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  1. Article ; Online: Positive mental health in psychotherapy: a qualitative study from psychotherapists' perspectives.

    Chang, Sherilyn / Sambasivam, Rajeswari / Seow, Esmond / Subramaniam, Mythily / Ashok Assudani, Hanita / Tan, Geoffrey Chern-Yee / Lu, Sharon Huixian / Vaingankar, Janhavi Ajit

    BMC psychology

    2022  Volume 10, Issue 1, Page(s) 111

    Abstract: Background: There is growing evidence in the literature on the use of positive mental health (PMH) interventions among clinical samples. This qualitative study aims to explore the definitions of PMH from psychotherapists' perspectives, and to examine ... ...

    Abstract Background: There is growing evidence in the literature on the use of positive mental health (PMH) interventions among clinical samples. This qualitative study aims to explore the definitions of PMH from psychotherapists' perspectives, and to examine views and attitudes related to the construct.
    Methods: Focus group discussions were conducted with psychotherapists at a tertiary psychiatric institute. Focus group sessions were transcribed verbatim and transcripts were analyzed using an inductive thematic approach.
    Results: Five themes related to psychotherapists' definition of PMH were identified: (1) acceptance; (2) normal functioning and thriving in life; (3) resilience; (4) positive overall evaluation of life; (5) absence of negative emotions and presence of positive emotion states. Themes related to views and attitudes towards PMH were: (1) novel and valuable for psychotherapy; (2) reservations with terminology; (3) factors influencing PMH.
    Conclusion: PMH in psychotherapy is a multidimensional concept that means more than symptom management and distress reduction in clients. There is potential value for its application in psychotherapy practice, though some concerns need to be addressed before it can be well integrated.
    MeSH term(s) Focus Groups ; Humans ; Mental Health ; Psychotherapists ; Psychotherapy ; Qualitative Research
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705921-2
    ISSN 2050-7283 ; 2050-7283
    ISSN (online) 2050-7283
    ISSN 2050-7283
    DOI 10.1186/s40359-022-00816-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Transdiagnostic clustering of self-schema from self-referential judgements identifies subtypes of healthy personality and depression.

    Tan, Geoffrey Chern-Yee / Wang, Ziying / Tan, Ethel Siew Ee / Ong, Rachel Jing Min / Ooi, Pei En / Lee, Danan / Rane, Nikita / Tey, Sheryl Yu Xuan / Chua, Si Ying / Goh, Nicole / Lam, Glynis Weibin / Chakraborty, Atlanta / Yew, Anthony Khye Loong / Ong, Sin Kee / Kee, Jin Lin / Lim, Xin Ying / Hashim, Nawal / Lu, Sharon Huixian / Meany, Michael /
    Tolomeo, Serenella / Lee, Christopher Asplund / Tan, Hong Ming / Keppo, Jussi

    Frontiers in neuroinformatics

    2024  Volume 17, Page(s) 1244347

    Abstract: Introduction: The heterogeneity of depressive and anxiety disorders complicates clinical management as it may account for differences in trajectory and treatment response. Self-schemas, which can be determined by Self-Referential Judgements (SRJs), are ... ...

