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) are useful for detecting axillary lymph node (ALN) metastasis in invasive ductal breast cancer (IDC); however, there is limited clinical evidence to demonstrate the effectiveness of the combination of PET/CT plus MRI. Further axillary surgery is not recommended against ALN micrometastasis (lesion ≤2 mm) seen in sentinel lymph nodes, especially for patients who received proper adjuvant therapy. We aimed to evaluate the efficacy of a prediction model based on PET/CT plus MRI for ALN macrometastasis (lesion >2 mm) and explore the possibility of risk stratification of patients using the preoperative PET/CT plus MRI and biopsy findings. Materials and methods: We retrospectively investigated 361 female patients (370 axillae; mean age, 56 years ± 12 [standard deviation]) who underwent surgery for primary IDC at a single center between April 2017 and March 2020. We constructed a prediction model with logistic regression. Patients were divided into low-risk and high-risk groups using a simple integer risk score, and the false negative rate for ALN macrometastasis was calculated to assess the validity. Internal validation was also achieved using a 5-fold cross-validation. Results: The PET/CT plus MRI model included five predictor variables: maximum standardized uptake value of primary tumor and ALN, primary tumor size, ALN cortical thickness, and histological grade. In the derivation (296 axillae) and validation (74 axillae) cohorts, 54% and 61% of patients, respectively, were classified as low-risk, with a false-negative rate of 11%. Five-fold cross-validation yielded an accuracy of 0.875. Conclusions: Our findings demonstrate the validity of the PET/CT plus MRI prediction model for ALN macrometastases. This model may aid the preoperative identification of low-risk patients for ALN macrometastasis and provide helpful information for PET/MRI interpretation.
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.989650
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Article ; Online: Solitary fibrous tumor of male breast: A case report and literature review.

Kawaguchi, Shun / Kinowaki, Keiichi / Tamura, Nobuko / Nishikawa, Aya / Shibata, Akio / Tanaka, Kiyo / Kobayashi, Yoko / Ogura, Takuya / Sato, Junichiro / Kawabata, Hidetaka

Medicine

2022 Volume 101, Issue 50, Page(s) e32199

Abstract: Background: Solitary fibrous tumors (SFT) are uncommon mesenchymal neoplasms which can arise in any anatomical location. Pleural SFTs have been most frequently documented; however, breast SFT is an exceedingly rare entity and seldom present in male ... ...

Abstract	Background: Solitary fibrous tumors (SFT) are uncommon mesenchymal neoplasms which can arise in any anatomical location. Pleural SFTs have been most frequently documented; however, breast SFT is an exceedingly rare entity and seldom present in male breast, with only 8 previously reported cases. Recently, STAT6 immunostaining was considered to be a definitive marker of SFT, however, no case of the male breast SFT showing STAT6 positivity preoperatively has been reported. Methods and results: We describe a case of breast SFT in a 73-year-old male patient with a 12-month history of a palpable breast mass. The only associated clinical symptom was bilateral gynecomastia. An ultrasound scan examination revealed an oval, well-circumscribed and hypoechoic mass with hypervascularity. A core-needle biopsy was performed, and microscopic examination with immunohistochemistry confirmed the diagnosis of SFT. He underwent a complete surgical resection with clear margins, and there were no signs of high cellularity, remarkable mitotic activity, pleomorphism, hemorrhage or necrosis. Conclusion: A perioperative immunohistochemical evaluation for diffuse and intense nuclear expression of STAT6 was helpful to distinguish SFT from myofibroblastoma. We, herein, describe the first case of SFT in a male breast, confirmed by STAT6 immunostaining positivity. We also conducted a literature review of all previous cases of breast SFTs.
Language	English
Publishing date	2022-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032199
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Article: [Moving forward to overcome infertility after breast cancer treatment].

Tamura, Nobuko / Shimizu, Chikako

Gan to kagaku ryoho. Cancer & chemotherapy

2015 Volume 42, Issue 3, Page(s) 272–275

Abstract: An increase in the number of young women with breast cancer together with improved outcomes after breast cancer treatments have lead healthcare providers and society in general to become more aware of fertility preservation. The potential for infertility ...