    Abstract Introduction: The heterogeneity of depressive and anxiety disorders complicates clinical management as it may account for differences in trajectory and treatment response. Self-schemas, which can be determined by Self-Referential Judgements (SRJs), are heterogeneous yet stable. SRJs have been used to characterize personality in the general population and shown to be prognostic in depressive and anxiety disorders.
    Methods: In this study, we used SRJs from a Self-Referential Encoding Task (SRET) to identify clusters from a clinical sample of 119 patients recruited from the Institute of Mental Health presenting with depressive or anxiety symptoms and a non-clinical sample of 115 healthy adults. The generated clusters were examined in terms of most endorsed words, cross-sample correspondence, association with depressive symptoms and the Depressive Experiences Questionnaire and diagnostic category.
    Results: We identify a 5-cluster solution in each sample and a 7-cluster solution in the combined sample. When perturbed, metrics such as optimum cluster number, criterion value, likelihood, DBI and CHI remained stable and cluster centers appeared stable when using BIC or ICL as criteria. Top endorsed words in clusters were meaningful across theoretical frameworks from personality, psychodynamic concepts of relatedness and self-definition, and valence in self-referential processing. The clinical clusters were labeled "Neurotic" (C1), "Extraverted" (C2), "Anxious to please" (C3), "Self-critical" (C4), "Conscientious" (C5). The non-clinical clusters were labeled "Self-confident" (N1), "Low endorsement" (N2), "Non-neurotic" (N3), "Neurotic" (N4), "High endorsement" (N5). The combined clusters were labeled "Self-confident" (NC1), "Externalising" (NC2), "Neurotic" (NC3), "Secure" (NC4), "Low endorsement" (NC5), "High endorsement" (NC6), "Self-critical" (NC7). Cluster differences were observed in endorsement of positive and negative words, latency biases, recall biases, depressive symptoms, frequency of depressive disorders and self-criticism.
    Discussion: Overall, clusters endorsing more negative words tended to endorse fewer positive words, showed more negative biases in reaction time and negative recall bias, reported more severe depressive symptoms and a higher frequency of depressive disorders and more self-criticism in the clinical population. SRJ-based clustering represents a novel transdiagnostic framework for subgrouping patients with depressive and anxiety symptoms that may support the future translation of the science of self-referential processing, personality and psychodynamic concepts of self-definition to clinical applications.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2023.1244347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparing feature selection and machine learning approaches for predicting

    Fong, Wei Jing / Tan, Hong Ming / Garg, Rishabh / Teh, Ai Ling / Pan, Hong / Gupta, Varsha / Krishna, Bernadus / Chen, Zou Hui / Purwanto, Natania Yovela / Yap, Fabian / Tan, Kok Hian / Chan, Kok Yen Jerry / Chan, Shiao-Yng / Goh, Nicole / Rane, Nikita / Tan, Ethel Siew Ee / Jiang, Yuheng / Han, Mei / Meaney, Michael /
    Wang, Dennis / Keppo, Jussi / Tan, Geoffrey Chern-Yee

    Frontiers in neuroinformatics

    2024  Volume 17, Page(s) 1244336

    Abstract: Introduction: Pharmacogenetics currently supports clinical decision-making on the basis of a limited number of variants in a few genes and may benefit paediatric prescribing where there is a need for more precise dosing. Integrating genomic information ... ...

    Abstract Introduction: Pharmacogenetics currently supports clinical decision-making on the basis of a limited number of variants in a few genes and may benefit paediatric prescribing where there is a need for more precise dosing. Integrating genomic information such as methylation into pharmacogenetic models holds the potential to improve their accuracy and consequently prescribing decisions. Cytochrome P450 2D6 (
    Methods: Buffy coat DNA methylation was quantified using the Illumina Infinium Methylation EPIC beadchip. CpG sites associated with
    Results: Overall, Elastic Net models of genetic features appeared to perform marginally better than heritability estimates and substantially better than Linear Regression and XGBoost models. The addition of nongenetic features appeared to improve performance for some but not all feature sets and probes. The best feature set and Machine Learning (ML) approach differed substantially between CpG sites and a number of top variables were identified for each model.
    Discussion: The development of SNP-based prediction models for CYP2D6 CpG methylation in Singaporean children of varying ethnicities in this study has clinical application. With further validation, they may add to the set of tools available to improve precision medicine and pharmacogenetics-based dosing.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2023.1244336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.