Abstract	An increase in the number of young women with breast cancer together with improved outcomes after breast cancer treatments have lead healthcare providers and society in general to become more aware of fertility preservation. The potential for infertility caused by cancer treatment is one of the most important quality-of-life issues for young women with cancer, and guidelines and decision-aids to support those who wish to have children after cancer treatment have been developed. To move forward, a prospective database needs to be developed in order to overcome safety concerns, and to allow network building among breast oncologists and reproductive specialists. A multidisciplinary team is also urgently needed to address psychosocial and ethical issues.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Female ; Fertility Preservation ; Hormone Replacement Therapy/adverse effects ; Humans ; Infertility, Female/etiology ; Infertility, Female/therapy ; Quality of Life
Chemical Substances	Antineoplastic Agents
Language	Japanese
Publishing date	2015-03
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Does breast-conserving surgery with radiotherapy in BRCA-mutation carriers significantly increase ipsilateral breast tumor recurrence? A systematic review and meta-analysis.

Nara, Miyako / Ishihara, Sakiko / Kitano, Atsuko / Tamura, Nobuko / Aruga, Tomoyuki / Kobayashi, Daiki / Nakamura, Seigo / Yamauchi, Hideko

Breast cancer (Tokyo, Japan)

2022 Volume 29, Issue 3, Page(s) 394–401

Abstract: Background: Breast-conserving surgery (BCS) is often preferred for localized, small breast cancers, but its safety and efficacy in BRCA-mutation carriers is still controversial. This meta-analysis aimed to determine whether there was any significant ... ...

Abstract	Background: Breast-conserving surgery (BCS) is often preferred for localized, small breast cancers, but its safety and efficacy in BRCA-mutation carriers is still controversial. This meta-analysis aimed to determine whether there was any significant difference in the incidence of ipsilateral breast tumor recurrence (IBTR) between BRCA-mutation carriers who underwent BCS and controls with sporadic breast cancer. Methods: A PubMed search was conducted through March 2020 to identify studies examining the risk of IBTR after BCS in BRCA-mutation carriers versus controls. The Cochrane risk-of-bias tool was used to assess the risk of bias. The pooled risk ratio (RR) was calculated using the random-effects model. Results: Thirteen studies involving 701 BRCA-mutation carriers and 4788 controls in total were eventually analyzed. In the meta-analysis, IBTR after BCS was significantly higher in BRCA-mutation carriers (RR: 1.589; 95% confidence interval (CI) 1.247-2.024; P < 0.001). Subgroup analysis of the follow-up time found that the RR for IBTR increased as the observation period lengthened (median follow-up: ≧ 7 years [RR: 1.505; 95% CI 1.184-1.913] and ≧ 10 years [RR: 1.601; 95% CI 1.201-2.132], respectively). However, a qualitative meta-analysis of overall survival in three cohort studies found no evidence to suggest a deterioration in overall survival in patients with BCS. Conclusions: The present study demonstrated that BRCA-mutation carriers with BCS have a higher risk of IBTR, which tended to persist for a long period and become more apparent with longer observation.
MeSH term(s)	Breast Neoplasms/genetics ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Female ; Humans ; Incidence ; Mastectomy, Segmental ; Mutation ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/surgery
Language	English
Publishing date	2022-02-25
Publishing country	Japan
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-022-01343-3
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Article ; Online: Effectiveness of PET/CT and VATS for detecting and treating internal mammary lymph node metastasis: a case series.

Kawaguchi, Shun / Tamura, Nobuko / Suzuki, Soichiro / Nishikawa, Aya / Shibata, Akio / Tanaka, Kiyo / Kobayashi, Yoko / Ogura, Takuya / Sato, Junichiro / Kinowaki, Keiichi / Shiiba, Masato / Ishihara, Makiko / Fujimori, Sakashi / Kawabata, Hidetaka

Japanese journal of clinical oncology

2023 Volume 53, Issue 7, Page(s) 562–571

Abstract: Objective: We occasionally observed internal mammary lymph node metastases of breast cancer in a clinical setting. However, unlike a standard treatment in axillary metastasis, surgical resection for internal mammary lymph node metastasis is not ... ...