    Tan, Geoffrey Chern-Yee / Chu, Carlton / Lee, Yu Teng / Tan, Clarence Chih King / Ashburner, John / Wood, Nicholas W / Frackowiak, Richard Sj

    NeuroImage

    2020  Volume 221, Page(s) 117087

    Abstract: The androgen receptor (AR), oestrogen receptor alpha (ESR1) and oestrogen receptor beta (ESR2) play essential roles in mediating the effect of sex hormones on sex differences in the brain. Using Voxel-based morphometry (VBM) and gene sizing in two ... ...

    Abstract The androgen receptor (AR), oestrogen receptor alpha (ESR1) and oestrogen receptor beta (ESR2) play essential roles in mediating the effect of sex hormones on sex differences in the brain. Using Voxel-based morphometry (VBM) and gene sizing in two independent samples (discovery n ​= ​173, replication ​= ​61), we determine the common and unique influences on brain sex differences in grey (GM) and white matter (WM) volume between repeat lengths (n) of microsatellite polymorphisms AR(CAG)n, ESR1(TA)n and ESR2(CA)n. In the hypothalamus, temporal lobes, anterior cingulate cortex, posterior insula and prefrontal cortex, we find increased GM volume with increasing AR(CAG)n across sexes, decreasing ESR1(TA)n across sexes and decreasing ESR2(CA)n in females. Uniquely, AR(CAG)n was positively associated with dorsolateral prefrontal and orbitofrontal GM volume and the anterior corona radiata, left superior fronto-occipital fasciculus, thalamus and internal capsule WM volume. ESR1(TA)n was negatively associated with the left superior corona radiata, left cingulum and left inferior longitudinal fasciculus WM volume uniquely. ESR2(CA)n was negatively associated with right fusiform and posterior cingulate cortex uniquely. We thus describe the neuroanatomical correlates of three microsatellite polymorphisms of steroid hormone receptors and their relationship to sex differences.
    MeSH term(s) Adolescent ; Adult ; Aged ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/diagnostic imaging ; Estrogen Receptor alpha/genetics ; Estrogen Receptor beta/genetics ; Female ; Gray Matter/anatomy & histology ; Gray Matter/diagnostic imaging ; Humans ; Hypothalamus/anatomy & histology ; Hypothalamus/diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Microsatellite Repeats ; Middle Aged ; Neuroimaging ; Polymorphism, Genetic ; Receptors, Androgen/genetics ; Sex Characteristics ; White Matter/anatomy & histology ; White Matter/diagnostic imaging ; Young Adult
    Chemical Substances AR protein, human ; ESR1 protein, human ; ESR2 protein, human ; Estrogen Receptor alpha ; Estrogen Receptor beta ; Receptors, Androgen
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2020.117087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3664: Show issues Location:
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  5. Article: "We Are All Trying to Find a Way to Help Ourselves": A Look at Self-Help Strategies Among Psychotherapy Clients.

    Chang, Sherilyn / Sambasivam, Rajeswari / Seow, Esmond / Tan, Geoffrey Chern-Yee / Lu, Sharon Huixian / Assudani, Hanita / Chong, Siow Ann / Subramaniam, Mythily / Vaingankar, Janhavi Ajit

    Frontiers in psychology

    2021  Volume 12, Page(s) 621085

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2021-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.621085
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  6. Article: Effect of aripiprazole as an adjunct to atypical antipsychotics on weight and metabolic profile: a 12-week open-label trial.

    Gupta, Bhanu / Chee, Kok-Seng / Neo, Li-Qi / Tang, Charmaine / Hariram, Jayaraman / Tan, Geoffrey Chern-Yee / Verma, Swapna / Basu, Sutapa / Appan, Deva-Priya / Ting, Chan-Chun / Abdin, Edimansyah / Lee, Jimmy

    Therapeutic advances in psychopharmacology

    2021  Volume 11, Page(s) 20451253211046765

    Abstract: Background: Atypical antipsychotics are widely prescribed, yet have been associated with weight gain and metabolic syndrome.: Aim: To study the effect of adjunct low-dose aripiprazole on weight and metabolic parameters of subjects on atypical ... ...