Abstract	Objective: We occasionally observed internal mammary lymph node metastases of breast cancer in a clinical setting. However, unlike a standard treatment in axillary metastasis, surgical resection for internal mammary lymph node metastasis is not prevalent because of unclear safety and benefits. Thus, we aimed to evaluate the diagnostic ability and clinical outcomes of positron emission tomography/computed tomography and video-assisted thoracoscopic surgery. Methods: We retrospectively investigated 34 patients with breast cancer with abnormal 18F-fluorodeoxyglucose uptake in internal mammary lymph nodes, at a single centre, between January 2015 and June 2022 and identified 11 female patients (mean age ± SD, 51.5 ± 12.9 years) who underwent video-assisted thoracoscopic surgery resection. Positron emission tomography/computed tomography was used to determine the clinical stage. We reviewed the surgical pathology of eleven and two patients who underwent direct-view internal mammary lymph node resection to calculate the positive predictive value of positron emission tomography/computed tomography. Results: Ipsilateral fluorodeoxyglucose accumulation was observed, with an average maximum standardized uptake value of 8.9 (range, 3.1-24.0). No perioperative complications occurred, and all patients who underwent video-assisted thoracoscopic surgery alone were discharged from the hospital on post-operative day 2 or 3. The estimated positive predictive value was 80%. All patients were alive, and seven of nine patients with metastasis were relapse-free, at a mean follow-up period of 17.9 months (range, 1-51). However, two patients had recurrence at 16 and 14 months after surgery for internal mammary lymph node relapse. Conclusions: Radiotherapy is the standard treatment for suspected internal mammary lymph node metastasis detected using positron emission tomography/computed tomography; however, we could safely perform minimally invasive video-assisted thoracoscopic surgery resection, leading to a definite pathological diagnosis.
MeSH term(s)	Humans ; Female ; Positron Emission Tomography Computed Tomography ; Thoracic Surgery, Video-Assisted ; Lymphatic Metastasis/pathology ; Retrospective Studies ; Positron-Emission Tomography/methods ; Neoplasm Recurrence, Local/pathology ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Fluorodeoxyglucose F18 ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyad032
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Zs.A 1298: Show issues

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Article ; Online: High-accuracy prediction of axillary lymph node metastasis in invasive lobular carcinoma using focal cortical thickening on magnetic resonance imaging.

Kawaguchi, Shun / Kinowaki, Keiichi / Tamura, Nobuko / Masumoto, Tomohiko / Nishikawa, Aya / Shibata, Akio / Tanaka, Kiyo / Kobayashi, Yoko / Ogura, Takuya / Sato, Junichiro / Kawabata, Hidetaka

Breast cancer (Tokyo, Japan)

2023 Volume 30, Issue 4, Page(s) 637–646

Abstract: Background: Invasive lobular carcinoma (ILC) grows diffusely in a single-cell fashion, sometimes presenting only subtle changes in preoperative imaging; therefore, axillary lymph node (ALN) metastases of ILC are difficult to detect using magnetic ... ...

Abstract	Background: Invasive lobular carcinoma (ILC) grows diffusely in a single-cell fashion, sometimes presenting only subtle changes in preoperative imaging; therefore, axillary lymph node (ALN) metastases of ILC are difficult to detect using magnetic resonance imaging (MRI). Preoperative underestimation of nodal burden occurs more frequently in ILC than in invasive ductal carcinoma (IDC), however, the morphological assessment for metastatic ALNs of ILC have not fully been investigated. We hypothesized that the high false-negative rate in ILC is caused by the discrepancy in the MRI findings of ALN metastases between ILC and IDC and aimed to identify the MRI finding with a strong correlation with ALN metastasis of ILC. Method: This retrospective analysis included 120 female patients (mean ± standard deviation age, 57.2 ± 11.2 years) who underwent upfront surgery for ILC at a single center between April 2011 and June 2022. Of the 120 patients, 35 (29%) had ALN metastasis. Using logistic regression, we constructed prediction models based on MRI findings: primary tumor size, focal cortical thickening (FCT), cortical thickness, long-axis diameter (LAD), and loss of hilum (LOH). Results: The area under the curves were 0.917 (95% confidence interval [CI] 0.869-0.968), 0.827 (95% CI 0.758-0.896), 0.754 (95% CI 0.671-0.837), and 0.621 (95% CI 0.531-0.711) for the FCT, cortical thickness, LAD, and LOH models, respectively. Conclusions: FCT may be the most relevant MRI finding for ALN metastasis of ILC, and although its prediction model may lead to less underestimation of the nodal burden, rigorous external validation is required.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Breast Neoplasms/pathology ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology ; Carcinoma, Lobular/diagnostic imaging ; Carcinoma, Lobular/surgery ; Carcinoma, Lobular/pathology ; Retrospective Studies ; Carcinoma, Ductal, Breast/pathology ; Lymph Nodes/pathology ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-04-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-023-01457-2
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Article ; Online: Time-series blood cytokine profiles correlate with treatment responses in triple-negative breast cancer patients.