    Abstract Background: Atypical antipsychotics are widely prescribed, yet have been associated with weight gain and metabolic syndrome.
    Aim: To study the effect of adjunct low-dose aripiprazole on weight and metabolic parameters of subjects on atypical antipsychotics (olanzapine, clozapine or risperidone).
    Methods: The study was carried out as an open-label trial with a fixed dose of 5 mg aripiprazole added to the patient's current antipsychotic for 12 weeks. The primary outcome measure was mean change in weight, while secondary outcome measures included change in waist circumference; fasting blood glucose; HbA1c; triglycerides; total, HDL and LDL cholesterol levels; functioning; and neurocognition.
    Results: For the overall study (
    Conclusions: The study adds support to the adjunctive use of aripiprazole to clozapine for weight loss and improvement in metabolic profile, and for reduction in cardiometabolic risk for patients on olanzapine.
    Trial registration: Clinicaltrials.gov identifier: NCT02949752.
    Language English
    Publishing date 2021-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2646542-5
    ISSN 2045-1261 ; 2045-1253
    ISSN (online) 2045-1261
    ISSN 2045-1253
    DOI 10.1177/20451253211046765
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  7. Article ; Online: Voxel-based morphometry reveals reduced grey matter volume in the temporal cortex of developmental prosopagnosics.

    Garrido, Lúcia / Furl, Nicholas / Draganski, Bogdan / Weiskopf, Nikolaus / Stevens, John / Tan, Geoffrey Chern-Yee / Driver, Jon / Dolan, Ray J / Duchaine, Bradley

    Brain : a journal of neurology

    2011  Volume 132, Issue Pt 12, Page(s) 3443–3455

    Abstract: Individuals with developmental prosopagnosia exhibit severe and lasting difficulties in recognizing faces despite the absence of apparent brain abnormalities. We used voxel-based morphometry to investigate whether developmental prosopagnosics show subtle ...

    Abstract Individuals with developmental prosopagnosia exhibit severe and lasting difficulties in recognizing faces despite the absence of apparent brain abnormalities. We used voxel-based morphometry to investigate whether developmental prosopagnosics show subtle neuroanatomical differences from controls. An analysis based on segmentation of T1-weighted images from 17 developmental prosopagnosics and 18 matched controls revealed that they had reduced grey matter volume in the right anterior inferior temporal lobe and in the superior temporal sulcus/middle temporal gyrus bilaterally. In addition, a voxel-based morphometry analysis based on the segmentation of magnetization transfer parameter maps showed that developmental prosopagnosics also had reduced grey matter volume in the right middle fusiform gyrus and the inferior temporal gyrus. Multiple regression analyses relating three distinct behavioural component scores, derived from a principal component analysis, to grey matter volume revealed an association between a component related to facial identity and grey matter volume in the left superior temporal sulcus/middle temporal gyrus plus the right middle fusiform gyrus/inferior temporal gyrus. Grey matter volume in the lateral occipital cortex was associated with component scores related to object recognition tasks. Our results demonstrate that developmental prosopagnosics have reduced grey matter volume in several regions known to respond selectively to faces and provide new evidence that integrity of these areas relates to face recognition ability.
    MeSH term(s) Adult ; Atrophy/congenital ; Atrophy/pathology ; Atrophy/physiopathology ; Brain Mapping ; Dominance, Cerebral/physiology ; Face ; Female ; Functional Laterality/physiology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pattern Recognition, Visual/physiology ; Prosopagnosia/pathology ; Prosopagnosia/physiopathology ; Social Behavior ; Temporal Lobe/pathology ; Temporal Lobe/physiopathology ; Visual Cortex/pathology ; Visual Cortex/physiopathology ; Visual Pathways/pathology ; Visual Pathways/physiopathology ; Visual Perception/physiology ; Young Adult
    Language English
    Publishing date 2011-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awp271
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    In stock of ZB MED Cologne/Königswinter

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