Saldajeno, Don Pietro / Kawaoka, Shinpei / Masuda, Norikazu / Tanaka, Sunao / Bando, Hiroko / Nishimura, Tomomi / Kadoya, Takayuki / Yamanaka, Takashi / Imoto, Shigeru / Velaga, Ravindranath M / Tamura, Nobuko / Aruga, Tomoyuki / Ikeda, Kazushi / Fukui, Yukiko / Maeshima, Yurina / Takada, Masahiro / Suzuki, Eiji / Ueno, Takayuki / Ogawa, Seishi /

Haga, Hironori / Ohno, Shinji / Morita, Satoshi / Kawaguchi, Kosuke / Toi, Masakazu

British journal of cancer

2024 Volume 130, Issue 6, Page(s) 1023–1035

Abstract: Background: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype. Partly due to its heterogeneity, it is currently challenging to stratify TNBC patients and predict treatment outcomes.: Methods: In this study, we ... ...

Abstract	Background: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype. Partly due to its heterogeneity, it is currently challenging to stratify TNBC patients and predict treatment outcomes. Methods: In this study, we examined blood cytokine profiles of TNBC patients throughout treatments (pre-treatment, during chemotherapy, pre-surgery, and 1 year after the surgery in a total of 294 samples). We analyzed the obtained cytokine datasets using weighted correlation network analyses, protein-protein interaction analyses, and logistic regression analyses. Results: We identified five cytokines that correlate with good clinical outcomes: interleukin (IL)-1α, TNF-related apoptosis-inducing ligand (TRAIL), Stem Cell Factor (SCF), Chemokine ligand 5 (CCL5 also known as RANTES), and IL-16. The expression of these cytokines was decreased during chemotherapy and then restored after the treatment. Importantly, patients with good clinical outcomes had constitutively high expression of these cytokines during treatments. Protein-protein interaction analyses implicated that these five cytokines promote an immune response. Logistic regression analyses revealed that IL-1α and TRAIL expression levels at pre-treatment could predict treatment outcomes in our cohort. Conclusion: We concluded that time-series cytokine profiles in breast cancer patients may be useful for understanding immune cell activity during treatment and for predicting treatment outcomes, supporting precision medicine. Trial registration: The study has been registered with the University Hospital Medical Information Network Clinical Trials Registry ( http://www.umin.ac.jp/ctr/index-j.htm ) with the unique trial number UMIN000023162. The association Japan Breast Cancer Research Group trial number is JBCRG-22. The clinical outcome of the JBCRG-22 study was published in Breast Cancer Research and Treatment on 25 March 2021. https://doi.org/10.1007/s10549-021-06184-w .
MeSH term(s)	Humans ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Cytokines/metabolism ; Chemokines ; Treatment Outcome ; Japan
Chemical Substances	Cytokines ; Chemokines
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-023-02527-0
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Article ; Online: A case of metaplastic carcinoma of the breast.

Tamura, Nobuko / Kinoshita, Takayuki

Japanese journal of clinical oncology

2011 Volume 41, Issue 8, Page(s) 1045

MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Carcinoma/diagnostic imaging ; Carcinoma/pathology ; Female ; Humans ; Mammography ; Middle Aged
Language	English
Publishing date	2011-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyr107
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Article ; Online: Reliability and validity of the Japanese version of the Chemotherapy-induced Alopecia Distress Scale.

Breast cancer (Tokyo, Japan)

2023 Volume 31, Issue 2, Page(s) 234–242

Abstract: Background: The Chemotherapy-induced Alopecia Distress Scale (CADS) is a patient-reported outcome measure for assessing distress associated with Chemotherapy-induced alopecia (CIA). This study aimed to confirm the psychometric validity of the Japanese ... ...

Abstract	Background: The Chemotherapy-induced Alopecia Distress Scale (CADS) is a patient-reported outcome measure for assessing distress associated with Chemotherapy-induced alopecia (CIA). This study aimed to confirm the psychometric validity of the Japanese version of the CADS (CADS-J). Methods: A total of 132 patients with breast cancer who developed CIA were asked to complete the CADS-J twice at 2 week intervals to confirm test-retest reliability. The body image domain of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) breast cancer-specific module, the self-esteem scale from the Rosenberg Self-Esteem Scale, and the emotional domain of the EORTC QLQ Core 30 were used to confirm the convergent validity of the CADS-J. The overall quality of life and physical domains of the EORTC QLQ Core 30 were used to confirm the discriminant validity of the CADS-J. Results: In total, 125 participants provided valid responses. The mean age was 52.2 years. The overall Cronbach's alpha for the CADS-J was 0.903. The intraclass correlation coefficients of the first and second responses were r = 0.874, r = 0.952, r = 0.911, and r = 0.959 for the physical domain, emotional domain, activity domain, and relationship domain, respectively. In terms of convergent validity, the total CADS-J score was moderately correlated with body image (r = - 0.63), self-esteem (r = - 0.48), and the emotional domain (r = - 0.61). Regarding discriminant validity, the total CADS-J score was weakly correlated with the overall quality of life (r = - 0.34) and physical domain (r = - 0.24). Conclusions: The CADS-J is psychometrically reliable and valid for evaluating the distress caused by CIA. It is expected to be used in daily practice and as an endpoint in various studies.
MeSH term(s)	Humans ; Middle Aged ; Female ; Quality of Life ; Breast Neoplasms/drug therapy ; Breast Neoplasms/psychology ; Reproducibility of Results ; Japan ; Alopecia/chemically induced ; Alopecia/diagnosis ; Alopecia/psychology ; Psychometrics/methods ; Antineoplastic Agents/adverse effects ; Surveys and Questionnaires
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-12-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-023-01528-4
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Article ; Online: The Role of Cardio-Ankle Vascular Index as a Predictor of Mortality in Patients on Maintenance Hemodialysis.

Murakami, Kouichi / Inayama, Emi / Itoh, Yukiko / Tuchiya, Shoji / Iwasaki, Masashi / Tamura, Nobuko / Suzuki, Toshihiko / Iwai, Noriko / Utino, Junji / Masai, Motoyuki / Nagayama, Daiji / Shirai, Kohji

Vascular health and risk management

2021 Volume 17, Page(s) 791–798

Abstract: Aim: Mortality rate of maintenance hemodialysis patients is known to be high. Cardio-ankle vascular index (CAVI) is an index reflecting the proper stiffness of the arterial tree from the origin of the aorta to the ankle. We aimed to clarify the utility ... ...

Abstract	Aim: Mortality rate of maintenance hemodialysis patients is known to be high. Cardio-ankle vascular index (CAVI) is an index reflecting the proper stiffness of the arterial tree from the origin of the aorta to the ankle. We aimed to clarify the utility of CAVI as a predictor of mortality in hemodialysis patients. The roles of age and nutritional conditions on survival were also examined. Methods: We followed 242 patients undergoing hemodialysis for 6 consecutive years. Data from 209 patients (mean age was 60 ± 11 years) excluding those with ankle-brachial index <0.90 were then analyzed. CAVI and heart to ankle pulse wave velocity (haPWV) were measured using Vasera 1500. Results: Thirty-eight hemodialysis patients who died during the 6-year period had higher age, cardiothoracic ratio (CTR), CAVI, and haPWV, and lower diastolic blood pressure, albumin, phosphate, and calcium phosphate product. The Kaplan-Meier curves for cumulative survival among the tertile groups showed that the mortality rate was higher in the highest tertile (T3) compared to T1/T2 for both CAVI and haPWV. Receiver operating characteristic (ROC) analysis revealed that CAVI had better discriminatory power for all-cause mortality compared to haPWV. In the Cox-proportional hazards analyses, 1 SD increase in both parameters contributed independently to all-cause mortality [CAVI: HR 1.595 (95% CI 1.108-2.297), haPWV: HR 1.695 (95% CI 1.185-2.425)], as well as age and CTR. Both parameters above the cut-offs estimated in the ROC analysis (CAVI ≥ 9.2, haPWV ≥ 8.9) also had independent contributions to mortality. Conclusion: Through the 6 consecutive years of follow-up in 209 HD patients, increased CAVI might represent a major modifiable risk factor for all-cause mortality. Further research is needed to examine whether CAVI-lowering interventions contribute to improved prognosis.
MeSH term(s)	Aged ; Ankle Brachial Index/methods ; Blood Pressure/physiology ; Cardio Ankle Vascular Index ; Female ; Humans ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Mortality ; Pulse Wave Analysis ; Renal Dialysis/adverse effects ; Renal Dialysis/mortality ; Vascular Stiffness
Language	English
Publishing date	2021-12-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/VHRM.S339769
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito